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Background: Labral repair has become the preferred method for the arthroscopic treatment of acetabular labral tears that are associated with femoroacetabular impingement (FAI) resulting in pain and dysfunction. Labral reconstruction is performed mainly in revision hip arthroscopy but can be utilized in the primary setting for absent or calcified labra. The purpose of this study was to compare the minimum 2-year patient-reported outcomes (PROs) and risk of revision or conversion to arthroplasty between primary labral reconstruction and primary labral repair. Methods: Patients with FAI who underwent primary hip arthroscopy with labral repair or reconstruction performed by the senior author between 2006 and 2018 were identified from a prospectively enrolled patient outcome registry. Exclusion criteria included confounding injuries, dysplasia, prior ipsilateral hip surgery, or a joint space of <2 mm. Patients who were 18 to 80 years old were eligible for inclusion. Multiple regression with inverse propensity score weighting was conducted to estimate the average treatment effect in the treated (ATT) for labral reconstruction versus labral repair with respect to postoperative PROs and the likelihood of subsequent surgery (revision hip arthroscopy or conversion to arthroplasty). PROend points included theHip Outcome Score Activities of Daily Living subscale (HOS-ADL), modified Harris hip score, Western Ontario and McMaster Universities Osteoarthritis Index total score (WOMAC), 12-Item Short Form Health Survey Physical Component Summary score (SF-12 PCS), and patient satisfaction. Results: A total of 150 hips undergoing primary labral reconstruction and 998 hips undergoing primary labral repair were included. The median follow-up time was 5.3 years in the reconstruction group and 5.8 years in the repair group. Compared with labral repair, labral reconstruction was associated with a higher risk of conversion to total hip arthroplasty (THA) (20% versus 7%; adjusted odds ratio, 3.2; 95% confidence interval [CI], 1.2 to 8.8; p = 0.024). Inverse propensity score-weighted multiple regression estimated a significant negative effect of labral reconstruction, relative to labral repair, on the postoperative values for the HOS-ADL (ATT, 23.3; 95% CI, 25.8 to 20.7; p = 0.012) and WOMAC (ATT, 2.6; 95% CI, 0.1 to 5.2; p = 0.044). Conclusions: Compared with primary labral reconstruction, primary labral repair resulted in better postoperative HOS-ADL and WOMAC values and decreased conversion to THA. These findings were demonstrated in both the unadjusted group comparisons and multivariable modeling. These data support the use of labral repair in the primary setting of labral tears and the reservation of labral reconstruction for more advanced labral pathology or for revision cases. [ABSTRACT FROM AUTHOR]

Accessible Summary: What is known on the subject: Peer research methodologies and methods are increasingly used in research, particularly to benefit from lived experiences.The experiences of peer researchers with severe mental illness are less common, including the impact on them of conducting peer‐led research. What the paper adds to existing knowledge: This paper shares the experience of peer research and suggests in the context of food insecurity, that it is not well understood by some healthcare professionals. What are the implications for practice: Implications include considerations around trauma‐informed care and the need for screening for food insecurity in mental healthcare settings. Research implications include providing training for peer research and needing to consider longevity of peer researcher relationships. Introduction: Food insecurity means that a person does not have access to sufficient nutritious food for normal growth and health. This can lead to health problems such as obesity, heart disease, diabetes and other long term chronic health conditions. People living with a severe mental illness are more likely to experience food insecurity than people without a severe mental illness. Aim: The aim of this paper is to present a lived experience narrative of two peer researchers. Peer researchers conducted interviews with adults with severe mental illness from Northern England as part of a funded research project. These interviews discussed experiences of food insecurity and strategies to tackle it and were conducted between March and December 2022. Thesis: The following paper does not discuss the results of the interviews themselves. Rather the narrative begins with an overview of peer research, before sharing the experiences of the two peer researchers in undertaking this project. Implications for Practice: This includes healthcare professionals understanding food insecurity, what it is and what it is not, thinking about trauma‐informed care, and screening for food insecurity. Peer research implications centre on adequate support and training, considerations to longevity of peer research relationships and reducing unnecessary research burden for peer researchers. [ABSTRACT FROM AUTHOR]

Background: Women with learning disabilities are less likely to access cervical and breast cancer screening when compared to the general population. The Social Ecological Model (SEM) was used to examine the inequalities faced by women with learning disabilities in accessing cervical and breast cancer screening in England, UK. Methods: The findings from a qualitative systematic review and a Q methodology study were triangulated. Framework analysis, in line with the SEM, was used to develop an integrated set of findings. Findings: Women with learning disabilities may lack knowledge of cancer symptoms, and cancer screening, as well as being scared about the process and getting the results. The attitudes of family and paid carers towards screening may influence women with learning disabilities' decisions as to whether screening is seen as favourable; support and training may ensure unbiased perspectives. Barriers were also associated with how cancer screening programmes are designed, such as postal invitations which assumes an ability to read. In addition, screening staff need to be aware of the general needs of people with learning disabilities, such as the benefits of easy‐to‐read documents. Lastly, multidisciplinary working is required so reasonable adjustments can be embedded into cancer screening pathways. Conclusion: This article highlights multiple methods to reduce the inequalities faced by women with learning disabilities, which can be achieved through reasonable adjustments. Embedding reasonable adjustments can support women with learning disabilities in making an informed decision and accessing screening if they choose to. This may result in women with learning disabilities getting a timely cancer diagnosis. Accessible Summary: Women with learning disabilities should be invited for checks to find out if they have cancer. Sometimes women with learning disabilities do not go for these checks, and we wanted to find out why.We found that women might not know about these checks or know what they will be asked to do in them. We found that women are also scared about going for the checks.Our results found there are a lot of things that can help women. Carers, nurses, and doctors can help women in knowing about the checks, and writing should have pictures to help women understand. Information can be given to women but these may not be routinely used.We found that women should be asked what can help them to go for the check. [ABSTRACT FROM AUTHOR]

Background: Violence within nighttime entertainment districts (NEDs) has been blamed on problematic masculinity and has predominantly been attributed to excessive alcohol intake and steroid use in men. In this report we conducted two studies to: (1) ascertain whether researchers could act as third-party raters of body weight and muscle mass in NED patrons; and (2) to examine the relationship between body self-image, inebriation, alcohol preloading behaviors and drug use in the NEDs. Methods: Study 1 employed an observational approach to establish inter-rater reliability for ratings of muscle mass and weight. In Study 2 data (n = 2,745) were collected through breathalyzing and questionnaires to examine individuals' self-image and drinking and drug-taking behaviors. Results: Participants' self-ratings of muscle and weight significantly differed from researchers' ratings, with males perceiving themselves as less muscular and females perceiving themselves as heavier. Perceived weight and muscle size did not relate to alcohol levels, but an interaction was found for female steroid users who perceived themselves as less muscular. Conclusions: Findings indicated a distortion in participants' perceived body image, with a desire for muscularity among both males and females. These results underscore the complex interplay between self-perception, societal ideals, and drug use in young NED patrons. [ABSTRACT FROM AUTHOR]

Six members of the 1,ω-bis(4-cyanobiphenyl-4′-yl) alkanes are reported and referred to as CBnCB in which n = 1, 15, 16, 17, 19 and 20 and indicates the number of methylene units in the spacer separating the two cyanobiphenyl units. The behaviour of CB3CB is revisited. The temperature dependence of the refractive indices, optical birefringence and dielectric permittivities measured in the nematic, N, phase for selected homologues are reported. The dimers with n ≥ 15 showed an enantiotropic N phase, and for the odd members the twist-bend nematic, NTB, phase was observed. CB3CB shows a direct NTB-isotropic, I, transition, whereas for CB1CB a virtual NTB-I transition is found. The temperature dependence of the bend elastic constant, K33, measured in the oblique helicoidal cholesteric state formed by mixtures of CBnCB with a chiral additive S811, shows strong non-monotonous behaviour with a deep minimum near the transition point to the NTB phase. The minimum value of ${K_{33}}$ K 33 decreases as n increases. The long even members of the CBnCB series show similar values of TNI to their odd-membered counterparts, but their estimated values of TNTBN are considerably lower. This is attributed to molecular shape and its effect on K33. [ABSTRACT FROM AUTHOR]

In 2011, the Government of Québec, Canada announced an ambitious twenty-five-year plan to develop the province's northern region—an area nearly twice the size of France. A centrepiece of the Plan Nord is to integrate the province's various Indigenous peoples in the sustainable development of the region. However, there are early warning signs of the potential for future conflict as some Indigenous groups mobilized opposition against proposed developments. This raises important questions: could the plan enhance prospects for improved cooperation between Indigenous peoples and non-Indigenous groups or is it likely to engender conflict? Which factors explain the diverging levels of support for the plan between the region's principal Indigenous peoples (i.e. Cree, Inuit, Innu)? The paper uses the 'sons of the soil' (SoS) conflict framework to theorize the mechanisms that can give rise to—or prevent the escalation of—Indigenous and non-Indigenous conflict in northern Québec. Though typically applied to case studies in the Global South, the SoS conflict framework provides a novel approach for understanding the contentious politics surrounding land, territory, and natural resource development in settler-colonial contexts. [ABSTRACT FROM AUTHOR]

Evidence accumulation models (EAMs) have become the dominant theoretical framework for rapid decision-making, and while many theoretically distinct variants exist, comparisons have proved challenging due to strong mimicry in their predictions about choice response time data. One solution to reduce mimicry is constraining these models with double responses, which are a second response that is made after the initial response. However, instructing participants that they are allowed to change their mind could influence their strategy for initial responding, meaning that explicit double responding paradigms may not generalise to standard paradigms. Here, we provide a validation of explicit double responding paradigms, by assessing whether participants' initial decisions – as measured by diffusion model parameters – differ based on whether or not they were instructed that they could change their response after their initial response. Across three experiments, our results consistently indicate that allowing for changes of mind does not influence initial responses, with Bayesian analyses providing at least moderate evidence in favour of the null in all cases. Our findings suggest that explicit double responding paradigms should generalise to standard paradigms, validating the use of explicit double responding in future rapid decision-making studies. [ABSTRACT FROM AUTHOR]

Advanced hybrid closed-loop (AHCL) therapy with the Medtronic MiniMed™ 780G system improves glycemia; however, the clinical outcomes in younger children remain less established. This pilot study aimed to explore the continuous glucose monitoring (CGM) metrics in very young children on AHCL. Children between 2 and 7 years of age and on insulin pump therapy were recruited. A 2-week phase in manual mode was followed by a 6-week AHCL phase. CGM metrics were analyzed to review glycemic outcomes. Out of 11 participants enrolled [mean (standard deviation [SD]) age 5.3 (0.8) years], 10 completed the study. Time in closed loop was 96.7 (3.9)%. In AHCL, participants had a mean (SD) time in range of 72.6 (7.4)% and spent 3.0 (1.74)% and 0.63 (0.46)% in time <70 and <54 mg/dL, respectively. AHCL is a feasible option for management of young children with type 1 diabetes. [ABSTRACT FROM AUTHOR]

Sea ice topography information can be obtained from altimetry but these data are spatially and temporally limited compared to recent synthetic aperture radar (SAR) missions such as the RADARSAT Constellation Mission (RCM). We analyze the relationship between sea ice roughness and height obtained from three Ice, Cloud, and Land Elevation Satellite (ICESat)‐2 tracks on two dates in March 2022, with RCM backscatter from 17 images in the McClintock Channel, Canadian Arctic. We analyze how this relationship varies with ice type, polarization, and incidence angle. We find particularly notable relationships between sea ice roughness and horizontal‐transmit/vertical‐receive backscatter for first‐year ice, and sea ice height and backscatter for multi‐year ice. We develop a preliminary model for winter sea ice roughness retrieval using RCM. In comparison with independent ICESat‐2 data in our study region, we find the model performs effectively at estimating a roughness distribution and key roughness statistics, and characterizes spatial variations in roughness at a sub‐kilometer scale. Plain Language Summary: Sea ice topography estimates are important for improving ocean‐climate models, understanding sea ice evolution, and planning ice travel. Estimates can be obtained from altimetry missions, but these data are spatially and/or temporally limited compared to recent synthetic aperture radar missions such as the C‐band RADARSAT Constellation Mission (RCM). By comparing RCM backscatter with measurements of height and roughness obtained using Ice, Cloud, and Land Elevation Satellite (ICESat)‐2 in the Canadian Arctic, we demonstrate the potential for using RCM to estimate sea ice topography. We show there is a notable relationship between sea ice roughness and backscatter on first‐year ice in late winter, particularly in the horizontal‐transmit/vertical‐receive channel, and a notable relationship between sea ice height and backscatter on multi‐year ice. We also observe that the relationship between the RCM signal and roughness varies with incidence angle. Based on this analysis we develop a preliminary model for winter sea ice roughness retrieval using RCM. In comparison with ICESat‐2 data, we find the model performs effectively at estimating key roughness statistics, and characterizes spatial variations in roughness at a sub‐kilometer scale. These findings will facilitate the use of RCM to validate geophysical models, map rough areas of ice, assess ice evolution and develop new topographic models. Key Points: Sea ice roughness measured by Ice, Cloud, and Land Elevation Satellite (ICESat)‐2 and horizontal‐transmit/vertical‐receive RADARSAT Constellation Mission (RCM) backscatter exhibit a notable relationship on late‐winter first‐year iceSea ice height, as measured by ICESat‐2, and RCM backscatter exhibit a notable relationship on late‐winter multi‐year iceWe develop/validate a model, based on comparison with ICESat‐2 data, for estimating sea ice roughness using RCM backscatter in the Arctic [ABSTRACT FROM AUTHOR]

We investigated the relationship between preloading motivations, alcohol consumption, intoxication, and alcohol related harms (ARHs), sampled in a night-time entertainment district (NED). The sample comprised 2,159 (1,109 males; 1,050 females) patrons entering Brisbane NEDs (Queensland, Australia) on Thursday, Friday, and Saturday nights between 9:00 pm and 1:00 am. We measured the patrons primary preloading motivations, their estimations of standard drinks consumed at preloading, their level of alcohol intoxication by breathalyser and their past experience of ARHs in the NED. 'Socialising' (29.98%) and 'saving money' (25.17%) were the most prominent preloading motivations followed by 'multiple' motivations (12.52%), and then by emotional motivations (2.46–4.02%). Minor significant differences were observed between preloading motivations in alcohol intoxication, but not for alcohol consumption. 'Get as drunk as possible' and 'feel comfortable/relaxed' preloading motivations were associated with higher occurrences of past ARHs. Individuals who preload often exceed recommended drinking guidelines to prevent ARHs before the night-out begins. Our findings suggest that it is the emotionally motivated alcohol consumers who are more likely to have experienced past harms in the NED. Implications for theoretical developments of preloading and the prevention of harmful preloading are discussed. [ABSTRACT FROM AUTHOR]

Generalized pustular psoriasis (GPP) is a form of pustular psoriasis that is distinguished by recurring or persistent outbreaks of non‐acral primary sterile pustules. These eruptions can occur with or without systemic inflammation. Various factors, such as medications, stress and viral infection, have been identified as potential triggers for GPP flares. While several cases have detailed GPP‐like eruptions in the setting of coronavirus disease 2019 (COVID‐19) infection, few have explored the interplay between infection and biologic use in the development of GPP. In this case, we detail the history and management of a 45‐year‐old male patient with a prior history of spondyloarthropathy managed on a tumour necrosis factor‐α inhibitor and recent COVID‐19 infection presenting with a new, spreading pustular rash. [ABSTRACT FROM AUTHOR]

Changes to the spatiotemporal patterns of wildfire are having profound implications for ecosystems and society globally, but we have limited understanding of the extent to which fire regimes will reorganize in a warming world. While predicting regime shifts remains challenging because of complex climate–vegetation–fire feedbacks, understanding the climate niches of fire regimes provides a simple way to identify locations most at risk of regime change. Using globally available satellite datasets, we constructed 14 metrics describing the spatiotemporal dimensions of fire and then delineated Australia's pyroregions—the geographic area encapsulating a broad fire regime. Cluster analysis revealed 18 pyroregions, notably including the (1) high‐intensity, infrequent fires of the temperate forests, (2) high‐frequency, smaller fires of the tropical savanna, and (3) low‐intensity, diurnal, human‐engineered fires of the agricultural zones. To inform the risk of regime shifts, we identified locations where the climate under three CMIP6 scenarios is projected to shift (i) beyond each pyroregion's historical climate niche, and (ii) into climate space that is novel to the Australian continent. Under middle‐of‐the‐road climate projections (SSP2‐4.5), an average of 65% of the extent of the pyroregions occurred beyond their historical climate niches by 2081–2100. Further, 52% of pyroregion extents, on average, were projected to occur in climate space without present‐day analogues on the Australian continent, implying high risk of shifting to states that also lack present‐day counterparts. Pyroregions in tropical and hot‐arid climates were most at risk of shifting into both locally and continentally novel climate space because (i) their niches are narrower than southern temperate pyroregions, and (ii) their already‐hot climates lead to earlier departure from present‐day climate space. Such a shift implies widespread risk of regime shifts and the emergence of no‐analogue fire regimes. Our approach can be applied to other regions to assess vulnerability to rapid fire regime change. [ABSTRACT FROM AUTHOR]

Proteostasis ensures the proper synthesis, folding, and trafficking of proteins and is required for cellular and organellar homeostasis. This network also oversees protein quality control within the cell and prevents accumulation of aberrant proteins, which can lead to cellular dysfunction and disease. For example, protein aggregates irreversibly disrupt proteostasis and can exert gain-of-function toxic effects. Although this process has been examined in detail for cytosolic proteins, how endoplasmic reticulum (ER)-tethered, aggregation-prone proteins are handled is ill-defined. To determine how a membrane protein with a cytoplasmic aggregation-prone domain is routed for ER-associated degradation (ERAD), we analyzed a new model substrate, TM-Ubc9ts. In yeast, we previously showed that TM-Ubc9ts ERAD requires Hsp104, which is absent in higher cells. In transient and stable HEK293 cells, we now report that TM-Ubc9ts degradation is largely proteasome-dependent, especially at elevated temperatures. In contrast to yeast, clipped TM-Ubc9ts polypeptides, which are stabilized upon proteasome inhibition, accumulate and are insoluble at elevated temperatures. TM-Ubc9ts cleavage is independent of the intramembrane protease RHBDL4, which clips other classes of ERAD substrates. These studies highlight an unappreciated mechanism underlying the degradation of aggregation-prone substrates in the ER and invite further work on other proteases that contribute to ERAD. [ABSTRACT FROM AUTHOR]

Music interventions in medicine have been shown to reduce anxiety and depression, decrease pain, and improve quality of life; however, a review of clinical music interventions in dermatology is lacking. Studies have shown that playing music for patients undergoing dermatologic procedures (Mohs surgery and anesthetic injections) can decrease pain and anxiety. Patients with pruritic conditions—such as psoriasis, neurodermatitis, atopic dermatitis, contact eczema, and situations requiring hemodialysis—have exhibited decreased levels of disease burden and pain when listening to preferred music, pre-chosen music, and live music. Studies suggest that listening to certain types of music may also alter serum cytokines, affecting the allergic wheal response. Additional research is necessary to determine the full potential and practical applications for clinical music interventions in dermatology. Future research should focus on targeting skin conditions that may benefit from the psychological, inflammatory, and immune effects of music. [ABSTRACT FROM AUTHOR]

As a medium-resolution multi-temporal data source, Sentinel-2 data has the potential to match the performance of using very-high-resolution (VHR) images in deep learning applications. To fully leverage the multi-temporal nature of Sentinel-2 data, we introduce the Deep Seasonal Network (DeepSN). This composite architecture combines a pre-trained deep convolutional neural network (DCNN) for visual feature extraction with a long short-term memory (LSTM) model to capture temporal information and make classification predictions. We evaluate the effectiveness of DeepSN on a Maasai Boma classification task in the Tanzania region. The DeepSN takes a sequence of four seasonal data, each spanning three months, for Boma prediction. Through cross-season validation experiments, we compare various advanced DCNNs and select EfficientNet as the backbone for DeepSN, as it performs the best. DeepSN with an EfficientNet backbone achieves a significant 19% improvement in the F1 score compared to plain EfficientNet for the Boma classification task. This work introduces a versatile composite architecture capable of handling multi-temporal data efficiently, providing flexibility in choosing the most suitable feature extraction backbone. The performance of DeepSN demonstrates the viability of utilizing medium-resolution multi-temporal data instead of high-resolution images for diverse tasks. [ABSTRACT FROM AUTHOR]

This paper summarizes recent work on the possible gravitational-wave signal from binary neutron-star mergers in which there is a crossover transition to quark matter. Although this is a small piece of a much more complicated problem, we discuss how the power spectral density function may reveal the presence of a crossover transition to quark matter. [ABSTRACT FROM AUTHOR]

City leaders around the world are setting ambitious targets for emissions reductions. Yet the pathway to achieving this remains largely unspecified. Starting with this objective, the paper explores the merits of deploying a mission-oriented framework within the context of a 'wicked problem' by looking at a mid-sized city, Glasgow, which has a target for net zero by 2030. Focusing on themes drawn from one high-emitting sector – transport – the paper points to the real-world policy implications that stem from such a mission-oriented approach to suggest aspects of the approach that may be usefully developed further. The latter hinges on a-priori considerations given to: agency, boundaries and inter-temporality, leading to questions about the nature and scope of wickedness and argues that core issues of wickedness – uncertainty, contestation and complexity – can be amplified in local and multi-layered policy making contexts. Key policy insights Many cities are looking to reduce emissions including establishing net zero targets and a mission-oriented framework – 'concrete targets within a challenge that act as frames and stimuli for innovation' (Mazzucato and Dibb, 2019) – has been a popular framing vehicle. Such a framework reveals challenges inherent in such a 'wicked problem' at urban scales, which are interwoven with regional and national issues, institutions and influences. Exploring these for Glasgow, which hosted COP26, we highlight the policy 'problem' and 'solution' space for mid-sized cities more generally. We highlight three dimensions that reflect the nature of the urban decarbonization challenge: agency – the responsibilities of various actors in delivering change; boundaries – the interactions between actions to reduce emissions alongside wider policy ambitions such as a 'Just Transition' and 'green jobs'; and intertemporal issues – including how ambitions for rapid change might interact with the glacial progress of structural policy change. [ABSTRACT FROM AUTHOR]

Background: Nighttime entertainment districts attract many people who pre-load with alcohol and other substances before entering licensed venues. Despite the harms and dangers associated with both alcohol pre-loading and drug use respectively, there is a paucity of research on drug and polysubstance pre-loading. Objectives: The primary objectives of this scoping review are to systematically map out the body of existing literature on drug and polysubstance pre-loading, discuss methodological potentials and pitfalls in field-based research, identify gaps in knowledge, and derive practical implications and opportunities for future research. Methods: Using the PRISMA (ScR) guidelines, we conducted a search of Medline, PsycINFO, Embase, Scopus, CINAHL, Social Services Abstracts, Sociological Abstracts, and Web of Science databases. We followed this up by conducting an author and citation analysis of relevant articles. Results: Of the 632 data sources identified, 338 articles were reviewed after removing duplicates. Overall, only nine articles were included and thematically analyzed. In our review and analysis of the literature, we find people who drug pre-load to be a particularly vulnerable subset of the population. We also posit that the point-of-entry design has greater sensitivity than the commonly used portal-in design. From this, we also draw attention to various time points where field-based researchers can provide intervention. Conclusions: Given the high prevalence of young adults engaging in the behavior, clinicians should consider pre-loading behaviors when assessing for risk and vulnerability. Field-based research would elucidate the full breadth and scope of the growing pre-loading phenomenon and the dangers associated with this practice. [ABSTRACT FROM AUTHOR]

Continuous glucose monitoring (CGM) systems are used in therapeutic decisions for diabetes management, however, the impact of body composition on CGM accuracy is not known. Body composition variables (body mass index [BMI], midarm circumference, percentage fat, and impedance) were collected in an observational study designed to determine the accuracy of an investigational Medtronic Guardian™ sensor 3. Seven days of sensor glucose data were analyzed from 112 participants >7 years of age with mean BMI Z score 0.48 (<18 years) and BMI 26.7 kg/m2 (≥18 years). The outcome was the absolute relative difference between the sensor and blood glucose readings. Data were analyzed using generalized estimating equations to account for correlation between repeated measures. No statistically significant associations between measures of body composition and device accuracy were found. Body composition does not have a meaningful impact on the accuracy of CGM systems. [ABSTRACT FROM AUTHOR]

Greenhouse gas (GHG) accounting of emissions from land use, land-use change, and forestry necessarily involves consideration of landscape fire. This is of particular importance for Australia given that natural and human fire is a common occurrence, and many ecosystems are adapted to fire, and require periodic burning for plant regeneration and ecological health. Landscape fire takes many forms, can be started by humans or by lightning, and can be managed or uncontrolled. We briefly review the underlying logic of greenhouse gas accounting involving landscape fire in the 2020 Australian Government GHG inventory report. The treatment of wildfire that Australia chooses to enact under the internationally agreed guidelines is based on two core assumptions (a) that effects of natural and anthropogenic fire in Australian vegetation carbon stocks are transient and they return to the pre-fire level relatively quickly, and (b) that historically and geographically anomalous wildfires in forests should be excluded from national anthropogenic emission estimates because they are beyond human control. It is now widely accepted that anthropogenic climate change is contributing to increased frequency and severity of forest fires in Australia, therefore challenging assumptions about the human agency in fire-related GHG emissions and carbon balance. Currently, the national inventory focuses on forest fires; we suggest national greenhouse gas accounting needs to provide a more detailed reporting of vegetation fires including: (a) more detailed mapping of fire severity patterns; (b) more comprehensive emission factors; (c) better growth and recovery models from different vegetation types; (d) improved understanding how fires of different severities affect carbon stocks; and (e) improved analysis of the human agency behind the causes of emissions, including ignition types and fire-weather conditions. This more comprehensive accounting of carbon emissions would provide greater incentives to improve fire management practices that reduce the frequency, severity, and extent of uncontrolled landscape fires. [ABSTRACT FROM AUTHOR]

The phenomenon of youth preloading with alcohol is related to increased rates of assault, injury and arrest. We have no empirical, field-based, research on the impact of preloading and alcohol use at a large-scale public event. Random samples of patrons were breathalysed (BrAC) on entry and exit of a horse racing/music event (n = 286), and questioned regarding their preloading, spending, and group characteristics. 79% of participants sampled at entry and 85% at exit reported preloading prior to the event. Of those who preloaded, 87% were observed to have BrAC readings over zero (with a mean BrAC of.071 at a median time of day of 12.29 pm). No differences were found between genders on preloading or BrAC at entry. Group size was found to explain 9% of the unique variance in entry BrAC. Those patrons who preloaded had significantly higher BrAC at exit, with preloading accounting for almost identical variance to the number of reported drinks consumed within the venue. Preloading at large-scale public events is highly endorsed by both male and female youth and is associated with a pattern of continued drinking throughout the course of the event. Interventions to manage risk are suggested. [ABSTRACT FROM AUTHOR]

Objective: To explore the impact of missing data on the accuracy of continuous glucose monitoring (CGM) metrics collected for a 2-week period in a clinical trial. Research Design and Methods: Simulations were conducted to examine the effect of various patterns of missingness on the accuracy of CGM metrics as compared with a "complete" data set. The proportion of missing data, the "block size" in which the data were missing, and the missing mechanism were modified for each "scenario." The degree of agreement between simulated and "true" glycemic measures under each scenario was presented as R2. Results: Under all missing patterns, R2 declined as the proportion of missing data increased, however, as the "block size" of missing data increased, the percentage of missing data had a more pronounced effect on the agreement between measures. For a 14-day CGM data set to be considered representative for percentage time in range (%TIR), at least 70% of CGM data should be available over at least 10 days (R2 > 0.9). Skewed outcome measures, such as percentage time below range and coefficient of variation, were more affected by missing data than the less skewed measures (%TIR, percentage time above range, mean glucose). Conclusions: Both the degree and pattern of missing data impact upon the accuracy of recommended CGM-derived glycemic measures. In planning research, an understanding of patterns of missing data in the study population is required to gauge the likely effects of missing data on outcome accuracy. Trial registration number: Australian New Zealand Clinic Trials Registry ACTRN12616000753459. [ABSTRACT FROM AUTHOR]

The synthesis and characterisation of four series of symmetric liquid crystal dimers containing either alkylthio or alkyloxy terminal chains are reported. The (E,E)-[pentane-1,5-diylbis(oxy-4,1-phenylene)]bis{N-[4-(alkyloxy)phenyl]methanimine}s, mO.O5O.Om and (E,E)-[hexane-1,6-diylbis(oxy-4,1-phenylene)]bis{N-[4-(alkyloxy)phenyl]methanimine}s, mO.O6O.Om series are nematogenic when the terminal chains are short whereas the higher homologues show the smectic A phase. The mO.O6O.Om series shows higher clearing temperatures regardless of the terminal chain length. The (E,E)-[pentane-1,5-diylbis(oxy-4,1-phenylene)]bis{N-[(alkylthio)phenyl]methanimine}s, mS.O5O.Sm series is solely nematogenic, and does not show liquid crystallinity when m ≥ 5. The (E,E)-[hexane-1,6-diylbis(oxy-4,1-phenylene)]bis{N-[(alkylthio)phenyl]methanimine}s, mS.O6O.Sm series, however, shows mesogenic behavior over the entire series, with the smectic C phase only emerging when the terminal chain is long, m ≥ 8. In general, for a given spacer length, the dimers containing alkyloxy chains show the highest clearing temperatures and the alkylthio chains the lowest. For the shortest terminal chains, however, the nematic–isotropic transition temperatures of the alkylthio materials are higher than those containing the alkyl chain. This behaviour is rather general and discussed in terms of steric and electronic interactions. [ABSTRACT FROM AUTHOR]

Polynyas are key sites of ice production during the winter and are important sites of biological activity and carbon sequestration during the summer. The Amundsen Sea Polynya (ASP) is the fourth largest Antarctic polynya, has recorded the highest primary productivity, and lies in an embayment of key oceanographic significance. However, knowledge of its dynamics, and of sub-annual variations in its area and ice production, is limited. In this study we primarily utilize Sentinel-1 synthetic aperture radar (SAR) imagery, sea ice concentration products, and climate reanalysis data, along with bathymetric data, to analyze the ASP over the period November 2016–March 2021. Specifically, we analyze (i) qualitative changes in the ASP's characteristics and dynamics, as well as quantitative changes in (ii) summer polynya area, and (iii) winter polynya area and ice production. From our analysis of SAR imagery we find that ice produced by the ASP becomes stuck in the vicinity of the polynya and sometimes flows back into the polynya, contributing to its closure and limiting further ice production. The polynya forms westward off a persistent chain of grounded icebergs that are located at the site of a bathymetric high. Grounded icebergs also influence the outflow of ice and facilitate the formation of a "secondary polynya" at times. Additionally, unlike some polynyas, ice produced by the polynya flows westward after formation, along the coast and into the neighboring sea sector. During the summer and early winter, broader regional sea ice conditions can play an important role in the polynya. The polynya opens in all summers, but record-low sea ice conditions in 2016/17 cause it to become part of the open ocean. During the winter, an average of 78 % of ice production occurs in April–May and September–October, but large polynya events often associated with high, southeasterly or easterly winds can cause ice production throughout the winter. While passive microwave data or daily sea ice concentration products remain key for analyzing variations in polynya area and ice production, we find that the ability to directly observe and qualitatively analyze the polynya at a high temporal and spatial resolution with Sentinel-1 imagery provides important insights about the behavior of the polynya that are not possible with those datasets. [ABSTRACT FROM AUTHOR]

Condensation of 2‐vinylanilines and conjugated aldehydes followed by an efficient light‐mediated cyclisation selectively yields either substituted tetrahydroquinolines with typically high dr, or in the presence of an iridium photocatalyst the synthesis of quinoline derivatives is demonstrated. These atom economical processes require mild conditions, with the substrate scope demonstrating excellent site selectivity and functional group tolerance, including azaarene‐bearing substrates. A thorough experimental mechanistic investigation explores multiple pathways and the key role that imine and iminium intermediates play in the absorption of visible light to generate reactive excited states. The synthetic utility of the reactions is demonstrated on gram scale quantities in both batch and flow, alongside further manipulation of the medicinally relevant products. [ABSTRACT FROM AUTHOR]

Condensation of 2‐vinylanilines and conjugated aldehydes followed by an efficient light‐mediated cyclisation selectively yields either substituted tetrahydroquinolines with typically high dr, or in the presence of an iridium photocatalyst the synthesis of quinoline derivatives is demonstrated. These atom economical processes require mild conditions, with the substrate scope demonstrating excellent site selectivity and functional group tolerance, including azaarene‐bearing substrates. A thorough experimental mechanistic investigation explores multiple pathways and the key role that imine and iminium intermediates play in the absorption of visible light to generate reactive excited states. The synthetic utility of the reactions is demonstrated on gram scale quantities in both batch and flow, alongside further manipulation of the medicinally relevant products. [ABSTRACT FROM AUTHOR]

The classic variant consisted of Touton giant cells and vacuolated mononuclear cells, while the transitional variant consisted of non-Touton giant cells with admixed vacuolated mononuclear cells and spindled cells. Keywords: foam cells; histiocytes; juvenile xanthogranuloma; papular xanthoma; xanthomatosis EN foam cells histiocytes juvenile xanthogranuloma papular xanthoma xanthomatosis 1 7 7 01/02/23 20230101 NES 230101 Papular xanthoma is a rare clinical entity with 53 cases previously reported in the literature. Papular xanthoma and JXG were considered the histopathologic differential diagnosis, and papular xanthoma was ultimately favored given the histopathologic findings. [Extracted from the article]

The General Aggression Model is one of the major frameworks that studies use to conceptualise the relationship between violent video games and aggression. Although commonly used, this model incorporates important personological and media characteristics into its formulation at a minimal level. As such, the purpose of the current research was to investigate the effect of four media types (violent video game, non-violent video game, violent book, and violent television show) on state anger and behavioural aggression. Analysis revealed no differences in state anger and behavioural aggression between the four media types. Regression analysis suggests that individuals with higher levels of impulsivity, increased emotional reactivity to the media, and frustration with the content of the media are more likely to have a higher state anger response to media exposure. Behavioural aggression was higher for those participants less disturbed by the media and with higher trait anger. Overall, these results suggest that personality and frustration are better predictors of anger and aggression in the context of media exposure. Implications for models of media aggression (such as the Immersive Media Prediction model) and future research are discussed. [ABSTRACT FROM AUTHOR]

This article describes the state of psychology and mental health in Belize. The article first provides a capsule description of the sociohistorical context of Belize, including history, geography, demographics, and human development level. Next, the article describes several salient societal challenges in Belize, including crime, unemployment, natural disasters, and family/gender-based violence. The article then proceeds to describe the history of mental health care in Belize, including notable psychologists, psychiatrists, and facilities, as well as training programs and modes of service provision. The article also describes recent efforts at development and modification of psychometric assessment tools relevant for use in Belize for diagnostic, educational, and clinical purposes. Finally, some attention is devoted to discussion of the role of traditional healing modalities and practitioners, and integration with allopathic practitioners. The article concludes by summarizing both enduring challenges and recent progress related to mental health in Belize. [ABSTRACT FROM AUTHOR]

Objectives: To understand knowledge of, attitudes towards and decision‐making around cervical and breast cancer screening in women with learning disabilities, family carers and paid carers. Methods: A Q methodology study involving 13 women with learning disabilities, three family carers and five paid care workers, from the North‐East of England. A Q‐sort of 28 statements was completed with all participants completing a post‐Q‐sort interview to understand the reason behind the card placements. Factor analysis was completed using PQMethod and interpreted using framework analysis. Results: Factor 1, named 'Personal choice and ownership', explores how women with learning disabilities want to be supported to make their own decision to attend cancer screening and explored their preferred support needs. Factor 2, named 'Protecting vs. enablement', portrayed the battle family carers and paid care workers felt to protect women with learning disabilities from harm, whilst feeling that they were supporting women with learning disabilities to decide to attend cancer screening. Eight consensus statements were identified indicating a shared perspective. Conclusions: Cancer screening services should ensure that women with learning disabilities are supported to make informed decisions to attend cancer screening and then be further supported throughout the cancer pathway. [ABSTRACT FROM AUTHOR]

Why does respect for persons involves accepting that persons have responsibilities, and not just authority, for their lives and interactions? I show how we can answer this question with a role-based view: respect for persons is an attitude of recognizing others for a social role they occupy. To fill in a role-based view, we need to describe the practice into which the pertinent role figures. To do this, my account draws on the Rousseauian idea of inflamed amour-propre. Roughly, respect for persons is an attitude of recognizing persons for the role they occupy in a social practice that helps solve the problem of inflamed amour-propre. [ABSTRACT FROM AUTHOR]

A neglected dimension of the fire regime concept is fire patchiness. Habitat mosaics that emerge from the grain of burned and unburned patches (pyrodiversity) are critical for the persistence of a diverse range of plant and animal species. This issue is of particular importance in frequently burned tropical Eucalyptus savannas, where coarse fire mosaics have been hypothesized to have caused the recent drastic population declines of small mammals. Satellites routinely used for fire mapping in these systems are unable to accurately map fine-grained fire mosaics, frustrating our ability to determine whether declines in biodiversity are associated with local pyrodiversity. To advance this problem, we have developed a novel method (we call 'double-differenced dNBR') that combines the infrequent (c. 16 days) detailed spatial resolution Landsat with daily coarse scale coverage of MODIS and VIIRS to map pyrodiversity in the savannas of Kakadu National Park. We used seasonal Landsat mosaics and differenced normalized burn ratio (dNBR) to define burned areas, with a modification to dNBR that subtracts long-term average dNBR to increase contrast. Our results show this approach is effective in mapping fine-scale fire mosaics in the homogenous lowland savannas, although inappropriate for nearby heterogenous landscapes. Comparison of this methods to other fire metrics (e.g., area burned, seasonality) based on Landsat and MODIS imagery suggest this method is likely accurate and better at quantifying fine-scale patchiness of fire, albeit it demands detailed field validation. [ABSTRACT FROM AUTHOR]

The article provides an assessment and overview of the life's work and career of Robert Levine, the leading psychologist anthropologist. His personal biography, awards, career, and accomplishments are described, along with his professional contributions. Special attention is devoted to his contributions to the cross-cultural examination of human development, including his advocacy and thinking regarding the utilization of mixed methods (qualitative and quantitative) and multidisciplinary (e.g., psychology, anthropology, demography, sociology, psychiatry, psychoanalytic) approaches. Attention is also given to description of his contributions to the history of psychological anthropology, to the intersection of culture and psyche, to person-centered studies of the Gusii in Kenya, and to comparative studies of human development, in India, Asia, Africa, and beyond. A critical assessment of the relevance of his fifty year career for culture and psychology today is offered. [ABSTRACT FROM AUTHOR]

Colonialism has disrupted Indigenous socioecological systems around the globe, including those supported by intentional landscape burning. Because most disruptions happened centuries ago, our understanding of Indigenous fire management is largely inferential and open to debate. Here, we investigate the ecological consequences of the loss of traditional Aboriginal fire management on fire-exposed savannas on the Arnhem Plateau, northern Australia, using the fire-sensitive conifer Callitris intratropica as a bio-indicator. We contrast Kakadu National Park, where traditional Aboriginal fire management was severely disrupted during the early twentieth century following Aboriginal relocation to surrounding settlements, and an adjacent Aboriginal estate where traditional Aboriginal fire management endures. Since 2006, traditional Aboriginal fire management at this site has been overlaid by a program of broad-scale institutionalized burning in the early dry season, designed to reduce greenhouse emissions. Using remote sensing, field survey, and dendrochronology, we show that on the Aboriginal estate, C. intratropica populations depend on the creation of a shifting patch mosaic of long unburned areas necessary for the recruitment of C. intratropica. However, the imposition of broad-scale fire management is disrupting this population patch dynamic. In Kakadu, there have been extreme declines of C. intratropica associated with widespread fires since the mid twentieth century and consequent proliferation of grass fuels. Fire management in Kakadu since 2007, designed to increase the size and abundance of patches of unburned vegetation, has not been able to reverse the population collapse of C. intratropica. Our study demonstrates that colonial processes including relocation of Indigenous people and institutional fire management can have deleterious consequences that are nearly irreversible because of hysteresis in C. intratropica population dynamics. [ABSTRACT FROM AUTHOR]

Background: Uncontrolled wildfires in Australian temperate Eucalyptus forests produce significant smoke emissions, particularly carbon dioxide (CO2) and particulates. Emissions from fires in these ecosystems, however, have received less research attention than the fires in North American conifer forests or frequently burned Australian tropical savannas. Here, we use the 2013 Forcett–Dunalley fire that caused the first recorded pyrocumulonimbus event in Tasmania, to understand CO2 and particulate matter (PM2.5) emissions from a severe Eucalyptus forest fire. We investigate the spatial patterns of the two emissions using a fine scale mapping of vegetation and fire severity (50 m resolution), and utilising available emission factors suitable for Australian vegetation types. We compare the results with coarse-scale (28 km resolution) emissions estimates from Global Fire Emissions Database (GFED) to determine the reliability of the global model in emissions estimation. Results: The fine scale inventory yielded total CO2 emission of 1.125 ± 0.232 Tg and PM2.5 emission of 0.022 ± 0.006 Tg, representing a loss of 56 t CO2 ha−1 and 1 t PM2.5 ha−1. The CO2 emissions were comparable to GFED estimates, but GFED PM2.5 estimates were lower by a factor of three. This study highlights the reliability of GFED for CO2 but not PM2.5 for estimating emissions from Eucalyptus forest fires. Our fine scale and GFED estimates showed that the Forcett–Dunalley fire produced 30% of 2013 fire carbon emissions in Tasmania, and 26–36% of mean annual fire emissions for the State, representing a significant single source of emissions. Conclusions: Our analyses highlight the need for improved PM2.5 emission factors specific to Australian vegetation, and better characterisation of fuel loads, particularly coarse fuel loads, to quantify wildfire particulate and greenhouse gas emissions more accurately. Current Australian carbon accountancy approach of excluding large wildfires from final GHG accounts likely exaggerates Tasmania's claim to carbon neutrality; we therefore recommend that planned and unplanned emissions are included in the final national and state greenhouse gas accounting to international conventions. Advancing these issues is important given the trajectory of more frequent large fires driven by anthropogenic climate change. [ABSTRACT FROM AUTHOR]

Commotio cordis is the second leading cause of sudden cardiac death in young athletes. Currently available chest protectors on the market are ineffective in preventing cases of commotio cordis in young athletes who play baseball. This study focused on using contour maps to identify specific baseball impact locations to the chest that may result in instances of commotio cordis to children during baseball games. By identifying these vulnerable locations, we may design and develop chest protectors that can provide maximum protection to prevent commotio cordis in young athletes. Simulation cases were run using the validated CHARM-10 chest model, a detailed finite element model representing an average 10-year-old child's chest. A baseball model was developed in company with the chest model, and then used to impact the chest at different locations. A 7 × 8 impact location matrix was designed with 56 unique baseball impact simulations. Left ventricle strain and pressure, reaction force between the baseball and chest, and rib deformations were analyzed. Left ventricle strain was highest from baseball impacts directly over the left ventricle (0.34) as well as impacts slightly lateral and superior to the cardiac silhouette (0.34). Left ventricle pressure was highest with impacts directly over the left ventricle (82.94 kPa). We have identified the most dangerous impact locations resulting in high left ventricle strain and pressure. This novel study provided evidence of where to emphasize protective materials for establishing effective chest protectors that will minimize instances of commotio cordis in young athletes. [ABSTRACT FROM AUTHOR]

There is a growing emphasis on reducing alcohol fueled violence. We do not know whether legislation to close nighttime entertainment districts (NEDs) earlier leads to decreased intoxication and fear of violence within the NED. We collected data before restrictive alcohol legislation (n = 2,670 participants) and again after legislation was introduced (n = 1,926 participants). Patrons were systematically assessed with surveys and breathalyzers as they exited Brisbane NEDs. Consistent with a 2-hour reduction in closing times, people left the NED substantially earlier. The exit intoxication levels of people did not change between pre- and post-legislation. After the legislation was introduced perceived risk of violence increased. Perceived alcohol scarcity leads to increased preloading. With only restrictive legislation on alcohol sales, people do not drink to lower levels of inebriation. [ABSTRACT FROM AUTHOR]

Advances in detection and treatment mean that over 50% of people diagnosed with colorectal cancer can expect to live for more than ten years following treatment. Studies show that colorectal cancer patients can experience numerous physical and psychological late effects. The aim of this study was to conduct a systematic review and qualitative synthesis on the experiences of living with colorectal cancer as a chronic illness. Electronic searches of online databases were undertaken of peer reviewed and grey literature. Forty-seven papers were eligible for inclusion in the review, capturing the experiences of over 700 participants, the findings from which were analysed using thematic synthesis. Three higher order concepts were identified which were prevalent across studies and countries and which related to the supportive care needs of patients; common physical and psychological late effects of cancer; and methods of psychosocial adjustment to living with and beyond colorectal cancer. The results are considered in the context of existing theoretical approaches to chronic illness and the need to develop a theoretical approach which fully encapsulates the experience of living with colorectal cancer as a chronic illness in order to inform interventions to support patient adjustment. [ABSTRACT FROM AUTHOR]

The nuclear equation of state (EOS) is an important component in the evolution of core-collapse supernovae. In this paper we make a survey of various EOSs in the literature and analyze their effect on spherical core-collapse models in which the effects of three-dimensional turbulence is modeled by a general relativistic formulation of Supernova Turbulence In Reduced-dimensionality (STIR). We show that the viability of the explosion is quite EOS dependent and that it best correlates with the early-time interior entropy density of the proto–neutron star. We check that this result is not progenitor dependent, although the lowest-mass progenitors show different explosion properties, due to the different pre-collapse nuclear composition. Larger central entropies also induce more vigorous proto–neutron star convection in our one-dimensional turbulence model, as well as a wider convective layer. [ABSTRACT FROM AUTHOR]

Commotio cordis is a sudden death mechanism that occurs when the heart is impacted during the repolarization phase of the cardiac cycle. This study aimed to investigate commotio cordis injury metrics by correlating chest force and rib deformation to left ventricle strain and pressure. We simulated 128 chest impacts using a simulation matrix which included two initial velocities, 16 impact locations spread across the transverse and sagittal plane, and four baseball stiffness levels. Results showed that an initial velocity of 17.88 m/s and an impact location over the left ventricle was the most damaging setting across all possible settings, causing the most considerable left ventricle strain and pressure increases. The impact force metric did not correlate with left ventricle strain and pressure, while rib deformations located over the left ventricle were strongly correlated to left ventricle strain and pressure. These results lead us to the recommendation of exploring new injury metrics such as the rib deformations we have highlighted for future commotio cordis safety regulations. [ABSTRACT FROM AUTHOR]

Objectives: Osteoarthritis (OA) is a common joint disease whose causes are not fully understood, but a longstanding hypothesis is that OA stems primarily from the cumulative effects of joint mechanical loading throughout life. Based on this wear and tear hypothesis, anthropologists have assumed that the presence of OA in archeological human skeletons can be interpreted as evidence of a highly physically active lifestyle. Here, we use guinea pigs to experimentally test the hypothesis that higher levels of routine physical activity result in greater OA degeneration. Materials and methods: Guinea pigs are a useful model for OA research because they spontaneously develop the disease in a manner similar to humans. One group of growing animals was housed for 22 weeks in a large room that promoted voluntary physical activity (4.8 km of movement per day, on average), while animals in another group were housed in small cages that restricted their mobility (n = 15/group). After the experiment, histological and microcomputed tomographic analyses were conducted focusing on the knees. Results: Rather than causing greater OA degeneration, elevated levels of routine physical activity resulted in significantly less knee cartilage deterioration, less synovial inflammation, smaller osteophytes, and maintenance of greater epiphyseal trabecular bone quantity. Discussion: These results are inconsistent with the hypothesis that high levels of routine physical activity drive the pathogenesis of OA and call into question typical interpretations of OA in studies of archeological human skeletons. [ABSTRACT FROM AUTHOR]

Rock shapes and heights around the InSight lander are examined to refine the degradation history of the 27 m‐diameter Homestead hollow. Results document decreasing average exposed rock height and increasing percentage of rocks where height comprises the short axis from outside to within the hollow and support prior models of ejecta deflation accompanied by hollow infilling. We estimate 0.3 m of deflation at the current rim that is realistic compared to rock relief, original ejecta thickness, and predicted aeolian contributions to infilling. We also find that shapes of embayed basalt rocks outside the hollow appear platy, bladed, and elongate in a triangular form factor plot, and more discoidal and bladed in an axes ratio plot. By contrast, expected shapes based on terrestrial studies of basalt rocks are mostly compact, compact platy, compact bladed, compact elongated, platy, bladed, and elongate in triangular form factor plots, and equant with lesser, but significant disc‐ and blade‐shaped rocks in axes ratio plots. We find addition of 10 cm to the heights of rocks near the hollow rim, to account for continued partial embedding in ejecta, yields the best match between observed and expected rock shapes. Exposure of small ejecta rocks in the hollow supports degradation rates of 10−4 m/Myr during most of hollow history. Results indicate that deflation from ejecta accompanied by downwind deposition in the hollow can account for the current degraded form of the crater. Our approach is a new tool for characterizing small crater degradation on regolith‐covered lava plains on Mars. Key Points: Rock heights and shapes at Homestead hollow indicate early transport of deflated ejecta sediments can account for infilling of the craterNear‐rim rock heights and shapes relative to the expected original versus remnant ejecta thickness indicates 30 cm deflation at the current rimExposure of later arriving, small ejecta rocks in the hollow supports very low estimates of degradation over most hollow history [ABSTRACT FROM AUTHOR]

Objective: Two common mood induction procedures (MIPs) use autobiographical recall (AR) or video clips. The first relies upon internal generation of mood states whereas the second presents external information to elicit emotion. Often new video clips are created for each experiment. However, no study has examined the efficacy and specificity of a freely available video clip compared to AR for use in other studies. Method: In the present experiment, participants watched either video clips or engaged in autobiographical recall to induce an emotional state. Participants were 53 University first year psychology students who took part for course credit. Results: The anger video clip was more effective compared to AR at increasing the target emotion (anger) and decreasing the non-target emotions - happiness and serenity. Compared to baseline both the video and AR anger scores were higher than sadness scores. Conclusion: The response to recalling personal events is more influenced by personality characteristics such as trait anger and neuroticism compared to the response to the video stimulus, which proved a cleaner stimulus. Implications for future research in both mood induction and media are discussed. [ABSTRACT FROM AUTHOR]

OBJECTIVE: Continuous glucose monitoring (CGM) can detect early dysglycemia in older children and adults with presymptomatic type 1 diabetes (T1D) and predict risk of progression to clinical onset. However, CGM data for very young children at greatest risk of disease progression are lacking. This study aimed to investigate the use of CGM data measured in children being longitudinally observed in the Australian Environmental Determinants of Islet Autoimmunity (ENDIA) study from birth to age 10 years. RESEARCH DESIGN AND METHODS: Between January 2021 and June 2023, 31 ENDIA children with persistent multiple islet autoimmunity (PM Ab+) and 24 age-matched control children underwent CGM assessment alongside standard clinical monitoring. The CGM metrics of glucose SD (SDSGL), coefficient of variation (CEV), mean sensor glucose (SGL), and percentage of time >7.8 mmol/L (>140 mg/dL) were determined and examined for between-group differences. RESULTS: The mean (SD) ages of PM Ab+ and Ab− children were 4.4 (1.8) and 4.7 (1.9) years, respectively. Eighty-six percent of eligible PM Ab+ children consented to CGM wear, achieving a median (quartile 1 [Q1], Q3) sensor wear period of 12.5 (9.0, 15.0) days. PM Ab+ children had higher median (Q1, Q3) SDSGL (1.1 [0.9, 1.3] vs. 0.9 [0.8, 1.0] mmol/L; P < 0.001) and CEV (17.3% [16.0, 20.9] vs. 14.7% [12.9, 16.6]; P < 0.001). Percentage of time >7.8 mmol/L was greater in PM Ab+ children (median [Q1, Q3] 8.0% [4.4, 13.0] compared with 3.3% [1.4, 5.3] in Ab− children; P = 0.005). Mean SGL did not differ significantly between groups (P = 0.10). CONCLUSIONS: CGM is feasible and well tolerated in very young children at risk of T1D. Very young PM Ab+ children have increased SDSGL, CEV, and percentage of time >7.8 mmol/L, consistent with prior studies involving older participants. [ABSTRACT FROM AUTHOR]

It is recommended that people with type 1 diabetes should generally aim to achieve glycated hemoglobin (HbA1c) <53 mmol/mol.[1],[2] Likewise, as defined by continuous glucose monitoring (CGM) metrics, the proposed general aims are to spend >70% time-in-range (TIR, 70-180 mg/dL), <4% below 70 mg/dL, <1% below 54 mg/dL, <25% above 180 mg/dL, and <5% above 250 mg/dL.[3] However, the proportion of individuals achieving the goals of CGM metrics among cohorts meeting target HbA1c is not much known. Percentage TIR was higher in participants who met target HbA1c, with less time in hyperglycemia but more time in hypoglycemia than individuals not meeting target HbA1c (Table 1). [Extracted from the article]

Introduction: While telemedicine usage has increased due to the COVID-19 pandemic, there remains little consensus about how spine surgeons perceive virtual care. The purpose of this study was to explore international perspectives of spine providers on the challenges and benefits of telemedicine.Methods: Responses from 485 members of AO Spine were analyzed, covering provider perceptions of the challenges and benefits of telemedicine. All questions were optional, and blank responses were excluded from analysis.Results: The leading challenges reported by surgeons were decreased ability to perform physical examinations (38.6%), possible increased medicolegal exposure (19.3%), and lack of reimbursement parity compared to traditional visits (15.5%). Fewer than 9.0% of respondents experienced technological issues. On average, respondents agreed that telemedicine increases access to care for rural/long-distance patients, provides societal cost savings, and increases patient convenience. Responses were mixed about whether telemedicine leads to greater patient satisfaction. North Americans experienced the most challenges, but also thought telemedicine carried the most benefits, whereas Africans reported the fewest challenges and benefits. Age did not affect responses.Conclusion: Spine surgeons are supportive of the benefits of telemedicine, and only a small minority experienced technical issues. The decreased ability to perform the physical examination was the top challenge and remains a major obstacle to virtual care for spine surgeons around the world, although interestingly, 61.4% of providers did not acknowledge this to be a major challenge. Significant groundwork in optimizing remote physical examination maneuvers and achieving legal and reimbursement clarity is necessary for widespread implementation. [ABSTRACT FROM AUTHOR]