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1. Exposure to inhaled particulate matter activates early markers of oxidative stress, inflammation and unfolded protein response in rat striatum.

Author

Guerra, R., Vera-Aguilar, E., Uribe-Ramirez, M., Gookin, G., Camacho, J., Osornio-Vargas, A.R., Mugica-Alvarez, V., Angulo-Olais, R., Campbell, A., Froines, J., Kleinman, T.M., and De Vizcaya-Ruiz, A.

Subjects
*OXIDATIVE stress, *BIOMARKERS, *INFLAMMATION, *NEOSTRIATUM, *RESPIRATORY therapy, *LABORATORY rats, *PROTEIN folding, *PARTICULATE matter
Abstract

Highlights: [•] Ultrafine PM induce HO-1 and SOD-2 expression and Nrf-2 activation in CNS. [•] Ultrafine PM induce activation of NF-κB and increase of IL-1β and TNFα in striatum. [•] Presence of UPR increase of XBP-1S and BiP in striatum after exposure to coarse PM. [ABSTRACT FROM AUTHOR]

Published
2013
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