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Many people support and stand by political candidates in the same way that a person might support a significant other. In two studies, we preliminarily explored the utility of a triangular theory of love proposed for political figures. In the first study, data from 87 university students were used to obtain results relating to levels of intimacy, passion, commitment, and satisfaction for a participant‐chosen political figure. We hypothesized that intimacy, passion, and commitment would predict higher levels of satisfaction with political figures. Correlational analyses revealed significant relationships between all three variables and satisfaction. In stepwise multiple regressions, intimacy and passion retained significant relationships with satisfaction. In the second study, 299 university students reported levels of intimacy, passion, commitment, and satisfaction for three political figures: Joe Biden, Donald Trump, and Barack Obama. All three variables were significantly correlated with satisfaction for each candidate. Stepwise multiple regression analyses revealed that intimacy and commitment, but not passion, predicted satisfaction for Joe Biden and Donald Trump. Intimacy, passion, and commitment significantly predicted satisfaction for Barack Obama. Voters may experience a kind of love for political figures, and understanding this relationship may have implications for helping voters make informed decisions during elections. [ABSTRACT FROM AUTHOR]

Background and Aims: During fasting, bodily homeostasis is maintained due to hepatic production of glucose (gluconeogenesis) and ketone bodies (ketogenesis). The main hormones governing hepatic fuel production are glucagon and glucocorticoids that initiate transcriptional programs aimed at supporting gluconeogenesis and ketogenesis. Methods: Using primary mouse hepatocytes as an ex vivo model, we employed transcriptomic analysis (RNA‐seq), genome‐wide profiling of enhancer dynamics (ChIP‐seq), perturbation experiments (inhibitors, shRNA), hepatic glucose production measurements and computational analyses. Results: We found that in addition to the known metabolic genes transcriptionally induced by glucagon and glucocorticoids, these hormones induce a set of genes encoding transcription factors (TFs) thereby initiating transcriptional cascades. Upon activation by glucocorticoids, the glucocorticoid receptor (GR) induced the genes encoding two TFs: CCAAT/enhancer‐binding protein beta (C/EBPβ) and peroxisome proliferator‐activated receptor alpha (PPARα). We found that the GR‐C/EBPβ cascade mainly serves as a secondary amplifier of primary hormone‐induced gene programs. C/EBPβ augmented gluconeogenic gene expression and hepatic glucose production. Conversely, the GR‐PPARα cascade initiated a secondary transcriptional wave of genes supporting ketogenesis. The cascade led to synergistic induction of ketogenic genes which is dependent on protein synthesis. Genome‐wide analysis of enhancer dynamics revealed numerous enhancers activated by the GR‐PPARα cascade. These enhancers were proximal to ketogenic genes, enriched for the PPARα response element and showed increased PPARα binding. Conclusion: This study reveals abundant transcriptional cascades occurring during fasting. These cascades serve two separated purposes: the amplification of the gluconeogenic transcriptional program and the induction of a gene program aimed at enhancing ketogenesis. [ABSTRACT FROM AUTHOR]

Background: We describe a technique to assess blood flow distal to the decannulation site after deployment of Perclose ProGlide (Abbott Vascular, Abbott Park, Ill) in patients on femoral veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support. Technique: An antegrade distal perfusion catheter was placed in all patients, and decannulation was primarily performed at bedside (N = 11/12). With the VA-ECMO circuit switched off, a needle was inserted into the arterial tubing, passed through the femoral arterial cannula into the artery. The arterial cannula was removed over a wire and the previously placed Proglide Perclose sutures were secured. Back bleeding from the antegrade distal perfusion catheter, confirmed using a three-way connector, indicated blood flow to the superficial femoral artery. This was followed by confirmation of blood flow to the lower leg using a Doppler ultrasound. Hemostasis of the antegrade perfusion catheter was achieved through manual compression. Results: We implemented this technique in 12 patients with a technical success rate of 100%. There were no ipsilateral leg ischemia, bleeding, pseudoaneurysm, or infection after decannulation. Conclusions: This technique allows prompt assessment of blood flow to the distal leg immediately following arterial decannulation. [ABSTRACT FROM AUTHOR]

Ferrying, the behaviour in which waterbirds transport their offspring on their backs while in the water, is a captivating behaviour that wildlife photographers and filmmakers frequently highlight in calendars, wildlife documentaries, magazines and nature photography books. In the avian research sphere, however, only a handful of studies have investigated this behaviour, leaving much remaining to be understood about its evolution. One pattern that appears to emerge at a cursory glance is that the species that ferry tend to also be diving species. We sought to build a dataset of species that ferry and compare its occurrence to five ecological factors: diving, coloniality, territoriality, parental care type, and clutch size. Finally, we found that ferrying has originated at least four times within Anseriformes and has also been lost in two separate lineages of waterfowl. We suggest that a variety of avian life history factors may have influenced the evolution of ferrying behaviour and should be the focus of future research on this topic. [ABSTRACT FROM AUTHOR]

An elementary embedding j : M → N between two inner models of ZFC is cardinal preserving if M and N correctly compute the class of cardinals. We look at the case N = V and show that there is no nontrivial cardinal preserving elementary embedding from M into V, answering a question of Caicedo. [ABSTRACT FROM AUTHOR]

The article discusses Hitler's 1939 Reichstag speech and the debate among historians regarding his intent to annihilate the Jews. It explores the gradual development of the Final Solution and the complexities of understanding Hitler's genocidal mentality. The article also delves into the legal and historical perspectives on intent in cases of genocide, drawing parallels to current events in Gaza. The author argues that while legal definitions may not fully apply, the events in Gaza exhibit characteristics of genocide, emphasizing the need for a nuanced understanding beyond strict legal definitions. [Extracted from the article]

Objective: In 2020, Army National Guard members demonstrated greater risk of suicide than their military and civilian counterparts. Though literature on deployment-related experiences and suicidal ideation (SI) is mixed, investigations of specific deployment-related experiences (e.g., injuries) may further elucidate the relationship between deployment and suicide risk. Deployment-related injuries, including pain severity and functional impairment, have been linked to increased risk of SI, and correlates like perceived burdensomeness (PB) and hopelessness. The current study sought to examine the cross-sectional relationship between deployment-related injuries, including pain severity and functional impairment, and severity of SI through PB and hopelessness. Method: Immediately post-deployment, Army National Guard members (N = 2,261) completed validated self-report measures on past-week SI, PB, hopelessness, and single items regarding injury sustained during deployment and associated functional impairment and pain severity. Results: Indirect effect analyses revealed that experience of deployment-related injury was related to SI through PB and hopelessness (R2 =.1993), functional impairment was related to SI through PB, and pain severity was related to SI through PB. Contrary to hypotheses, hopelessness was not associated with SI when PB was simultaneously considered. Conclusions: Army National Guard members who develop a sense of PB related to their injury and functional impairment of that injury may be at increased risk for suicidal ideation. Military suicide-prevention efforts may be potentiated through targeting distorted cognitions such as PB and hopelessness, especially in service members who have been injured. [ABSTRACT FROM AUTHOR]

Alternatives to conventional chemical treatments for parasitic diseases in fish are needed. Microalgal‐sourced fatty acid ethyl esters (FAEEs) have shown an antiparasitic effect against Gyrodactylus turnbulli infection in guppies. Here, we tested a range of commercial FAEEs of various carbon chain lengths and unsaturation levels against two fish parasites. Guppies and barramundi infected with G. turnbulli and Trichodina sp., respectively, were used. The most effective FAEE, after excluding those toxic to fish, was ethyl laurate (12:0). For both parasites, the LD50 was 18.75 μM within 250 min of incubation. Ethyl eicosapentaenoate (20:5n3) was the next most effective FAEE against G. turnbulli, and dihomo‐γ‐linolenic acid ethyl ester (20:3n6) and ethyl α‐linolenate (18:3n3) were the next most effective against Trichodina sp. In addition, FAEEs prepared from the microalga Phaeodactylum tricornutum residue, after fucoxanthin extraction, were examined against Trichodina sp. infection in barramundi for the first time. LD85 and LD100 was achieved at 2.5 and 5 μL mL−1 of the FAEE preparation, respectively. In vivo, immersion of infected barramundi in 1.25 μL mL−1 of this preparation for 24 h reduced infection prevalence from 100% to 53% and was non‐toxic to fish. [ABSTRACT FROM AUTHOR]

The primary claim of this essay is that historical fluency is required for effective work in crafting legal and policy interventions as a part of public health emergency preparedness and response (PHEPR). At a broad level, public health law is explicitly recognized as a key systems-level component of PHEPR practice. 1 This essay therefore focuses on the extent to which historical fluency is necessary or at least useful to all aspects of PHEPR that draw on or deploy legal and policy mechanisms (e.g. design, planning, implementation, dissemination, monitoring and evaluation, etc.). The essay collectively refers to these legal and policy mechanisms as epidemic law and policy response (ELAPR). Part I explains the concept of historical fluency. Part II explores the foundations of public health law both as a way of highlighting key structural features of ELAPR and in supporting the claim that historical fluency is critical for ELAPR. Part III applies the previous arguments to a specific case study to highlight the promise and power of historical fluency – the outbreak of bubonic plague in San Francisco in 1900. Tracking this essay's pragmatic focus, part IV offers several recommendations for how specifically historical fluency in public health law and ethics can be operationalized in PHEPR practice and policy. Part V summarizes and concludes. [ABSTRACT FROM AUTHOR]

The article discusses research aimed to describe the content, quality, and readability of online sources of information relevant to home-based care. Cited are the method used to determine the average quality and readability for each webpage, websites that have higher quality ratings, and the challenges facing the average American when searching for online information on home-based care.

ABSTRACT Medullary thyroid carcinoma (MTC) is an uncommon neuroendocrine tumour that is usually asymptomatic at its onset and therefore may not present clinically until the patient has developed advanced or metastatic disease. Common metastatic sites include cervical lymph nodes, liver, bone and lung. This is the case of a patient who presented with an incidental posterior mediastinal mass. Because the posterior mediastinum is an unusual location for MTC, MTC was not a consideration and preliminary histopathological testing did not include calcitonin, which would have been diagnostic. This case highlights the importance of testing for calcitonin more regularly when encountering a mass of unknown origin with neuroendocrine morphology, which may lead to earlier detection of MTC and thus improved prognosis. [ABSTRACT FROM AUTHOR]

This paper answers a question of Usuba [Extendible cardinals and the mantle, Arch. Math. Logic 58(1–2) (2019) 71–75], establishing the optimality of the large cardinal assumption of his remarkable theorem that if there is an extendible cardinal, there is a minimum inner model from which the universe of sets can be obtained as a forcing extension. [ABSTRACT FROM AUTHOR]

AbstractMost research about augmentative and alternative communication (AAC) has focused on improving use of and access to speech generating devices (SGDs). However, many adults with significant physical and developmental disabilities express a preference for unaided, embodied forms of communication. This study used conversation analysis (CA) techniques to analyze the forms and functions of embodied communication that occurred during interactions between a young man who used unaided, embodied communication and an SGD to communicate with a familiar communication partner. Close analysis revealed that embodied resources were required for both unaided and aided forms of communication. Furthermore, both participants used their bodies to establish interactional spaces with different focal points during interaction, which placed different demands on the aided speaker. Unfortunately, when the SGD was the focal point, problematic demands were placed on the aided speaker, which in turn resulted in increased embodied effort on his part. The forms and functions of the body, differences in the participants’ interactions when communication did and did not involve the SGD, and implications for research and practice are all reported and discussed. [ABSTRACT FROM AUTHOR]

AbstractWe examined social competence, learning-related disorders, and school engagement in relation to grade point average (GPA) among three groups of children adopted by heterosexual and same-sex couples: 84 adopted privately, 29 internationally, and 20 from foster care. Structural equation modeling showed that increased school engagement predicts higher GPA, increased social competence predicts higher GPA via increased school engagement, and learning-related disorders predict lower GPA directly and via lower school engagement. Learning-related disorders had an equivalent or larger impact on GPA among children adopted privately than internationally or from foster care, potentially because diagnoses were made later. Learning needs should be considered regardless of adoption type. [ABSTRACT FROM AUTHOR]

The distribution of the ecologically damaging invasive Cuban Treefrog (CTF, Anura, Hylidae, Osteopilus septentrionalis) in the USA is documented primarily by users of invasive species applications (apps) such as the Early Detection and Distribution Mapping System (EDDMapS). The purpose of this case study was to investigate spatial and temporal patterns in EDDMapS’s CTF records from Florida, USA. With the accessibility of geolocated records and machine learning algorithms, predicted species distribution models (SDMs) need to be revisited to explore their accuracy as new records become available. Utilizing the machine learning TreeNet® Classification algorithm, I constructed an SDM from records uploaded in 1999–2020, mean monthly temperature and rainfall patterns from 1999–2020, 2020 United States census data, and proximity to water and residential land cover types. Of the 1,042 geolocated records, the mean annual number of entries was more than 30 times greater from 2010–2020 than years prior, indicating greater utilization of the app with time. Residential areas and wetland land cover categories represented 35.2%, and 29.8%, respectively, of the locations where the CTF had been recorded. The variables mean monthly temperature and minimum temperature during the coldest quarter contributed the greatest contribution to the model with predicted suitable areas primarily in southern Florida. Using 2021–2023 records to validate the SDM, 96.7% of the 398 geolocated records were associated with a relative occurrence index ≥ 0.80, indicating the model’s predicted suitable areas performed well. Regional programs that aim to train, mentor, and incentivize the public to report geolocated presence and absence observations with microhabitat descriptions would improve the accuracy of predicted suitable areas for invasive species whose records derive mainly from invasive species monitoring apps. [ABSTRACT FROM AUTHOR]

This article is structured as a conversation between scholars Jess A. Goldberg and Marquis Bey, grounded in the arguments of Bey's recent book Black Trans Feminism, published in 2022 by Duke University Press. Rather than an overview or summary of Bey's book, the conversation digs into particular dimensions of Bey's arguments and analyses. It begins by situating Black Trans Feminism in relation to the topic of the special issue of WSQ in which the article appears, with Goldberg asking Bey to explain their thinking around "the unbearable" or the abject as they relate to the framework of black trans feminism. From there, the conversation turns to the roles of affect, desire, and disagreement in feminist theorization and argument as well as an extended consideration of metaphors of "holding" in Bey's work and beyond. The conversation closes with a critical and loving exchange over questions of violence in abolitionist politics and movements and the risks we take on in trying to abolish the conditions of unbearable life at various levels. [ABSTRACT FROM AUTHOR]

Certain aspects of the temporal dimension in analysis are taken up in light of Steinbock's illuminating exploration of a Winnicott case report. Following Steinbock's portrayal of the interrelation of linear and non-linear time dimensions, some consideration is given to the many different kinds of time encountered in analysis, and to the function of the frame in creating a specifically analytic experience of time duration. The concept of Transitional time is proposed to describe this peculiarly analytic state of consciousness in which heterodox qualities of psychical experience can be woven together, and the multi-dimensionality of time itself is integrated into the experience of going-on-being. [ABSTRACT FROM AUTHOR]

Purpose: Common respiratory infections were significantly reduced during the COVID-19 pandemic due to general protective and hygiene measures. The gradual withdrawal of these non-pharmaceutical interventions (NPI) was associated with a notable increase in these infections, particularly in pediatric and adult otorhinolaryngology. The aim of this retrospective monocentric study was to evaluate the impact of NPI during the COVID-19 pandemic on the incidence and severity of acute mastoiditis (AM). Methods: Pre-pandemic clinical data of AM cases from 2011 to 2019 were compared with infection counts from January 2020 to June 2023 for seasonal periodicity, age-specific differences, pathogens, and complication rates in a German third-level hospital. Results: Out of 196 patients with AM 133 were children, the majority between 1 and 5 years of age. Complications of AM, such as meningitis, brain abscess, and sinus vein thrombosis, were more common in adults (87%) than in children (17%). Morbidity and mortality rates were similar before, during and after the pandemic. Pneumococci were the most common pathogen in both age groups, with a post-pandemic cumulation of Streptococcus pyogenes infections in children. While pre-pandemic cases clustered in spring, seasonality was absent in all age groups during the main phase of the pandemic. The cessation of NPI caused a steep rise in AM cases in both age groups starting from December 2022. Conclusion: NPI during the COVID-19 pandemic reduced the incidence of AM. Their reversal led to a substantial increase in the incidence of AM during the post-pandemic period, which may be due to a general increase in viral respiratory infections and an insufficiently trained immune system. [ABSTRACT FROM AUTHOR]

Modeling the behavior of a prototype cantilevered X‐ray adaptive mirror (held from one end) demonstrates its potential for use on high‐performance X‐ray beamlines. Similar adaptive mirrors are used on X‐ray beamlines to compensate optical aberrations, control wavefronts and tune mirror focal distances at will. Controlled by 1D arrays of piezoceramic actuators, these glancing‐incidence mirrors can provide nanometre‐scale surface shape adjustment capabilities. However, significant engineering challenges remain for mounting them with low distortion and low environmental sensitivity. Finite‐element analysis is used to predict the micron‐scale full actuation surface shape from each channel and then linear modeling is applied to investigate the mirrors' ability to reach target profiles. Using either uniform or arbitrary spatial weighting, actuator voltages are optimized using a Moore–Penrose matrix inverse, or pseudoinverse, revealing a spatial dependence on the shape fitting with increasing fidelity farther from the mount. [ABSTRACT FROM AUTHOR]

The American Diabetes Association and the European Association for the Study of Diabetes published a 2022 consensus report recommending changes in diabetes care. This Perspective raises three concerns: with how the report summarizes evidence, how it frames the social determinants of health (SDOH), and with its transnational composition and conflicts of interest. The Perspective analyzes three new clinical recommendations that change the role of metformin from first-line therapy to a first-line option, for the inclusion of weight management as a co-primary treatment goal with glycemic control for patients without cardiac or renal complications, and for addition of the SDOH as a universal component of diabetes care together with lifestyle changes and self-management support. The Perspective considers how the poor evidence assessments of the recommendations and the imprecise framing of the SDOH introduce bias. The composition of the panel's membership poorly represents and accounts for the challenges faced by vulnerable US communities or safety net providers. The report is placed in a historical context for diabetes of organized medicine's failures to overcome prejudices and promote health equity. The Perspective concludes that the report perpetuates a pattern of prejudice within organized medicine at the expense of scientific precision and health equity. [ABSTRACT FROM AUTHOR]

Faculty online learning communities (FOLCs) can help faculty effectively adopt and persist in using research-based curricula. This paper documents faculty perspectives on the value they gained from participating in a multi-year FOLC designed to help them implement an inquiry-based physical science curriculum. Personal value narratives were collected from 11 volunteer FOLC participants. In the narratives, participants responded to prompts regarding their initial reasons for participation, activities they engaged in, and values they gained, as well as how participation impacted their profession, social connections, professional practice, and ability to influence their world as teachers. Qualitative analysis shows that the values faculty gained through their participation in the FOLC could be associated with four major areas of impact: teaching, community, leadership and personal development. The first two aligned with the initial goals of the FOLC, while the latter two emerged organically through participation over its four-year duration. The methods used to assess value creation in the NGPET FOLC and the findings from this study can inform other professionals who aspire to create and sustain a long-standing faculty development community and understand its impacts. [ABSTRACT FROM AUTHOR]

During the COVID-19 pandemic, school board members played a prominent role in deciding reopening plans. Using an original large-scale survey of board members, our goal is to understand how the polarized, political context of pandemic responses shaped the decision-making processes of members as they experienced dramatic increases in workload. We find school board members are much more likely to identify at the extremes of partisan identity, as strong Democrats or strong Republicans. How they identified mattered in who they trusted to tell them information, how much control they felt the board should have in the process of reopening plans, and who should interpret data about COVID. If the other party was in power at the state level, members from opposing parties had less trust in state sources. Most school board elections are nonpartisan, but that does not mean that the members themselves do not strongly identify with a party. [ABSTRACT FROM AUTHOR]

The collapse of ice shelves could expose tall ice cliffs at ice sheet margins. The marine ice cliff instability (MICI) is a hypothesis that predicts that, if these cliffs are tall enough, ice may fail structurally leading to self-sustained retreat. To date, projections that include MICI have been performed with a single model based on a simple parameterization. Here, we implement a physically motivated parameterization in three ice sheet models and simulate the response of the Amundsen Sea Embayment after a hypothetical collapse of floating ice. All models show that Thwaites Glacier would not retreat further in the 21st century. In another set of simulations, we force the grounding line to retreat into Thwaites' deeper basin to expose a taller cliff. In these simulations, rapid thinning and velocity increase reduce the calving rate, stabilizing the cliff. These experiments show that Thwaites may be less vulnerable to MICI than previously thought, and model projections that include this process should be re-evaluated. [ABSTRACT FROM AUTHOR]

Simple Summary: This study explores the use of intraoperative magnetic resonance imaging (iMRI) in the surgical resection of brain metastases (BMs). The research aims to determine how iMRI can improve the precision of tumor removal, thereby enhancing patient outcomes. By providing real-time, high-resolution images during surgery, iMRI assists surgeons in achieving more complete tumor resection, potentially reducing recurrence rates and improving survival chances. Integrating iMRI into surgical protocols helps preserve neurological functions, especially for patients with BM in critical brain areas. This study highlights the safety and effectiveness of iMRI in neurosurgery and suggests its broader adoption for the better management of BMs. Intraoperative magnetic resonance imaging (iMRI) has witnessed significant growth in the field of neurosurgery, particularly in glioma surgery, enhancing image-guided neuronavigation and optimizing the extent of resection (EOR). Despite its extensive use in the treatment of gliomas, its utility in brain metastases (BMs) remains unexplored. This study examined the effect of iMRI on BM resection. This retrospective study was conducted at the neurosurgical center of the University Hospital of the Technical University of Munich and involved 25 patients with BM who underwent resection using 3-Tesla iMRI between 2018 and 2022. Volumetric measurements of the resected contrast-enhancing metastases were performed using preoperative, intraoperative, and postoperative MRI images. The Karnofsky Performance Score (KPS) and neurological status of the patients were assessed pre- and postoperatively. Local recurrence and in-brain progression were reported in patients who underwent follow-up MRI at 3 and 6 months postoperatively. In this cohort (n = 25, mean age 63.6 years), non-small-cell lung cancer (NSCLC) was the most common origin (28%). The mean surgical duration was 219.9 min, and that of iMRI was 61.7 min. Indications for iMRI were primarily associated with preoperative imaging, suggesting an unclear entity that is often suspicious for glioma. Gross total resection (GTR) was achieved in 21 patients (84%). Continued resection was pursued after iMRI in six cases (24%), resulting in an improved EOR of 100% in five cases and 97.6% in one case. Neurological status postoperatively remained stable in 60%, improved in 24%, and worsened in 16% of patients. No wound healing or postoperative complications were observed. Among the thirteen patients who underwent follow-up MRI 3 months postoperatively, one patient showed local recurrence at the site of resection, and seven patients showed in-brain progression. Of the eight patients who underwent a 6-month follow-up MRI, two showed local recurrence, while three exhibited in-brain progression. The observed favorable profiles of GTR, coupled with the notable absence of wound-healing problems and acute postoperative complications, affirm the safety and feasibility of incorporating iMRI into the neurosurgical workflow for resecting BM with specific indications. The real-time imaging capabilities of iMRI offer unparalleled precision, aiding meticulous tumor delineation and informed decision-making, ultimately contributing to improved patient outcomes. Although our experience suggests the potential benefits of iMRI as a safe tool for enhancing EOR, we acknowledge the need for larger prospective clinical trials. Comprehensive investigations on a broader scale are imperative to further elucidate the specific indications for iMRI in the context of BMs and to study its impact on survival. Rigorous prospective studies will refine our understanding of the clinical scenarios in which iMRI can maximize its impact, guiding neurosurgeons toward more informed and tailored decision-making. [ABSTRACT FROM AUTHOR]

Mesoporous hydroxyapatite (HA) is widely used in various applications, such as the biomedical field, as a catalytic, as a sensor, and many others. The aim of this work was to obtain HA powders by means of chemical precipitation in a medium containing a polymer—polyvinyl alcohol or polyvinylpyrrolidone (PVP)—with concentrations ranging from 0 to 10%. The HA powders were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, atomic emission spectroscopy with inductively coupled plasma, electron paramagnetic resonance, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The specific surface area (SSA), pore volume, and pore size distributions were determined by low-temperature nitrogen adsorption measurements, and the zeta potential was established. The formation of macropores in powder agglomerates was determined using SEM and TEM. The synthesis in 10% PVP increased the SSA from 101.3 to 158.0 m2/g, while the ripening for 7 days led to an increase from 112.3 to 195.8 m2/g, with the total pore volume rising from 0.37 to 0.71 cm3/g. These materials could be classified as meso-macroporous HA. Such materials can serve as the basis for various applications requiring improved textural properties and may lay the foundation for the creation of bulk 3D materials using a technique that allows for the preservation of their unique pore structure. [ABSTRACT FROM AUTHOR]

The collapse of ice shelves could expose tall ice cliffs at ice sheet margins. The marine ice cliff instability (MICI) is a hypothesis that predicts that, if these cliffs are tall enough, ice may fail structurally leading to self-sustained retreat. To date, projections that include MICI have been performed with a single model based on a simple parameterization. Here, we implement a physically motivated parameterization in three ice sheet models and simulate the response of the Amundsen Sea Embayment after a hypothetical collapse of floating ice. All models show that Thwaites Glacier would not retreat further in the 21st century. In another set of simulations, we force the grounding line to retreat into Thwaites' deeper basin to expose a taller cliff. In these simulations, rapid thinning and velocity increase reduce the calving rate, stabilizing the cliff. These experiments show that Thwaites may be less vulnerable to MICI than previously thought, and model projections that include this process should be re-evaluated. [ABSTRACT FROM AUTHOR]

Objective: Meditation apps are the most widely used mental health apps. The precise mechanisms underlying their effects remain unclear. In particular, the degree to which affect experienced during meditation is associated with outcomes has not been established. Method: We used the meditation app arm of a recently completed randomized controlled trial comparing a self-guided meditation app (Healthy Minds Program) to a waitlist control. Predominantly distressed public school employees (n = 243, 80.9% with clinically elevated depression and/or anxiety) reported positive and negative affect during meditation practice. Data were analyzed using two-level multivariate latent growth curve models (observations nested within participants) that simultaneously attended to both positive and negative affect. We examined whether positive and negative affect during meditation changed over time and whether these changes were associated with changes in psychological distress (parent trial's preregistered primary outcome) at posttest or 3-month follow-up. Results: On average, participants reported decreased negative affect but no change in positive affect during meditation over time. Increased positive affect and decreased negative affect during meditation were associated with improvements in distress at posttest and follow-up. Change in positive affect was a stronger predictor of distress at follow-up than change in negative affect. Conclusions: Despite notions embedded within mainstream mindfulness meditation training that deemphasize the importance of the affective experience of practice (i.e., nonjudgmental awareness of present moment experience, regardless of valence), results indicate that these experiences contain signals associated with outcomes. Monitoring affect during meditation may be worthwhile to guide intervention delivery (i.e., measurement-based care, precision medicine). What is the public health significance of this article?: This study suggests that affect experienced during meditation is associated with both short- and long-term changes in psychological distress that occur in the context of smartphone app-delivered meditation training. While both increases in positive affect and decreases in negative affect were associated with improvements in distress, increases in positive affect were the stronger predictor of long-term improvements in distress. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate the clinical significance of preoperative spectral domain optical coherence tomography (OCT) of the retinal nerve fiber layer (RNFL) thickness in identifying glaucoma and better managing patients scheduled for routine cataract surgery. Setting: Department of Ophthalmology, Shaare Zedek Medical Center, Jerusalem, Israel. Design: Retrospective cohort study. Methods: Consecutive patients scheduled for cataract surgery were enrolled from February 2022 to August 2022. Participants underwent routine OCT RNFL studies which were evaluated by a glaucoma specialist. Findings were compared with those of preoperative fundus biomicroscopic examinations conducted by the referring ophthalmologist. The main outcomes were the incidence of newly detected glaucoma based on OCT RNFL findings and the consequent changes in patient management. Results: In total, 486 patients met the inclusion criteria of whom 112 (23%) had abnormal RNFL. 31 patients (6.4%) had abnormal OCT RNFL findings attributed to comorbidities other than glaucoma, and 81 patients (16.7%) were suspected to have glaucoma based on their OCT RNFL findings, from which 44 patients (9%) were newly diagnosed with glaucoma or as glaucoma suspects, resulting in management modifications that included routine glaucoma follow-up (25 patients, 5.1%), initiation of intraocular pressure-lowering treatment (12 patients, 2.5%), and conversion to combined cataract-glaucoma surgery (7 patients, 1.4%). Conclusions: OCT RNFL for cataract surgery candidates proved valuable in detecting glaucoma that had not been revealed by standard fundus biomicroscopic examination. The additional information provided by OCT RNFL can potentially enhance patient management and optimize outcomes. [ABSTRACT FROM AUTHOR]

Phantom limb pain, a common challenge for amputees, lacks effective treatment options. Vibration therapy is a promising non-pharmacologic intervention for reducing pain intensity, but its efficacy in alleviating phantom limb pain requires further investigation. This study focused on developing prosthesis liners with integrated vibration motors to administer vibration therapy for phantom limb pain. The prototypes developed for this study addressed previous issues with wiring the electronic components. Two transfemoral amputees participated in a four-week at-home trial, during which they used the vibration liner and rated their initial and final pain intensity on a numeric rating scale each time they had phantom pain. Semi-structured interviews were conducted to gather feedback following the at-home trial. Both participants described relaxing and soothing sensations in their residual limb and phantom limb while using vibration therapy. One participant reported a relaxation of his phantom limb sensations, while both participants noted a decrease in the intensity of their phantom limb pain. Participants said the vibration liners were comfortable but suggested that the vibration could be stronger and that aligning the contacts could be easier. The results of this study highlight the potential effectiveness of using vibration therapy to reduce the intensity of phantom limb pain and suggest a vibration liner may be a feasible mode of administering the therapy. Future research should address optimizing the performance of the vibration liners to maximize their therapeutic benefits. [ABSTRACT FROM AUTHOR]

The ultra-Orthodox population in Israel demonstrates a higher natural growth rate compared to the general population, yet the employment rate among ultra-Orthodox men remains significantly lower. This phenomenon can be attributed to the concept of the religious club model (Berman, 2000), which posits that strict requirements and club goods foster a strong commitment to the religious community. By utilizing individual-level data collected from 256 ultra-Orthodox men and employing K-Means clustering analysis, we identified two distinct types based on their demonstrated levels of voluntary sacrifice which only partially overlapped the club's formal admission criteria. Our findings illustrate the ultra-Orthodox religious club as inherently limited in its ability to enforce religious norms and prohibitions and as a result it is variably effective in filtering out 'free riders' and may not reward nonmembers despite their demonstrably consistently high adherence ('wannabes'). Our findings also reveal a positive association between wage expectations and the likelihood of ultra-Orthodox men entering the labor market, implying a potential trade-off between earning potential and the extent of social fines. Interestingly, our results also offer insight into the increased adherence to Halacha (Jewish religious law), despite the rise in real wages. Furthermore, our simulation offers policymakers a tool to evaluate the necessary incentives to encourage greater participation of ultra-Orthodox men in the labor market. This has implications for both enhancing economic outcomes and understanding the intricate interplay between religion, social norms, and employment decisions. [ABSTRACT FROM AUTHOR]

Background: Histopathological examination is adequate for the diagnosis of most cutaneous melanocytic neoplasms. However, there is a subset that is either difficult to definitively diagnose or would have diagnostic disagreement upon review by multiple dermatopathologists if a more exhaustive review was performed. Methods: Melanocytic lesions underwent an independent, blinded diagnostic histopathological review of hematoxylin and eosin‐stained sections. Each lesion was reviewed by three to six dermatopathologists and categorized as benign, malignant, or unknown malignant potential (UMP). Diagnoses were grouped as concordant (all the same designation); opposing (received benign and malignant designations); majority (single designation with the highest number of diagnoses, no benign/malignant opposing designations); and non‐definitive (equal number of non‐opposing designations [i.e., benign/UMP or malignant/UMP]). Lesions with equivocal designations (concordant or majority UMP, opposing, majority, and non‐definitive) were utilized in a patient treatment model of projected surgical treatment discrepancies. Results: In total, 3317 cases were reviewed, and 23.8% of lesions received equivocal diagnoses. Of these, 7.3% were majority benign, 4.8% were majority malignant, 2.7% were majority UMP, 0.5% were concordant UMP, 6.9% were opposing, and 1.6% were non‐definitive. Patient treatment models of those with equivocal lesions (n = 788) revealed a potential of overall surgical treatment variations ranging from 18% to 72%, with the highest variation amongst lesions with opposing, non‐definitive, or majority UMP (40%–72%) diagnoses. Conclusion: Histopathologic review in this large cohort demonstrated substantial diagnostic variation, with 23.8% of cases receiving equivocal diagnoses. We identified diagnostic ambiguity even in lesions where a definitive diagnosis was previously rendered by a single real‐world dermatopathologist. The combined clinical impact of diagnostic discordance or a final diagnosis of UMP is highlighted by high diagnosis‐dependent treatment variation in the patient treatment model, which could be underreported in a real‐world setting, where review by more than one to two dermatopathologists is relatively rare. [ABSTRACT FROM AUTHOR]

The objective of this narrative review is to advocate for improved comprehensive care of patients with obesity and infertility. Persons with an increased body mass index have less successful reproductive outcomes, and recently, new medications to treat neuroendocrine hormone imbalances are producing meaningful weight loss akin to surgical interventions. For the first time, obesity is publicly being recognized as a disease. These medications contain the newest generation of glucagon-like peptide 1 receptor agonists and deserve our attention for several reasons: regardless of body mass index, many patients will be using them; it is necessary to understand the mode of action, side effects, and implications for anesthetic procedures and pregnancy; and it is important to evaluate when they could be used to improve health outcomes and/or access to fertility care. [ABSTRACT FROM AUTHOR]

There is growing interest in working with beavers (Castor canadensis and Castor fiber) to restore and maintain ecosystem function, improve hydrologic conditions and build climate resiliency in freshwater ecosystems. Beaver translocation into historically occupied but degraded systems has been increasingly applied as a restoration practice over the last two decades. Knowledge of beaver distributions on the landscape is critical to understanding where and when beaver translocations may be effective. However, current understanding of beaver occupancy and translocation success is limited by uncertainty, subjectivity and inefficiency associated with available monitoring methods. We evaluated the efficacy and spatial inference associated with environmental DNA (eDNA) techniques for detecting beaver presence in natural wetland and stream systems in the Cascade mountains of Washington State. We conducted eDNA sampling paired with radio‐tracking of translocated beavers at four relocation sites from October 2020 through October 2022 to elucidate spatial patterns of site use, eDNA detection probability and eDNA quantity. We found that eDNA techniques detected beaver rapidly over long distances – up to 2.9 km from known locations within the first week after release – and reliably detected beavers when they were upstream, with positive detections in 92.4% of downstream eDNA samples collected 1–3 months after release. We also found that eDNA quantity decreased with increasing distance from beaver and increased with the amount of upstream beaver activity. Our study suggests that eDNA is a sensitive tool for monitoring translocated beaver and can provide spatial information on beaver location and site use within a stream system. Hence, eDNA methods could be a valuable tool for rapid inventory and assessment of beaver occupancy and our findings highlight important implications for using eDNA to monitor other semi‐aquatic mammal species that share similar life histories. [ABSTRACT FROM AUTHOR]

Background: Local surgical excision of T1 rectal adenocarcinoma is a well-established approach. Yet, there are still open questions regarding the recurrence rates and its risk factors. Methods: A retrospective multicenter study including all patients who underwent local excision of early rectal cancer with an open or MIS approach and had a T1 lesion from 2010 to 2020 in six academic centers. Data included demographics, preoperative studies, surgical findings, postoperative outcomes, and local and systemic recurrence. A univariable and multivariable logistic regression analysis was performed to identify risk factors for recurrence. Results: Overall, 274 patients underwent local excision of rectal lesions. Of them, 97 (35.4%) patients with a T1 lesion were included in the cohort. The mean age was 69 ± 10.5 years, and 42 (43.3%) were female. The mean distance of the lesions from the anal verge was 7.8 ± 3.2 cm, and the average tumor size was 2.7 ± 1.6 cm. Eighty-two patients (85%) had a full-thickness resection. Eight patients (8%) had postoperative complications. Kikuchi classification of submucosal (SM) involvement was reported in 29 (30%) patients. Twelve patients had SM1, two SM2, and fifteen SM3. Following pathology, 24 patients (24.7%) returned for additional surgery or treatment. The overall recurrence rate was 14.4% (14 patients), with 11 patients having a local recurrence and 6 having a systemic metastatic recurrence, 3 of which had both. The mean time for recurrence was 2.78 ± 2.8 years and the overall mortality rate was 11%. On univariable and multivariable logistic regression analysis of recurrence vs. non-recurrence groups, the strongest and most significant association and possible risk factors for recurrence were larger lesions (4.3 vs. 2.5 cm, p < 0.001) with an OR of 6.67 (CI—1.82–24.36), especially for tumors larger than 3.5 cm, mucinous histology (14.3% vs. 1.2%, p = 0.004, OR of 14.02, CI—1.13–173.85), and involved margins (41.7% vs. 16.2%, p = 0.003, OR of 9.59, CI—2.14–43.07). The open transanal excision (TAE) approach was also identified as a possible significant risk factor in univariant analysis, while SM3 level penetration showed only a trend. Conclusion: Surgical local excision of T1 rectal malignancy is a safe and viable option. Still, one in four patients received additional treatment. There is an almost 15% chance for recurrence, especially in large tumors, mucinous histology, or involved margin cases. These high-risk patients might warrant additional intervention and stricter surveillance protocols. [ABSTRACT FROM AUTHOR]

Purpose: The widespread adoption of online purchasing has prompted increasing concerns about product safety, and regulators are beginning to hold e-commerce sites accountable for dangerous product defects. For online consumers, understanding the many inherent safety risks among the extensive array of products they browse is a formidable task. The authors attempt to address this problem via a client-side software artifact that warns shoppers about potential product safety hazards at the point of sale. Design/methodology/approach: In this study, the authors built four candidate designs and assessed their effectiveness by means of a large randomized controlled experiment (n = 466). The authors define effectiveness as significant changes in dependent variables associated with health behaviors and technology adoption. Findings: The authors find that all of the designs score high on adoption likelihood, that designs incorporating highlighting and scoring are better at increasing safety knowledge and that simpler designs are better at enhancing safety awareness. Originality/value: These findings will inform the design of safety information dissemination systems and open new areas of safety awareness enhancement research. More generally, the authors introduce a novel method of testing text visualization variations and their impact on behavioral decisions. [ABSTRACT FROM AUTHOR]

Recent years have seen a growing sociological interest in meaning. In fact, some argue that sociology cannot confront its foundational questions without addressing meaning. Yet sociologists mean many things when they talk about meaning. We propose a practical approach that conceptualizes meaning as an instance of an actor interpreting a stimulus. Reviewing existing literature, we find that most sociological accounts understand interpretation either as categorization or as semantic association. We show that an integrated approach is analytically useful for conceptualizing shared interpretation and the process by which people coordinate their interpretations. This provides a framework for addressing interpretative heterogeneity when studying attitudinal or behavioral variance. We conclude by highlighting how recent advances in computational linguistics have opened exciting new possibilities for the study of interpretation, and suggest several avenues for future research. [ABSTRACT FROM AUTHOR]

Globally, one in three individuals needs at least one assistive product. The primary objective of this study was to conduct a survey of Pakistani rehabilitation service providers to determine what proportion provide assistive technology and if their characteristics (including geographical region, education, and experience) are associated with adherence to the service delivery process. The secondary objective was to determine if individuals that provide assistive technology adhere to a standard assistive technology service delivery process. The tertiary objective was to determine if the providers that adhered to a standard delivery process had characteristics that differed from the rest of the service providers. An online survey composed of multiple-choice questions was distributed to physiotherapists, community-based healthcare workers, and related rehabilitation professions through a convenience sampling method. SPSS Statistics was used to develop correlation matrices to determine Pearson's coefficient of number of steps, education level, experience level and continuing education received. There were 71 respondents from 4 Pakistani provinces. 53.5% of respondents stated they provide assistive technology. There was participation in most steps of the service delivery process. There is weak correlation between number of steps and education level, number of steps and experience level, and number of steps and continuing education received. While the majority of respondents provide assistive technology, a significant proportion (46.5%) don't. This may suggest there is a need for additional advocacy and awareness raising of the benefits of and how to access assistive technology in Pakistan. Pakistan implemented a Rapid Assistive Technology Assessment and determined that only 22% of the population that needs an assistive device has had their needs met. From a relatively small sample, this study investigated if there is a presence of assistive technology service delivery in Pakistan and whether traditional education, experience, or continuing education promotes participation in the assistive technology service delivery process. This study found a presence of assistive technology service delivery in Pakistan, but found weak correlations between participation in the service delivery process with traditional education, experience, and continuing education. These findings suggest that there is room for additional advocacy and awareness training on assistive technology in Pakistan. [ABSTRACT FROM AUTHOR]

Parent mental health challenges in the postpartum and early parenthood have profound implications for parent, child, and family well‐being. Little research has focused on postpartum mental health challenges and barriers to help‐seeking among queer birthing people, including members of this community who may be particularly vulnerable to mental health difficulties, such as queer cis women partnered with men, trans/nonbinary parents, and queer parents who are young, low‐income, and/or of color. This mixed‐methods study of queer parents (n = 99), all of whom were assigned female at birth (AFAB) and gave birth to a child within the past several years, explores parents' postpartum mental health difficulties and perceived barriers to seeking help. Using a structural stigma framework, this study found that participants reported high rates of postpartum mental health difficulties (89%) and reported various barriers to seeking support including fears of discrimination and being deemed “unfit” by providers, which might lead to child welfare system involvement. Young parents and low‐income parents were particularly fearful of child welfare system contact and potential child removal. Factors that encouraged help‐seeking (e.g., desire to be a good parent; partner pressure to seek help) and implications for family practitioners are discussed. [ABSTRACT FROM AUTHOR]

Background: Vietnam is experiencing an increasing prevalence of hypertension in its adult population. In addition to medical therapy, modifying adverse lifestyle practices is important for effective blood pressure control. There are limited data on unhealthy lifestyle practices in patients with chronic diseases, however, particularly among hypertensive patients living in rural Vietnam. Our study objectives were to examine the prevalence of unhealthy lifestyle practices and associated factors among rural Vietnamese adults with uncontrolled hypertension. Methods: Data from the baseline survey of a cluster randomized trial among hypertensive Vietnamese adults (2017–2022) were utilized. Information on unhealthy lifestyle practices including smoking, excessive alcohol consumption, physical inactivity, and inadequate fruit and vegetable intake was collected from study participants. The primary study outcome was having ≥2 unhealthy lifestyle practices. A multivariable logistic regression model was used to examine factors associated with the primary study outcome. Results: The mean age of the 671 patients was 67 years and 45.0% were men. Nearly three out of every four participants had one or fewer unhealthy practices, 24.0% had two, and 3.3% had three or all four unhealthy lifestyle practices. Men, individuals who did unpaid work or were unemployed, and individuals with hypertension level III were more likely to have ≥2 unhealthy lifestyle practices, whereas individuals with higher education were less likely to have ≥2 unhealthy lifestyle practices compared with respective comparison groups. Conclusions: We observed a high prevalence of unhealthy lifestyle practices among rural Vietnamese patients with uncontrolled hypertension. Several demographic factors were associated with a greater number of unhealthy lifestyle practices. Newer interventions and educational programs encouraging lifestyle modification practices are needed to control hypertension among adults living in rural settings of Vietnam. [ABSTRACT FROM AUTHOR]

AbstractRadiotherapy treatment planning is a challenging large-scale optimization problem plagued by uncertainty. Following the robust optimization methodology, we propose a novel, spatially based uncertainty set for robust modeling of radiotherapy planning, producing solutions that are immune to unexpected changes in biological conditions. Our proposed uncertainty set realistically captures biological radiosensitivity patterns that are observed using recent advances in imaging, while its parameters can be personalized for individual patients. We exploit the structure of this set to devise a compact reformulation of the robust model. We develop a row-generation scheme to solve real, large-scale instances of the robust model. This method is then extended to a relaxation-based scheme for enforcing challenging, yet clinically important, dose–volume cardinality constraints. The computational performance of our algorithms, as well as the quality and robustness of the computed treatment plans, are demonstrated on simulated and real imaging data. Based on accepted performance measures, such as minimal target dose and homogeneity, these examples demonstrate that the spatially robust model achieves almost the same performance as the nominal model in the nominal scenario, and otherwise, the spatial model outperforms both the nominal and the box-uncertainty models. [ABSTRACT FROM AUTHOR]

The US health care system has significant room for growth to achieve the Quintuple Aim. Reforming the relationship between payers and providers is pivotal to enhancing value-based care (VBC). The Payvider model, a joint approach to care and coverage rooted in vertical integration, is a potential solution. The authors aimed to investigate academic medical institutions adopting this model, termed Academic Payviders. All Association of American Medical Colleges (AAMC)-member allopathic medical schools were evaluated to identify programs meeting the inclusion criteria of offering both medical care and insurance coverage to patients via partnership with a payer or ownership of, or by, a payer. Twenty-five Academic Payvider systems were identified from 171 total AAMC-member programs. Most programs were founded after 2009 (n = 20), utilized a provider-dominant structural model (n = 17), and offered health plans to patients via Medicare Advantage (n = 23). Passage of the Affordable Care Act, recent trends in health care consolidation, and increased political and financial prioritization of social determinants of health (SDOH) may help to explain the rise of this care and coverage model. The Academic Payvider movement could advance academic medicine toward greater acceptance of VBC via innovations in medical education, resource stewardship in residency, and the establishment of innovative leadership positions at the administrative level. [ABSTRACT FROM AUTHOR]

Background: Clinician burnout has become a major issue in the USA, contributing to increased mental health challenges and problems with quality of care, productivity, and retention. Objective: The objective of this study was to understand primary care clinicians' perspectives on burnout during the COVID-19 pandemic as well as their perspectives on the causes of burnout and strategies to improve clinician well-being. Approach: This qualitative research involved in-depth interviews with 27 primary care clinicians practicing in a range of settings across the USA. Semi-structured interviews lasted between 60 and 90 min and were conducted using Zoom video conferencing software between July 2021 and February 2023. Transcripts were analyzed in NVivo software using multiple cycles of coding. Key Results: Clinicians shared their experiences with burnout and mental health challenges during the COVID-19 pandemic. Contributors to burnout included high levels of documentation, inefficiencies of electronic health record (EHR) systems, high patient volume, staffing shortages, and expectations for responding to patient emails and telephone calls. The majority of participants described the need to work after clinic hours to complete documentation. Many clinicians also discussed the need for health system leaders to make sincere efforts to enhance work-life balance and create a culture of health and well-being for health professionals. Suggested strategies to address these issues included supportive leadership, accessible mental health services, and additional administrative time to complete documentation. Conclusions: The results of this study provide an in-depth view of participating primary care clinicians' experiences and perceptions of burnout and other mental health challenges. These viewpoints can improve awareness of the issues and strategies to improve the health and well-being of our clinician workforce. Strategies include aligning payment models with the best approaches for delivering quality patient care, reducing administrative burden related to documentation, and redesigning EHR systems with a human factors approach. [ABSTRACT FROM AUTHOR]

While the use of Hebrew was much in decline in most parts of Germany by the end of the eighteenth century, a considerable number of modern Hebrew texts were being published in Breslau with the specific goal of promoting and maintaining the relevance of Hebrew. The article presents a group portrait of the authors who promoted this consolidation of Hebrew study and modern Hebrew writing. It focuses on Mordechai Roch, a lesser-known author whose maskilic activity spanned more than three decades and thus linked the early attempts of the 1790s with a new flowering of Hebrew writing in the 1810s. [ABSTRACT FROM AUTHOR]

Nuisance is once again a hot topic in legal practice and scholarship. Public nuisance law is at the center of efforts to hold product manufacturers, energy companies, and internet platforms liable for billions in losses. Scholars have in turn offered competing accounts of the legitimacy and scope of this form of liability. Meanwhile, private nuisance has been the subject of renewed academic attention, including the issuance of new Restatement provisions, that aim to make sense of its distinctive features. Unfortunately, to date, these two lines of inquiry have mostly been pursued in isolation, a pattern that reflects the prevailing wisdom (famously articulated by William Prosser and others) that the two nuisances share nothing beyond a common name. To the contrary, this Article maintains that the key to practical and theoretical progress in this complex area of law is to appreciate that the two nuisances are variants of the same general concept. As variants, they do indeed differ: a private nuisance is a wrong involving the violation of another's right to use and enjoy their property, whereas public nuisance in the first instance does not turn on the violation of private property rights. And yet both nuisances involve wrongful interferences with others' access to, or use of, physical spaces or resources. By attending to and appreciating this common core, lawyers, judges, and scholars will be better positioned to develop nuisance law in a consistent and principled manner. [ABSTRACT FROM AUTHOR]

For the last decade or more, circulation numbers of physical materials have declined in academic libraries across the United States. In the spring of 2020, the COVID-19 pandemic drastically altered society and daily life, not to mention library functions. In particular, fears of contagion via physical surfaces and transmission by contact led many libraries to shutter their in-person services or temporarily close altogether. The circulation of physical materials was hit particularly hard, as the ability to browse shelves, check out items, access interlibrary loan, and a host of other similar services were curtailed. This article will examine the statistical markers of physical material handling (checkouts, renewals, item browses, etc.) for two years before and after the pandemic, to reach conclusions about how COVID-19 impacted usage, what we can tell about general patterns in circulation before and due to these changes, and ultimately what these numbers tell us about the future of traditional material use. [ABSTRACT FROM AUTHOR]

"Taxonomy of an Enslaved Heart" opens up the figuration of heartache, so common to sentimental writings, to consider how it can signify anatomical pain as well. What does it mean to read figuratively—accepting that every instance of a heart broken or throbbing or heavy indexes emotional pain addressing the reader's sympathy—and, at the same time, to literalize these instances, so that each one refers to a specific episode in the history of a circulatory system? This essay attempts to hold both in tension, even as they resist each other. Attending to texts by Harriet Jacobs, Mary Prince, Sojourner Truth, and James Baldwin, the essay argues for what it calls the story of the heart: a minoritized account of pain that deforms sentimental language to register at once somatically, mentally, and intersubjectively. Because of its insecure legibility, the story of the heart subverts the biopolitical logic of legitimacy that traps many patients who are Black, disabled, or both today. What emerges from holding figuration with literalization subtly shifts the illnesses we know and the conditions by which we know them. [ABSTRACT FROM AUTHOR]

Praying mantids (Mantodea: Mantidae) are iconic insects that have captivated biologists for decades, especially the species with cannibalistic copulatory behavior. This behavior has been cited as evidence that insects lack nociceptive capacities and cannot feel pain; however, this behaviorally driven hypothesis has never been rigorously tested at the genetic or functional level. To enable future studies of nociceptive capabilities in mantids, we sequenced and assembled a draft genome of the Chinese praying mantis (Tenodera sinensis) and identified multiple classes of nociceptive ion channels by comparison to orthologous gene families in Arthropoda. Our assembly—produced using PacBio HiFi reads—is fragmented (total size = 3.03 Gb; N50 = 1.8 Mb; 4,966 contigs), but is highly complete with respect to gene content (BUSCO complete = 98.7% [odb10_insecta]). The size of our assembly is substantially larger than that of most other insects, but is consistent with the size of other mantid genomes. We found that most families of nociceptive ion channels are present in the T. sinensis genome; that they are most closely related to those found in the damp-wood termite (Zootermopsis nevadensis); and that some families have expanded in T. sinensis while others have contracted relative to nearby lineages. Our findings suggest that mantids are likely to possess nociceptive capabilities and provide a foundation for future experimentation regarding ion channel functions and their consequences for insect behavior. [ABSTRACT FROM AUTHOR]

The article discusses the concept of dread and its pervasiveness in today's world. The author argues that dread is a response to the inescapable and worsening conditions of our time, such as pandemics, environmental crises, and violence. The article also explores how dread intersects with race, class, and gender, and how it affects different groups differently. The author calls for collective action and the establishment of institutions that promote collective justice as a means to address and alleviate dread. [Extracted from the article]