1. Mid-term prognostic value of coronary artery disease in patients undergoing transcatheter aortic valve implantation: A meta-analysis of adjusted observational results.
- Author
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D'Ascenzo, F., Conrotto, F., Giordana, F., Moretti, C., D'Amico, M., Salizzoni, S., Omedè, P., La Torre, M., Thomas, M., Khawaja, Z., Hildick-Smith, D., Ussia, Gp., Barbanti, M., Tamburino, C., Webb, John, Schnabel, R.B., Seiffert, M., Wilde, S., Treede, H., and Gasparetto, V.
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CORONARY disease , *META-analysis , *SCIENTIFIC observation , *HEALTH outcome assessment , *MULTIVARIATE analysis , *PROGNOSIS ,AORTIC valve surgery - Abstract
Abstract: Aims: Coronary artery disease (CAD) negatively affects prognosis in patients undergoing surgical aortic valve replacement, being currently evaluated in the most common used risk score. Our meta-analysis aims to clarify the prognostic role of CAD on mid-term survival in patients undergoing TAVI. Methods and results: Studies reporting multivariate predictors of adverse outcomes in patients undergoing TAVI were systematically searched for and pooled, when appropriate, using a random-effect method. 960 citations were first screened and finally 7 studies (2472 patients) were included. Diagnosis of CAD was reported in 52%(42–65) of patients and 1169 Edwards SAPIEN and 1303 CoreValve prostheses were implanted. After a median follow up of 452days (357–585) 24% of patients (19–33) died, and 23 (14–32) for cardiovascular death. At pooled analysis of multivariate approach, diagnosis of coronary artery disease did not increase risk of death (OR 1.0, 95% CI, confidence interval, 0.67–1.50 I2 0%). Conclusion: CAD does not affect mid-term TAVI outcome: this finding should be weighted to accurately evaluate risk and strategies for patients with severe aortic stenosis. [Copyright &y& Elsevier]
- Published
- 2013
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