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The proportion of the world's older adults and of its dementia cases is increasing in low and middle-income countries. This is particularly true in Colombia. There, the number of individuals with dementia may increase five-fold by 2050. Yet research is lacking on dementia in such settings. This work estimates the prevalence of dementia in a community-dwelling population in Colombia. It also assesses how gender-based differences in cardiovascular conditions and socioeconomic disparities affect dementia. This work analyzes data on 2000 respondents at least 60 years of age in the Health, Well-Being, And Aging (SABE) study in Bogota. Respondents with dementia are those who have cognitive impairment and at least two limitations in instrumental activities of daily living. The SABE study finds 8.4% of respondents have dementia. Age, cardiovascular risks, and socioeconomic disparities contributed to higher odds of dementia. The contributors to dementia can differ for men and women. For example, socioeconomic disparities were a larger contributor to dementia for women than men. The findings support the cognitive reserve hypothesis on dementia. This holds that pre-existing cognitive processes and compensatory mechanisms influence dementia. Women in Latin America are more likely to suffer from socioeconomic disparities that limit their cognitive reserve. This research points to several policy implications that can help offset these disparities and reduce the prevalence of dementia. [ABSTRACT FROM AUTHOR]

The article focuses on the Role of Gait Speed in Dementia, and the secondary Analysis from the SABE Colombia Study. Topics discussed include Gait speed (GS) is a predictor of negative outcomes in older adults and in those in risk to develop cognitive impairment; and this study aimed to evaluate the relationship between GS and dementia in a representative sample of Colombian older adults.

Introduction: Early markers of neurodegeneration provide an opportunity to detect, monitor, and initiate interventions in individuals who have an increased risk of developing dementia. Here, we investigated whether the Timed Up and Go (TUG) test is associated with early brain neurodegeneration and whether the TUG test could be a marker of cognitive decline in people with subjective cognitive decline (SCD). Methods: This is a longitudinal analysis of the Dementia Disease Initiation Study, a prospective, community-based, cohort study from Norway, designed to investigate early markers of cognitive impairment and dementia. Participants were classified as SCD and healthy controls (HC). The main studied variables were the TUG test and cognition as measured by the Mini-Mental State Examination and the Consortium to Establish a Registry for Alzheimer's Disease memory composite score. Additionally, we investigated the cross-sectional association of brain morphology with the TUG using 1.5T-MRI. Results: The sample included 45 participants (SCD = 21, HC = 24) followed during a mean time of 1.50 ± 0.70 years. At baseline, the cognitive performance did not differ between the groups, but TUG was longer in SCD. Slower baseline TUG was associated with a faster cognitive decline in both groups and it was also associated with reduced cortical thickness especially in motor, executive, associative, and somatosensory cortical regions in people with SCD. Discussion/Conclusion: TUG predicted cognitive change in individuals with SCD, and there was a negative association between TUG and cortical thickness. TUG is a promising cheap and noninvasive marker of early cognitive decline and may help initiate interventions in individuals who have an increased risk of dementia. [ABSTRACT FROM AUTHOR]

Purpose: The present study aims to explore the association between the quality of life (QoL) score and the clinical and sociodemographic variables in patients with the PSEN1-E280A mutation. We also seek to evaluate the differences between the QoL reported by the patients (P-QoL) and the scores reported by the caregivers (C-QoL). Methods: An analysis of 75 patients with the PSEN1-E280A mutation with mild cognitive impairment and dementia was performed. We used the Quality of Life in Alzheimer Disease (QoL-AD) survey to evaluate QoL as an outcome and evaluated its association with sociodemographic, lifestyle, clinical, and past medical history variables. Results: The largest difference in the median of the QoL-AD score was in those who needed help to eat, those with moderate or severe dementia, those classified as frail or pre-frail, those with moderate social risk, and those with depression. Also, C-QoL was lower than the P-QoL, and the QoL-AD of individuals with severe dementia was lower than for milder forms of the disease. Not needing help to eat, not having a stressful situation in the past 3 months, and the years of education were positively correlated with QoL-AD in the linear model. Conclusion: As studies in similar populations with AD, factors with more impact on QoL are those related to loss of functionality and independence. These factors are also associated with variables related to the current literature with the burden of the disease for the caregivers. [ABSTRACT FROM AUTHOR]

Background: There has been an increase in the incidence of ischemic stroke in young adults. It is believed that it is due to the increase in traditional cardiovascular risk factors. This change has affected the quality of life of young adults. Aims: To describe the most common etiologies and risk factors in patients aged ≤ 50 who had ischemic stroke between 2011 and 2018. Methodology: A cross-sectional study of patients under 50 years who had ischemic stroke between 2011 and 2018 who were evaluated at a comprehensive center in Bogotá, Colombia. We carried out a descriptive analysis of comorbidities, the Trial of Org for Acute Stroke (TOAST), the National Institute of Health Stroke Scale (NIHSS), and the modified Rankin Scale (mRS). Results: A total of 152 patients were included, out of which 50.66% were men. The most frequent traditional risk factors were smoking history (19%), history of high blood pressure (18%), presence of cardiovascular disease (17%), and history of migraine (15%). The most common etiological subgroups were those classified as "other determined etiologies" (33.5%) and "undetermined etiology" (33.5%), while the most common etiology was carotid or vertebral artery dissection (23%). Conclusion: This study demonstrates the need to make a deep evaluation of the past medical history, laboratory tests, and new risk factors in young adults. On the other hand, modifiable cardiovascular risk factors top the list, showing the need to implement health promotion strategies for young adults. [ABSTRACT FROM AUTHOR]

• We found a positive longitudinal correlation between physical activity and cognition in Korean subjects older than 50 years. • Performing regular physical activity could have a protective effect on the cognitive decline associated with aging. • Physical activity is cheap and accessible. It can benefit older adults' health in many areas, especially on cognition. As the world's population ages, the prevalence of cognitive impairment associated with age increases. This increase is particularly pronounced in Asia and South-America. The objective of this study was to investigate separately the longitudinal association of physical activity and cognitive function in; older adults in Mexico and South Korea. This is a secondary analysis of two surveys, The Mexican Health and aging Study (MHAS) (n = 5853) and Korean Longitudinal Study of aging (KLoSA) (n = 5188), designed to study the aging process of older adults living in Mexico and South Korea. Participants older than 50 years were selected from rural and urban areas achieving a representative sample. Physical activity was assessed using self-report. Cognition was assessed using Cross-Cultural Cognitive Examination (CCCE) and Minimental state examination (MMSE) in Mexico and South Korea respectively. Here we investigate the longitudinal association between physical activity and cognition during 3 years for MHAS and 4 years for KLoSA using multiple linear regression analyses. The prevalence of physical activity was 40.68 % in MHAS and 35.57 % in KLoSA. In the adjusted longitudinal multivariate analysis, an independent association was found between physical activity and MMSE score OR 0.0866 (CI 0.0266-0.1467 p-value 0.0047) in the Korean older adults, while there was no significant association in MHAS. Physical activity could have a protective effect on the cognitive decline associated with aging in the Korean population. [ABSTRACT FROM AUTHOR]

• The diagnosis of DLB is a challenge and people with DLB have poor prognosis. • In Latin America, there are no precise reports of the prevalence of DLB. • COL-DLB aims to describe DLB in Colombia and to explore biomarkers usefulness. • COL-DLB will provide a first panorama of the DLB in Colombia. [ABSTRACT FROM AUTHOR]