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Purpose: To explore the relationship between single-nucleotide polymorphisms (SNPs) in complement factor I (CFI), interleukin-8 (IL-8), transferrin (TF), and transferrin receptor 2 (TFR2) and age-related macular degeneration (AMD) in a northeastern Chinese population. Methods: A total of 400 AMD patients (200 wet AMD and 200 dry AMD) and 200 controls were enrolled in this study, and genetic polymorphisms in the above genes were detected by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP). The χ2 test was used to compare differences in allele frequencies in each group, and the associations of genotype frequencies with AMD were determined by multivariate logistic regression analysis. Results: Our research shows that CFI rs141853578, IL-8 rs2227543, TF rs8177178 and TFR2 rs2075674 are associated with the incidence of AMD. In wet AMD, allele T of CFI rs141853578, IL-8 rs2227543 and TFR2 rs2075674 may be a risk factor. Allele A of TF rs8177178 may increase the risk of dry AMD. Conclusions:CFI rs141853578, IL-8 rs2227543, TF rs8177178 and TFR2 rs2075674 genetic polymorphisms are associated with the occurrence of AMD in a northeastern Chinese population, especially wet AMD. [ABSTRACT FROM AUTHOR]

Ionospheric inhomogeneous plasma produced by single point chemical release has simple space-time structure, and cannot impact radio wave frequencies higher than Very High Frequency (VHF) band. In order to produce more complicated ionospheric plasma perturbation structure and trigger instabilities phenomena, multiple-point chemical release scheme is presented in this paper. The effects of chemical release on low latitude ionospheric plasma are estimated by linear instability growth rate theory that high growth rate represents high irregularities, ionospheric scintillation occurrence probability and high scintillation intension in scintillation duration. The amplitude scintillations and the phase scintillations of 150 MHz, 400 MHz, and 1000 MHz are calculated based on the theory of multiple phase screen (MPS), when they propagate through the disturbed area. [ABSTRACT FROM AUTHOR]

Metal cesium (Cs) vapor, released at an altitude in the upper atmosphere, generates an artificial space plasma cloud with high electron density. It can act as a scatter to realize radio communication across an over-the-horizon distance. A full-life model of radio propagation via an artificial plasma cloud is established based on its space–time evolution in this article. In addition, this model is verified by the sounding data of the rocket release experiment carried out in the United States. The multipath effect of plasma cloud scattering is studied by using ray tracing, and then, the coherent bandwidth is estimated for this spatial channel. Also, the theoretical channel model of artificial plasma cloud is established by using its space–time evolution and atmospheric wind field parameters. Considering common modulation modes and receiver noise levels, the potential communication performance is evaluated by using the proposed channel model, such as the transmission rate, the bit error rate (BER), and the available time for building up and maintaining communication links. It is shown that the maximal communication rate is up to 200 kb/s, BER overall maintains below 10−7, and the available time for a single release is about 30–60 min; for the case of this article, they are release mass of 2–10 kg, communication distances of 400–1200 km, and radio frequencies of 30–70 MHz at the VHF band. This demonstrates that the artificial channel can propagate radio waves at a much higher frequency, wider bandwidth, and higher rate than those of HF communication. Hopefully, it could be a solution to overcome the intolerable shortcoming and adverse effects on HF communication due to ionospheric disturbances especially in cases of maritime, emergency, and minimum communications [ABSTRACT FROM AUTHOR]