Search

Introduction Pathogen Inactivation allows to overcome microbial contamination and growth related to storage of platelets concentrates ( PC) at room temperature. The aim of our study was to evaluate the platelet storage lesion extending the storage period of pathogen inactivated platelet concentrates over 7 days using an automated cytometry assay panel. Methods We analyzed 43 concentrates subjected to pathogen inactivation ( CPPI) at 3, 5 and 7 days evaluating: platelet count, mean platelet volume, platelets at low optical density, platelets at high density, GPIIb- IIIa glycoprotein, platelet microparticles, lactate dehydrogenase. The collection bags (Fenwal) and the IBS kit made in PL2410/ PL2411 are approved for the conservation of PC up to 7 days. Data analysis was performed with anova test. Results All the parameters except small platelets and PMP were statistically different among day 7 vs. 3 and day 7 vs. 5. Conclusions Our study showed a progressive modification of pathogen inactivated platelet concentrates observed up to 7 days. The persistence of the secretory pool and the presence of the platelet membrane fibrinogen receptor suggest the persistence of a potential hemostatic efficacy. Clinical studies are necessary to directly correlate this type of analysis to 24 h recovery or survival of transfused platelets in humans. [ABSTRACT FROM AUTHOR]

Due to the awareness of the exhaustion of energy resources, some studies on construction techniques, linked to local traditions, to readily available materials, to low load energy and to self- building are been carried out. The high recyclability of natural materials that can be used in low-cost buildings (such as clay, straw, bamboo, wood) associated with construction techniques capable of exploiting the principles of bioclimatic architecture for energy needs, allow us to create building environmentally conscious and responsible. This study was developed according to the following steps: at first, we proceeded to collect information on the state of art. In particular, we analyzed different types of construction based on clay solutions (rammed earth - pisè, hand-formed bricks - adobe, lightened earth, weight-reduced blocks -massoni, cob, extruded blocks, compressed blocks) and different types of materials and/or compositions of clay/sand/straw mixture (clay and straw, clay and wood, clay and minerals aggregates). A series of earthen construction projects has been investigated, in order to identify their technology choices and design, in relation to operational, manufacturing, and constructive aspects. These data were then compared in terms of energy performance, maintainability, flexibility, comfort. The next step involved the design of a habitation module of transitory residencies with wooden framework and outside walls in lighter earth hand-formed blocks. At the same time the project of a special block (made of clay and fibers derived from foliage of common reed -Arundo Donax) was developed, to meet the needs of sustainability and ease of construction. An experimental test on this block was carried out, aimed at the identification of mechanical performance in relation to the different compositions of the mixtures. [ABSTRACT FROM AUTHOR]

Dystrophies are generally classified into progressive, such as Duchenne, Becker, the Emery-Dreifuss, the Central Core, the Nemaline, the King Denborough and congenital and mitochondrial myopathies, which can be present at birth. General anesthesia in myopathic poses several problems. The patient may be a child with initial symptoms, which must be subjected to muscle biopsy or a patient with overt myopathy, with all the events muscular, respiratory and cardiac related to it, to be submitted to any operation under general anesthesia even if regional blocks are also possible. For this reason, it becomes crucial an initial framework preoperative of the myopathic patient. [ABSTRACT FROM AUTHOR]

Summary Pallister–Killian syndrome is characterized by tetrasomy of the short arm of chromosome 12p, which produces mental retardation of varying degrees and dysmorphic characteristics. We describe anaesthesia in a 2-year-old child affected by this syndrome who underwent surgery for orchidopexy. Anaesthetic consisted of an inhalation mixture of O2 , N2 O and sevoflurane, together with an inguinal block with ropivacaine and administration of alfentanil plus ketorolac. Tracheal intubation was uneventful. No complications of any type were observed. [ABSTRACT FROM AUTHOR]

Focuses on anesthesia management in a patient with Aicardi's Syndrome or an epileptic encephalopathy. Characteristics of the Aicardi's Syndrome; Admittance of a 2-year-old female child with the syndrome who underwent inhalation anesthesia for muscle biopsy; Problems encountered during the operation.

Presents the case of a child with Costello syndrome, aged one year and eight months, that required anesthesia for left orchidopexy. Observation of abundant tracheobronchial secretions, chest retractions and a tendency to arterial oxygen desaturation; Need for an accurate and complete history with special attention to gastrointestinal reflux and vomiting.

Considering the high frequency of bleeding complications following fibrinolytic treatment, caudal blockade could be used in association with lower doses of tissue plasminogen activator as a possible new therapeutic approach in management of arterial thrombosis in neonates. [ABSTRACT FROM AUTHOR]

Presents a letter to the editor about anesthesia for a child with Wolf-Hirshhorn syndrome.