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We show that in the de Broglie–Bohm interpretation of quantum mechanics the motion of a single particle near a nodal line is ruled by simple laws. A numerical investigation supports the validity of these laws. Consequences on the appearance of chaotic motion are also discussed. [Copyright &y& Elsevier]

This paper describes a high-throughput sample preparation procedure combined with LC–MS/MS analysis to measure paclitaxel in human plasma. Paclitaxel and an internal standard were extracted from plasma by a semi-automated robotic method using liquid–liquid extraction. Thereafter compounds were separated on a RP C18 column. Detection was by a PE Sciex API 3000 mass spectrometer equipped with a TurboIonSpray™ interface. The compounds were detected in positive ion mode using the mass transition m/z 854.6→286.2 and m/z 831.6→263.2 for paclitaxel and the internal standard, respectively. The limit of quantitation for paclitaxel was 1 ng/ml with an imprecision of 5.2% following extraction of 0.1 ml of plasma. Linearity was confirmed over the whole calibration range (1–1000 ng/ml) with correlation coefficients higher than 0.99 indicating good fits of the regression models. The inter and intra-day precision was better than 9.5% and the accuracy ranged from 90.3 to 104.4%. The assay was simple, fast, specific and exhibited excellent ruggedness. [Copyright &y& Elsevier]

METHOD: We investigated the association of total serum cholesterol concentrations and subsequent overall and coronary mortality in 304 patients aged > or =65 discharged from hospital after acute myocardial infarction. RESULTS: There was no association between total cholesterol concentrations and mortality due to either coronary heart disease or to all causes in all patients or, separately, in men, women, patients younger than 75 and patients aged 75 years and older. [ABSTRACT FROM AUTHOR]