1. Size dependent properties of Gd3+-free versus Gd3+-doped carbon dots for bioimaging application.
- Author
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Zhylkybayeva, Nazym, Paliienko, Konstantin, Topchylo, Anna, Zaderko, Alexander, Géloën, Alain, Borisova, Tatiana, Grishchenko, Liudmyla, Mariychuk, Ruslan, Skryshevsky, Valeriy, Mussabek, Gauhar, and Lysenko, Vladimir
- Subjects
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MAGNETIC resonance imaging , *OPTICAL properties , *INFRARED spectroscopy , *CELL imaging , *LIGHT scattering - Abstract
Gd3+- free carbon dots (CDs) were synthesized by one-step solvothermal method using urea, citric acid and 3-(trifluoromethyl)aniline as precursors. Additionally, Gd3+-doped CDs were prepared by incorporating gadolinium chloride (Gd3+ ions) into the synthesis. Size selection of the purified CDs was achieved through filter membranes ranging from 3 kDa to 100 kDa. The chemical composition and optical properties of the obtained samples were characterized by Energy dispersive X-ray (EDX), Fourier-transform infrared spectroscopy (FTIR), Dynamic Light Scattering (DLS), proton relaxation time measurements, Ultraviolet–visible (UV-vis) and fluorescence spectroscopies. A comparative analysis revealed a strong size-dependent behavior in the optical properties of both Gd3+-doped and Gd3+-free CDs. Furthermore, in vitro tests confirmed the non-cytotoxicity of Gd3+-doped CDs, indicating their potential applicability in biomedicine for magnetic resonance imaging (MRI) and red fluorescence-based cell and tissue imaging. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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