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In this research, we examine the extent to which charitable support for the stigmatized can be enhanced by a moral claim, which occurs when a stigmatized person is attributed an unselfish (versus self-interested) motive for a socially desirable behavior. We find that prospective donors infer a more positive morality when a moral claim is made about a stigmatized person in need, which leads to a greater willingness to provide them with charitable support. The effect does not occur when the same moral claim is made for a person in equivalent need who is accepted or honored in society. We find that moral claims are effective when based on unsubstantiated statements about a mentally ill person’s morality (Study 1), when a drug thief volunteers to help flood victims, rather than helps them as part of her employment (Study 2), and when a homeless criminal returns a lost wallet to do the right thing, rather than to receive a reward (Study 3). The research contributes to our understanding of the role of moral judgments that lead to social rejection and provides insights into how the negative stereotypes that affect the stigmatized can be changed. [ABSTRACT FROM AUTHOR]

Community organizing can play a critical role as a grassroots form of democratic activism which challenges austerity politics sweeping the globe. What is required is not only a democratization of the state through counter-hegemonic political victories, but in the US as well as the UK politicized social movements and grassroots community organizing tied to progressive and radical praxis. The Community Organisers Programme (COP) in England, which trained and hired more than 500 community organizers between 2011 and 2015, can serve as a contradictory example of manipulating the austerity state to include funding community organizing. Without connection to political victories and effective grassroots organizing, the COP remained, like the most prevalent types of training in the US in and outside of social work, a moderated form of democratization and an extension of the neoliberal austerity state, intentionally or not. The voices heard here working in the field demanded a more politicized form of training. This contribution emphasizes voices from the field regarding three aspects: the limited and problematic training content in the COP, the moderated community organizing education which fit with contemporary trends in community organizing in the US, and the surprising political sophistication of those interviewed who understood the highly critical need of more effective training to help address our extraordinary contemporary challenges. [ABSTRACT FROM AUTHOR]

The elderly population is increasing at a rapid rate, and the need for effectively supporting independent living has become crucial. Wearable sensors can be helpful, but these are intrusive as they require adherence by the elderly. Thus, a semi-anonymous (no image records) vision-based non-intrusive monitoring system might potentially be the answer. As everyone has to eat, we introduce a first investigation into how eating behavior might be used as an indicator of performance changes. This study aims to provide a comprehensive model of the eating behavior of individuals. This includes creating a visual representation of the different actions involved in the eating process, in the form of a state diagram, as well as measuring the level of performance or decay over time during eating. Also, in studies that involve humans, getting a generalized model across numerous human subjects is challenging, as indicative features that parametrize decay/performance changes vary significantly from person to person. We present a two-step approach to get a generalized model using distinctive micro-movements, i.e., (1) get the best features across all subjects (all features are extracted from 3D poses of subjects) and (2) use an uncertainty-aware regression model to tackle the problem. Moreover, we also present an extended version of EatSense, a dataset that explores eating behavior and quality of motion assessment while eating. [ABSTRACT FROM AUTHOR]

Timely information about the need to thin forests is vital in forest management to maintain a healthy forest while maximizing income. Currently, very-high-spatial-resolution remote sensing data can provide crucial assistance to experts when evaluating the maturity of thinnings. Nevertheless, this task is still predominantly carried out in the field and demands extensive resources. This paper presents a deep convolutional neural network (DCNN) to detect the necessity and urgency of carrying out thinnings using only remote sensing data. The approach uses very-high-spatial-resolution RGB and near-infrared orthophotos; a canopy height model (CHM); a digital terrain model (DTM); the slope; and reference data, which, in this case, originate from spruce-dominated forests in the Austrian Alps. After tuning, the model achieves an F1 score of 82.23% on our test data, which indicates that the model is usable in a practical setting. We conclude that DCNNs are capable of detecting the need to carry out thinnings in forests. In contrast, attempts to assess the urgency of the need for thinnings with DCNNs proved to be unsuccessful. However, additional data, such as age or yield class, have the potential to improve the results. Our investigation into the influence of each individual input feature shows that orthophotos appear to contain the most relevant information for detecting the need for thinning. Moreover, we observe a gain in performance when adding the CHM and slope, whereas adding the DTM harms the model's performance. [ABSTRACT FROM AUTHOR]

Fear of disease may act as a barrier to screening or early diagnosis. This cross-sectional survey of 355 people attending outpatient clinics at one Australian hospital found that cancer (34%) and dementia (29%) were the most feared diseases. Participants aged 65 years and over feared dementia the most. [ABSTRACT FROM AUTHOR]

Objective: Transcranial direct current stimulation (tDCS) has been advocated for various neurological conditions, including epilepsy. A 1–4‐mA cathodal current applied to the scalp over a seizure focus can reduce spikes and seizures. This series of four patients with focal status epilepticus is among the first case series to demonstrate benefit of tDCS in the critical care setting. Methods: Patients in the intensive care unit were referred for tDCS treatment when focal status epilepticus or clinically relevant lateralized periodic discharges did not resolve with conventional antiseizure medications and anesthetics. Battery‐powered direct cathodal current at 2 mA was delivered by an ActivaDose (Caputron) tDCS device via a saline‐soaked sponge on the scalp over the seizure focus. Anode was on the contralateral forehead or shoulder. Treatment was for 30 min, repeated twice in a day, then again 1–4 times more over the next few days. Results: Three females and one male, aged 34–68 years, were treated. Etiologies of status epilepticus were posterior reversible encephalopathy syndrome in association with immunosuppressants for a liver transplant, perinatal hypoxic–ischemic injury, a prior cardioembolic parietal stroke, and central nervous system lupus. tDCS led to significant reduction of interictal spikes (.78 to.38/s, p <.0001) in three cases and electrographic seizures (3.83/h to 0/h, p <.001) in two cases. Medication reductions were enabled in all cases subsequent to tDCS. The only side effect of tDCS was transient erythema under the sponge in one case. Two patients died of causes unrelated to tDCS, one was discharged to a nursing home, and one became fully responsive as seizures were controlled with tDCS. Significance: Spikes and electrographic seizure frequency significantly improved within 1 day of tDCS. Results are potentially confounded by multiple ongoing changes in medications and treatments. These results might encourage further investigation of tDCS in the critical care setting, but verification by controlled studies will be required. [ABSTRACT FROM AUTHOR]

Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional changes to the cerebral vasculature contribute to disease pathology and cognitive decline in Alzheimer's disease (AD). In this review, we discuss the contribution of cerebral amyloid angiopathy and non‐amyloid small vessel disease in AD, and the accompanying changes to the density, maintenance and remodelling of vessels (including alterations to the composition and function of the cerebrovascular basement membrane). We consider how abnormalities of the constituent cells of the neurovascular unit – particularly of endothelial cells and pericytes – and impairment of the blood‐brain barrier (BBB) impact on the pathogenesis of AD. We also discuss how changes to the cerebral vasculature are likely to impair Aβ clearance – both intra‐periarteriolar drainage (IPAD) and transport of Aβ peptides across the BBB, and how impaired neurovascular coupling and reduced blood flow in relation to metabolic demand increase amyloidogenic processing of APP and the production of Aβ. We review the vasoactive properties of Aβ peptides themselves, and the probable bi‐directional relationship between vascular dysfunction and Aβ accumulation in AD. Lastly, we discuss recent methodological advances in transcriptomics and imaging that have provided novel insights into vascular changes in AD, and recent advances in assessment of the retina that allow in vivo detection of vascular changes in the early stages of AD. [ABSTRACT FROM AUTHOR]

The average error rate in liver cirrhosis classification on B-mode ultrasound images using the traditional pattern recognition approach is still too high. In order to improve the liver cirrhosis classification performance, image correction methods and a convolution neural network (CNN) approach are focused on. The impact of image correction methods on region of interest (ROI) images that are input into the CNN for the purpose of classifying liver cirrhosis based on data from B-mode ultrasound images is investigated. In this paper, image correction methods based on tone curves are developed. The experimental results show positive benefits from the image correction methods by improving the image quality of ROI images. By enhancing the image contrast of ROI images, the image quality improves and thus the generalization ability of the CNN also improves. [ABSTRACT FROM AUTHOR]

Light flashes, patterns, or color changes can provoke seizures in up to 1 in 4000 persons. Prevalence may be higher because of selection bias. The Epilepsy Foundation reviewed light‐induced seizures in 2005. Since then, images on social media, virtual reality, three‐dimensional (3D) movies, and the Internet have proliferated. Hundreds of studies have explored the mechanisms and presentations of photosensitive seizures, justifying an updated review. This literature summary derives from a nonsystematic literature review via PubMed using the terms "photosensitive" and "epilepsy." The photoparoxysmal response (PPR) is an electroencephalography (EEG) phenomenon, and photosensitive seizures (PS) are seizures provoked by visual stimulation. Photosensitivity is more common in the young and in specific forms of generalized epilepsy. PS can coexist with spontaneous seizures. PS are hereditable and linked to recently identified genes. Brain imaging usually is normal, but special studies imaging white matter tracts demonstrate abnormal connectivity. Occipital cortex and connected regions are hyperexcitable in subjects with light‐provoked seizures. Mechanisms remain unclear. Video games, social media clips, occasional movies, and natural stimuli can provoke PS. Virtual reality and 3D images so far appear benign unless they contain specific provocative content, for example, flashes. Images with flashes brighter than 20 candelas/m2 at 3‐60 (particularly 15‐20) Hz occupying at least 10 to 25% of the visual field are a risk, as are red color flashes or oscillating stripes. Equipment to assay for these characteristics is probably underutilized. Prevention of seizures includes avoiding provocative stimuli, covering one eye, wearing dark glasses, sitting at least two meters from screens, reducing contrast, and taking certain antiseizure drugs. Measurement of PPR suppression in a photosensitivity model can screen putative antiseizure drugs. Some countries regulate media to reduce risk. Visually‐induced seizures remain significant public health hazards so they warrant ongoing scientific and regulatory efforts and public education. [ABSTRACT FROM AUTHOR]

Background: Social housing provides homes for some of the most vulnerable in society. Those in social housing often have complex issues that may require support. Limited research has examined the unmet needs of those living in social housing from the tenant perspective. This exploratory study aimed to embark on filling this gap.Methods: A cross-sectional study survey of adult social housing tenants in New South Wales, Australia. Consenting tenants completed a survey asking about their support needs across five domains: transport, employment and financial stress; housing and safety; health and health behaviour; access to services; and control over one's life. Negative binomial regression analysis was used to examine associations between the mean number of support needs and characteristics.Results: Of the 104 tenants invited, 101 agreed to participate (97%) of which 100 completed the survey. Paying unexpected bills' (43%), feeling sad or anxious (40%), feelings of anger or frustration (34%), and memory or concentration problems (33%) were the most prevalent reported needs. Other needs included antisocial behaviour from neighbours (31%) and having control in the direction your life is taking (27%). Seventy-five percent of tenants reported at least one need, with an average of seven needs across the sample (median 5.5, range 0-24). Tenants who identified as Aboriginal or Torres Strait Islander had a higher number of needs compared to other tenants (RR 1.87 95% CI 1.08 to 3.35).Conclusions: More research describing tenant wellbeing needs is required to guide initiatives improving tenant wellbeing. Development of a standardised tool to measure and prioritise tenant wellbeing needs would be beneficial. There is a need for well-controlled research to establish the potential effectiveness and cost effectiveness of initiatives implemented at the policy or housing provider level. Future research must consider the multifaceted needs of this population. Further, Aboriginal and Torres Strait Islander people are generally overrepresented in social housing in Australia, and in this study Aboriginal and Torres Strait Islander tenants reported a higher number of needs compared to non-Aboriginal and Torres Strait Islander tenants. Given this, future research should ensure measurement tools or strategy initiatives are culturally sensitive and appropriate, and are developed in collaboration with Aboriginal and Torres Strait Islander communities. [ABSTRACT FROM AUTHOR]

Together, the data show convincingly that Ang-II activation of pericyte AT1R causes capillary constriction (it remains possible that Ang-II activation of non-vascular AT1R cells may also contribute). Ang-II signalling via AT1R is normally balanced by counter-regulatory AT2R signalling and ACE-2 mediated conversion of Ang-II to Ang-(1-7) resulting in counter-regulatory MasR signalling. Graph: Figure 1 SARS-CoV-2 impairs cerebral blood flow by potentiating Ang-II-mediated pericyte-induced capillary constriction following internalization of ACE-2. [Extracted from the article]

Most invasive species are not studied during their initial colonization of ecosystems to which they were recently introduced. Rather, research is typically performed after invasive species are well established and causing harm to the native biodiversity. Thus, novel adaptations of invasive species during their initial invasions are rarely identified. The California kingsnake (Lampropeltis californiae) is an invasive species in the Canary Islands that originated via escape or release from captive populations. Previous studies have demonstrated several morphological differences between the native California population and the invasive populations on Gran Canaria Island, particularly in regard to color pattern and body mass. In this study, we assessed the reproductive condition of 1,538 museum specimens of L. californiae from the native range, and 668 from Gran Canaria. Our results show that 57.1% of female L. californiae from Gran Canaria were gravid versus 13.4% of those from California. Moreover, average follicle size and clutch size were both greater in the invasive range (20.3 and 65%). In addition, there was a marked phenological shift in the invasive populations, among which follicles appeared 60 days sooner than in the native range. These differences can possibly be attributed to a larger body mass in the invasive populations, a lack of interspecific competition, origination from the pet trade, increased selection for large clutch sizes, and/or increased climate suitability in the invaded habitats. Overall, these reproductive and phenological attributes appear to constitute advantages for L. californiae during the invasion of this newly encountered ecosystem. The phenomenon of reproductive plasticity might generally be advantageous for rapid irruption of snakes on islands. [ABSTRACT FROM AUTHOR]

Organizational respondents often provide misleading or patently false information on job applications, personality tests, and other self-reports. Nevertheless, the degree to which socially desirable responding (SDR) threatens the validity of organizational self-reports remains controversial in academic research. The present research contends that the true level of SDR in organizational measures has often been underestimated because the SDR scales used to detect this bias (i.e., the Balanced Inventory of Desirable Responding and the Marlowe–Crowne Social Desirability Scale) were never intended for use in organizational settings. We therefore develop and validate the SDR-O, which is a short, unidimensional scale designed to measure the impression management component of socially desirable responding in the workplace and other organizational contexts. We demonstrate that the SDR-O is a valid measure of the conscious tendency of organizational respondents to create an overly positive (i.e., inauthentic) impression via their answers to questions. Our research has important implications for academic and managerial research on the wide array of organizational topics that have a desirability component, including employee personality traits, performance, ethics, citizenship, and deviance. • The authors develop and validate a measure of socially desirable responding for organizations. • The scale reflects inauthentic impression management rather than self-deceptive enhancement. • The scale advances our understanding of the range of topics that have a desirability component. • The research finds that the new measure is superior to the BIDR-IM in organizational settings. [ABSTRACT FROM AUTHOR]

The importance of high-acuity foveal vision to visual search can be assessed by denying foveal vision using the gaze-contingent Moving Mask technique. Foveal vision was necessary to attain normal performance when searching for a target letter in alphanumeric displays, Perception & Psychophysics, 62 (2000) 576-585. In contrast, foveal vision was not necessary to correctly locate and identify medium-sized target objects in natural scenes, Journal of Experimental Psychology: Human Perception and Performance, 40 (2014) 342-360. To explore these task differences, we used grayscale pictures of real-world scenes which included a target letter (Experiment 1: T, Experiment 2: T or L). To reduce between-scene variability with regard to target salience, we developed the Target Embedding Algorithm (T.E.A.) to place the letter in a location for which there was a median change in local contrast when inserting the letter into the scene. The presence or absence of foveal vision was crossed with four target sizes. In both experiments, search performance decreased for smaller targets, and was impaired when searching the scene without foveal vision. For correct trials, the process of target localization remained completely unimpaired by the foveal scotoma, but it took longer to accept the target. We reasoned that the size of the target may affect the importance of foveal vision to the task, but the present data remain ambiguous. In summary, the data highlight the importance of extrafoveal vision for target localization, and the importance of foveal vision for target verification during letter-in-scene search. [ABSTRACT FROM AUTHOR]

Suzaku X-ray observations of the Type Ia supernova remnant (SNR) 3C 397 discovered exceptionally high mass ratios of Mn/Fe, Ni/Fe, and Cr/Fe, consistent with a near M Ch progenitor white dwarf (WD). The Suzaku observations have established 3C 397 as our best candidate for a near- M Ch SNR Ia, and opened the way to address additional outstanding questions about the origin and explosion mechanism of these transients. In particular, subsequent XMM–Newton observations revealed an unusually clumpy distribution of iron group elemental (IGE) abundances within the ejecta of 3C 397. In this paper, we undertake a suite of two-dimensional hydrodynamical models, varying both the explosion mechanism – either deflagration-to-detonation (DDT), or pure deflagration – WD progenitors, and WD progenitor metallicity, and analyse their detailed nucleosynthetic abundances and associated clumping. We find that pure deflagrations naturally give rise to clumpy distributions of neutronized species concentrated towards the outer limb of the remnant and confirm DDTs have smoothly structured ejecta with a central concentration of neutronization. Our findings indicate that 3C 397 was most likely a pure deflagration of a high central density WD. We discuss a range of implications of these findings for the broader SN Ia progenitor problem. [ABSTRACT FROM AUTHOR]

Purpose: To report a case who required a thoracic endovascular stenting (TEVAR) following the deployment of frozen elephant trunk due to false lumen expansion Case Report: A 47 years old male patient undergone emergency repair of acute type A aortic dissection in 2011 with bioprosthetic aortic root conduit. Seven years later he presented with moderate aortic valve disease and expanding chronic dissection of the aortic arch, therefore a redo operation with replacement of the prosthetic aortic valve, ascending aorta, total arch and deployment of frozen elephant trunk and he was discharged in good health. Several days post discharge he presented with new onset of chest pain and a new dissection involved the thoracoabdominal aorta was noted pressing on the true lumen and the frozen elephant trunk. Following a multi-disciplinary team meeting, TEVAR was deemed as a most appropriate approach and this was achieved successfully, and patient was discharged. At 1 year of follow up, he remains well and asymptomatic. Conclusion: Close imaging follow-up following deployment of a FET is mandatory. A new acute Type B aortic dissection distal to the FET, that causes false lumen propagation parallel to the stented portion, is a surgical emergency and further intervention mandated. [ABSTRACT FROM AUTHOR]

Populations of the western spadefoot (Spea hammondii) in southern California occur in one of the most urbanized and fragmented landscapes on the planet and have lost up to 80% of their native habitat. Orange County is one of the last strongholds for this pond-breeding amphibian in the region, and ongoing restoration efforts targeting S. hammondii have involved habitat protection and the construction of artificial breeding ponds. These efforts have successfully increased breeding activity, but genetic characterization of the populations, including estimates of effective population size and admixture between the gene pools of constructed artificial and natural ponds, has never been undertaken. Using thousands of genome-wide single-nucleotide polymorphisms, we characterized the population structure, genetic diversity, and genetic connectivity of spadefoots in Orange County to guide ongoing and future management efforts. We identified at least 2, and possibly 3 major genetic clusters, with additional substructure within clusters indicating that individual ponds are often genetically distinct. Estimates of landscape resistance suggest that ponds on either side of the Los Angeles Basin were likely interconnected historically, but intense urban development has rendered them essentially isolated, and the resulting risk of interruption to natural metapopulation dynamics appears to be high. Resistance surfaces show that the existing artificial ponds were well-placed and connected to natural populations by low-resistance corridors. Toad samples from all ponds (natural and artificial) returned extremely low estimates of effective population size, possibly due to a bottleneck caused by a recent multi-year drought. Management efforts should focus on maintaining gene flow among natural and artificial ponds by both assisted migration and construction of new ponds to bolster the existing pond network in the region. [ABSTRACT FROM AUTHOR]

The article discusses the role of cyclin-dependent kinase 13 in cancer and its interaction with RNA molecules. Topics include examines the CDKs are involved in cell division and transcription control, and CDK13 is identified as a tumor-suppressive gene in melanoma; and considered the mutations or down-regulation of CDK13 are associated with increased oncogenic activity and decreased survival. CDK13 mutants act in a dominant-negative manner, impeding the function of wild-type CDK13.

Environmental and development discourses in China can be categorised into three narrative motifs framing human–nature relationships: peasant, indigenous, and community. Indigenous and community narratives have been widely adopted by environmental NGOs (eNGOs) in China in promoting community‐based natural resource management projects, but there has been very limited critical research on such phenomena. Analysis of socio‐economic change in two ethnic minority communities in Yunnan shows that neither narrative theme is fully internalised by the relevant communities. Instead narratives may be strategically modified or even rejected by local communities. This is due to different agendas being held by local communities and eNGOs, and two factors pertinent to rural China: the incompatibility of concepts of 'community' in Chinese and international contexts results in confusion, and a lack of recent territorial and cultural claims by rural communities since the collectivist era makes it difficult to construct the identity of a community. It remains challenging for eNGOs in China to advocate either community or indigenous narratives in contexts of rapid socio‐economic change. [ABSTRACT FROM AUTHOR]

Highlights • We present a behavometrics method via a 3D dynamic face speaking a private passcode. • We establish the first public speech-driven 3D dynamic face dataset S3DFM. • The 3D speaking face features are repeatable and distinctive for behavometrics. • The method is robust against spoofing and head pose variations. • The method is applicable to any passcode and is invariant to speaking speed. Abstract Face biometrics have achieved remarkable performance over the past decades, but unexpected spoofing of the static faces poses a threat to information security. There is an increasing demand for stable and discriminative biological modalities which are hard to be mimicked and deceived. Speech-driven 3D facial motion is a distinctive and measurable behavior-signature that is promising for biometrics. In this paper, we propose a novel 3D behaviometrics framework based on a "3D visual passcode" derived from speech-driven 3D facial dynamics. The 3D facial dynamics are jointly represented by 3D-keypoint-based measurements and 3D shape patch features, extracted from both static and speech-driven dynamic regions. An ensemble of subject-specific classifiers are then trained over selected discriminative features, which allows for a discriminant speech-driven 3D facial dynamics representation. We construct the first publicly available Speech-driven 3D Facial Motion dataset (S3DFM) that includes 2D-3D face video plus audio samples from 77 participants. The experimental results on the S3DFM show that the proposed pipeline achieves a face identification rate of 96.1%. Detailed discussions are presented, concerning anti-spoofing, head pose variation, video frame rate, and applicability cases. We also give comparison with other baselines on "deep" and "shallow" 2D face features. [ABSTRACT FROM AUTHOR]

Large‐scale ecological restoration programs across the world involve a voluminous demand for native seeds of diverse native plant species. In this article, we explore how institutional systems have operated and impacted native seed supply in Brazil. Native seed supply for restoration is essentially a community‐based activity which faces broad barriers to operating within regulations because of requirements for excessive and costly technical documentation, scarcity of seed laboratories, and lack of instructions for native seed quality testing. Although decentralized seed networks have stimulated arrangements for local organizations to promote seed supply, policies constrain the development of local capacities and the ongoing sustainability of these organizations. These conditions have resulted in a vast network of informal collectors and producers who are largely "invisible" and unknown to the regulatory authorities. Policies have decentralized responsibilities from the state without devolving decision‐making power to the multiple stakeholders engaged in policy elaboration. The policies maintain the centralized regulation of native seed supply. After examining Brazilian seed networks' experiences and conducting discussions with stakeholders and experts, we suggest adapting the current regulations to more local level contexts, encompassing the following strategies: (1) ensuring native seed origin and identity; (2) relaxation of the laboratory accreditation process for native seed quality assurance; (3) fostering seed markets for restoration; (4) research to provide technological innovation; (5) supporting local, diverse, and small seed‐based businesses. [ABSTRACT FROM AUTHOR]

The transcription cycle of RNA polymerase II (Pol II) is regulated by a set of cyclin-dependent kinases (CDKs). Cdk7, associated with the transcription initiation factor TFIIH, is both an effector CDK that phosphorylates Pol II and other targets within the transcriptional machinery, and a CDK-activating kinase (CAK) for at least one other essential CDK involved in transcription. Recent studies have illuminated Cdk7 functions that are executed throughout the Pol II transcription cycle, from promoter clearance and promoter-proximal pausing, to co-transcriptional chromatin modification in gene bodies, to mRNA 3´-end formation and termination. Cdk7 has also emerged as a target of small-molecule inhibitors that show promise in the treatment of cancer and inflammation. The challenges now are to identify the relevant targets of Cdk7 at each step of the transcription cycle, and to understand how heightened dependence on an essential CDK emerges in cancer, and might be exploited therapeutically. [ABSTRACT FROM AUTHOR]

Abstract Dysfunctional inflammatory pathways are associated with an increased risk of cancer, including colorectal cancer. We have previously identified and enriched for a self-renewing, colon cancer stem cell (CCSC) subpopulation in primary sporadic colorectal cancers (CRC) and a related subpopulation in ulcerative colitis (UC) patients defined by the stem cell marker, aldehyde dehydrogenase (ALDH). Subsequent work demonstrated that CCSC-initiated tumors are dependent on the inflammatory chemokine, CXCL8, a known inducer of tumor proliferation, angiogenesis and invasion. Here, we use RNA interference to target CXCL8 and its receptor, CXCR1, to establish the existence of a functional signaling pathway promoting tumor growth initiated by sporadic and colitis CCSCs. Knocking down either CXCL8 or CXCR1 had a dramatic effect on inhibiting both in vitro proliferation and angiogenesis. Likewise, tumorigenicity was significantly inhibited due to reduced levels of proliferation and angiogenesis. Decreased expression of cycle cell regulators cyclins D1 and B1 along with increased p21 levels suggested that the reduction in tumor growth is due to dysregulation of cell cycle progression. Therapeutically targeting the CXCL8-CXCR1 signaling pathway has the potential to block sustained tumorigenesis by inhibiting both CCSC- and pCCSC-induced proliferation and angiogenesis. [ABSTRACT FROM AUTHOR]

Presents the paper daguerreotypes of George Robinson Fardon documenting the impact of the California Gold Rush of 1849. Early years of the gold rush; Birth of the Vigilance Committee of 1851; Rebirth of the committee in 1856; Documentation of the Ad Hoc justice.

Purpose: The majority of research on psychological outcomes for cancer patients has focussed on the role of individual characteristics, and disease and treatment factors. There has been very little exploration of the potential contribution of the treatment clinic to these outcomes. This study explored whether there is variation among clinics in cancer patients' psychological outcomes.Methods: Cancer outpatients were recruited from 22 medical oncology and haematology clinics in Australia. Participants completed a pen and paper survey including the Hospital Anxiety and Depression Scale (HADS), as well as sociodemographic, disease and treatment characteristics.Results: Of those eligible to participate, 4233 (82%) consented and 2811 (81% of consenters) returned the completed survey. There was no statistically significant variation in HADS depression scores across clinics. Some difference in anxiety scores derived from the HADS questionnaire between clinics (p = 0.03) was found with the percentage of between-clinic variation estimated to be 1.11%. However, once all demographic, disease and treatment predictors were adjusted for there was no statistical differences between clinics (percent of between-clinic variation = 0.53%; p = 0.1415).Conclusions: Psychological outcomes were not found to vary between clinics. Other sources of variation including patient characteristics may over-ride between-clinic variability, if it exists. [ABSTRACT FROM AUTHOR]

Abstract: The arroyo southwestern toad is a specialized and federally endangered amphibian endemic to the coastal plains and mountains of central and southern California and northwestern Baja California. It is largely unknown how long these toads live in natural systems, how their population demographics vary across occupied drainages, and how hydrology affects age structure. We used skeletochronology to estimate the ages of adult arroyo toads in seven occupied drainages with varying surface water hydrology in southern California. We processed 179 adult toads with age estimates between 1 and 6 years. Comparisons between skeletochronological ages and known ages of PIT tagged toads showed that skeletochronology likely underestimated toad age by up to 2 years, indicating they may live to 7 or 8 years, but nonetheless major patterns were evident. Arroyo toads showed sexual size dimorphism with adult females reaching a maximum size of 12 mm greater than males. Population age structure varied among the sites. Age structure at sites with seasonally predictable surface water was biased toward younger individuals, which indicated stable recruitment for these populations. Age structures at the ephemeral sites were biased toward older individuals with cohorts roughly corresponding to higher rainfall years. These populations are driven by surface water availability, a stochastic process, and thus more unstable. Based on our estimates of toad ages, climate predictions of extreme and prolonged drought events could mean that the number of consecutive dry years could surpass the maximum life span of toads making them vulnerable to extirpation, especially in ephemeral freshwater systems. Understanding the relationship between population demographics and hydrology is essential for predicting species resilience to projected changes in weather and rainfall patterns. The arroyo toad serves as a model for understanding potential responses to climatic and hydrologic changes in Mediterranean stream systems. We recommend development of adaptive management strategies to address these threats. [ABSTRACT FROM AUTHOR]

The definition of who has epilepsy, classification of seizure types, and types of epilepsy have all recently been revised. The classical definition of epilepsy as a person having two or more unprovoked seizures more than 24 hours apart has been expanded also to include those with one seizure and a high likelihood (more than 60%) of having another. In the new definition, epilepsy is considered to be resolved when a person is seizure-free for 10 years, the terminal 5 being off seizure medicines, or when an age-dependent syndrome has been outgrown. The new seizure type classification revises the 1981 system but maintains the primary distinction of focal- versus generalized-onset seizures. Seizures also can be of unknown onset. Focal seizures may demonstrate retention or impairment of awareness, resulting in focal-aware or focal-impaired awareness seizures. Several new focal and generalized seizure types are introduced. Classification of the epilepsies is now by grouping of seizure types, etiologies, comorbidities, and epilepsy syndromes. The goal of the new terminology is greater clarity of communication and more accurate grouping of seizure types for research. Neurodiagnostic technologists can be of great help in observing clinical and electrographic features that will define the type of seizure. [ABSTRACT FROM AUTHOR]

Urosaurus nigricaudus is a phrynosomatid lizard endemic to the Baja California Peninsula in Mexico. This work presents a chromosome-level genome assembly and annotation from a male individual. We used PacBio long reads and HiRise scaffolding to generate a high-quality genomic assembly of 1.87 Gb distributed in 327 scaffolds, with an N50 of 279 Mb and an L50 of 3. Approximately 98.4% of the genome is contained in 14 scaffolds, with 6 large scaffolds (334–127 Mb) representing macrochromosomes and 8 small scaffolds (63–22 Mb) representing microchromosomes. Using standard gene modeling and transcriptomic data, we predicted 17,902 protein-coding genes on the genome. The repeat content is characterized by a large proportion of long interspersed nuclear elements that are relatively old. Synteny analysis revealed some microchromosomes with high repeat content are more prone to rearrangements but that both macro- and microchromosomes are well conserved across reptiles. We identified scaffold 14 as the X chromosome. This microchromosome presents perfect dosage compensation where the single X of males has the same expression levels as two X chromosomes in females. Finally, we estimated the effective population size for U. nigricaudus was extremely low, which may reflect a reduction in polymorphism related to it becoming a peninsular endemic. [ABSTRACT FROM AUTHOR]

This article focuses on the broad and challenging question of how to resource transformative grassroots organizations. These organizations not only carry the grievances of women, immigrants and workers, but build collective action, support the emergence of leadership, and connect to larger social movements. We explore how the resourcing and democratic legitimacy of such grassroots movements transgresses presumed boundaries between popular politics and manipulated participation and whether diversifying funding sources helps make genuine community organizing more or less likely. We ask how these organizations pay staff, support education, and continue to survive while also challenging power. In addition, how do they contend with forms of state support that privilege very narrow and depoliticized agendas? We conclude that there are radical grassroots organizations that have, to a limited degree, successfully negotiated these tensions. Our examples from England and Quebec, along with our wider analysis, provide a snapshot of the possibilities of diversifying funding for community organizing by adding public funding to the mix. But our critical perspective also highlights the values, infrastructure, and scale needed to advance community organizing and related social movements beyond these examples. [ABSTRACT FROM AUTHOR]

The International League Against Epilepsy ( ILAE) presents a revised operational classification of seizure types. The purpose of such a revision is to recognize that some seizure types can have either a focal or generalized onset, to allow classification when the onset is unobserved, to include some missing seizure types, and to adopt more transparent names. Because current knowledge is insufficient to form a scientifically based classification, the 2017 Classification is operational (practical) and based on the 1981 Classification, extended in 2010. Changes include the following: (1) 'partial' becomes 'focal'; (2) awareness is used as a classifier of focal seizures; (3) the terms dyscognitive, simple partial, complex partial, psychic, and secondarily generalized are eliminated; (4) new focal seizure types include automatisms, behavior arrest, hyperkinetic, autonomic, cognitive, and emotional; (5) atonic, clonic, epileptic spasms, myoclonic, and tonic seizures can be of either focal or generalized onset; (6) focal to bilateral tonic-clonic seizure replaces secondarily generalized seizure; (7) new generalized seizure types are absence with eyelid myoclonia, myoclonic absence, myoclonic-atonic, myoclonic-tonic-clonic; and (8) seizures of unknown onset may have features that can still be classified. The new classification does not represent a fundamental change, but allows greater flexibility and transparency in naming seizure types. [ABSTRACT FROM AUTHOR]

This companion paper to the introduction of the International League Against Epilepsy ( ILAE) 2017 classification of seizure types provides guidance on how to employ the classification. Illustration of the classification is enacted by tables, a glossary of relevant terms, mapping of old to new terms, suggested abbreviations, and examples. Basic and extended versions of the classification are available, depending on the desired degree of detail. Key signs and symptoms of seizures (semiology) are used as a basis for categories of seizures that are focal or generalized from onset or with unknown onset. Any focal seizure can further be optionally characterized by whether awareness is retained or impaired. Impaired awareness during any segment of the seizure renders it a focal impaired awareness seizure. Focal seizures are further optionally characterized by motor onset signs and symptoms: atonic, automatisms, clonic, epileptic spasms, or hyperkinetic, myoclonic, or tonic activity. Nonmotor-onset seizures can manifest as autonomic, behavior arrest, cognitive, emotional, or sensory dysfunction. The earliest prominent manifestation defines the seizure type, which might then progress to other signs and symptoms. Focal seizures can become bilateral tonic-clonic. Generalized seizures engage bilateral networks from onset. Generalized motor seizure characteristics comprise atonic, clonic, epileptic spasms, myoclonic, myoclonic-atonic, myoclonic-tonic-clonic, tonic, or tonic-clonic. Nonmotor (absence) seizures are typical or atypical, or seizures that present prominent myoclonic activity or eyelid myoclonia. Seizures of unknown onset may have features that can still be classified as motor, nonmotor, tonic-clonic, epileptic spasms, or behavior arrest. This 'users' manual' for the ILAE 2017 seizure classification will assist the adoption of the new system. [ABSTRACT FROM AUTHOR]

Volumes of data illustrate the severity of the crisis affecting amphibians, where > 32% of amphibians worldwide are threatened with declining populations. Although there have been isolated victories, the current approach to the issue is unsuccessful. We suggest that a radically different approach, something akin to human emergency response management (i.e. the Incident Command System), is one alternative to addressing the inertia and lack of cohesion in responding to amphibian issues. We acknowledge existing efforts and the useful research that has been conducted, but we suggest that a change is warranted and that the identification of a new amphibian chytrid provides the impetus for such a change. Our goal is to recognize that without a centralized effort we (collectively) are likely to fail in responding to this challenge. [ABSTRACT FROM PUBLISHER]

Transcription by RNA polymerase (RNAP) II is regulated at multiple steps by phosphorylation, catalyzed mainly by members of the cyclin-dependent kinase (CDK) family. The CDKs involved in transcription have overlapping substrate specificities, but play largely non-redundant roles in coordinating gene expression. Novel functions and targets of CDKs have recently emerged at the end of the transcription cycle, when the primary transcript is cleaved, and in most cases polyadenylated, and transcription is terminated by the action of the “torpedo” exonuclease Xrn2, which is a CDK substrate. Collectively, various functions have been ascribed to CDKs or CDK-mediated phosphorylation: recruiting cleavage and polyadenylation factors, preventing premature termination within gene bodies while promoting efficient termination of full-length transcripts, and preventing extensive readthrough transcription into intergenic regions or neighboring genes. The assignment of precise functions to specific CDKs is still in progress, but recent advances suggest ways in which the CDK network and RNAP II machinery might cooperate to ensure timely exit from the transcription cycle. [ABSTRACT FROM PUBLISHER]

Background: Colorectal cancer (CRC) survivors are at increased risk of developing the disease again. Surveillance guidelines are aimed at maximising the early detection of recurring or new cancers and pre-cancerous polyps. The frequency and type of surveillance recommended depends on the type of treatment for the initial CRC, the extent of colonoscopic investigation prior to treatment and the results of previous surveillance tests. This paper aimed to test the effect of a paper-based educational intervention to improve adherence to colonoscopy following treatment for colorectal cancer.Methods: People with a diagnosis of colorectal cancer within the last 10 months, aged ≥18 and English speaking were recruited through a population-based cancer registry in Australia. Participants were randomly allocated to either the intervention or control. Participants completed an interview at baseline. Self-reported participation in colonoscopy was obtained at 12 month followup by survey. Those allocated to the control received a generic pamphlet on colorectal cancer treatment; while intervention participants received a letter which provided specific information about guideline recommendations for surveillance colonoscopy. Rates of guideline adherence were compared between groups. The guideline recommendations for the timing of surveillance colonoscopy changed part way through the study. This change occurred after all intervention materials had been sent, but prior to all participants completing the 12 month follow up. Post hoc analyses were conducted to assess adherence to the new guidelines.Results: Of the 767 participants, 604 (79%) had had surgery, had stage I - III disease and completed the baseline interview within 12 months of diagnosis (intervention = 305; control = 299). There was no significant difference between those adherent to surveillance colonoscopy guidelines, in the control (67, 27%) and intervention groups (80, 31%) at followup (difference = 4.3% (95%CI:-3.7%, 12%), χ 2(1df) = 1.09, P = 0.296). Overall, 246 (49%) participants were adherent to the new guidelines, compared to 147 (29%) adherent to the old guidelines.Conclusions: Results indicate the paper-based educational intervention is not effective in improving adherence to colorectal cancer surveillance guidelines for colonoscopy.Trial Registration Number: ACTRN12609000628246 Registration date: 28/07/2009. [ABSTRACT FROM AUTHOR]

Neuromodulation (neurostimulation) is a relatively new and rapidly growing treatment for refractory epilepsy. Three varieties are approved in the US: vagus nerve stimulation (VNS), deep brain stimulation (DBS) and responsive neurostimulation (RNS). This article reviews thalamic DBS for epilepsy. Among many thalamic sub-nuclei, DBS for epilepsy has been targeted to the anterior nucleus (ANT), centromedian nucleus (CM), dorsomedial nucleus (DM) and pulvinar (PULV). Only ANT is FDA-approved, based upon a controlled clinical trial. Bilateral stimulation of ANT reduced seizures by 40.5% at three months in the controlled phase (p =.038) and 75% by 5 years in the uncontrolled phase. Side effects related to paresthesias, acute hemorrhage, infection, occasional increased seizures, and usually transient effects on mood and memory. Efficacy was best documented for focal onset seizures in temporal or frontal lobe. CM stimulation may be useful for generalized or multifocal seizures and PULV for posterior limbic seizures. Mechanisms of DBS for epilepsy are largely unknown, but animal work points to changes in receptors, channels, neurotransmitters, synapses, network connectivity and neurogenesis. Personalization of therapies, in terms of connectivity of the seizure onset zone to the thalamic sub- nucleus and individual characteristics of the seizures, might lead to improved efficacy. Many questions remain about DBS, including the best candidates for different types of neuromodulation, the best targets, the best stimulation parameters, how to minimize side effects and how to deliver current noninvasively. Despite the questions, neuromodulation provides useful new opportunities to treat people with refractory seizures not responding to medicines and not amenable to resective surgery. [ABSTRACT FROM AUTHOR]

Common symptoms of focal seizures include hot or cold skin sensations or a "rising sense" through the body. E.P. has received speaker and/consultancy fees from Biogen, Eisai, GW Pharma, Sanofi, Takeda, and UCB. S.W. has received unrestricted educational grants from UCB Pharma and Eisai. [Extracted from the article]

Review of specimens of long-tailed shrews (Mammalia, Soricidae, Sorex) from the northwestern United States in the National Museum of Natural History (USNM), Washington, DC, has revealed the presence of the Olympic Shrew, Sorex rohweri Rausch et al., 2007, in the Coastal Range west of the Willamette Valley in Oregon. This determination nearly doubles the documented distribution for this species and increases the species diversity of soricids in Oregon to eleven. Sorex rohweri is relatively uncommon, but it occurs in a variety of forest successional stages and even clear cuts, as long as there is nearby forest and trees are allowed to regenerate. All USNM specimens from Washington formerly identified as S. cinereus streatori Merriam, 1895 are instead referable to the Olympic Shrew. The distribution of S. c. streatori is thereby restricted to the Pacific coasts of British Columbia north of the lower Frasier River and southcentral Alaska. Our study highlights the importance of taking and preserving high-quality voucher specimens in a collection where they are readily available for re-study. [ABSTRACT FROM AUTHOR]

Aim The islands of the Tropical Oceanic Pacific ( TOP) host both local radiations and widespread, colonizing species. The few phylogeographical analyses of widespread species often point to recent human-aided expansions through the Pacific, suggesting that the communities are recently assembled. Here we apply multilocus data to infer biogeographical history of the gekkonid lizard, Gehyra oceanica, which is widespread, but for which prior analyses suggested a pre-human history and in situ diversification. Location Tropical Oceanic Pacific. Methods We generated a data set including mt DNA and diagnostic SNPs for 173 individuals of G. oceanica spanning Micronesia, Melanesia, and Polynesia. For a subset of these individuals, we also sequenced nuclear loci. From these data, we performed maximum likelihood and Bayesian inference to reveal major clades. We also performed Bayesian clustering analyses and coalescence-based species delimitation tests to infer the number of species in this area. Results We found evidence for six independent evolutionary lineages (candidate species) within G. oceanica that diverged between the Pliocene and the early Pleistocene, with high diversity through northern Melanesia, and pairing of northern Melanesian endemic taxa with widespread lineages across Micronesia and Polynesia. Main conclusions The islands of northern Melanesia not only have unrecognized diversity, but also were the source of independent expansions of lineages through the more remote northern and eastern Pacific. These results highlight the very different evolutionary histories of island faunas on remote archipelagos versus those across Melanesia and point to the need for more intensive studies of fauna within Melanesia if we are to understand the evolution of diversity across the tropical Pacific. [ABSTRACT FROM AUTHOR]

Community-based initiatives for meeting social need and promoting social change are widespread and expanding throughout the globe. Part of conservative Prime Minister David Cameron’s Big Society alternative to the Big State is the Community Organiser Programme (COP). Begun in 2011 the COP met goals to hire and train 500 “senior” community organizers and educate and engage 4500 volunteers in community organizing basics by 2015. Obvious contradictions and limits about its neoliberal underpinnings, theory of change, and selected organizing models notwithstanding, COP is one of the boldest initiatives in the field in a generation, not the least because it is funded by the national government. Its innovativeness is especially evident in comparison to efforts in the US, where community organizing is heavily reliant on charitable donations and where, in our contemporary political economy, public-funded hiring and training of community organizers is unheard. [ABSTRACT FROM PUBLISHER]

Several companies are developing an EEG recording system that uses dry, wireless electrodes, and one has recently been approved by the Food and Drug Administration (FDA) for medical use. Today, the quality of EEG signals recorded by these dry systems may not always match those of conventionally applied electrodes, but the gap is closing fast. As dry, wireless EEG systems find their way into hospitals and clinics over the next few years, the job of the EEG technologist will change. Dry systems can be placed on like a cap and, after a few minutes of adjustment, begin broadcasting EEG. No longer will it be as necessary to spend time meticulously measuring, cleaning, affixing, and adjusting electrodes on the scalp. This upcoming time of rapid change can be an opportunity to redefine the role of the EEG technologist. [ABSTRACT FROM AUTHOR]

The article presents the discussion on G1 kinase targeting the transcription to drive cell cycle commitment including RNA processing and chromatin-modifying machineries.

Aims: To examine the published literature on patient adherence to physiotherapist prescribed self-management strategies in order to describe: changes in the proportion of publications over time; methodological quality of non-intervention and intervention-based studies; types of measures used to assess patient adherence and the reported accuracy of those measures. Methods: A comprehensive search of eight electronic databases was conducted, covering the period from January 1995 to November 2014. Data were extracted and coded for the number and proportion of articles that were: i) non data-based; ii) data-based, no new data (reviews); Hi) data-based, new data. The methodological quality of non-intervention and intervention publications was assessed using the Effective Public Health Practice Project Quality Assessment Tool, and data were extracted regarding the type and accuracy of adherence measures reported in these publications. Results: A total of 80 relevant papers were identified. Of these, 49 non-intervention and intervention quantitative study designs underwent methodological assessment, with only 14 studies (29%) assessed as being of at least moderate quality. Fifty-three different measures of patient adherence were recorded from the 49 included studies, with only 5 of the 49 included studies (10%) reporting statistical evidence to support accuracy of the adherence measures applied. Conclusions: The results indicate that despite a trend towards intervention-based studies and reviews over the last 20 years, the methodological quality of studies on patient adherence could be improved. Accurate and standardised measures of patient adherence are needed for any future research involving patient adherence to physiotherapist prescribed self-management strategies. [ABSTRACT FROM AUTHOR]

A new paradigm in oncology establishes a spectrum of tumorigenic potential across the heterogeneous phenotypes within a tumor. The cancer stem cell hypothesis postulates that a minute fraction of cells within a tumor, termed cancer stem cells (CSCs), have a tumor-initiating capacity that propels tumor growth. An application of this discovery is to target this critical cell population using chemotherapy; however, the process of isolating these cells is arduous, and the rarity of CSCs makes it difficult to test potential drug candidates in a robust fashion, particularly for individual patients. To address the challenge of screening drug libraries on patient-derived populations of rare cells, such as CSCs, we have developed a drug-eluting microarray, a miniaturized platform onto which a minimal quantity of cells can adhere and be exposed to unique treatment conditions. Hundreds of drug-loaded polymer islands acting as drug depots colocalized with adherent cells are surrounded by a nonfouling background, creating isolated culture environments on a solid substrate. Significant results can be obtained by testing <6% of the cells required for a typical 96-well plate. Reliability was demonstrated by an average coefficient of variation of 14% between all of the microarrays and 13% between identical conditions within a single microarray. Using the drug-eluting array, colorectal CSCs isolated from two patients exhibited unique responses to drug combinations when cultured on the drug-eluting microarray, highlighting the potential as a prognostic tool to identify personalized chemotherapeutic regimens targeting CSCs. [ABSTRACT FROM AUTHOR]

BACKGROUND: The Institute of Medicine (IOM) recommended 6 objectives for achieving patient-centered care. However, most patient-reported outcome measures developed with cancer populations fail to address all 6 patient-centeredness dimensions. The Quality of Patient-Centered Cancer Care (QPCCC) measure was developed on the basis of IOM recommendations, and the measure's validity, reliability, and floor and ceiling effects were examined. METHODS: The development of the QPCCC measure included interviews with hematological cancer survivors and feedback from hematologists and cancer patients. To evaluate the measure's psychometric properties, hematological cancer survivors were identified via 2 cancer registries and were mailed the QPCCC measure. To examine test-retest reliability, a second QPCCC measure was mailed to survivors 7 to 14 days after they had returned the first measure. RESULTS: Overall, 545 hematological cancer survivors completed the 48-item QPCCC measure. Exploratory factor analysis revealed a 10-factor structure with factor loadings > 0.40. The subscales were labeled Treatment Delivery, Treatment Decision Making, Coordinated and Integrated Care, Emotional Support, Timely Care, Follow-Up Care, Respectful Communication, Patient Preferences and Values, Cancer Information, and Equitable Care. The QPCCC measure demonstrated acceptable internal consistency for all subscales (Cronbach's α = .73-.94). When test-retest reliability was assessed, 4 items demonstrated substantial agreement ( > 0.60), whereas 40 items showed moderate agreement (κ = 0.41-0.60). Ceiling effects were present for 8 subscales. CONCLUSIONS: The QPCCC measure has acceptable face and content validity, construct validity, and internal consistency. However, the measure's discriminant validity and test-retest reliability could be improved. The QPCCC measure could be used to improve patient-centered cancer care. [ABSTRACT FROM AUTHOR]

This article discusses community organizing (CO) in the United States. It is not a comprehensive survey of the entirety of CO in the US context, but instead addresses key components over time and critical themes in CO using particular examples to draw out central lessons for the field. Critical themes include CO's broad proliferation and organizational diversity, inherent political and contested nature, dialectic contextualization, and limited success. Contemporary efforts such as Asset-based Community Development, ACORN, the Tea Party, immigrant rights organizing, Occupy Wall Street, and the Right to the City Alliance are used to flesh out these critical themes as well as illustrate the current landscape and challenges for CO in the US. [ABSTRACT FROM AUTHOR]

Objective: Patient-reported outcome measures (PROMs) that assess the quality of patient-centred cancer care have failed to measure all six patient-centredness dimensions endorsed by the Institute of Medicine (IOM). This study is the first to use the Quality of Patient-Centered Cancer Care (QPCCC) measure that covers all six IOM patient-centredness dimensions to examine haematological cancer survivors' perceptions of care and characteristics associated with perceived quality of care. Methods: Haematological cancer survivors diagnosed in the last 6 years and aged 18-80 years were recruited from two Australian state population-based cancer registries. Survivors were mailed the 48-item QPCCC measure. Results: Overall, 545 haematological cancer survivors completed the measure. Areas of care most commonly identified as delivered were hospital staff showing respect to survivors (93%) and making sure the correct treatment was received (93%). Aspects of care most frequently nominated as not delivered were hospital staff helping family and friends (34%) or the survivor (32%) to find other people with similar experiences to talk to. Characteristics associated with survivors perceiving higher quality care was delivered included being employed, having private health insurance, being younger, a Non-Hodgkin lymphoma diagnosis and more recent diagnosis. Being depressed or stressed was associated with perceived lower quality of care. Conclusions: Provision of peer support programs that allow haematological cancer survivors and families and friends to talk to others in similar situations could be improved. Using PROMs to identify areas where cancer survivors perceive improvements are needed is essential to quality improvement efforts. [ABSTRACT FROM AUTHOR]