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Your search keyword '"Ferrara, J.L.M."' showing total 32 results
Start Over Author "Ferrara, J.L.M." Database Academic Search Index
32 results on '"Ferrara, J.L.M."'

1. Graft-versus-host disease.

Author

Ferrara, J.L.M. and Deeg, H.J.

Subjects
*BONE diseases
Abstract

Discusses the mechanisms of graft-versus-host disease (GVHD), a chief complication of allogeneic bone marrow transplantations. Definition and cause of GVHD; Acute, chronic, and syngeneic GVHD; Prevention and treatment of GVHD.

Published
1991

5. Persistence of pulmonary pathology and abnormal lung function in IL-3/GM-CSF/IL-5 βc receptor-deficient mice despite correction of alveolar proteinosis after BMT.

Author

Cooke, K.R., Nishinakamura, R., Martin, T.R., Kobzik, L., Brewer, J., Whitsett, J.A., Bungard, D., Murray, R., and Ferrara, J.L.M.

Subjects
*BONE marrow transplantation, *LUNGS, *LYMPHOCYTES, *HISTOLOGY
Abstract

Mice deficient for the IL-3/GM-CSF/IL-5 βc receptor (βcR KO) develop lung disease similar to that seen in human pulmonary alveolar proteinosis (PAP) which includes lymphocytic infiltration around airways and vessels and the progressive accumulation of surfactant and macrophages within the alveolar space. We investigated bone marrow transplantation (BMT) as a curative treatment of PAP in βcR KO mice by semiquantitative histologic analysis and evaluation of pulmonary function. BMT from wild-type (WT) donors into lethally irradiated βcR KO recipients (WT → KO) led to the complete resolution of alveolar protein accumulation and to normalization of BAL fluid cellularity and macrophage morphology. However, detailed microscopic analysis of lung tissue revealed the persistence of significant cellular infiltrates in WT → KO recipients which were equivalent to those seen in KO → KO animals. Evaluation of pulmonary function demonstrated that only dynamic compliance (Cay.) and not airway conductance (GO was significantly improved in the WT → KO group compared to KO → KO animals and that both of these measurements remained significantly abnormal when compared to WT → WT controls. We conclude, that although BMT for PAP reverses alveolar macrophage and protein accumulation, it does not decrease the interstitial inflammatory component of this disease. The importance of this residual pathology is demonstrated by the incomplete correction of alveolar function (C[subdyn].) and lack of improvement in increased airway resistance (GL). These findings may have important implications with regard to the extent that BMT can be considered a potential curative procedure... [ABSTRACT FROM AUTHOR]

Published
1997
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18. Conditioning with Clofarabine and Busulfan X 4 (CloBu4) For Non-Remission Hematologic Malignancies Including Aml Is Well Tolerated, Facilitates Secure Engraftment, And Exhibits Significant Anti-Tumor Activity

Author

Magenau, J., Pawarode, A., Buck, T., Jones, D., Kato, K., Frame, D., Kujawski, L., Erba, H.P., Khaled, Y., Peres, E.M., Krijanovski, O.I., Reddy, P., Kitko, C., Choi, S., Yanik, G., Braun, T., Ferrara, J.L.M., Levine, J.E., and Mineishi, S.

Published
2009
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31. Erratum: Acute graft-versus-host disease does not require alloantigen expression on host epithelium.

Author

Teshima, T., Ordemann, R., Reddy, P., Gagin, S., Liu, C., Cooke, K.R., and Ferrara, J.L.M.

Subjects
*EPITHELIUM, *MEDICINE, *PERIODICALS
Abstract

Presents a correction to the article 'Acute graft-versus-host disease does not require alloantigen expression on host epithelium,' published in the September 2002 issue of the journal 'Nature Medicine.'

Published
2002
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32. Rituximab Treatment of Low Platelet Counts in a Patient with Chronic Graft-versus-Host Disease.

Author

Ratanatharathorn, V., Carson, E., Reynolds, C., Ayash, L.J., Levine, J., Yanik, G., Silver, S.M., Ferrara, J.L.M., and Uberti, J.P.

Subjects
*RITUXIMAB, *BLOOD platelets, *GRAFT versus host disease, *COMPLICATIONS from organ transplantation
Abstract

Describes the rituximab treatment of low platelet counts in a patient with chronic graft-versus-host disease. Stem cell transplantation in persons with leukemia; Evaluation of the effectiveness of rituximab in treating thrombocytopenia; Patient's clinical course before and after the study; Increase in patient's platelet count after the drug administration.

Published
2000
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