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Introduction/Aims: Fatiguability and perceived fatigue are common unrelated symptoms in ambulatory individuals with spinal muscular atrophy (SMA). Ratings of perceived exertion (RPE) measures the sense of effort during an activity and has been used as a proxy for fatigue. Relationships between perceived fatigue, fatiguability, and RPE have been described in healthy populations, but the relationship in SMA has not been examined. Methods: Eighteen ambulatory individuals with SMA and 16 age‐matched controls (age, 13 to 57 years; 26 [76.5%] males) performed the 6‐minute walk test (6MWT) and cardiopulmonary exercise tolerance test (CPET) and completed the International Physical Activity Questionnaire‐‐‐short form (IPAQ). RPE was collected during the CPET and 6MWT. Fatiguability was measured during the 6MWT. Physical activity (PA) volume was calculated using the IPAQ. Wilcoxon rank‐sum tests were used to compare groups. Spearman correlation coefficients evaluated associations between variables. SMA subgroups were predetermined using 6MWT distances of over or under 300 meters. Results: There were no significant associations between fatiguability and RPE or PA in SMA (P >.05). PA was strongly associated with 6MWT RPE (r = 0.71) in SMA individuals who walked fewer than 300 meters (n = 7). There were no significant associations between any variables in controls (P >.05). Discussion: RPE is not associated with fatiguability in SMA. The possible association of PA and RPE may reflect the increased intensity of the 6MWT in weaker patients. RPE represents a sense of effort during exercise and should not be used as a substitute for fatiguability but may be a measure of patient experience during exercise. See Editorial on pages 6–7 in this issue. [ABSTRACT FROM AUTHOR]

INTRODUCTION: Anemia is a common health problem with nonspecific symptoms often overlooked leading to adverse health outcomes. This study aims to assess the clinical profile, types, and etiologies of anemia. MATERIAL AND METHODS: In this hospital based cross-sectional study, patients with anemia were enrolled through convenience sampling. Relevant history, physical examination, and investigations were performed. Statistical package for social sciences software version 20 was used to enter and analyze the data. Categorical variables were expressed as frequencies and percentages. Continuous variables were expressed as median (range). The associations were analyzed by using Fisher's exact test or Chi-square test, as appropriate. RESULTS: Out of 193 patients, 151 (78.2%) were females. The median age was 49 years (range 18-87 years). Most frequent symptoms were easy fatiguability (76.2%), breathlessness on exertion (30.1%), and light headedness (21.8%). Most frequent signs were pallor (75.6%), tachycardia (23.8%), glossitis (16.1%), and nail changes (15.5%). Majority (79.3%) had moderate and 17.1% had severe anemia. Iron deficiency (59.1%) and anemia of inflammation (28%) were common etiologies. Iron deficiency anemia was most commonly due to nutritional deficiency. Age was significantly associated with the type and etiology of anemia. CONCLUSION: Moderate anemia was the most common presentation. Easy fatiguability, breathlessness on exertion, and light headedness were most common symptoms, while pallor, tachycardia, glossitis, and nail changes were the most common signs. Iron deficiency anemia and anemia of inflammation were most common etiologies. Iron deficiency anemia was more common in younger patients, while anemia of inflammation was more common in older patients. [ABSTRACT FROM AUTHOR]