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Keratins (KRTs), the intermediate filament-forming proteins of epithelial cells, are extensively used as diagnostic biomarkers in cancers and associated with tumorigenesis and metastasis in multiple cancers. However, the diverse expression patterns and prognostic values of KRTs in melanoma have yet to be elucidated. In the current study, we examined the transcriptional and clinical data of KRTs in patients with melanoma from GEO, TCGA, ONCOMINE, GEPIA, cBioPortal, TIMER and TISIDB databases. We found that the mRNA levels of KRT1/2/5/6/8/10/14/15/16/17 were significantly differential expressed between primary melanoma and metastatic melanoma. The expression levels of KRT1/2/5/6/10/14/15/16/17 were correlated with advanced tumor stage. Survival analysis revealed that the high transcription levels of KRT1/5/6/14/15/16/17 were associated with low overall survival in melanoma patients. GSEA analysis indicated that the most involved hallmarks pathways were P53 pathway, KRAS signaling, estrogen response early and estrogen response late. Furthermore, we found some correlations among the expression of KRTs and the infiltration of immune cells. Our study may provide novel insights for the selection of prognostic biomarkers for melanoma. [ABSTRACT FROM AUTHOR]

Flexible perovskite solar cells (pero-SCs) possessing high efficiency and low fabrication cost have been considered as the promising wearable energy supply devices in the near future. However, the intrinsic brittleness of the commonly used transparent conducting oxide electrodes is one of the limitations for the mechanical stability of flexible pero-SCs. Here we demonstrate the improved mechanical stability of flexible pero-SCs consisting of ultrathin Au electrode and vapour-deposited perovskite film. The thermal annealing-free perovskite film fabrication by vapour deposition is beneficial to the stability of the ultrathin Au electrode and contributes to the improved mechanical stability of the flexible pero-SCs. The power conversion efficiency for flexible pero-SCs maintains 74% of their initial efficiencies after 2000 bending cycles with a bending radius of 3.5 mm. [ABSTRACT FROM AUTHOR]