Search

Se aborda el binomio cadenas productivas y territorio, identificándose dos tipos de desarrollo: el "enclave" del Secano Interior y el de "encadenamiento potencial" entre dicho enclave y la Conurbación del Gran Concepción. Los beneficios de la cadena productiva forestal-celulosa, de importancia mundial, no llegan a su territorio, que permanece en la precariedad. El Gran Concepción, segunda conurbación industrial de importancia nacional, no logra conectarse virtuosamente con su entorno cercano mediante sus redes económicas, ni tampoco con la cadena forestal-celulosa del Secano Interior. El artículo se basa en datos de flujos económicos a partir de la matriz insumo-producto de 2008, en encuestas efectuadas en el contexto de un proyecto del Fondo Nacional de Desarrollo Regional (fndr, 2008), y en el estudio sobre Chile y sus tipos de desarrollo (Falabella, 2000 y 2002). Finalmente, se plantea la necesidad de generar una plataforma política territorial para el desarrollo económico que facilite la rearticulación productiva. [ABSTRACT FROM AUTHOR]

This article formed part of a presentation made by the Chilean sociologist Gonzalo Falabella at the First Citizens' Forum for Tolerance and Non-discrimination, which took place in Santiago de Chile in March 1995. The subject arose out of the experiences and conversations of a group of professional men, who were searching for a new identity. [ABSTRACT FROM AUTHOR]

Insulin resistance in type 2 diabetes mellitus (T2DM) may be due to a chronic inflammation of the visceral adipose tissue (VAT) leading to local and systemic increases in proinflammatory cytokines. Microencapsulated porcine Sertoli cells (MC-pSC), by provision of immunomodulatory and trophic factors, have been successfully used to reduce such inflammation in rodent animal models of type 1 diabetes with no complications or deleterious side effects. Herein, we have begun to investigate this novel and safe therapeutic approach in the spontaneously obese nonhuman primate with spontaneous, insulin-dependent T2DM. After MC-pSC intraperitoneal injection we have evaluated, throughout a 6-month follow-up period, daily ad libitum fed glucose levels, daily exogenous insulin supplementation, biweekly body weight measurements, periodic fasting blood glucose concentrations, glycated hemoglobin (HbA1c) levels, glucose tolerance tests (GTT), and fluorescence-activated cell sorting cytometry (FACS) assessment of peripheral blood mononuclear cells. Very preliminarily, we have observed a slight reduction in fasting (FPG) and mean nonfasting (NF) plasma glucose levels. We found minimal changes, only in 1 animal, in daily exogenous insulin requirements and HbA1c levels. Flow cytometric analysis was associated with decrease in CD8+ cells only in 1 recipient with a reduction in mean regulatory T Cells (Treg), whereas interestingly, decrease of B lymphocytes was observed in both animals. These results may suggest that this novel MC-SC-based transplantation protocol might possibly impact the metabolic status of T2DM in higher mammals that are close to humans. [ABSTRACT FROM AUTHOR]