12 results on '"Eluf-Neto J"'
Search Results
2. Autopsy and ill-defined cause of death in the state of Sao Paulo, Brazil.
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Rozman MA and Eluf-Neto J
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OBJECTIVE: To investigate the proportion of deaths with an ill-defined cause in the Brazilian state of Sao Paulo between 1980 and 2002, taking into account the influence of autopsies on this proportion. METHOD: Data on the number of deaths were obtained from the Brazilian Ministry of Health. The communities of the state of Sao Paulo were divided into three groups: (1) municipalities with a service to verify the cause of death (and that may conduct an autopsy), (2) municipalities without a cause of death verification service, and (3) the region of Baixada Santista, which had an extremely large increase in the proportion of deaths from ill-defined causes between 1980 and 1995. The impact of autopsies on the proportion of deaths with an ill-defined cause was defined based on the classification made by the first physician evaluating the cause of death, that is, the physician who referred the case to the verification service for autopsy or who completed the death certificate without referring the case to the verification service. Deaths from external causes were excluded, since autopsy is mandatory in these cases. The following were evaluated: (1) proportion of cases classified by the first evaluating physician as having an ill-defined cause, (2) proportion of autopsies in relation to the total number of deaths (except from external causes), and (3) proportion of deaths classified as ill-defined by the first evaluating physician but explained by the autopsy. RESULTS: The proportion of deaths classified by the first evaluating physician as having an ill-defined cause increased over the 1980-2002 period in all three groups studied: the municipalities with a verification service, the municipalities without a verification service, and in the Baixada Santista region. For the state of Sao Paulo overall, the increase was almost 30% over that 1980-2002 period. For the 1998-2002 period, the average proportion of autopsies compared to the total number of deaths (except from external causes) was 21.2% in the municipalities with a verification service, 6.4% in the municipalities without a verification service, and 2.6% in Baixada Santista. The proportion of deaths in 1998-2002 initially classified as having an ill-defined cause but that was explained by autopsy was 92.9% in the municipalities with a verification service, 32.5% in the municipalities without a verification service, and 10.7% in Baixada Santista. CONCLUSIONS: The performance of autopsies accounts for the difference in proportional mortality with an ill-defined cause in the three groups of communities studied. The increase in the number of deaths classified as ill-defined by the first evaluating physician occurring in the state of Sao Paulo over the 1980-2002 period suggests an important decline in the quality of death certificates completed at that first level. More research should be done on the reasons for that change. [ABSTRACT FROM AUTHOR]
- Published
- 2006
3. Re: 'Determinants of quality of interview and impact on risk estimates in a case-control study of bladder cancer'.
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Eluf-Neto J
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- 2009
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4. Trends in stroke incidence, mortality and case fatality rates in Joinville, Brazil: 1995-2006.
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Cabral NL, Gonçalves AR, Longo AL, Moro CH, Costa G, Amaral CH, Souza MV, Eluf-Neto J, Fonseca LA, Cabral, N L, Gonçalves, A R R, Longo, A L, Moro, C H C, Costa, G, Amaral, C H, Souza, M V, Eluf-Neto, J, and Fonseca, L Augusto M
- Abstract
Background: Studying stroke rates in a whole community is a rational way to assess the quality of patient care and primary prevention. However, there are few studies of trends in stroke rates worldwide and none in Brazil.Objective: Established study methods were used to define the rates for first ever stroke in a defined population in Brazil compared with similar data obtained and published in 1995.Methods: All stroke cases occurring in the city of Joinville during 2005-2006 were prospectively ascertained. Crude incidence and mortality rates were determined, and age adjusted rates and 30 day case fatality were calculated and compared with the 1995 data.Results: Of the 1323 stroke cases registered, 759 were first ever strokes. The incidence rate per 100 000 was 105.4 (95% CI 98.0 to 113.2), mortality rate was 23.9 (95% CI 20.4 to 27.8) and the 30 day case fatality was 19.1%. Compared with the 1995 data, we found that the incidence had decreased by 27%, mortality decreased by 37% and the 30 day case fatality decreased by 28%.Conclusions: Using defined criteria we showed that in an industrial southern Brazilian city, stroke rates are similar to those from developed countries. A significant decrease in stroke rates over the past decade was also found, suggesting an improvement in primary prevention and inpatient care of stroke patients in Joinville. [ABSTRACT FROM AUTHOR]- Published
- 2009
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5. Adherence to nutritional interventions in head and neck cancer patients: a systematic scoping review of the literature.
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de Oliveira Faria, S., Alvim Moravia, R., Howell, D., and Eluf Neto, J.
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HEAD tumors , *CINAHL database , *PROFESSIONS , *MEDICAL information storage & retrieval systems , *INFORMATION storage & retrieval systems , *MEDICAL databases , *ORAL drug administration , *SYSTEMATIC reviews , *DIET therapy , *CANCER patients , *PATIENT compliance , *LITERATURE reviews , *MEDLINE , *NECK tumors , *NUTRITIONAL status - Abstract
Background: Dietary counselling provided by a dietitian, with or without oral nutritional supplements, can impact on nutritional and clinical outcomes in head and neck cancer (HNC) patients undergoing radiotherapy. However, little is known about the role of adherence to oral nutritional interventions in this population. This review aimed to map the literature for evidence of adherence to oral nutritional interventions in HNC patients undergoing radiotherapy and to identify gaps in knowledge in this field. Methods: A scoping review methodology was used to identify studies, extract data, and collate and summarise results. We searched Medline, Embase, Cochrane Central and CINAHL, from the earliest available time up to 8 January 2020. Results: In total, 2315 unique articles were identified, 163 studies were assessed in full and niner were included in the scoping review. The use of different measures to assess adherence and variability in the timing of the assessments was noted across studies. Despite identifying studies that have measured adherence to oral nutritional interventions, very few studies monitored its influence on clinical and nutritional outcomes in HNC patients or reported factors related to adherence. Conclusions: A robust evidence base is lacking for adherence to oral nutritional intervention in HNC patients. Overall, further studies evaluating the impact of oral nutritional interventions in HNC patients undergoing radiotherapy should measure adherence to the intervention. Early recognition of non‐adherence and the contributing factors could ensure intensification of nutritional support and better health outcomes. [ABSTRACT FROM AUTHOR]
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- 2021
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6. How much do smoking and alcohol consumption explain socioeconomic inequalities in head and neck cancer risk?
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Boing, A. F., Ferreira Antunes, J. L., Brasilino de Carvalho, M., Francisco de Góis Filho, J., Kowalski, L. P., Michaluart Jr., P., Eluf-Neto, J., Boffetta, P., and Wüsch-Filho, V.
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ANALYSIS of variance , *CONFIDENCE intervals , *STATISTICAL correlation , *ALCOHOL drinking , *EMPLOYMENT , *EPIDEMIOLOGY , *MEDICAL cooperation , *METROPOLITAN areas , *MULTIVARIATE analysis , *RESEARCH , *RESEARCH funding , *SMOKING , *LOGISTIC regression analysis , *DATA analysis , *SOCIOECONOMIC factors , *EDUCATIONAL attainment , *DISEASE incidence , *CASE-control method - Abstract
Background A higher burden of head and neck cancer has been reported to affect deprived populations. This study assessed the association between socioeconomic status and head and neck cancer, aiming to explore how this association is related to differences of tobacco and alcohol consumption across socioeconomic strata. Methods We conducted a case-control study in São Paulo, Brazil (1998-2006), including 1017 incident cases of oral, pharyngeal and laryngeal cancer, and 951 sex- and age-matched controls. Education and occupation were distal determinants in the hierarchical approach; cumulative exposure to tobacco and alcohol were proximal risk factors. Outcomes of the hierarchical model were compared with fully adjusted ORs. Results Individuals with lower education (OR 2.27; 95% CI 1.61 to 3.19) and those performing manual labour (OR 1.55; 95% CI 1.26 to 1.92) had a higher risk of disease. However, 54% of the association with lower education and 45% of the association with manual labour were explained by proximal lifestyle exposures, and socioeconomic status remained significantly associated with disease when adjusted for smoking and alcohol consumption. Conclusions Socioeconomic differences in head and neck cancer are partially attributable to the distribution of tobacco smoking and alcohol consumption across socioeconomic strata. Additional mediating factors may explain the remaining variation of socioeconomic status on head and neck cancer. [ABSTRACT FROM AUTHOR]
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- 2011
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7. TP53 and EGFR mutations in combination with lifestyle risk factors in tumours of the upper aerodigestive tract from South America.
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Szymańska, K., Levi, J. E., Menezes, A., Wünsch-Filho, V., Eluf-Neto, J., Koifman, S., Matos, E., Daudt, A. W., Curado, M. P., Villar, S., Pawlita, M., Waterboer, T., Boffetta, P., Hainaut, P., and Brennan, P.
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GENES , *GENETIC mutation , *CANCER risk factors ,ALIMENTARY canal cancer - Abstract
Cancers of the upper aerodigestive tract [(UADT): oral cavity, pharynx, larynx and oesophagus] have high incidence rates in some parts of South America. Alterations in the TP53 gene are common in these cancers. In our study, we have estimated the prevalence and patterns of TP53 mutations (exons 4–10) in 236 UADT tumours from South America in relation to lifestyle risk factors, such as tobacco smoking and alcohol drinking. Moreover, we have conducted a pilot study of EGFR mutations (exons 18–21) in 45 tumours from the same population. TP53 mutation prevalence was high: 59% of tumours were found to carry mutant TP53. We found an association between TP53 mutations and tobacco smoking and alcohol drinking. The mutation rate increased from 38% in never-smokers to 66% in current smokers (P-value for trend = 0.09). G:C>T:A transversions were found only in smokers (15%). Alcohol drinkers carried more G:C>A:T transitions (P = 0.08). Non-exposed individuals were more probable to carry G:C>A:T transitions at CpG sites (P = 0.01 for never-smokers and P < 0.001 for never-drinkers). EGFR mutations were found in 4% of cases. Inactivation of TP53 by mutations is a crucial molecular event in the UADT carcinogenesis and it is closely related to exposure to lifestyle risk factors. EGFR mutations do not appear to be a common event in UADT carcinogenesis in this population. [ABSTRACT FROM PUBLISHER]
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- 2010
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8. Incidence and risk factors for agranulocytosis in Latin American countries -- the Latin Study.
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Hamerschlak N, Maluf E, Cavalcanti AB, Júnior ÁA, Eluf-Neto J, Falcão RP, Lorand-Metze IGH, Goldenberg D, Santana CL, Rodrigues DOW, Passos LNM, Coelho EOM, Pintão MCT, de Souza HM, Borbolla JR, and Pasquini R
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Purpose: LATIN is a multinational case-control study designed to identify risk factors for agranulocytosis and to estimate the incidence rate of the disease in some Latin American countries.Methods: Each study site in Brazil, Argentina and Mexico conducted an active search of agranulocytosis patients in hematology clinics and looked for possible associations with drug use.Results: The overall incidence rate was 0.38 cases per 1 million inhabitant-years. Agranulocytosis patients more often took medications already associated with agranulocytosis than controls (p = 0.01), mainly methimazole (OR 44.2, 95% CI 6.8 to infinity). The population attributable risk percentage (etiologic fraction) was 56%. The use of nutrient supplements was more frequent among patients than controls (p = 0.03).Conclusions: Agranulocytosis seems to be very rare in Latin America. The lower than expected number of cases identified during the study period precluded estimation of the risk associated to individual drugs, with the exception of methimazol. However, this is the longest series of agranulocytosis cases ever gathered in Latin America, and information on drug exposures was collected prospectively. The conclusion is that drug-induced agranulocytosis does not seem to be a major public health problem in the study regions. [ABSTRACT FROM AUTHOR]
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- 2008
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9. Herpes simplex virus-2 as a human papillomavirus cofactor in the etiology of invasive cervical cancer.
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Smith JS, Herrero R, Bosetti C, Muñoz N, Bosch FX, Eluf-Neto J, Castellsagué X, Meijer CJL, Van den Brule AJC, Franceschi S, Ashley R, International Agency for Research on Cancer (IARC). Multicentric Cervical Cancer Study Group, Smith, Jennifer S, Herrero, Rolando, Bosetti, Cristina, Muñoz, Nubia, Bosch, F Xavier, Eluf-Neto, José, Castellsagué, Xavier, and Meijer, Chris J L M
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Background: Human papillomavirus (HPV) infection is the main cause of invasive cervical cancer, but cofactors may act in conjunction with HPV. We performed a pooled analysis of seven case-control studies to examine the effect of one possible HPV cofactor, herpes simplex virus-2 (HSV-2) infection, in the etiology of invasive cervical cancer.Methods: Blood and exfoliated cervical specimens were obtained from 1263 case patients with invasive cervical cancer (1158 with squamous-cell carcinomas and 105 with adeno- or adenosquamous-cell carcinomas) and 1117 age-matched control subjects. Western blot analysis and/or an enzyme-linked immunosorbent assay were used to detect type-specific serum antibodies to HSV-2 and HSV-1, and Chlamydia trachomatis serum antibodies were detected using a micro-immunofluorescence assay. HPV DNA was detected using a polymerase chain reaction assay. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were computed from unconditional logistic regression models.Results: Overall, HSV-2 seropositivity was higher among case patients with squamous-cell carcinoma (44.4%, 95% CI = 41.5% to 47.3%) or adeno- or adenosquamous-cell carcinoma (43.8%, 95% CI = 34.2% to 53.5%) than among control subjects (25.6%, 95% CI = 23.0% to 28.2%). Cervical specimens from 1098 (94.8%) squamous-cell carcinoma case patients, 95 (90.5%) adeno- or adenosquamous carcinoma case patients, and 164 (14.7%) control subjects were positive for HPV DNA. Among the HPV DNA-positive women, HSV-2 seropositivity was associated with increased risks of squamous-cell carcinoma (OR = 2.19, 95% CI = 1.41 to 3.40) and adeno- or adenosquamous-cell carcinoma (OR = 3.37, 95% CI = 1.47 to 7.74) after adjustment for potential confounders. A similar association between HSV-2 seropositivity and squamous-cell carcinoma risk was observed after further controlling for markers of sexual behavior (OR = 1.96, 95% CI = 1.24 to 3.09). Among control subjects, HSV-2 seropositivity was associated with markers of sexual behavior, but not with cervical HPV DNA positivity.Conclusion: HSV-2 infection may act in conjunction with HPV infection to increase the risk of invasive cervical carcinoma. [ABSTRACT FROM AUTHOR]- Published
- 2002
10. Male circumcision, penile human papillomavirus infection, and cervical cancer in female partners.
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Castellsagué X, Bosch FX, Muñoz N, Meijer CJL, Shah KV, de Sanjosé S, Eluf-Neto J, Ngelangel CA, Chichareon S, Smith JS, Herrero R, Franceschi S, and International Agency for Research on Cancer Multicenter Cervical Cancer Study Group
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- 2002
11. Prevalence and determinants of human papillomavirus genital infection in men.
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Franceschi, S., Castellsague, X., DalMaso, L., Smith, J.S., Plummer, M., Ngelangel, C., Chichareon, S., Eluf-Neto, J., Shah, K.V., Snijders, P.J.F., Meijer, C.J.L.M., Bosch, F.X., Munoz, N., Castellsagué, X, Dal Maso, L, and Muñoz, N
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CERVICAL cancer , *CANCER in women , *PAPILLOMAVIRUS diseases , *TRANSMISSION of papillomavirus diseases , *PAPILLOMAVIRUSES , *PENIS , *HUMAN sexuality , *CASE-control method , *CANCER , *SPOUSES , *DISEASE prevalence , *TUMORS , *ODDS ratio , *CARCINOMA in situ , *INFECTIOUS disease transmission , *DISEASE complications ,CERVIX uteri tumors - Abstract
Four-hundred-forty-five husbands of women with invasive cervical carcinoma, 165 of women with in situ cervical cancer, and 717 of control women (age range 19-82 years) were interviewed and a sample of exfoliated cells from the penis obtained in seven case-control studies conducted by the International Agency for Research on Cancer. The characteristics of human papillomavirus-positive and human papillomavirus-negative husbands were compared using odds ratios and 95% confidence intervals. Thirteen per cent of the husbands of control women, 18% of the husbands of women with invasive cervical carcinoma, and 21% of the husbands of in situ cervical carcinoma women were positive for penile human papillomavirus DNA. Human papillomavirus 16 was detected in 45 husbands, human papillomavirus 18, 31 or 33 in 19, and human papillomavirus 6/11 in 6, but the majority of human papillomavirus infection (158) was with other or unspecified human papillomavirus types. The same human papillomavirus type was seldom identified in both husband and wife. The strongest variation in penile human papillomavirus infection was by country, with percentages among the husbands of control women ranging between 3% in Spain and 39% in Brazil. Having had over 50 lifetime sexual partners, compared with only one, was associated with an odds ratio of 2.3. [ABSTRACT FROM AUTHOR]
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- 2002
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12. Prevalence and risk factors for herpes simplex virus type 2 infection among middle-age women in Brazil and the Philippines.
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Smith, Jennifer S., Herrero, Rolando, Munoz, Nubia, Eluf-Neto, Jose, Ngelangel, Cora, Bosch, F. Xavier, Ashley, Rhoda L., Smith, J S, Herrero, R, Muñoz, N, Eluf-Neto, J, Ngelangel, C, Bosch, F X, and Ashley, R L
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HERPES simplex , *DISEASES in middle-aged women , *DISEASE risk factors - Abstract
Background: Data comparing type-specific herpes simplex virus type 2 (HSV-2) seroprevalence and risk factors between comparable populations are largely unavailable, particularly from less-developed countries.Goal: To examine the seroprevalence of HSV-2 infection and the risk factors for this infection among women in São Paulo, Brazil, and Manila, the Philippines.Study Design: Altogether, 552 middle-aged women participating as control subjects in two cervical cancer studies were screened for type-specific HSV-2 antibodies.Results: Herpes simplex virus type 2 seroprevalence was higher in Brazil (42%) than in the Philippines (9.2%). The mean ages of Brazilian (n = 181) and Filipino (n = 371) women were 52.4 and 46.6 years, respectively. Brazilian participants had more lifetime sexual partners, less education, and more often a husband with other sexual partners than Filipino women. Herpes simplex virus type 2 was independently associated with younger age at first intercourse in both countries. More than one lifetime sexual partner, a husband with other sexual partners, urban/semi-urban residence, and no history of condom use were HSV-2 risk factors in Brazil, but not in the Philippines, where long-term hormonal contraceptive use was associated with increased risk.Conclusions: The higher HSV-2 seroprevalence in Brazil than in the Philippines may be explained largely by differences in the sexual behavior of women and their husbands. Herpes simplex virus type 2 seroprevalence data may be used as a marker of past sexual behavior for the direct comparison of different population groups. [ABSTRACT FROM AUTHOR]- Published
- 2001
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