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The article deals with a cross-staff discovered inside a wooden chest on the wreck site of the man-of-war Kronan (1676), located off the east coast of the island of O¨land in the Baltic Sea. It is dated 166[1], and besides now being the earliest known complete cross-staff, it is in several respects unique. A theory that the cross-staff from Kronan, due to its rough graduation and somewhat antiquated design, was used mainly for symbolic reasons, widens the fields of research and interpretation of the material culture. [Copyright &y& Elsevier]

The aim of this study was to visualize non-invasively the uptake of platinum in tumours and tissues after treatment with cisplatin. 191Pt-cisplatin was synthesized from 191PtCl4 with rigorous pharmaceutical quality control. The uptake of platinum by both tumorous and healthy tissues was studied by gamma camera imaging in 14 patients, 5 of whom showed a clear uptake of platinum in regions corresponding to known tumour sites. Maximum concentrations of platinum in the tumours were on average 4.9±1.0 μg/g, when normalized to an administered amount of 180 mg cisplatin. In all the patients, the liver was the organ that showed the highest uptake. Platinum uptake was also seen in the spleen, gall bladder, gastrointestinal tract, bladder, kidneys, ureter, neck and mediastinum and urogenital region. By using in-house production of 191Pt-cisplatin, it was possible to monitor the uptake of platinum in tumorous tissues and healthy organs. [ABSTRACT FROM AUTHOR]