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This article explores the relationship between hidradenitis suppurativa (HS), systemic inflammatory response syndrome (SIRS), and sepsis. It analyzes data from the National Inpatient Sample (NIS) to compare outcomes of patients with HS and sepsis to those without HS. The study finds that patients with HS who were hospitalized with sepsis had lower mortality rates and shorter hospital stays compared to patients without HS. The most common cause of hospitalization and in-hospital deaths in both groups was sepsis from an unspecified organism. The article also includes a sensitivity analysis that suggests sepsis in HS may be overdiagnosed and discusses the limitations of the NIS database. It suggests that patients with HS without other clinical causes for sepsis should be considered to have systemic inflammatory response syndrome caused by HS exacerbation itself. [Extracted from the article]