1. Inferring within-host bottleneck size: A Bayesian approach.
- Author
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Dybowski, R., Restif, O., Price, D.J., and Mastroeni, P.
- Subjects
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BACTERIAL diseases in animals , *LABORATORY animal diseases , *BOTTLENECKS (Manufacturing) , *MICROBIAL invasiveness , *BAYESIAN analysis - Abstract
Recent technical developments in microbiology have led to new discoveries on the within-host dynamics of bacterial infections in laboratory animals. In particular, they have highlighted the importance of stochastic bottlenecks at the onset of invasive disease. A number of approaches exist for bottleneck-size estimation with respect to within-host bacterial infections; however, some are more appropriate than others under certain circumstances. A Bayesian comparison of several approaches is made in terms of the availability of isogenic multitype bacteria (e.g., WITS), knowledge of post-bottleneck dynamics, and the suitability of dilution with monotype bacteria. A sampling approach to bottleneck-size estimation is also introduced. The results are summarised by a guiding flowchart, which we hope will promote the use of quantitative models in microbiology to refine the analysis of animal experiment data. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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