1. Superb ruthenium(ii) complex melody: Uncovering its hidden catalytic and biological properties.
- Author
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Duman, Sibel, Dervişoğlu, Gökhan, Özdemir, Fethi Ahmet, Şerbetçi, Zafer, Erdener, Diğdem, and Dayan, Osman
- Subjects
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RUTHENIUM , *GRAM-positive bacteria , *METHANOLYSIS , *GRAM-negative bacteria , *MELODY - Abstract
Aliphatic/aromatic nitrogen-substituted ligands have a very important role in ruthenium chemistry. Polydentate ligands with N-substituted pyridine rings are notable for their ability to easily modify the electronic and steric properties of ruthenium. In this study, the catalytic and biological activities of the [RuCl 2 (NNN)(CH 3 CN)] (NNN: 2,6-di(1H-pyrazol-3-yl)pyridine)) complex were examined for two different applications. Firstly, the superb Ru(II) complex was used to catalyze the methanolysis of NaBH 4 , and its initial rate was calculated as 69360 mLH 2 min−1g cat −1. Secondly, the biological activities of the superb Ru(II) complex were examined. Accordingly, it was determined that this homogeneous complex showed anti-microbial activity on all bacteria used in the study, among the Gram-positive bacteria used in the study, the best result belongs to the Bacillus cereus EMC 19 bacterium with 8 mm, while among the Gram-negative bacteria, the best zone diameter belongs to the Pseudomonas aeruginosa DSM 50071 bacterium with 5 mm. However, it was observed that zone diameters varied between 8 mm and 3 mm. Compared to the control group, it was determined that 0.25 mg/mL concentration had 94.87%, 0.5 mg/mL concentration 96.10%, 1 mg/mL concentration 96.50%, and 2 mg/mL concentration 97.09% cytotoxic activity on the SH-SY5Y cell line. it was determined that all doses of the superb Ru(II) complex used in the study showed anti-cancer activity, but the anticancer activity shown at low doses was statistically more significant at the p < 0.05 level. [Display omitted] • Use of homogeneous superb ruthenium(II) complex during methanolysis of NaBH 4. • Kinetic studies for the superb Ru(II) complex catalyzing the methanolysis of NaBH 4. • Calculation of activation parameters for catalytic the methanolysis reaction. • Investigation of anti-cancer and anti-microbial properties of superb Ru(II) complex. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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