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Interventions designed to promote perspective taking are increasingly prevalent in educational settings, and are also being considered for applications in other domains. Thus far, these perspective-taking interventions (PTIs) have largely escaped philosophical attention, however they are sometimes prima facie morally problematic in at least two respects: they are neither transparent nor easy to resist. Nontransparent or hard-to-resist PTIs call for a moral defense and our primary aim in this paper is to provide such a defense. We offer two arguments for the view that an exemplar PTI is morally permissible even though it is plausibly neither transparent nor easy to resist. The first argument appeals to an analogy between PTIs and permissible deceptive research practices. The second appeals to the way in which PTIs draw participants' attention to their reasons for action. We also respond to the objection that, by imposing a particular conception of the good, PTIs violate liberal neutrality. [ABSTRACT FROM AUTHOR]

In this article, we argue that rational persuasion can be a pro tanto wrong and that online platforms possess features that are especially conducive to this wrong. We begin by setting out an account of rational persuasion. This consists of four jointly sufficient conditions for rational persuasion and is intended to capture the core, uncontroversial cases of such persuasion. We then discuss a series of wrong-making features which are present in methods of influence commonly thought of as pro tanto wrong, such as manipulation and paternalism. It is next shown that these wrong-making features are also present in a range of cases that are, by the jointly sufficient conditions already established, rational persuasion, and so some forms of rational persuasion are pro tanto wrong, including in some ways that have not previously been remarked upon. Finally, we demonstrate that online settings possess a number of features that are especially conducive to wrongful rational persuasion. [ABSTRACT FROM AUTHOR]

A commentary to the article "Philosophy, Reasons and Reproduction: Gene Editing and Genetic Selection," by J. McMahan and J. Savulescu published in the issue is presented. Topics covered include the problem with the authors' response to a possible objection to their claims concerning gene editing and genetic selection, the issue with the accounts of comparative benefit that the authors have in mind and the suggestion on how the authors should have responded.

Psychological literature indicates that actions performed with the assistance of cognition‐enhancing biomedical technologies are often deemed to be less praiseworthy than similar actions performed without such assistance. This study examines (i) whether this result extends to the bioenhancement of moral capacities, and (ii) if so, what explains the effect of moral bioenhancement on perceived praiseworthiness. The findings indicate that actions facilitated by morally bioenhanced individuals are considered less deserving of praise than similar actions facilitated by 'traditional' moral enhancement—for example, moral self‐education. This diminished praise does not seem to be driven by an aversion to (moral) bioenhancement per se. Instead, it appears to be primarily attributable to a perceived lack of effort exerted by bioenhanced individuals in the course of their moral enhancement. Our findings advance the philosophical discourse on the foundations of praise in the context of moral bioenhancement by elucidating the empirical basis underlying some assumptions commonly employed to argue for or against the permissibility of moral bioenhancement. [ABSTRACT FROM AUTHOR]

In discussions of nudging, transparency is often taken to be important; it is often suggested that a significant moral consideration to take into account when nudging is whether the nudge is transparent. Another consideration taken to be relevant is whether the nudge is easy to resist. Sometimes, these two considerations are taken to be importantly related: if we have reason to make nudges easy to resist, then we have reason to make them transparent, insofar as a nudge's transparency is relevant to whether the nudge is easy to resist. In this paper, we critically scrutinize this view. First, we draw out the purported connections between transparency and resistibility, combining them into what we call the Resistibility-to-Transparency Argument (RTA). Then, we do some conceptual groundwork elaborating on different forms of transparency mentioned in the debate. With this in place, we argue that in order to be plausible, the RTA must appeal to certain forms of transparency; those on which the transparency of a nudge depends on the nudgee's ability to become aware of the relevant facts about the nudge. We then argue against the common assumption that in order for a nudge to be easy to resist for an individual, that individual needs to have the capacity to easily become aware of the relevant nudge facts. We conclude that the connection between the easy resistibility of a nudge and its transparency is, at best, a weak one. [ABSTRACT FROM AUTHOR]

Temporal patterns in stream chemistry provide integrated signals describing the hydrological and ecological state of whole catchments. However, stream chemistry integrates multi-scale signals of processes occurring in both the catchment and stream. Deconvoluting these signals could identify mechanisms of solute transport and transformation and provide a basis for monitoring ecosystem change. We applied trend analysis, wavelet decomposition, multivariate autoregressive state-space modeling, and analysis of concentration–discharge relationships to assess temporal patterns in high-frequency (15 min) stream chemistry from permafrost-influenced boreal catchments in Interior Alaska at diel, storm, and seasonal time scales. We compared catchments that varied in spatial extent of permafrost to identify characteristic biogeochemical signals. Catchments with higher spatial extents of permafrost were characterized by increasing nitrate concentration through the thaw season, an abrupt increase in nitrate and fluorescent dissolved organic matter (fDOM) and declining conductivity in late summer, and flushing of nitrate and fDOM during summer rainstorms. In contrast, these patterns were absent, of lower magnitude, or reversed in catchments with lower permafrost extent. Solute dynamics revealed a positive influence of permafrost on fDOM export and the role of shallow, seasonally dynamic flowpaths in delivering solutes from high-permafrost catchments to streams. Lower spatial extent of permafrost resulted in static delivery of nitrate and limited transport of fDOM to streams. Shifts in concentration–discharge relationships and seasonal trends in stream chemistry toward less temporally dynamic patterns might therefore indicate reorganized catchment hydrology and biogeochemistry due to permafrost thaw. [ABSTRACT FROM AUTHOR]

Andreas Schmidt and Neil Levy have recently defended nudging against the objection that nudges fail to treat nudgees as rational agents. Schmidt rejects two theses that have been taken to support the objection: that nudges harness irrational processes in the nudgee, and that they subvert the nudgee's rationality. Levy rejects a third thesis that may support the objection: that nudges fail to give reasons. I argue that these defences can be extrapolated from nudges to some nonconsensual neurointerventions; if Schmidt's and Levy's defences succeed, then some nonconsensual neurointerventions neither harness irrationality, nor subvert rationality, nor fail to give reasons. This, I claim, poses a challenge both to opponents of nonconsensual neurointerventions, and to defenders of nudging. [ABSTRACT FROM AUTHOR]

Some suggest that gene editing human embryos to prevent genetic disorders will be in one respect morally preferable to using genetic selection for the same purpose: gene editing will benefit particular future persons, while genetic selection would merely replace them. We first construct the most plausible defence of this suggestion—the benefit argument—and defend it against a possible objection. We then advance another objection: the benefit argument succeeds only when restricted to cases in which the gene-edited child would have been brought into existence even if gene editing had not been employed. Our argument relies on a standard account of comparative benefit which has recently been criticised on the grounds that it succumbs to the so-called 'pre-emption problem'. We end by considering how our argument would be affected were the standard account revised in an attempt to evade this problem. We consider three revised accounts and argue that, on all three, our critique of the benefit argument stands. [ABSTRACT FROM AUTHOR]

Treatment effect waning (TEW) refers to the attenuation of treatment effects over time. Assumptions of a sustained immuno-oncologic treatment effect have been a source of contention in health technology assessment (HTA). We review how TEW has been addressed in HTA and in the wider scientific literature. We analysed company submissions to English language HTA agencies and summarised methods and assumptions used. We subsequently reviewed TEW-related work in the ISPOR Scientific Presentations Database and conducted a targeted literature review (TLR) for evidence of the maintenance of immuno-oncology (IO) treatment effects post-treatment discontinuation. We found no standardised approach adopted by companies in submissions to HTA agencies, with immediate TEW most used in scenario analyses. Independently fitted survival models do however suggest TEW may often be implicitly modelled. Materials in the ISPOR scientific database suggest gradual TEW is more plausible than immediate TEW. The TLR uncovered evidence of durable survival in patients treated with IOs but no evidence that directly addresses the presence or absence of TEW. Our HTA review shows the need for a consistent and appropriate implementation of TEW in oncology appraisals. However, the TLR highlights the absence of direct evidence on TEW in literature, as TEW is defined in terms of relative treatment effects—not absolute survival. We propose a sequence of steps for analysts to use when assessing whether a TEW scenario is necessary and appropriate to present in appraisals of IOs. [ABSTRACT FROM AUTHOR]

Permafrost underlies one-quarter of the Northern Hemisphere but is at increasing risk of thaw from climate warming. Recent studies across the Arctic have identified areas of rapid permafrost degradation from both top-down and lateral thaw. Of particular concern is thawing syngenetic "yedoma" permafrost which is ice-rich and has a high carbon content. This type of permafrost is common in the region around Fairbanks, Alaska, and across central Alaska expanding westward to the Seward Peninsula. A major knowledge gap is relating belowground measurements of seasonal thaw, permafrost characteristics, and residual thaw layer development with aboveground ecotype properties and thermokarst expansion that can readily quantify vegetation cover and track surface elevation changes over time. This study was conducted from 2013 to 2020 along four 400 to 500 m long transects near Fairbanks, Alaska. Repeat active layer depths, near-surface permafrost temperature measurements, electrical resistivity tomography (ERT), deep (> 5 m) boreholes, and repeat airborne light detection and ranging (lidar) were used to measure top-down permafrost thaw and map thermokarst development at the sites. Our study confirms previous work using ERT to map surface thawed zones; however, our deep boreholes confirm the boundaries between frozen and thawed zones that are needed to model top-down, lateral, and bottom-up thaw. At disturbed sites seasonal thaw increased up to 25 % between mid-August and early October and suggests measurements to evaluate active layer depth must be made as late in the fall season as possible because the projected increase in the summer season of just a few weeks could lead to significant additional thaw. At our sites, tussock tundra and spruce forest are associated with the lowest mean annual near-surface permafrost temperatures while mixed-forest ecotypes are the warmest and exhibit the highest degree of recent temperature warming and thaw degradation. Thermokarst features, residual thaw layers, and taliks have been identified at all sites. Our measurements, when combined with longer-term records from yedoma across the 500 000 km 2 area of central Alaska, show widespread near-surface permafrost thaw since 2010. Projecting our thaw depth increases, by ecotype, across the yedoma domain, we calculate a first-order estimate that 0.44 Pg of organic carbon in permafrost soil has thawed over the past 7 years, which, for perspective, is an amount of carbon nearly equal to the yearly CO 2 emissions of Australia. Since the yedoma permafrost and the variety of ecotypes at our sites represent much of the Arctic and subarctic land cover, this study shows remote sensing measurements, top-down and bottom-up thermal modeling, and ground-based surveys can be used predictively to identify areas of the highest risk for permafrost thaw from projected future climate warming. [ABSTRACT FROM AUTHOR]

When it comes to determining how healthcare resources should be allocated, there are many factors that could—and perhaps should—be taken into account. One such factor is a patient's responsibility for his or her illness, or for the behavior that caused it. Policies that take responsibility for the unhealthy lifestyle or its outcomes into account—responsibility-sensitive policies—have faced a series of criticisms. One holds that agents often fail to meet either the control or epistemic conditions on responsibility with regard to their unhealthy lifestyles or their outcomes. Another holds that even if patients sometimes are responsible for these items, we cannot know whether a particular patient is responsible for them. In this article, we propose a type of responsibility-sensitive policy that may be able to surmount these difficulties. Under this type of policy, patients are empowered to change to a healthier lifestyle by being given what we call a 'Golden Opportunity' to change. Such a policy would not only avoid concerns about patients' fulfilment of conditions on responsibility for their lifestyles, it would also allow healthcare authorities to be justified in believing that a patient who does not change her lifestyle is responsible for the unhealthy lifestyle. We conclude with a discussion of avenues for further work, and place this policy in the broader context of the debate on responsibility for health. [ABSTRACT FROM AUTHOR]

Christine Clavien and Samia Hurst1 (henceforth C-H) make at least three valuable contributions to the literature on responsibility and healthcare. They offer an admirably clear and workable set of criteria for determining a patient's degree of responsibility for her health condition; they deploy those criteria to cast doubt on the view that patients with lifestyle-related conditions are typically significantly responsible for their conditions; and they outline several practical difficulties that would be raised by any attempt to introduce responsibility-sensitive healthcare funding. I am sympathetic to the general thrust of their argument, share—at least tentatively—their policy conclusions, and was persuaded by much of the detail of their argument. However, I do have three critical comments. [ABSTRACT FROM AUTHOR]

Permafrost thawing could increase soil contaminant mobilization in the environment. Our objective was to quantify metal accumulation capacities for plant species and functional groups common to Alaskan military training ranges where elevated soil metal concentrations were likely to occur. Plant species across multiple military training range sites were collected. Metal content in shoots and roots was compared to soil metal concentrations to calculate bioconcentration and translocation factors. On average, grasses accumulated greater concentrations of Cr, Cu, Ni, Pb, Sb, and Zn relative to forbs or shrubs, and bioconcentrated greater concentrations of Ni and Pb. Shrubs bioconcentrated greater concentrations of Sb. Translocation to shoots was greatest among the forbs. Three native plants were identified as candidate species for use in metal phytostabilization applications. Elymus macrourus, a grass, bioconcentrated substantial concentrations of Cu, Pb, and Zn in roots with low translocation to shoots. Elaeagnus commutata, a shrub, bioconcentrated the greatest amounts of Sb, Ni, and Cr, with a low translocation factor. Solidago decumbens bioconcentrated the greatest amount of Sb among the forbs and translocated the least amount of metals. A combination of forb, shrub, and grass will likely enhance phytostabilization of heavy metals in interior Alaska soils through increased functional group diversity. [ABSTRACT FROM AUTHOR]

Objective: Spinal Manipulative Therapy (SMT) is a routinely applied treatment modality for various musculoskeletal conditions, including low back pain. The precise mechanisms by which SMT elicits its effects are largely unknown, but recent research supports a multi-system explanation recognizing both biomechanical and neurophysiological mechanisms. Although the evaluation of changes in clinical presentation is complex, objective neurophysiological measures of sensitivity to movement (e.g. neurodynamic tests) can be a valuable clinical indicator in evaluating the effects of SMT. This review aimed to synthesize current literature investigating the effects of SMT on lower limb neurodynamics. Method: Eight electronic databases were systematically searched for randomized controlled trials (RCT) that applied SMT (against any control) and evaluated lower limb neurodynamics (Passive Straight Leg Raise or Slump Test). Selection and data extraction were conducted by one researcher, reviewed by a second author. Risk of bias (RoB) was assessed using the Cochrane Back Review Group criteria. Results: Eight RCTs were included, one with high RoB. SMT produced a clinically meaningful (≥6⁰) difference in five of these studies compared with inert control, hamstring stretching, and as an adjunct to conventional physiotherapy, but not compared with standard care, as an adjunct to home exercise and advice, or when comparing different SMT techniques. Findings compared to sham were mixed. When reported, effects tentatively lasted up to 6 weeks post-intervention. Conclusion: Limited evidence suggests SMT-improved range of motion and was more effective than some other interventions. Future research, using standardized Neurodynamic tests, should explore technique types and evaluate longer-term effects. Level of Evidence: 1a [ABSTRACT FROM AUTHOR]

Several authors have recently claimed that we each possess a right against interference with our minds. However, it remains unclear how this claim is to be justified. I offer a novel argument in defence of it. The argument is intuitive—appealing centrally to intuitions regarding cases—and abductive—taking the form of an inference to the best explanation; I offer a series of cases involving intuitively wrongful interventions, argue that five somewhat promising attempts to account for the wrongfulness of these interventions leave some of this wrongfulness unexplained, and show that my proposed alternative explanation, which invokes a right against mental interference, can account for this residual wrongfulness. [ABSTRACT FROM AUTHOR]

Limamou Laye (1844-1909) redefined the concept of the Mahdi with his proclamation. Though the concept of Mahdi has a history of variations across the Islamic world, Limamou Laye added a previously unknown characteristic: Mahdi as reincarnation of Muhammed. This article explores the history of the concept of the Mahdi focusing on the Sunni and Shi'a traditions. On the 24 May 1883, Libasse Thiaw (later known as Limamou Laye) proclaimed himself the Mahdi. His proclamation went on to say that he was the Prophet Muhammed returned to earth. Studying this event historically begs the question, why was this particular detail added to an honored Islamic messianic tradition? The answer lies in the history and geographical positioning of the Lebu, the ethnicity to which Libasse Thiaw belonged. I argue that three cultural influences helped shaped the Lebu expression of the Mahdi. The first influence was the Lebu traditional religious belief system. The second was Islam as expressed and practiced in the Senegambia. The third was the Christianity that the French brought with them to the area. [ABSTRACT FROM AUTHOR]

Permafrost hosts a community of microorganisms that survive and reproduce for millennia despite extreme environmental conditions, such as water stress, subzero temperatures, high salinity, and low nutrient availability. Many studies focused on permafrost microbial community composition use DNA-based methods, such as metagenomics and 16S rRNA gene sequencing. However, these methods do not distinguish among active, dead, and dormant cells. This is of particular concern in ancient permafrost, where constant subzero temperatures preserve DNA from dead organisms and dormancy may be a common survival strategy. To circumvent this, we applied (i) LIVE/DEAD differential staining coupled with microscopy, (ii) endospore enrichment, and (iii) selective depletion of DNA from dead cells to permafrost microbial communities across a Pleistocene permafrost chronosequence (19,000, 27,000, and 33,000 years old). Cell counts and analysis of 16S rRNA gene amplicons from live, dead, and dormant cells revealed how communities differ between these pools, how they are influenced by soil physicochemical properties, and whether they change over geologic time. We found evidence that cells capable of forming endospores are not necessarily dormant and that members of the class Bacilli were more likely to form endospores in response to long-term stressors associated with permafrost environmental conditions than members of the Clostridia, which were more likely to persist as vegetative cells in our older samples. We also found that removing exogenous "relic" DNA preserved within permafrost did not significantly alter microbial community composition. These results link the live, dead, and dormant microbial communities to physicochemical characteristics and provide insights into the survival of microbial communities in ancient permafrost. [ABSTRACT FROM AUTHOR]

Background: Antimicrobial resistance (AMR) is a global public health disaster driven largely by antibiotic use in human health care. Doctors considering whether to prescribe antibiotics face an ethical conflict between upholding individual patient health and advancing public health aims. Existing literature mainly examines whether patients awaiting consultations desire or expect to receive antibiotic prescriptions, but does not report views of the wider public regarding conditions under which doctors should prescribe antibiotics. It also does not explore the ethical significance of public views or their sensitivity to awareness of AMR risks or the standpoint (self-interested or impartial) taken by participants. Methods: An online survey was conducted with a sample of the U.S. public (n = 158). Participants were asked to indicate what relative priority should be given to individual patients and society-at-large from various standpoints and in various contexts, including antibiotic prescription. Results: Of the participants, 50.3% thought that doctors should generally prioritize individual patients over society, whereas 32.0% prioritized society over individual patients. When asked in the context of AMR, 39.2% prioritized individuals whereas 45.5% prioritized society. Participants were significantly less willing to prioritize society over individuals when they themselves were the patient, both in general (p =.001) and in relation to AMR specifically (p =.006). Conclusions: Participants' attitudes were more oriented to society and sensitive to collective responsibility when informed about the social costs of antibiotic use and when considered from a third-person rather than first-person perspective. That is, as participants came closer to taking the perspective of an informed and impartial "ideal observer," their support for prioritizing society increased. Our findings suggest that, insofar as antibiotic policies and practices should be informed by attitudes that are impartial and well-informed, there is significant support for prioritizing society. [ABSTRACT FROM AUTHOR]

We seek to develop a plausible conception of genetic parenthood, taking a recent discussion by Heidi Mertes as our point of departure. Mertes considers two conceptions of genetic parenthood—one invoking genetic resemblance and the other genetic inheritance—and presents counter‐examples to both conceptions. We revise Mertes' second conception so as to avoid these and related counter‐examples. [ABSTRACT FROM AUTHOR]

Strategies to increase influenza vaccination rates have typically targeted healthcare professionals (HCPs) and individuals in various high-risk groups such as the elderly. We argue that they should (instead or as well) focus on increasing vaccination rates in children. Because children suffer higher influenza incidence rates than any other demographic group, and are major drivers of seasonal influenza epidemics, we argue that influenza vaccination strategies that serve to increase uptake rates in children are likely to be more effective in reducing influenza-related morbidity and mortality than those targeting HCPs or the elderly. This is true even though influenza-related morbidity and mortality amongst children are low, except in the very young. Further, we argue that there are no decisive reasons to suppose that children-focused strategies are less ethically acceptable than elderly or HCP-focused strategies. [ABSTRACT FROM AUTHOR]

We address the issue of whether, why and under what conditions, quarantine and isolation are morally justified, with a particular focus on measures implemented in the developing world. We argue that the benefits of quarantine and isolation justify some level of coercion or compulsion by the state, but that the state should be able to provide the strongest justification possible for implementing such measures. While a constrained form of consequentialism might provide a justification for such public health interventions, we argue that a stronger justification is provided by a principle of State Enforced Easy Rescue: a state may permissibly compel individuals to engage in activities that entail a small cost to them but a large benefit to others, because individuals have a moral duty of easy rescue to engage in those activities. The principle of State Enforced Easy Rescue gives rise to an Obligation Enforcement Requirement: the state should create the conditions such that submitting to coercive or compulsive measures becomes a fundamental moral duty of individuals, i.e. a duty of easy rescue. When the state can create such conditions, it has the strongest justification possible for implementing coercive or compulsive measures, because individuals have a moral duty to temporarily relinquish the rights that such measures would infringe. Our argument has significant implications for how public health emergencies in the developing world should be tackled. Where isolation and quarantine measures are necessary, states or the international community have a moral obligation to provide certain benefits to those quarantined or isolated. [ABSTRACT FROM AUTHOR]

In the Arctic, the snowpack forms the major interface between atmospheric and terrestrial cycling of mercury (Hg), a global pollutant. We investigated Hg dynamics in an interior Arctic tundra snowpack in northern Alaska during two winter seasons. Using a snow tower system to monitor Hg trace gas exchange, we observed consistent concentration declines of gaseous elemental Hg (Hg0gas) from the atmosphere to the snowpack to soils. The snowpack itself was unlikely a direct sink for atmospheric Hg0 gas. In addition, there was no evidence of photochemical reduction of HgII to Hg0 gas in the tundra snowpack, with the exception of short periods during late winter in the uppermost snow layer. The patterns in this interior Arctic snowpack thus differ substantially from observations in Arctic coastal and temperate snowpacks. We consistently measured low concentrations of both total and dissolved Hg in snowpack throughout the two seasons. Chemical tracers showed that Hg was mainly associated with local mineral dust and regional marine sea spray inputs. Mass balance calculations show that the snowpack represents a small reservoir of Hg, resulting in low inputs during snowmelt. Taken together, the results from this study suggest that interior Arctic snowpacks are negligible sources of Hg to the Arctic. [ABSTRACT FROM AUTHOR]

Abstract: Selection against embryos that are predisposed to develop disabilities is one of the less controversial uses of embryo selection technologies (ESTs). Many bio‐conservatives argue that while the use of ESTs to select for non‐disease‐related traits, such as height and eye‐colour, should be banned, their use to avoid disease and disability should be permitted. Nevertheless, there remains significant opposition, particularly from the disability rights movement, to the use of ESTs to select against disability. In this article we examine whether and why the state could be justified in restricting the use of ESTs to select against disability. We first outline the challenge posed by proponents of ‘liberal eugenics’. Liberal eugenicists challenge those who defend restrictions on the use of ESTs to show why the use of these technologies would create a harm of the type and magnitude required to justify coercive measures. We argue that this challenge could be met by adverting to the risk of harms to future persons that would result from a loss of certain forms of cognitive diversity. We suggest that this risk establishes a pro tanto case for restricting selection against some disabilities, including dyslexia and Asperger's syndrome. [ABSTRACT FROM AUTHOR]

Abstract: Bioethicists sometimes defend compromise positions, particularly when they enter debates on applied topics that have traditionally been highly polarised, such as those regarding abortion, euthanasia and embryonic stem cell research. However, defending compromise positions is often regarded with a degree of disdain. Many are intuitively attracted to the view that it is almost always problematic to defend compromise positions, in the sense that we have a significant moral reason not to do so. In this paper, we consider whether this common sense view can be given a principled basis. We first show how existing explanations for the problematic nature of compromise fall short of vindicating the common sense view, before offering our own explanation, which, we claim, comes closer to vindicating that view. We argue that defending a compromise will typically have two epistemic costs: it will corrupt attempts to use the claims of ethicists as testimonial evidence, and it will undermine standards that are important to making epistemic progress in ethics. We end by suggesting that the epistemic costs of compromise could be reduced by introducing a stronger separation between ethical debate aimed at fulfilling the epistemic role of ethics, and ethical debate that aims to directly produce good policy or practice. [ABSTRACT FROM AUTHOR]

In a paper recently published in this journal, Navin and Largent argue in favour of a type of policy to regulate non-medical exemptions from childhood vaccination which they call 'Inconvenience'. This policy makes it burdensome for parents to obtain an exemption to child vaccination, for example, by requiring parents to attend immunization education sessions and to complete an application form to receive a waiver. Navin and Largent argue that this policy is preferable to 'Eliminationism', i.e. to policies that do not allow non-medical exemptions, because Inconvenience has been shown to maintain exemption rates low while not harming parents by forcing them to do something that goes against their beliefs. We argue that it is at least doubtful that Inconvenience is ethically preferable to Eliminationism: while the latter disregards the value of liberty, Inconvenience disregards the value of fairness in the distribution of the burdens entailed by the preservation of a public good like herd immunity. We propose a variant of Inconvenience, which we call 'Contribution', which we think is preferable to the versions of Inconvenience discussed by Navin and Largent in that it successfully strikes a balance between the values of parents' liberty, fairness and expected utility. [ABSTRACT FROM AUTHOR]

Atmospheric mercury (Hg) is deposited to Polar Regions during springtime atmospheric mercury depletion events (AMDEs) that require halogens and snow or ice surfaces. The fate of this Hg during and following snowmelt is largely unknown. We measured Hg, major ions, and stable water isotopes from the snowpack through the entire spring melt runoff period for two years. Our small (2.5 ha) watershed is near Barrow (now Utqiaġvik), Alaska. We measured discharge, made 10 000 snow depths, and collected over 100 samples of snow and meltwater for chemical analysis in 2008 and 2009 from the watershed snowpack and ephemeral stream channel. Results show an "ionic pulse" of mercury and major ions in runoff during both snowmelt seasons, but major ion and Hg runoff concentrations were roughly 50% higher in 2008 than in 2009. Though total discharge as a percent of total watershed snowpack water equivalent prior to the melt was similar in both years (36% in 2008 melt runoff and 34% in 2009), it is possible that record low precipitation in the summer of 2007 led to the higher major ion and Hg concentrations in 2008 melt runoff. Total dissolved Hg meltwater runoff of 14.3 (± 0.7) mg/ha in 2008 and 8.1 (± 0.4) mg/ha in 2009 is five to seven times higher than that reported from other arctic watersheds. We calculate 78% of snowpack Hg was exported with snowmelt runoff in 2008 and 41% in 2009. Our results suggest AMDE Hg complexed with Cl- or Br- may be less likely to be photochemically reduced and re-emitted to the atmosphere prior to snowmelt, and we estimate that roughly 25% of the Hg in snowmelt is attributable to AMDEs. Projected Arctic warming, with more open sea ice leads providing halogen sources that promote AMDEs, may provide enhanced Hg deposition, reduced Hg emission and, ultimately, an increase in snowpack and snowmelt runoff Hg concentrations. [ABSTRACT FROM AUTHOR]

Germline Gene Editing ( GGE) has enormous potential both as a research tool and a therapeutic intervention. While other types of gene editing are relatively uncontroversial, GGE has been strongly resisted. In this article, we analyse the ethical arguments for and against pursuing GGE by allowing and funding its development. We argue there is a strong case for pursuing GGE for the prevention of disease. We then examine objections that have been raised against pursuing GGE and argue that these fail. We conclude that the moral case in favour of pursuing GGE is stronger than the case against. This suggests that pursuing GGE is morally permissible and indeed morally desirable. [ABSTRACT FROM AUTHOR]

Case: A 23-year-old active-duty military service member sustained an unusual irreducible fracture-dislocation of the ankle joint. Preoperative computed tomography showed an anterolateral tibial (Chaput) fragment entrapped within the distal syndesmosis, preventing adequate reduction. An open reduction of the fragment was performed in the operating room, which allowed near-anatomic reduction and internal fixation of the tibiotalar joint. At the 21-month follow-up visit, the patient remained on active duty in the Navy without limitations. Conclusion: To our knowledge, this rare injury pattern, an interposed Chaput fragment preventing closed reduction of the syndesmosis in a skeletally mature patient, has not previously been described in the literature. An open reduction and internal fixation of the Chaput fragment allowed near-anatomic reduction of the tibiotalar joint. [ABSTRACT FROM AUTHOR]

This article examines one kind of conscientious refusal: the refusal of healthcare professionals to treat sexual dysfunction in individuals with a history of sexual offending. According to what I call the orthodoxy, such refusal is invariably impermissible, whereas at least one other kind of conscientious refusal—refusal to offer abortion services—is not. I seek to put pressure on the orthodoxy by (1) motivating the view that either both kinds of conscientious refusal are permissible or neither is, and (2) critiquing two attempts to buttress it. [ABSTRACT FROM AUTHOR]

Lead (Pb) and antimony (Sb) contamination pose a major environmental risk at firing ranges and threaten land sustainability. Methods for the stabilization of metal (loid) contaminants are necessary to prevent off-site migration of metals in surface and ground water or from soil erosion. In the present study, two remediation treatments (ferric chloride/calcium carbonate and nanoscale zero-valent iron (nZVI)) were applied to flow-through soil columns containing four types of soils (sand, sandy loam, loamy sand, and silty loam) to study Pb and Sb behavior. Water runoff was continuously monitored for three months prior to amendment addition and for the following ten months. Soils were characterized before and after reaction. We found Sb was more mobile than Pb in all soil systems and was primarily present in the dissolved fraction whereas Pb was associated with both soil organic matter (SOM) and Fe colloids. Dominant Pb solid phase species were comprised of Pb0, PbO, PbCO 3 , and Pb sorbed to Fe(III) oxides while Sb was present as fully oxidized Sb(V) in soil and soil solution. The nZVI addition had minimal impact on Pb and Sb immobilization compared to control soil. The FeCl 2 and CaCO 3 amendment decreased pore water Sb concentrations by >80% for all soil types and >96% reduction in the fine- and coarse-grained soil types (silt loam and sand). Lead was initially mobilized coinciding with a decrease in pH from the hydrolysis of Fe(II) in solution. Additional soil treatments have the potential to be effective for system-wide immobilization with adequate additions of CaCO 3 buffer. Though this study focused on bullet fragment weathering as a source of Pb and Sb the results have application to environmental monitoring and remediation efforts at mining or industrial runoff sites. [Display omitted] • Ferric chloride/calcium carbonate soil additions reduced Sb concentrations by >80%. • Sb more mobile than Pb in column runoff from unamended sand and silt loam soil types. • Pb associated with soil organic matter and Fe colloids while Sb found dissolved. • Distinct distributions of Pb formed in column soils. [ABSTRACT FROM AUTHOR]

A central tenet of medical ethics holds that it is permissible to perform a medical intervention on a competent individual only if that individual has given informed consent to the intervention. Yet it occasionally seems morally permissible to carry out non-consensual medical interventions on competent individuals for the purpose of infectious disease control (IDC). We describe two different moral frameworks that have been invoked in support of non-consensual IDC interventions and identify five desiderata that might be used to guide assessments of the moral permissibility of such interventions on either kind of fundamental justification. We then consider what these desiderata imply for the justifiability of carrying out non-consensual medical interventions that are designed to facilitate rehabilitation amongst serious criminal offenders. We argue that these desiderata suggest that a plausible case can be made in favor of such interventions. [ABSTRACT FROM AUTHOR]

Sex offenders are sometimes offered or required to undergo pharmacological interventions intended to diminish their sex drive (anti-libidinal interventions or ALIs). In this paper, we argue that much of the debate regarding the moral permissibility of ALIs has been founded on an inaccurate assumption regarding their intended purpose--namely, that ALIs are intended solely to realise medical purposes, not correctional goals. This assumption has made it plausible to assert that ALIs may only permissibly be administered to offenders with their valid consent, in line with the approach taken to most other interventions with a medical aim. However, we argue that, contrary to this assumption, the state's intention in relation to at least some ALIs is, at least in part, to achieve correctional objectives. We evaluate two legal regimes for ALI provision--section 645 of the California Penal Code and the mental health regime in England and Wales. In each case, we identify the state's implicit purpose in imposing ALIs and argue that the Californian and English regimes both serve as counterexamples to the view that ALIs are intended solely for medical purposes. While the moral implications of our argument are not straightforward, it raises the question whether consent is required for permissible imposition of ALIs, and more generally, whether the moral permissibility of crime-preventing interventions using medical means should be assessed against the standards of medical ethics or against those of criminal justice ethics. [ABSTRACT FROM AUTHOR]

In some situations a number of agents each have the ability to undertake an initiative that would have significant effects on the others. Suppose that each of these agents is purely motivated by an altruistic concern for the common good. We show that if each agent acts on her own personal judgment as to whether the initiative should be undertaken, then the initiative will be undertaken more often than is optimal. We suggest that this phenomenon, which we callthe unilateralist’s curse, arises in many contexts, including some that are important for public policy. To lift the curse, we propose aprinciple of conformity, which would discourage unilateralist action. We consider three different models for how this principle could be implemented, and respond to an objection that could be raised against it. [ABSTRACT FROM PUBLISHER]

Solar panel performance can be impacted when panel surfaces are coated with substances like dust, dirt, snow, or ice that scatter and/or absorb light and may reduce efficiency. As a consequence, time and resources are required to clean solar panels during and after extreme weather events or whenever surface coating occurs. Treating solar panels with chemical coatings that shed materials may decrease the operating costs associated with solar panel maintenance and cleaning. This study investigates three commercial coatings for use as self-cleaning glass technologies. Optical and thermal properties (reflectivity, absorption, and transmission) are investigated for each coating as well as their surface wettability and particle size. Incoming solar radiation was continuously monitored and snow events were logged to estimate power production capabilities and surface accumulation for each panel. In terms of power output, the commercial coatings made little impact on overall power production compared to the control (uncoated) panels. This was attributable to the overall high transmission, low absorption, and low reflection of each of the commercial coatings, making their presence on the surface of solar panels have minimal impact besides to potentially shed snow While the coatings made no observable difference to increase power production compared to the control panels, the shedding results from video monitoring suggest both the hydrophilic or hydrophobic test coatings decreased snow accumulation to a greater extent than the control panels (uncoated). Controlling the wettability properties of the solar panel surfaces has the potential to limit snow accumulation when compared to uncoated panel surfaces. • Both hydrophilic and hydrophobic coatings decreased snow on solar panel surfaces. • Coatings on solar panel surface did not impact power production over 9-months. • Solar panel surface coatings did reduce solar panel temperatures by 3–5 °C in summer. [ABSTRACT FROM AUTHOR]

Parents typically favour their own children over others'. For example, most parents invest more time and money in their own children than in other children. This parental partiality is usually regarded as morally permissible, or even obligatory, but it can have undesirable distributive effects. For example, it may create unfair or otherwise undesirable advantages for the favoured child. A number of authors have found it necessary to justify parental partiality in the face of these distributive concerns, and they have typically done so by appealing to features of the parent-child relationship. Parental partiality is said to be justified, despite its undesirable distributive effects, in part because the parent enjoys a special kind of relationship with her child. In this paper, I raise a problem for such relational defences of parental partiality. I report empirical findings suggesting that parental partiality will frequently create advantages-sometimes undesirable-not only for one's children, but also for one's more distant descendants; I argue that the creation of these latter advantages stands as much in need of justification as does the creation of advantages for one's own children; and I claim that existing relational defences do not clearly contain the resources necessary to deliver such a justification. I then examine three possible responses to this problem. [ABSTRACT FROM AUTHOR]

Reproductive genetic technologies ( RGTs) allow parents to decide whether their future children will have or lack certain genetic predispositions. A popular model that has been proposed for regulating access to RGTs is the 'genetic supermarket'. In the genetic supermarket, parents are free to make decisions about which genes to select for their children with little state interference. One possible consequence of the genetic supermarket is that collective action problems will arise: if rational individuals use the genetic supermarket in isolation from one another, this may have a negative effect on society as a whole, including future generations. In this article we argue that RGTs targeting height, innate immunity, and certain cognitive traits could lead to collective action problems. We then discuss whether this risk could in principle justify state intervention in the genetic supermarket. We argue that there is a plausible prima facie case for the view that such state intervention would be justified and respond to a number of arguments that might be adduced against that view. [ABSTRACT FROM AUTHOR]

Case: A healthy young adult underwent irrigation and debridement after experiencing minimal blunt trauma involving the ankle. Culture of synovial fluid demonstrated growth of group-B streptococci. Magnetic resonance imaging of the joint at three months of follow-up demonstrated synovitis without signs of osteomyelitis. At one year of follow-up, the patient reported resolution of pain and return of range of motion to normal baseline. Conclusion: Septic arthritis of the ankle can lead to joint destruction if not immediately diagnosed and treated. Empiric antimicrobial therapy should be administered while awaiting bacterial identification on the basis of culture of synovial fluid. Group-B streptococci are a more common cause of septic arthritis in the pediatric and peripartum populations; however, hematogenous spread can translocate these bacteria from the genitourinary tract to joints in all age groups. [ABSTRACT FROM AUTHOR]

Many critics of bioenhancement go to considerable lengths to establish the existence of reasons against pursuing bioenhancements but do little to establish the absence of reasons in favor. This suggests that they accept what Allen Buchanan has called the conclusive reasons view (CRV). According to this view, our reasons against bioenhancement are obviously decisive, so there is no need to balance them against countervailing reasons. Buchanan criticizes the CRV by showing that the reasons most commonly adduced against bioenhancement are not decisive, or, at least, not obviously so.In this article, I suggest that both Buchanan and the authors to whom he is responding underestimate the strength of the case for the CRV. There are, I argue, harm-based reasons against bioenhancement that provide stronger support to the CRV than the reasons that have most often been adduced by critics of enhancement. However, I then argue that even these harm-based reasons are not obviously decisive. Thus, I ultimately agree with Buchanan about the falsity of the CRV, though I disagree with him about the reasons for its falsity. [ABSTRACT FROM PUBLISHER]

Opponents of biomedical enhancement frequently adopt what Allen Buchanan has called the "Personal Goods Assumption." On this assumption, the benefits of biomedical enhancement will accrue primarily to those individuals who undergo enhancements, not to wider society. Buchanan has argued that biomedical enhancements might in fact have substantial social benefits by increasing productivity. We outline another way in which enhancements might benefit wider society: by augmenting civic virtue and thus improving the functioning of our political communities. We thus directly confront critics of biomedical enhancement who argue that it will lead to a loss of social cohesion and a breakdown in political life. [ABSTRACT FROM AUTHOR]

Criminal offenders are sometimes required, by the institutions of criminal justice, to undergo medical interventions intended to promote rehabilitation. Ethical debate regarding this practice has largely proceeded on the assumption that medical interventions may only permissibly be administered to criminal offenders with their consent. In this article I challenge this assumption by suggesting that committing a crime might render one morally liable to certain forms of medical intervention. I then consider whether it is possible to respond persuasively to this challenge by invoking the right to bodily integrity. I argue that it is not. [ABSTRACT FROM AUTHOR]

A number of concerns have been raised about the possible future use of pharmaceuticals designed to enhance cognitive, affective, and motivational processes, particularly where the aim is to produce morally better decisions or behavior. In this article, we draw attention to what is arguably a more worrying possibility: that pharmaceuticals currently in widespread therapeutic use are already having unintended effects on these processes, and thus on moral decision making and morally significant behavior. We review current evidence on the moral effects of three widely used drugs or drug types: (i) propranolol, (ii) selective serotonin reuptake inhibitors, and (iii) drugs that effect oxytocin physiology. This evidence suggests that the alterations to moral decision making and behavior caused by these agents may have important and difficult-to-evaluate consequences, at least at the population level. We argue that the moral effects of these and other widely used pharmaceuticals warrant further empirical research and ethical analysis. [ABSTRACT FROM AUTHOR]

Kelly Sorensen defends a model of the relationship between effort and moral worth in which the effort exerted in performing a morally desirable action contributes positively to the action's moral worth, but the effort required to perform the action detracts from its moral worth. I argue that Sorensen's model, though on the right track, is mistaken in three ways. First, it fails to capture the relevance of counterfactual effort to moral worth. Second, it wrongly implies that exerting unnecessary effort confers moral worth on an action. Third, it fails to adequately distinguish between cases in which effort is required because of defects of moral character and those in which effort is required because of barriers external to moral character, such as social pressures or non-moral cognitive deficits. I suggest three amendments to Sorensen's model that correct these three defects. [ABSTRACT FROM AUTHOR]

Highlights: [•] Artificial organisms need not pose greater risks than derived organisms. [•] The creation of artificial life would not support any form of biological reductionism. [•] Artificial life forms might have uncertain functional status. [•] But this is irrelevant to their moral status. [•] The genealogy of an organism makes no difference to its moral status. [Copyright &y& Elsevier]

In several jurisdictions, sex offenders may be offered chemical castration as an alternative to further incarceration. In some, agreement to chemical castration may be made a formal condition of parole or release. In others, refusal to undergo chemical castration can increase the likelihood of further incarceration though no formal link is made between the two. Offering chemical castration as an alternative to further incarceration is often said to be partially coercive, thus rendering the offender's consent invalid. The dominant response to this objection has been to argue that any coercion present in such cases is compatible with valid consent. In this article, we take a different tack, arguing that, even if consent would not be valid, offering chemical castration will often be supported by the very considerations that underpin concerns about consent: considerations of autonomy. This is because offering chemical castration will often increase the offender's autonomy, both at the time the offer is made and in the future. [ABSTRACT FROM AUTHOR]

Existing debate on procreative selection focuses on the well-being of the future child. However, selection decisions can also have significant effects on the well-being of others. Moreover, these effects may run in opposing directions; some traits conducive to the well-being of the selected child may be harmful to others, whereas other traits that limit the child’s well-being may preserve or increase that of others. Prominent selection principles defended to date instruct parents to select a child, of the possible children they could have, likely to have a good (or nonbad) life, but they do not instruct parents to independently take the well-being of others into account. We refer to these principles as individualistic selection principles. We propose a new selection principle—Procreative Altruism—according to which parents have significant moral reason to select a child whose existence can be expected to contribute more to (or detract less from) the well-being of others than any alternative child they could have. We present the case for adopting Procreative Altruism alongside any of the major individualistic selection principles proposed to date and defend this two-principle model against a range of objections. [ABSTRACT FROM PUBLISHER]