10 results on '"Di Concilio, Rosanna"'
Search Results
2. Asymptomatic intracranial aneurysms in beta-thalassemia: a three-year follow-up report.
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Manara, Renzo, Caiazza, Martina, Di Concilio, Rosanna, Ciancio, Angela, De Michele, Elisa, Maietta, Caterina, Capalbo, Daniela, Russo, Camilla, Roberti, Domenico, Casale, Maddalena, Elefante, Andrea, Esposito, Fabrizio, Ponticorvo, Sara, Russo, Andrea Gerardo, Canna, Antonietta, Cirillo, Mario, Perrotta, Silverio, and Tartaglione, Immacolata more...
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INTRACRANIAL aneurysms , *ANTERIOR cerebral artery , *PATIENT compliance , *SUBARACHNOID hemorrhage , *MAGNETIC resonance angiography , *NATURAL history - Abstract
Background: No information is currently available regarding the natural history of asymptomatic intracranial aneurysms in beta-thalassemia, raising several concerns about their proper management.Methods: We performed a prospective longitudinal three-year-long MR-angiography study on nine beta-thalassemia patients (mean-age 40.3 ± 7.5, six females, 8 transfusion dependent) harboring ten asymptomatic intracranial aneurysms. In addition, we analyzed the clinical files of all adult beta-thalassemia patients (160 patients including those followed with MR-angiography, 121 transfusion dependent) referring to our Centers between 2014 and 2019 searching for history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms.Results: At the end of the three-year-long follow-up, no patient showed any change in the size and shape of the aneurysms, none presented new intracranial aneurysms or artery stenoses, none showed new brain vascular-like parenchymal lesions or enlargement of the preexisting ones. Besides, in our database of all adult beta-thalassemia patients, no one had history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms.Conclusions: Incidental asymptomatic intracranial aneurysms do not seem to be associated, in beta-thalassemia, with an increased risk of complications (enlargement or rupture) at least in the short term period, helping to optimize human and economic resources and patient compliance during their complex long-lasting management. [ABSTRACT FROM AUTHOR] more...- Published
- 2020
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Catalog
3. Non-transfusion-dependent thalassemia in Italy: less blues, no role of reds.
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Tartaglione, Immacolata, Manara, Renzo, di Concilio, Rosanna, Quarta, Antonella, Ruffo, Giovan Battista, De Michele, Elisa, Ammendola, Federica, Foderini, Maria Vittoria, Raimo, Simona, Santangelo, Gabriella, and Perrotta, Silverio more...
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HUMAN experimentation , *THALASSEMIA , *TEST anxiety , *STATE-Trait Anxiety Inventory - Abstract
1 Correlation between Beck Depression Inventory (BDI) scores and hemoglobin levels among non-transfusion-dependent thalassemia patients (p=0.15, r: 0.2) According to our findings, Italian NTDT patients present with a strikingly different psychological profile than the Lebanese group, with a lower depression prevalence rate, in spite of the peculiar period of testing. Study discordance could be partly explained by the slightly higher mean hemoglobin levels in Italian NTDT patients, even though in the whole sample range of hemoglobin levels (7.4-11.5 g/dL) we did not find a sign of inverse correlation with depression severity. The different behavioral profile among Italian and Lebanese beta-thalassemia patients should be considered when approaching NTDT patients: trying to measure the effectiveness of an experimental anemia drug with the improvement of depression scores could be counterproductive, as the linear model suggested by Mihailescu does not apply to other groups. [Extracted from the article] more...
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- 2022
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4. Nucleated red blood cells and soluble transferrin receptor in thalassemia syndromes: relationship with global and ineffective erythropoiesis.
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Danise, Paolo, Amendola, Giovanni, Di Concilio, Rosanna, Cillari, Enrico, Gioia, Maria, Di Palma, Anna, Avino, Daniela, Rigano, Paolo, and Maggio, Aurelio
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ERYTHROCYTES , *HEMOGLOBINOPATHY , *ERYTHROPOIESIS , *THALASSEMIA , *BLOOD transfusion , *HEMATOLOGY - Abstract
Background: The technology to recognize nucleated red blood cells (NRBC) automatically has only recently been developed. Modern hematology analyzers allow for rapid and accurate NRBC counts. The goal of our study was to evaluate NRBC counts and the concentrations of serum transferrin receptor (sTfR) in patients affected by different thalassemia syndromes and hereditary spherocytosis. We wished to gain a better understanding of the meaning of the presence of NRBC in peripheral blood and the relationship of the two parameters with effective and ineffective erythropoiesis in the different thalassemia syndromes. Methods: NRBC counts in peripheral blood were evaluated in a large group of patients with thalassemia (36 thalassemia major, 55 thalassemia intermedia and 61 Sβ-thalassemia patients) and compared with data from 29 patients with hereditary spherocytosis; in all the patients the concentration of sTfR was evaluated as an index of global erythropoiesis. Results: The NRBC count showed a good relationship with ineffective erythropoiesis: highest counts were observed in the thalassemia syndromes characterized by almost completely ineffective erythropoiesis. NRBCs were absent in patients affected by hereditary spherocitosis, a disease characterized by effective erythropoiesis. Conclusions: The NRBC count can be useful for better defining ineffective erythropoiesis in patients with thalassemia, and can help optimize transfusion therapy in severe thalassemia syndromes. Clin Chem Lab Med 2009;47:1539–42. [ABSTRACT FROM AUTHOR] more...
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- 2009
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5. Auditory cortex hypoperfusion: a metabolic hallmark in Beta Thalassemia.
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Manara, Renzo, Ponticorvo, Sara, Perrotta, Silverio, Barillari, Maria Rosaria, Costa, Giuseppe, Brotto, Davide, Di Concilio, Rosanna, Ciancio, Angela, De Michele, Elisa, Carafa, Pasquale Alessandro, Canna, Antonietta, Russo, Andrea Gerardo, Troisi, Donato, Caiazza, Martina, Ammendola, Federica, Roberti, Domenico, Santoro, Claudia, Picariello, Stefania, Valentino, Maria Sole, and Inserra, Emanuela more...
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AUDITORY cortex , *BETA-Thalassemia , *PERFUSION , *SENSORINEURAL hearing loss , *CHELATION therapy , *ADULTS - Abstract
Background: Sensorineural hearing loss in beta-thalassemia is common and it is generally associated with iron chelation therapy. However, data are scarce, especially on adult populations, and a possible involvement of the central auditory areas has not been investigated yet. We performed a multicenter cross-sectional audiological and single-center 3Tesla brain perfusion MRI study enrolling 77 transfusion-dependent/non transfusion-dependent adult patients and 56 healthy controls. Pure tone audiometry, demographics, clinical/laboratory and cognitive functioning data were recorded.Results: Half of patients (52%) presented with high-frequency hearing deficit, with overt hypoacusia (Pure Tone Average (PTA) > 25 dB) in 35%, irrespective of iron chelation or clinical phenotype. Bilateral voxel clusters of significant relative hypoperfusion were found in the auditory cortex of beta-thalassemia patients, regardless of clinical phenotype. In controls and transfusion-dependent (but not in non-transfusion-dependent) patients, the relative auditory cortex perfusion values increased linearly with age (p < 0.04). Relative auditory cortex perfusion values showed a significant U-shaped correlation with PTA values among hearing loss patients, and a linear correlation with the full scale intelligence quotient (right side p = 0.01, left side p = 0.02) with its domain related to communication skills (right side p = 0.04, left side p = 0.07) in controls but not in beta-thalassemia patients. Audiometric test results did not correlate to cognitive test scores in any subgroup.Conclusions: In conclusion, primary auditory cortex perfusion changes are a metabolic hallmark of adult beta-thalassemia, thus suggesting complex remodeling of the hearing function, that occurs regardless of chelation therapy and before clinically manifest hearing loss. The cognitive impact of perfusion changes is intriguing but requires further investigations. [ABSTRACT FROM AUTHOR] more...- Published
- 2021
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6. Headache in beta-thalassemia: An Italian multicenter clinical, conventional MRI and MR-angiography case-control study.
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Tartaglione, Immacolata, Caiazza, Martina, Di Concilio, Rosanna, Ciancio, Angela, De Michele, Elisa, Maietta, Caterina, Valentino, Maria Sole, Russo, Camilla, Roberti, Domenico, Casale, Maddalena, Elefante, Andrea, Femina, Gianluca, Esposito, Fabrizio, Ponticorvo, Sara, Russo, Andrea G., Canna, Antonietta, Ermani, Mario, Cirillo, Mario, Perrotta, Silverio, and Manara, Renzo more...
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PSYCHIATRIC rating scales , *HEADACHE , *SINUS thrombosis , *CASE-control method , *INTRACRANIAL aneurysms , *TENSION headache - Abstract
A strikingly increased headache prevalence was recently noted in Sri Lankan beta-thalassemia patients, raising several concerns regarding long-term neurological involvement in this condition. We interviewed on headache occurrence and characteristics 102 Italian beta-thalassemia patients and 129 healthy controls. 3T-MRI, MR-angiography, MR-venography, cognitive and psychiatric findings were considered. Headache was diagnosed in 39/102 (38.2%) beta-thalassemia patients without significant phenotype-related differences and in 51/129 (39.5%) controls. Patients and controls did not differ significantly regarding episode number (5.9 ± 6.2 vs 5.4 ± 4.4 days/month), subjective severity-score (6.8 ± 1.4 vs 7.1 ± 1.3), age-at-onset (24.3 ± 13.0 vs 19.5 ± 9.6 years) and headache-subtype rate. No main demographic, clinical or laboratory data was associated with headache but female gender. Headache was not associated with white matter lesions (number or maximal diameter), intracranial aneurysms, intracranial artery stenoses or venous sinus thrombosis. Cognitive and psychiatric evaluations were worse in beta-thalassemia, however, headache did not correlate with full-scale Intelligence Quotient (75.4 ± 18.0 vs 76.7 ± 15.3, with and without headache, respectively) or Brief Psychiatric Rating Scale scores (29.1 ± 2.7 vs 28.5 ± 3.4). Among Italian beta-thalassemia patients, headache does not seem to be more common or severe than in the general population. In addition, patients with headache do not seem to present increased conventional MRI, MR-angiography and cognitive/psychiatric changes. [ABSTRACT FROM AUTHOR] more...
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- 2020
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7. No increased cerebrovascular involvement in adult beta-thalassemia by advanced MRI analyses.
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Russo, Andrea Gerardo, Ponticorvo, Sara, Tartaglione, Immacolata, Caiazza, Martina, Roberti, Domenico, Elefante, Andrea, Casale, Maddalena, Di Concilio, Rosanna, Ciancio, Angela, De Michele, Elisa, Canna, Antonietta, Cirillo, Mario, Perrotta, Silverio, Esposito, Fabrizio, and Manara, Renzo more...
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BETA-Thalassemia , *DIFFUSION tensor imaging , *MAGNETIZATION transfer , *THERAPEUTICS - Abstract
Beta-thalassemia-related anemia and chronic hypercoagulative state are supposed to cause cumulative cerebrovascular damage with consequent parenchymal/vascular changes and functional impairment. However, recent conventional MRI/MR-angiography investigations failed to show an increased cerebrovascular involvement in beta-thalassemia patients managed according to current treatment guidelines, in spite of significantly decreased full-scale IQ scores. We therefore investigated those patients and controls by means of advanced quantitative MRI analyses (based on magnetization transfer and diffusion tensor imaging) searching for signs of possible cerebrovascular injuries undetected by conventional MRI/MR-angiography. The 3 T-MRI study protocol included diffusion tensor imaging and 3D-multi-echo FLASH sequences for magnetization transfer analysis. Whole-brain voxel-based analyses showed that magnetization transfer, fractional anisotropy, and mean, radial and axial diffusivity do not differ between healthy controls and beta-thalassemia patients (considered as a whole group or as distinct transfusion dependent and non-transfusion dependent subgroups). No correlation emerged between all the considered MRI metrics and cognitive findings (full-scale IQ) or the main clinical and laboratory data. According to our findings, adult neurologically-asymptomatic beta-thalassemia patients (regardless of clinical severity) do not seem to present an increased disease-related cerebrovascular vulnerability compared to healthy controls downsizing the need of regular brain MRI monitoring, at least when the current treatment guidelines are followed. [ABSTRACT FROM AUTHOR] more...
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- 2019
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8. Brain functional impairment in beta‐thalassaemia: the cognitive profile in Italian neurologically asymptomatic adult patients in comparison to the reported literature.
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Tartaglione, Immacolata, Manara, Renzo, Caiazza, Martina, Carafa, Pasquale Alessandro, Caserta, Violetta, Ferrantino, Teresa, Granato, Ilaria, Ippolito, Noemi, Maietta, Caterina, Oliveto, Tiziana, Casale, Maddalena, Di Concilio, Rosanna, Ciancio, Angela, De Michele, Elisa, Russo, Camilla, Elefante, Andrea, Ponticorvo, Sara, Russo, Andrea Gerardo, Femina, Gianluca, and Canna, Antonietta more...
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WECHSLER Adult Intelligence Scale , *BRAIN - Abstract
Summary: Cognitive involvement in beta‐thalassaemia is strikingly controversial and poorly studied in adulthood. This multicentre prospective study investigated 74 adult neurologically‐asymptomatic beta‐thalassaemia patients (mean‐age 34·5 ± 10·3 years; 53 transfusion‐dependent [TDT], 21 non‐transfusion dependent [NTDT]) and 45 healthy volunteers (mean‐age 33·9 ± 10·7 years). Participants underwent testing with Wechsler Adult Intelligence Scale‐Fourth Edition (WAIS‐IV), Brief Psychiatric Rating Scale (BPRS) and multiparametric brain 3T‐magnetic resonance imaging (MRI) for parenchymal, vascular and iron content evaluation. Patients had lower Full‐Scale Intelligence Quotient (FSIQ) than controls (75·5 ± 17·9 vs. 97·4 ± 18·1, P < 0·0001) even after correction for education level. Compared to TDT, NTDT showed a trend of higher FSIQ (P = 0·08) but a similar cognitive profile at WAIS‐subtests. FSIQ correlated with total and indirect bilirubin (P < 0·0001 and P = 0·002, respectively); no correlation was found with splenectomy, intracranial MRI/magnetic resonance‐angiography findings, brain tissue iron content or other disease‐related clinical/laboratory/treatment data. FSIQ did not correlate with BPRS scores, although the latter were higher among patients (28·74 ± 3·1 vs. 27·29 ± 4·8, P = 0·01) mainly because of increased depression and anxiety levels. Occupation rate was higher among controls (84·4% vs. 64·9%, P = 0·004) and correlated with higher FSIQ (P = 0·001) and education level (P = 0·001). In conclusion, Italian adult beta‐thalassaemia patients seem to present a characteristic cognitive profile impairment and an increased rate of psychological disorders with possible profound long‐term socio‐economic consequences. [ABSTRACT FROM AUTHOR] more...
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- 2019
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9. No evidence of increased cerebrovascular involvement in adult neurologically‐asymptomatic β‐Thalassaemia. A multicentre multimodal magnetic resonance study.
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Tartaglione, Immacolata, Russo, Camilla, Elefante, Andrea, Caiazza, Martina, Casale, Maddalena, Di Concilio, Rosanna, Ciancio, Angela, De Michele, Elisa, Amendola, Giovanni, Gritti, Paolo, Carafa, Pasquale A., Ferrantino, Teresa, Centanni, Antonella, Ippolito, Noemi, Caserta, Violetta, Oliveto, Tiziana, Granato, Ilaria, Femina, Gianluca, Esposito, Fabrizio, and Ponticorvo, Sara more...
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LACUNAR stroke , *MAGNETIC resonance , *MAGNETIC resonance angiography , *SINUS thrombosis , *INTRACRANIAL aneurysms , *VENOUS thrombosis - Abstract
Summary: Multi‐factorial causes jeopardize brain integrity in β‐thalassaemia. Intracranial parenchymal and vascular changes have been reported among young β‐thalassaemia patients but conventional magnetic resonance imaging (MRI) findings are contradictory making early MRI and magnetic resonance angiography (MRA)/venography monitoring a matter of debate. This study prospectively investigated 75 neurologically asymptomatic β‐thalassaemia patients (mean‐age 35·2 ± 10·7 years; 52/75 transfusion‐dependent; 41/75 splenectomised) using a 3T magnetic resonance scanner; clinical, laboratory and treatment data were also collected. White matter ischaemic‐like abnormalities, intracranial artery stenoses, aneurysms and sinus venous thrombosis were compared between patients and 56 healthy controls (mean‐age 33·9 ± 10·8 years). No patient or control showed silent territorial or lacunar strokes, intracranial artery stenoses or signs of sinus thrombosis. White matter lesions were found both in patients (35/75, 46·7%) and controls (28/56, 50·0%), without differences in terms of number (4·0 ± 10·6 vs. 4·6 ± 9·1, P = 0·63), size and Fazekas' Score. Intracranial aneurysms did not differ between patients and controls for incidence rate (7/75, 9·3% vs. 5/56, 8·9%), size and site. Vascular and parenchymal abnormality rate did not differ according to treatments or clinical phenotype. According to this study, asymptomatic β‐thalassaemia patients treated according to current guidelines do not seem to carry an increased risk of brain and intracranial vascular changes, thus weakening recommendations for regular brain MRI monitoring. [ABSTRACT FROM AUTHOR] more...
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- 2019
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10. Role of the cold shock domain protein A in the transcriptional regulation of HBG expression.
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Petruzzelli, Raffaella, Gaudino, Sara, Amendola, Giovanni, Sessa, Raffaele, Puzone, Stella, Di Concilio, Rosanna, d'Urzo, Giovanna, Amendolara, Maria, Izzo, Paola, and Grosso, Michela
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THALASSEMIA , *SICKLE cell anemia , *GENE expression , *GENETIC polymorphisms , *HEMOGLOBINOPATHY - Abstract
Impaired switching from fetal haemoglobin (HbF) to adult globin gene expression leads to hereditary persistence of fetal haemoglobin (HPFH) in adult life. This is of prime interest because elevated HbF levels ameliorate β-thalassaemia and sickle cell anaemia. Fetal haemoglobin levels are regulated by complex mechanisms involving factors linked or not to the β-globin gene ( HBB) locus. To search for factors putatively involved in the expression of the γ-globin genes ( HBG1, HBG2), we examined the reticulocyte transcriptome of three siblings who had different HbF levels and different degrees of β-thalassaemia severity although they had the same ΗBA- and ΗΒB cluster genotypes. By mRNA differential display we isolated the cDNA coding for the cold shock domain protein A (CSDA), also known as dbpA, previously reported to interact in vitro with the HBG2 promoter. Expression studies performed in K562 and in primary erythroid cells showed an inverse relationship between HBG and CSDA expression levels. Functional studies performed by Chromatin Immunoprecipitation and reporter gene assays in K562 cells demonstrated that CSDA is able to bind the HBG2 promoter and suppress its expression. Therefore, our study demonstrated that CSDA is a trans-acting repressor factor of HBG expression and modulates the HPFH phenotype. [ABSTRACT FROM AUTHOR] more...
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- 2010
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