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Summary Processing exogenous and endogenous proteins for presentation by major histocompatibility complex (MHC) molecules to T cells is the defining function of antigen-presenting cells (APC) as major regulatory cells in the acquired immune response. MHC class II-restricted antigen presentation to CD4 T cells is achieved by an essentially common pathway that is subject to variation with regard to the location and extent of degradation of protein antigens and the site of peptide binding to MHC class II molecules. These subtle variations reveal a surprising flexibility in the ways a diverse peptide repertoire is displayed on the APC surface. This diversity may have profound consequences for the induction of immunity to infection and tumours, as well as autoimmunity and tolerance. [ABSTRACT FROM AUTHOR]

Examines the immune responses to linear epitopes on the PorB protein of Neisseria meningitidis in patients with systemic meningococcal disease. Mapping of the B-cell epitopes; Inhibition efficiency of peptide D63b2.

Identifies the linear B-cell epitopes (BCE) using synthetic peptides derived from the class three outer-membrane protein (OMP) of Neisseria meningitidis. Analyses of linear epitopes recognized by human serum; Mapping of the serotype 15epitopes by murine monoclonal antibodies; Kinetics of the IgG response; Competition experiments.