1. Circulating Cancer-Associated Macrophage-like Cells as a Blood-Based Biomarker of Response to Immune Checkpoint Inhibitors.
- Author
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Magri, Valentina, De Renzi, Gianluigi, Marino, Luca, De Meo, Michela, Siringo, Marco, Gelibter, Alain, Gareri, Roberta, Cataldi, Chiara, Giannini, Giuseppe, Santini, Daniele, Nicolazzo, Chiara, and Gazzaniga, Paola
- Subjects
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IMMUNE checkpoint inhibitors , *IMMUNE response , *NON-small-cell lung carcinoma , *BIOMARKERS , *PROGRESSION-free survival - Abstract
Evidence has been provided that circulating cancer-associated macrophage-like cell (CAM-L) numbers increase in response to chemotherapy, with an inverse trend compared to circulating tumor cells (CTCs). In the era of evolving cancer immunotherapy, whether CAM-Ls might have a potential role as predictive biomarkers of response has been unexplored. We evaluated whether a serial blood evaluation of CTC to CAM-L ratio might predict response to immune checkpoint inhibitors in a cohort of non-small-cell lung cancer patients. At baseline, CTCs, CAM-Ls, and the CTC/CAM-L ratio significantly correlate with both progression-free survival (PFS) and overall survival (OS). The baseline CTC/CAM-L ratio was significantly different in early progressors (4.28 ± 3.21) compared to long responders (0.42 ± 0.47) (p = 0.001). In patients treated with immune checkpoint inhibitors, a CTC/CAM-L ratio ≤ 0.25 at baseline is associated with better PFS and OS. A baseline CTC/CAM-L ratio ≤ 0.25 is statistically significant to discriminate early progressions from durable response. The results of the present pilot study suggest that CAM-Ls together with CTCs could play an important role in evaluating patients treated with cancer immunotherapy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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