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Covering: up to the end of 2009 [ABSTRACT FROM AUTHOR]

Fluorine is the most electronegative element in the periodic table. When bound to carbon it forms the strongest bonds in organic chemistry and this makes fluorine substitution attractive for the development of pharmaceuticals and a wide range of speciality materials. Although highly polarised, the C–F bond gains stability from the resultant electrostatic attraction between the polarised Cδ and Fδ– atoms. This polarity suppresses lone pair donation from fluorine and in general fluorine is a weak coordinator. However, the C–F bond has interesting properties which can be understood either in terms of electrostatic/dipole interactions or by considering stereoelectronic interactions with neighbouring bonds or lone pairs. In this tutorial review these fundamental aspects of the C–F bond are explored to rationalise the geometry, conformation and reactivity of individual organofluorine compounds. [ABSTRACT FROM AUTHOR]

An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[18F]fluororibose, a novel [18F]-fluorinated sugar suitable for positron emission tomography (PET) applications. [ABSTRACT FROM AUTHOR]

An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[18F]fluororibose, a novel [18F]-fluorinated sugar suitable for positron emission tomography (PET) applications. [ABSTRACT FROM AUTHOR]

The synthesis of the stereospecifically fluorinated difluoro- and trifluoro- rac-3 and rac-4 is described where the fluorine atoms are positioned adjacent/vicinal to each other and the physical characteristics of these candidate liquid crystals including negative dielectric anisotropy are measured and rationalised. [ABSTRACT FROM AUTHOR]