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Female and male cooperative breeders can use different strategies to maximize reproduction and fitness over their lifetimes. Answering questions about fitness in cooperative breeders requires long-term studies as well as complete data on group composition and size which can be exceedingly difficult to obtain. Using a long-term genetic data set of complete group pedigrees, I asked how lifetime reproductive characteristics of female and male gray wolves (Canis lupus) differed. I predicted that genetic relatedness to helpers would be higher for females than males due to philopatric behavior of female wolves, group size would be similar between the sexes, females would inherit breeding positions from within groups more often than males due to differences in dispersal strategies between the sexes, males would have more lifetime mates and produce more young than females because of polygamy, and females would breed for more years than males due to the likelihood that females would still breed (with a new partner) after a mate died or was expelled from the group. I documented complete lifetime breeding histories for 11 male and 18 female wolves in Idaho, United States, 2008 to 2018. Genetic relatedness to helpers, group size, number of mates, pups, and years breeding did not differ between the sexes. Females, however, inherited breeding positions within groups far more often than males. Individuals who secured breeding positions generally reproduced for 2 seasons and commonly had more than 1 partner during their lifetimes if they were able to maintain their breeding position longer. Direct fitness varied greatly within female and male breeding wolves. [ABSTRACT FROM AUTHOR]

Background and Aims: Metabolic dysfunction‐associated steatohepatitis (MASH) with bridging fibrosis is a critical stage in the evolution of fatty liver disease. Second harmonic generation/two‐photon excitation fluorescence (SHG/TPEF) microscopy with artificial intelligence (AI) provides sensitive and reproducible quantitation of liver fibrosis. This methodology was applied to gain an in‐depth understanding of intra‐stage fibrosis changes and septa analyses in a homogenous, well‐characterised group with MASH F3 fibrosis. Methods: Paired liver biopsies (baseline [BL] and end of treatment [EOT]) of 57 patients (placebo, n = 17 and tropifexor n = 40), with F3 fibrosis stage at BL according to the clinical research network (CRN) scoring, were included. Unstained sections were examined using SHG/TPEF microscopy with AI. Changes in liver fibrosis overall and in five areas of liver lobules were quantitatively assessed by qFibrosis. Progressive, regressive septa, and 12 septa parameters were quantitatively analysed. Results: qFibrosis demonstrated fibrosis progression or regression in 14/17 (82%) patients receiving placebo, while the CRN scoring categorised 11/17 (65%) as 'no change'. Radar maps with qFibrosis readouts visualised quantitative fibrosis dynamics in different areas of liver lobules even in cases categorised as 'No Change'. Measurement of septa parameters objectively differentiated regressive and progressive septa (p <.001). Quantitative changes in individual septa parameters (BL to EOT) were observed both in the 'no change' and the 'regression' subgroups, as defined by the CRN scoring. Conclusion: SHG/TPEF microscopy with AI provides greater granularity and precision in assessing fibrosis dynamics in patients with bridging fibrosis, thus advancing knowledge development of fibrosis evolution in natural history and in clinical trials. [ABSTRACT FROM AUTHOR]

PURPOSE: We present and validate a rule-based algorithm for the detection of moderate to severe liver-related immune-related adverse events (irAEs) in a real-world patient cohort. The algorithm can be applied to studies of irAEs in large data sets. METHODS: We developed a set of criteria to define hepatic irAEs. The criteria include: the temporality of elevated laboratory measurements in the first 2-14 weeks of immune checkpoint inhibitor (ICI) treatment, steroid intervention within 2 weeks of the onset of elevated laboratory measurements, and intervention with a duration of at least 2 weeks. These criteria are based on the kinetics of patients who experienced moderate to severe hepatotoxicity (Common Terminology Criteria for Adverse Events grades 2-4). We applied these criteria to a retrospective cohort of 682 patients diagnosed with hepatocellular carcinoma and treated with ICI. All patients were required to have baseline laboratory measurements before and after the initiation of ICI. RESULTS: A set of 63 equally sampled patients were reviewed by two blinded, clinical adjudicators. Disagreements were reviewed and consensus was taken to be the ground truth. Of these, 25 patients with irAEs were identified, 16 were determined to be hepatic irAEs, 36 patients were nonadverse events, and two patients were of indeterminant status. Reviewers agreed in 44 of 63 patients, including 19 patients with irAEs (0.70 concordance, Fleiss' kappa: 0.43). By comparison, the algorithm achieved a sensitivity and specificity of identifying hepatic irAEs of 0.63 and 0.81, respectively, with a test efficiency (percent correctly classified) of 0.78 and outcome-weighted F1 score of 0.74. CONCLUSION: The algorithm achieves greater concordance with the ground truth than either individual clinical adjudicator for the detection of irAEs. [ABSTRACT FROM AUTHOR]

The open-air Epipalaeolithic (Geometric Kebaran) site of Neve David (Mount Carmel, Israel) has played an important role in reconstructing scenarios of sedentarization in the Levant since its initial excavation in the 1980s, and has been seen as heralding later Natufian socioeconomic adaptations. However, little was known about the site's formation processes and spatial organization, hindering the testing of this view. Employing new field data from Neve David, we present a combined macro- and microscopic analyses of the spatial and temporal distribution of lithics, faunal remains, phytoliths and wood ash, interpreted with the aid of ethnoarchaeological data and comparison to other Palaeolithic sites in the region. Post-depositional disturbance seems to be minimal at Neve David and we therefore suggest that the spatial distribution of the finds mostly represents human use of space. Throughout the thick sequence of occupation episodes, distinct division of space and well-preserved trampled occupation surfaces are generally lacking. We suggest that this pattern represents reduced mobility, as prolonged human activity blurs the primary depositional signal of the activity remains. The density of the finds generally increases in the upper layers of the site. Accordingly, we hypothesize that at the beginning of activity, the duration of occupation was longer and only later in the sequence of events was there an increase in group size. Our findings further highlight the position of the Geometric Kebaran as a pivotal stage in understanding the gap between the preceding highly mobile societies and the succeeding sedentary and demographically-larger Natufian societies. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate the effectiveness of prophylactic mesh placement in reducing the incidence of parastomal hernias following colostomy, ileostomy, and ileal conduit formation. Methods: A systematic review identified relevant studies evaluating parastomal hernia incidence with prophylactic mesh use during stoma formation. Pairwise meta-analysis and network meta-analysis using Bayesian modeling were performed. Results: 25 studies, consisting of 16 randomized control trials (RCT), 6 follow up studies, and 3 retrospective cohort studies, were included. Prophylactic mesh led to significantly fewer parastomal hernias beyond 6 months follow-up (OR 0.43, 95% CI 0.33–0.58). Hernias were reduced with mesh for both ileal conduits and colostomies. When analyzing hazard ratios (HRs), only 6 studies were included, and a statistically significant difference was observed among both randomized controlled trials (RCTs) (HR 0.75 [0.53, 0.92], p = 0.01) and non-RCTs (HR 0.57 [0.36, 0.92], p = 0.02). Network meta-analysis found the retromuscular approach with mesh had the lowest hernia rate. Regression was non-significant for variations between study types. Conclusion: This meta-analysis demonstrated prophylactic mesh placement during ostomy creation significantly reduced parastomal hernia risk, more prominently beyond 6 months, consistently across randomized trials and observational studies for urologic and gastrointestinal ostomies. The retromuscular technique was most effective. [ABSTRACT FROM AUTHOR]

Lake Mattamuskeet, the largest lake in North Carolina, USA, has undergone decades‐long eutrophication causing reduced water quality and promoting cyanobacterial blooms that may produce toxins. It is therefore necessary to evaluate the cyanobacterial diversity of the lake and their toxigenic potential. We present draft genomes of Microcystis, Pelatocladus, Raphidiopsis, and Umezakia strains isolated from Lake Mattamuskeet. The whole‐genome shotgun projects for Umezakia ovalisporum BLCC‐F208, Microcystis sp. BLCC‐F209, Microcystis sp. BLCC‐F210, Pelatocladus sp. BLCC‐F211, U. ovalisporum BLCC‐F215, and Raphidiopsis BLCC‐F218 have been deposited in GenBank under accession numbers JBHFLK000000000, CP169647, JBHFLL000000000, JBHFLM000000000, JBHFLN000000000, and JBHFLO000000000, respectively. Based on the genomic analysis, several biosynthetic gene clusters (BCGs) with varying degrees of similarity to known toxic and bioactive compound gene clusters were identified across the different cyanobacterial strains. [ABSTRACT FROM AUTHOR]

The article in Circulation discusses a case of a 59-year-old woman with a history of bicuspid aortic valve replacement who presented with nonspecific symptoms, negative blood cultures, and elevated inflammatory markers. The patient was diagnosed with Bartonella henselae bioprosthetic aortic valve endocarditis, associated glomerulonephritis, and leukocytoclastic vasculitis. The diagnosis was challenging due to the overlap with systemic inflammatory conditions and the difficulty in traditional infectious testing. The case highlights the importance of multidisciplinary teams in solving complex diagnostic cases and the need for updated criteria for Bartonella endocarditis. [Extracted from the article]

Do political practitioners have good intuitions about how to persuade the public? Longstanding theories that political elites' messages have large effects on public opinion and the large sums spent to secure some practitioners' messaging advice suggest they should. However, findings regarding the surprising limits of expert forecasts in other domains suggest they may not. In this paper, we evaluate how well political practitioners can predict which messages are most persuasive. We measured the effects of N = 172 messages about 21 political issues using a large-sample survey experiment (N = 67,215 respondent-message observations). We then asked both political practitioners (N = 1,524 practitioners, N = 22,763 predictions) and laypeople (N = 21,247 respondents, N = 63,442 predictions) to predict the efficacy of these messages. The practitioners we surveyed ranged widely in their experience and expertise with persuasive message design. We find that: (a) political practitioners and laypeople both performed barely better than chance at predicting persuasive effects; (b) once accounting for laypeople's inflated expectations about the average size of effects, practitioners did not predict meaningfully better than laypeople; (c) these results held even for self-identified issue experts and highly experienced practitioners; and (d) practitioners' experience, expertise, information environment, and demographics did not meaningfully explain variation in their accuracy. Our findings have theoretical implications for understanding the conditions likely to produce meaningful elite influence on public opinion as well as practical implications for practitioners. [ABSTRACT FROM AUTHOR]

ABSTRACT During the illustrious career of Martin C. Mihm Jr., MD, the diagnosis of melanoma underwent significant changes, to which he made many contributions. In early descriptions, melanomas were fungating tumor masses that were obviously malignant, and highly lethal. In seminal work by Dr. Mihm and his mentor, Wallace H. Clark, Jr., MD, the early phases of development of these neoplasms were recognized and distinguished from the more advanced disease. It was generally believed that the early stage of melanoma, termed radial growth phase (RGP) and characterized by absence of vertical growth phase (VGP) and by favorable microstaging attributes could be recognized, excised, and cured, thus preventing the development of advanced disease. However, strenuous efforts in this direction over several decades have resulted in little or no change in mortality, leading to the recognition that many of these neoplasms, at least, may not be true biological malignancies, and to the conclusion that overdiagnosis commonly occurs in this disease, which is defined as representing diagnosis as melanoma of a neoplasm that would not have had the capacity to cause death or symptoms in the lifetime of the host. Although there may be other subsets of neoplasms in this category, an important category of overdiagnosis in melanomas is concentrated in T1a melanomas that lack VGP. If these neoplasms can be recognized with sensitive and specific criteria, which may already be available, changes in terminology may be appropriate, recognizing that some of them may have low malignant potential, whereas others may have no capacity at all for metastasis and may not warrant the use of the term “melanoma.” [ABSTRACT FROM AUTHOR]

Catheter-based renal sympathetic denervation (RDN) reduced blood pressure (BP) in multiple randomized sham-controlled trials of patients with uncontrolled hypertension (HTN). We tested proof-of-concept for a more selective treatment strategy, exclusively targeting these areas to improve the efficiency of the procedure. The SPYRAL DYSTAL Pilot study was designed to mirror the SPYRAL HTN-OFF MED Pivotal study, enabling comparison with a propensity score adjusted active-control group. Patients were antihypertensive medication-free for one month before undergoing BP assessment. Those with office BP of 150–180/>90 mmHg and with an ambulatory systolic BP of 140–170 mmHg were selected to undergo open label treatment, delivering energy only to the distal main renal arteries and first order branches. Patients from DYSTAL were compared with patients who underwent maximized RF RDN treatment in the prior randomized OFF MED trial at 3 months. After 3 months, patients resumed antihypertensive medications as indicated. Safety and efficacy outcomes were assessed post hoc through 12 months. The SPYRAL DYSTAL Pilot study treated 56 HTN patients. Baseline office systolic BP (OSBP) and 24-h ambulatory systolic BP (ASBP) were similar between DYSTAL and OFF MED patient groups. The number of ablations (32.3 ± 8.0 vs 46.6 ± 15.3, p < 0.001), procedure time (67 ± 21 min vs 99 ± 36 min; p < 0.001), and contrast volume (173 ± 77 cc vs 208 ± 96 cc; p = 0.014) were significantly lower with the simplified treatment strategy. OSBP and ASBP changes compared with baseline were −9.0 and −1.4 mmHg at 3 months, −20.3 and −13.9 mmHg at 6 months, and −20.3 and −16.6 mmHg at 12 months, respectively. During the medication up-titration phase, BP reductions among DYSTAL patients were similar to reductions observed in OFF MED through 12 months, with comparable number of drugs (1.4 and 1.5 medications, respectively (P=NS)). Two adverse events related to guidewire placement were reported. In this pilot study, focusing ablation treatment on the distal main and proximal branch renal arteries was performed, resulting in fewer RF lesions, and reduced contrast volume and procedure time. Whether BP reductions are similar between a selective vs. maximized RDN approach requires further prospective study. • Renal denervation reduces blood pressure in patient with uncontrolled hypertension. • We assessed whether a more targeted RDN strategy has similar efficacy. • The more targeted approach significantly improved procedural efficiency. • Further studies are needed to fully evaluate the efficacy of the targeted approach. [ABSTRACT FROM AUTHOR]

Although rarely appreciated, the collaboration that brought Felix Klein and Sophus Lie together in 1869 had mainly to do with their common interests in the new field of line geometry. As mathematicians, Klein and Lie identified with the latest currents in geometry. Not long before, Klein's mentor Julius Plücker launched the study of first- and second-degree line complexes, which provided much inspiration for Klein and Lie, though both were busy exploring a broad range of problems and theories. Klein used invariant theory and other algebraic methods to study the properties of line complexes, whereas Lie set his eyes on those aspects related to analysis and differential equations. Much later, historians and mathematicians came to treat the collaboration between Klein and Lie as a famous early chapter in the history of transformation groups, a development often identified with Klein's "Erlangen Program" from 1872. The present detailed account of their joint work and mutual interests provides a very different picture of their early research, which had relatively little to do with group theory. This essay shows how the geometrical interests of Klein and Lie reflected contemporary trends by focusing on the central importance of quartic surfaces in line geometry. [ABSTRACT FROM AUTHOR]

• Enfortumab vedotin/pembrolizumab shows highest overall survival (HR 0.47, 95% CrI: 0.38–0.58). • Avelumab monotherapy significantly improves survival (HR 0.69, 95% CrI: 0.56–0.86). • Combination therapy enfortumab/pembrolizumab enhances progression-free survival (HR 0.45, 95% CrI: 0.38–0.54). • Avelumab monotherapy exhibits highest odds of overall response rate. • PD-L1 positive and negative patients both might benefit from the analyzed therapies. Metastatic urothelial carcinoma (muC) has historically had few effective therapeutic options. Recently, immune checkpoint inhibitors (ICIs), were introduced as therapeutic options for cisplatin-ineligible patients, however, direct head-to-head trials comparing these treatments are lacking. To address this gap, this study employs a Bayesian framework to indirectly compare the performance of ICIs as first-line agents for muC. A systematic review was performed to identify randomized controlled trials evaluating different ICI for mUC. Data was inputted into Review Manager 5.4 for pairwise meta-analysis. Data was then used to build a network in R Studio. These networks were used to model 200,000 Markov Chains via MonteCarlo sampling. The results are expressed as hazard ratios (HR) with 95% credible intervals (CrI). Six studies with 5,449 patients were included, 3,255 received ICI monotherapy or combination. Moreover, a total of 3,006 had PD-L1 positive tumors and 2,362 were PD-L1 negative. Median overall survival (OS) ranged from 12.1 to 31.5 months across the studies, with the combination of enfortumab vedotin and pembrolizumab demonstrating the most substantial reduction in the risk of death (HR 0.47 [95% CrI: 0.38, 0.58]), followed by avelumab monotherapy (HR 0.69 [95% CrI: 0.56, 0.86]). The limitations of this network meta-analysis include variability in study follow-up duration, lack of standardized methods for assessing PD-L1 positivity, and potential bias introduced by control arms with poorer survival outcomes across included trials. The enfortumab vedotin/pembrolizumab combination significantly improved survival and response rates. Avelumab showed notable single-agent activity. These findings provide a valuable framework to guide clinical decision-making and highlight priority areas for future research, including biomarker refinement and novel combination strategies to enhance antitumor immunity in this challenging malignancy. [ABSTRACT FROM AUTHOR]

This paper explores the minimum energy that would be required to provide all energy-using services currently used the U.S. office building sector if they were all provided by thermodynamically ideal devices that do not violate physical law. Data from the U.S. DOE and the General Services Administration were used to identify office building workspace services, equipment, occupancy and schedules. Internal building loads were estimated after identifying or conservatively approximating the thermodynamically ideal power required for each service. The average thermodynamically ideal office building in the U.S. would use 2.2 kWh/m2-yr or less, which represents 1.0% of the current average end-use consumption in the sector. Such a large gap between the thermodynamic limit and today’s practice is related to the fact that the energy performance of all the internal gain producing equipment in buildings is far from ideal along with the HVAC equipment and envelope components. Ideal office buildings would use 69.7% of their energy for cooking and related domestic water heating and cooling; illumination accounts for a smaller portion, consuming 17.5%, while office equipment and cooling would use 6.9% and 5.9% of the total consumption, respectively. Dramatic reductions come from the elimination of heating energy and air distribution energy brought about by ideal adiabatic building envelopes and frictionless air distribution. Cooling energy is virtually eliminated by the combination of greatly reduced cooling loads and ideal Carnot equipment. But the thermodynamically ideal office equipment would use two orders of magnitude less energy than today as well. [ABSTRACT FROM AUTHOR]

The document provides an update on clinical practice guidelines for managing patients with sarcoma, rare and complex malignant tumors of bone and soft tissue. It highlights the importance of multidisciplinary expertise for optimal outcomes and discusses the need for equitable access to diagnosis and treatment for rare cancers. The guidelines focus on treatment at specialized sarcoma centers, management of retroperitoneal sarcoma, and pediatric patients with sarcoma. Recommendations emphasize timely referral to specialized centers to reduce local recurrence and surgical complications, improve limb conservation, and overall survival. The document encourages leveraging evidence-based recommendations to advocate for equitable access to specialized sarcoma care for all patients and families. [Extracted from the article]

Zinc and selenium are essential minerals for human nutrition. Reliable biomarkers of zinc status and selenium status in humans are therefore important. This work investigates a novel portable X-ray fluorescence (XRF) method with the ability to rapidly assess zinc and selenium in nail clippings. This approach used a mono-energetic X-ray beam to excite characteristic X-rays from the clippings. Nail clippings were obtained from the Mother and Infant Nutrition Investigation (MINI), a study designed to assess nutrition in a population of women and their breastfed children in New Zealand. Twenty mother-infant pairings were selected to provide nail clippings at two time points (visit 1 at 3 months postpartum; visit 2 at 6 months postpartum). Nail clippings from each mother-infant pairing were divided into three groupings of clippings prior to analysis: those obtained from a big toe of the mother, those from the other toes of the mother, and those from the toes and fingers of the infant. Clippings were prepared and mounted prior to XRF measurement, providing four distinct fragments from each clipping grouping. These fragments were assessed by XRF using a measurement time of either 300 s (visit 1) or 180 s (visit 2). XRF results were determined through both an automated system output and an analysis of the X-ray energy spectrum. Following this assessment of zinc and selenium with the non-destructive XRF method, clippings were measured for zinc and selenium concentration using a "gold standard" technique of inductively coupled plasma mass spectrometry (ICP-MS). Mean ICP-MS concentrations ranged from 122 μg/g to 127 μg/g for zinc, and from 0.646 μg/g to 0.659 μg/g for selenium. Precision, assessed by a relative standard deviation of measurement, was superior for ICP-MS relative to XRF. For both zinc and selenium, XRF results were compared with ICP-MS concentrations. Linear equations of best fit were determined for each comparison between XRF and ICP-MS results. Coefficients of determination (r2) were stronger for zinc (from 0.74 to 0.95) than selenium (from 0.53 to 0.70). A decrease in XRF measurement time from 300 s to 180 s did not appear to adversely affect the correlation between XRF and ICP-MS results. Using the mono-energetic portable XRF method, the correlation of XRF zinc results with ICP-MS zinc concentrations was improved over previous findings, and selenium measurement was reported for the first time. The method may prove useful for future applications to trace element analysis using nail clippings as a biomarker. [ABSTRACT FROM AUTHOR]

Hydrogen technologies will be necessary to decarbonize heavy-duty transportation, such as Class 8 trucks. While there have already been multiple successful hydrogen truck pilots, and multiple on-going commercial operations in Europe, there are still major challenges that can limit further deployment. The on-board storage technology utilized today, 700 bar Type 4 vessels, does not provide sufficient energy density to meet the demands of many truck fleet operators. One potential solution is on-board cryo-compressed hydrogen storage, which can offer greater energy densities, reduced storage cost, and help achieve diesel-like performance. Herein, we evaluate cryo-compressed hydrogen Class 8 trucks under a representative commercial operating profile. The thermodynamic evolution of state is evaluated, and key system design changes and their performance impact are detailed. We show useable hydrogen densities of 67 g/L, with no vent losses over the weekend, and a driving range of 1200 km (746 miles). We conclude with a comparison against 700 bar and liquid hydrogen storage technologies. Ultimately, this work provides a foundational framework to compare various hydrogen technologies for the heavy-duty truck market. • H 2 -fueled heavy trucks are necessary for mitigating climate change. • Cryo-compressed H 2 (CcH 2) holds promise for cost effective, long range heavy trucks. • CcH 2 weight and volume storage performance is similar to LH 2 and sLH 2 vessels. • Zero evaporative losses are anticipated due to robust thermal endurance. [ABSTRACT FROM AUTHOR]

Simple Summary: Hepatocellular carcinoma is the most common type of liver cancer and is often seen in people with chronic liver diseases. For patients with hepatocellular carcinoma who cannot receive surgery, other treatments include atezolizumab plus bevacizumab, sorafenib, or lenvatinib. We compared the length of life among 1874 United States veterans who received these therapies, both in the overall population of patients and in groups by race/ethnicity. The results showed that the risk of death was 30% lower with atezolizumab plus bevacizumab compared with sorafenib, and 26% lower compared with lenvatinib. These trends were consistent across White, Black, and Hispanic patients. Thus, patients who received atezolizumab plus bevacizumab had improved survival outcomes compared with those treated with sorafenib or lenvatinib, regardless of race or ethnicity. Background/Objectives: This study evaluated comparative overall survival (OS) of United States veterans with unresectable hepatocellular carcinoma (uHCC) receiving first-line (1L) atezolizumab plus bevacizumab vs. sorafenib or lenvatinib, overall and across racial and ethnic groups. Methods: In this retrospective study, patients with uHCC who initiated atezolizumab plus bevacizumab (post-2020) or sorafenib or lenvatinib (post-2018) were identified from the Veterans Health Administration National Corporate Data Warehouse (1 January 2017–31 December 2022). Patient characteristics were evaluated in the year prior to 1L treatment initiation. Kaplan–Meier and multivariable Cox regression methods were used to compare OS starting from treatment between cohorts, both overall and by race and ethnicity. Results: Among the 1874 patients included, 405 (21.6%) received 1L atezolizumab plus bevacizumab, 1016 (54.2%) received sorafenib, and 453 (24.2%) received lenvatinib, with a median follow-up time of 8.5, 7.6, and 8.2 months, respectively. Overall, patients receiving atezolizumab plus bevacizumab had longer unadjusted median OS (12.8 [95% CI: 10.6, 17.1] months) than patients receiving sorafenib (8.0 [7.1, 8.6] months) or lenvatinib (9.5 [7.8, 11.4] months; both log-rank p < 0.001). After adjustment, atezolizumab plus bevacizumab was associated with a reduced risk of death by 30% vs. sorafenib (adjusted HR: 0.70 [95% CI: 0.60, 0.82]) and by 26% vs. lenvatinib (0.74 [0.62, 0.88]; both p < 0.001). OS trends in the White, Black, and Hispanic patient cohorts were consistent with that of the overall population. Conclusions: Atezolizumab plus bevacizumab was associated with improved survival outcomes compared with sorafenib and lenvatinib in patients with uHCC, both overall and across racial and ethnic subgroups. [ABSTRACT FROM AUTHOR]

The growth of partisan media presents new challenges for political consultants. Informed by social identity theory and truth-default theory, this paper examines how U.S. voters react to politicians in combative news interviews. Experiment 1 (N = 320) establishes that an ingroup politician gains more trust among ingroup voters when interviewed by cross-partisan media accusing the politician of deception than when interviewed more congenially by co-partisan media. Experiment 2 (N = 131) finds that perceived media hostility increases Democrats’ and Republicans’ trust in a politician regardless of whether the interviewer accuses the politician of deception or is congenial. Experiment 3 (N = 126) replicates the findings when a Democrat is accused of deception on Fox News. The study tested a moderated mediation model, finding that Republican and Democratic voters do not react differently in the process. The discussion highlights the practical and theoretical implications of hostile media perceptions and ingroup–outgroup partisan bias in a polarized media environment with conflicting exposure to live fact-checking and deception detection. [ABSTRACT FROM AUTHOR]

Surveillance of wildlife virus impacts can be passive or active. Both approaches have their strengths and weaknesses, especially regarding cost and knowledge that can be gained. Monitoring of rabbit haemorrhagic disease virus (GI.1 and GI.2) in South Australia has utilised both strategies and their methods and gained insights are discussed. Active strategies to monitor the continuing impact of rabbit haemorrhagic disease virus 2 (GI.2) on susceptible lagomorphs in countries such as the USA, Mexico, South Africa, Spain, France and Portugal are encouraged to gain critical insights into the evolution, spread and impact of this virus. Furthermore, there are lessons here for the international monitoring of diseases in wildlife, particularly where there is a risk of them becoming zoonotic. [ABSTRACT FROM AUTHOR]

The main objective of this study is to characterize the virus associated with faba bean (Vicia faba L.) crops in the Department of Nariño (Colombia). Faba bean is an important food source, but it faces challenges from viral diseases such as "pod mottle." This disease manifests with symptoms such as leaf chlorosis, dwarfism, and pod lesions. Viral characterization is conducted through seed transmission tests, mechanical transmission, RT-PCR, and transmission electron microscopy (TEM). The results show that the virus morphology consists of spherical and enveloped particles that range between 80-100nm in diameter. RT-PCR and sequencing of the nucleocápside gen (558bp) reveals the virus is Orthotospovirus tomatomaculae (Tomato spotted wilt virus) with a 97% homology. Seed transmission is 2% while mechanical transmission is 40%. This is the first report of an Orthotospovirus affecting faba bean in Nariño, posing a risk to food security. [ABSTRACT FROM AUTHOR]

Simple Summary: MicroRNAs (miRNAs) play a significant role as epigenetic regulators in cancer. IsomiRs are miRNA molecules that undergo small modifications during miRNA processing, which can affect their stability and their interaction with mRNA targets. While some isomiRs are linked to specific cancers, many, including those in the lung, remain understudied. To address this, small RNA sequencing data from lung adenocarcinoma (LUAD) and adult non-malignant lung (ANL) samples were analyzed to quantify isomiR expression. This analysis identified 16 A-to-I edited isomiRs, 213 5′ isomiRs, 128 3′ adenylated isomiRs, and 100 3′ uridylated isomiRs. A-to-I editing rates correlated with the expression of editing enzymes ADAR and ADARB1, both deregulated in LUAD. LUAD samples had lower A-to-I editing and 3′ adenylation rates compared to ANL. Machine learning models based on isomiR data effectively distinguished ANL from stage I/II LUAD samples, suggesting that isomiRs hold potential as cancer biomarkers. Background: MicroRNAs (miRNAs) modulate the expression of oncogenes and tumor suppressor genes, functioning as significant epigenetic regulators in cancer. IsomiRs are miRNA molecules that have undergone small modifications during miRNA processing. These modifications can alter an isomiR's binding stability with mRNA targets, and certain isomiRs have been implicated in the development of specific cancers. Still, the isomiRomes of many tissues, including the lung, have not been characterized; Methods: In this study, we analyzed small RNA sequencing data for three cohorts of lung adenocarcinoma (LUAD) and adult non-malignant lung (ANL) samples. Results: We quantified isomiR expression and found 16 A-to-I edited isomiRs expressed in multiple cohorts, as well as 213 5′ isomiRs, 128 3′ adenylated isomiRs, and 100 3′ uridylated isomiRs. Rates of A-to-I editing at editing hotspots correlated with mRNA expression of the editing enzymes ADAR and ADARB1, which were both observed to be deregulated in LUAD. LUAD samples displayed lower overall rates of A-to-I editing and 3′ adenylation than ANL samples. Support vector machines and random forest models were trained on one cohort to distinguish ANL and stage I/II LUAD samples using reads per million (RPM) and frequency data for different types of isomiRs. Models trained on A-to-I editing rates at editing hotspots displayed high accuracy when tested on the other two cohorts and compared favorably to classifiers trained on miRNA expression alone; Conclusions: We have identified isomiRs in the human lung and found that their expression differs between non-malignant and tumor tissues, suggesting they hold potential as cancer biomarkers. [ABSTRACT FROM AUTHOR]

Politicians tend to try deflecting scandals. Based on an attribution theory-driven perspective on persuasion, however, politicians should proactively confess. In a preregistered, multiple-message design, we conduct controlled, random assignment experiments. A mediation model is tested. Inspired by crisis communication's change-of-meaning concept, the first variable appraises the extent to which voters perceive that the messaging indicates the politician is engaging in a cover-up. The second linkage is the politician's credibility. The outcome variable is voters' behavioral intentions. In Experiment 1 (N  =   905 U.S. voters), stealing thunder and apologizing outperform stonewalling, changing the subject, sequentially apologizing plus deflecting, or silence. Experiment 2 (N  =   277) finds that, in a sex scandal, stealing thunder and apologizing continue to perform equally well. Our theoretical contribution resides in enhancing the explanatory power of theories designed to explain image repair, as well as empirically testing the independent and combined role of apology and stealing thunder. [ABSTRACT FROM AUTHOR]

This brief review highlights some of the structure–activity relationships of classic serotonergic psychedelics. In particular, we discuss structural features of three chemotypes: phenethylamines, ergolines and certain tryptamines, which possess psychedelic activity in humans. Where they are known, we point out the underlying molecular mechanisms utilized by each of the three chemotypes of psychedelic molecules. With a focus on the 5‐HT2A receptor subtype, a G‐protein coupled receptor known to be the primary target of psychedelics, we refer to several X‐ray and cryoEM structures, with a variety of ligands bound, to illustrate the underlying atomistic basis for some of the known pharmacological observations of psychedelic drug actions. [ABSTRACT FROM AUTHOR]

Malignant pleural effusion (MPE) is a common cancer complication. Clinical and economic implications of different recurrent MPE treatment pathways have not been evaluated fully. What clinical outcomes, complications, health care resource use, and costs are associated with various rapidly recurrent MPE treatment pathways? This retrospective cohort study using Surveillance, Epidemiology and End Results Medicare data (2011-2015) included patients 66 to 90 years of age with rapidly recurrent MPE. Rapid recurrence was defined as receipt of a second pleural procedure within 14 days of the first thoracentesis, including nondefinitive repeated thoracentesis or a definitive treatment option including chest tube, indwelling pleural catheter (IPC), or thoracoscopy. Among 8,378 patients with MPE, 3,090 patients (36.9%) had rapidly recurrent MPE (mean ± SD age, 75.9 ± 6.6 years; 45.6% male; primary cancer, 62.9% lung and 37.1% other). Second pleural procedures were nondefinitive thoracentesis (62.3%), chest tube (17.1%), IPC (13.2%), or thoracoscopy (7.4%). A third pleural procedure was required more frequently if the second pleural procedure was nondefinitive thoracentesis vs chest tube placement, IPC placement, or thoracoscopy (70.3% vs 44.1% vs 17.9% vs 14.4%, respectively). The mean number of subsequent pleural procedures over the patient's lifetime varied significantly among the procedures (1.74, 0.82, 0.31, and 0.22 procedures for patients receiving thoracentesis, chest tube, IPC, and thoracoscopy, respectively; P <. 05). Average total costs after the second pleural procedure to death adjusted for age at primary cancer diagnosis, race, year of second pleural procedure, Charlson comorbidity index, cancer stage at primary diagnosis, and time from primary cancer diagnosis to diagnostic thoracentesis were lower with IPC ($37,443; P <.0001) or chest tube placement ($40,627; P =.004) vs thoracentesis ($47,711). Patients receiving thoracoscopy ($45,386; P =.5) incurred similar costs as patients receiving thoracentesis. Early definitive treatment was associated with fewer subsequent procedures and lower costs in patients with rapidly recurrent MPE. [Display omitted] [ABSTRACT FROM AUTHOR]

Extreme cold temperatures were observed in July and August 2023, coinciding with the WINFLY (winter fly-in) period of mid to late August into September 2023, meaning aircraft operations into McMurdo Station and Phoenix Airfield were adversely impacted. Specifically, with temperatures below −50°C, safe flight operation was not possible because of the risk of failing hydraulics and fuel turning to gel onboard the aircraft. The cold temperatures were measured across a broad area of the Antarctic, from East Antarctica toward the Ross Ice Shelf, and stretching across West Antarctica to the Antarctic Peninsula. A review of automatic weather station measurements and staffed station observations revealed a series of sites recording new record low temperatures. Four separate cold phases were identified, each a few days in duration and occurring from mid-July to the end of August 2023. A brief analysis of 500-hPa geopotential height anomalies shows how the mid-tropospheric atmospheric environment evolves in relation to these extreme cold temperatures. The monthly 500-hPa geopotential height anomalies show strong negative anomalies in August. Examination of composite geopotential height anomalies during each of the four cold phases suggests various factors leading to cold temperatures, including both southerly off-content flow and calm atmospheric conditions. Understanding the atmospheric environment that leads to such extreme cold temperatures can improve prediction of such events and benefit Antarctic operations and the study of Antarctic meteorology and climatology. [ABSTRACT FROM AUTHOR]

In antiquity, apologetic defences often included appeals to an ancient past. Fundamental to the ancient mind was a notion that favoured primitive wisdom over contemporary culture, antiquity over novel discoveries. In the ongoing clashes between cultures and ethnicities which signified the Hellenistic era, this notion was often combined with a competitive search for communal recognition and validity. This article offers a survey of Jewish authors in Hellenistic times, who engaged in this battle for old age. The article shows how various Jewish writers employed the antiquity argument through comparative historiography, in which they traced the roots of civilization to ancient heroes of Israel. The article ends with a discussion on the logic, structure, and purpose of the antiquity argument. [ABSTRACT FROM AUTHOR]

To improve the performance of Cu(In,Ga)Se2 thin-film photovoltaic devices, a robust understanding of the dominant diffusion pathways of the alloy species In and Ga is needed. Here, the most probable defect complexes and mechanisms for In and Ga diffusion are identified with the aid of density functional theory. The binding energies and migration barriers for these complexes are calculated in bulk CuInSe2 and CuGaSe2. Analytic models and kinetic lattice Monte Carlo simulations are employed to predict the diffusivity of In and Ga under variations in composition and temperature. We find that a model based on coulombic interactions between group III antisites and vacancies on the Cu-sublattice produces results that match well with experiment. [ABSTRACT FROM AUTHOR]

We describe a multiple electronic state adaptation of the mapping approach to surface hopping introduced recently by Mannouch and Richardson [J. Chem. Phys. 158, 104111 (2023)]. Our modification treats populations and coherences on an equal footing and is guaranteed to give populations in any electronic basis that tend to the correct quantum–classical equilibrium values in the long-time limit (assuming ergodicity). We demonstrate its accuracy by comparison with exact benchmark results for three- and seven-state models of the Fenna–Matthews–Olson complex, obtaining electronic populations and coherences that are significantly more accurate than those of fewest switches surface hopping and at least as good as those of any other semiclassical method we are aware of. Since these results were obtained by adapting the scheme of Mannouch and Richardson, we go on to compare our results with theirs for a variety of problems with two electronic states. We find that their method is sometimes more accurate, especially in the Marcus inverted regime. However, in other situations, the accuracies are comparable, and since our scheme can be used with multiple electronic states it can be applied to a wider variety of electronically nonadiabatic systems. [ABSTRACT FROM AUTHOR]

Psychologists and other clinical therapists often focus on the psychological processes that result from the fact that human beings will one day die, not death anxiety/afterlife anxiety itself. Nevertheless, existential concerns are death concerns, and any anxiety associated with death should be understood through that lens—as resulting from concerns about death. Understanding how one views the amount of time left to live, and how this perception influences motives, goal cognitions, mood, and well-being, is of great importance from a humanistic–existential perspective. Socioemotional selectivity theory and the concept of future time perspective (FTP) capture these phenomena and have the potential to operationalize perspectives of time constraints within existential psychology. The present work attempts to show how FTP may be used to operationalize the problem of time from an existential perspective, specifically targeting the existential themes of death, meaning, isolation, and freedom. Clinical implications of considering FTP as an existential construct are discussed, as are limitations and future directions. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate the effectiveness of prophylactic mesh placement in reducing the incidence of parastomal hernias following colostomy, ileostomy, and ileal conduit formation. Methods: A systematic review identified relevant studies evaluating parastomal hernia incidence with prophylactic mesh use during stoma formation. Pairwise meta-analysis and network meta-analysis using Bayesian modeling were performed. Results: 25 studies, consisting of 16 randomized control trials (RCT), 6 follow up studies, and 3 retrospective cohort studies, were included. Prophylactic mesh led to significantly fewer parastomal hernias beyond 6 months follow-up (OR 0.43, 95% CI 0.33–0.58). Hernias were reduced with mesh for both ileal conduits and colostomies. When analyzing hazard ratios (HRs), only 6 studies were included, and a statistically significant difference was observed among both randomized controlled trials (RCTs) (HR 0.75 [0.53, 0.92], p = 0.01) and non-RCTs (HR 0.57 [0.36, 0.92], p = 0.02). Network meta-analysis found the retromuscular approach with mesh had the lowest hernia rate. Regression was non-significant for variations between study types. Conclusion: This meta-analysis demonstrated prophylactic mesh placement during ostomy creation significantly reduced parastomal hernia risk, more prominently beyond 6 months, consistently across randomized trials and observational studies for urologic and gastrointestinal ostomies. The retromuscular technique was most effective. [ABSTRACT FROM AUTHOR]

This article highlights the work of Martin C. Mihm, MD, in the field of pediatric dermatology, specifically his contributions to caring for children with birthmarks and vascular anomalies. It focuses on a project that aimed to develop mouse models for testing strategies to treat giant congenital melanocytic nevi (GCMN) without surgery. Mihm's expertise as a dermatopathologist and his dedication to helping children made him an invaluable collaborator on this project. The article also discusses the establishment of clinics and enhanced therapies for children with GCMNs, as well as the research conducted using genetically engineered mouse models. Overall, Mihm's passion and expertise greatly contributed to the success of this project. [Extracted from the article]

Conventional wisdom holds and previous research confirms that for a political candidate, atheism is anathema. But the United States is becoming a more secular nation. Does secularization mean that atheists are acceptable to some Americans, specifically Democrats and voters with low religiosity? Can concerns about atheists be assuaged by appealing to the superordinate identity of “patriotic American”? Drawing on four survey experiments, we find that Democrats are more supportive of an atheist, Republicans less—producing a null effect overall. Furthermore, voters’ reactions to an atheist are not driven by the office, but are shaped by both their partisanship and religiosity. Voters’ negative attitudes are partially assuaged by framing an atheist as a patriotic war hero. As the secular population grows in the United States, it seems likely that atheists will emerge as candidates for elected office. Our data suggest that, contrary to conventional wisdom, atheist candidates are potentially electable. [ABSTRACT FROM AUTHOR]

Drug‐induced liver injury (DILI) presents unique challenges in clinical practice. While some types of DILI are mild and resolve quickly after removing the drug, other situations are more complex, with competing aetiologies or underlying liver disease. Guidelines from professional societies agree that the liver biopsy retains a role in understanding and managing DILI in certain situations. Liver biopsy allows characterization of the histological pattern of injury as well as assessment of severity. Inflammatory infiltrates, bile duct injury or loss and vascular injury are all revealed by liver biopsy. Communication between the hepatopathologist and clinical team with clinicopathological correlation of the findings is necessary for the best determination of causality and differentiation from other diseases of exclusion, like autoimmune hepatitis and graft‐versus‐host disease. This review highlights important aspects of the role of liver biopsy in DILI evaluation. [ABSTRACT FROM AUTHOR]

The Open MPI for Exascale (OMPI-X) project was one of two in the Exascale Computing Project (ECP) focused on advancing the MPI ecosystem. The OMPI-X team worked with other MPI Forum members to champion several important features for inclusion in the MPI 4.0, 4.1, and upcoming 5.0 MPI standard versions, in support of the needs of exascale applications and systems. The team also worked with the larger Open MPI community to bring implementations of these new features and other enhancements into Open MPI, one of the leading open-source implementations of the MPI interface. This paper describes the motivation for the work of the OMPI-X project in the context of exascale computing needs, the nature of the resulting new capabilities in the MPI standard, and how they were implemented in the Open MPI library. Features include improved support for "MPI + X" programming models through partitioned communications and support for user-level threading, sessions, fault tolerance through the user-level fault mitigation (ULFM) and Reinit models, and other features. We also discuss enhancements to Open MPI providing improved performance and scalability for existing features, such as collective operations, one-sided operations, support for the Slingshot-11 interconnect of the initial exascale systems, and how the OMPI-X team worked to improve quality assurance for the Open MPI library, particularly on platforms of interest to the Department of Energy community. [ABSTRACT FROM AUTHOR]

Introduction: Controlled ankle motion (CAM) boots are a below‐knee orthotic device prescribed for the management of foot and ankle injuries to reduce ankle range of motion (RoM) and offload the foot and ankle whilst allowing continued ambulation during recovery. There is a lack of clarity within the current literature surrounding the biomechanical understanding and effectiveness of CAM boots. Aims: To summarise the biomechanical effects of CAM boot wear as an orthotic for restricting ankle RoM and offloading the foot. Methods: A systematic literature review was conducted in accordance with the PRISMA 2020 guidelines. All papers were independently screened by two authors for inclusion. Methodological quality was appraised using Joanna Briggs Critical Appraisal checklists. A narrative synthesis of all eligible papers was produced. Results: Thirteen studies involving 197 participants (113 male and 84 female) were included. All studies were quasi‐randomised and employed a within‐study design, of which 12 studies included a control group and a range of CAM boots were investigated. CAM boots can be seen to restrict ankle RoM, however, neighboring joints such as the knee and hip do have kinetic and kinematic compensatory alterations. Plantar pressure of the forefoot is effectively redistributed to the hindfoot by CAM boots. Conclusion: The compensatory mechanisms at the hip and knee joint during CAM boot wear could explain the secondary site pain often reported in patients, specifically at the ipsilateral knee and contralateral hip. Although CAM boots can be used to restrict ankle motion, this review has highlighted a lack of in‐boot kinematic analyses during CAM boot use, where tracking markers are placed on the anatomical structure rather than on the boot, or through video fluoroscopy, urging the need for a more robust methodological approach to achieve this. There is a need for studies to assess the biomechanical alterations caused by CAM boots in populations living with foot and ankle pathologies. Future research, adopting a longitudinal study design, is required to fully understand the effectiveness of CAM boots for rehabilitation. [ABSTRACT FROM AUTHOR]

Surface energy partitioning directly connects to the urban heat island effect, which consequently changes regional climate, the health of the urban dwellers, and anthropogenic energy use. In order to quantify land-atmosphere fluxes from urban areas and the impact of the level of intensity of development, we use seven site-years of land-atmosphere flux data from three locations averaged to seasonal timescales through binning by temperature. Additionally, all three of our study sites include urban rivers, allowing us to examine urban areas with high and low amounts of potential evapotranspiration. As expected, the urban river decreases the Bowen Ratio of observed fluxes, primarily through lowering sensible heat fluxes. Latent heat fluxes are positively correlated with urban density with coming from the river areas and negatively correlated with latent and sensible heat fluxes when coming from the urban river. We conclude that effective urban redevelopment guidelines can adopt this knowledge to decrease the urban heat island effect and reach sustainability targets to counteract increased temperatures from climate change. [ABSTRACT FROM AUTHOR]

INTRODUCTION: Percutaneous nephrolithotomy (PCNL) is the gold-standard treatment for large renal stones. One potentially significant complication of PCNL is blood loss, which can result in transfusion requirement and poorer stone-free outcomes. Tranexamic acid (TXA) has emerged as a promising intervention, administered systemically (TXA-S) or as part of irrigation fluid (TXA-I) in endourology. This study aimed to comprehensively analyze existing evidence regarding the applications of TXA in PCNL through a Bayesian network meta-analysis, offering insights into its efficacy and comparative effectiveness. METHODS: In February 2022, a PRISMA-compliant systematic review (PROSPERO registration number CRD42021270593) was performed to identify randomized controlled clinical trials (RCT) on TXA as either systemic therapy or in irrigation fluid. Studies in languages other than English and Spanish were not considered. A Bayesian network was built using results from identified studies to create models that were later run through Markov Chain Monte Carlo sampling through 200 000 iterations. RESULTS: Eight RCTs compared TXA-S vs. placebo, one TXA-I vs. placebo, and one TXA-I vs. TXA-S. TXA-I had lower risk of transfusion (relative risk [RR] 0.63 [0.47,0.84], SUCRA 0.950) than TXA-S (RR 0.79 [0.65,0.95], SUCRA 0.545). TXA-I had a lower risk of complications (RR 0.38 [0.21,0.67], SUCRA=0.957) compared to TXA-S (RR 0.55 [0.39, 0.78], SUCRA 0.539). TXA-I had a lower postoperative decrease in hemoglobin (mean difference [MD] -1.2 [1.3, 1.0], SUCRA 0.849) compared to TXA-S (MD-0.97 [-1.0, -0.93], SUCRA 0.646]). CONCLUSIONS: TXA, regardless of the route of administration, is an effective intervention in decreasing bleeding, postoperative complications, and risk of transfusion when compared with placebo. Further studies directly comparing TXA-S to TXA-I would be useful to determine the optimal route of delivery. [ABSTRACT FROM AUTHOR]

Matrix Schubert varieties are affine varieties arising in the Schubert calculus of the complete flag variety. We give a formula for the Castelnuovo–Mumford regularity of matrix Schubert varieties, answering a question of Jenna Rajchgot. We follow her proposed strategy of studying the highest-degree homogeneous parts of Grothendieck polynomials, which we call Castelnuovo–Mumford polynomials. In addition to the regularity formula, we obtain formulas for the degrees of all Castelnuovo–Mumford polynomials and for their leading terms, as well as a complete description of when two Castelnuovo–Mumford polynomials agree up to scalar multiple. The degree of the Grothendieck polynomial is a new permutation statistic which we call the Rajchgot index; we develop the properties of Rajchgot index and relate it to major index and to weak order. [ABSTRACT FROM AUTHOR]

ABSTRACT Human‐caused mortality can be pervasive and even highly selective for individuals in groups of cooperative breeders. Many studies of cooperative breeders, however, do not address human‐caused mortality. Similarly, studies focused on the effects of human‐caused mortality on wildlife populations often do not consider the ecology of cooperative breeders. We searched the literature and identified 58 studies where human‐caused mortality affected a group characteristic, vital rate, or population state of a cooperative breeder. Of studies reporting population growth or decline, 80% reported a link between human‐caused mortality and population declines in cooperative breeders. Such studies often did not identify the mechanism behind population declines, but 28% identified concurrent declines in adult survival and another 21% reported concurrent declines in recruitment or reproduction. There was little overlap between the cooperative breeding and human‐caused mortality literatures, limiting our ability to accrue knowledge. Future work would be beneficial if it (i) identified the vital rate(s) causing population declines, (ii) leveraged management actions such as lethal removal to ask questions about the ecology of group‐living in cooperative breeders, and (iii) used insights from cooperative breeding theory to inform management actions and conservation of group‐living species. [ABSTRACT FROM AUTHOR]

This article attempts to identify the anonymous Franciscan bishop who, according to the Lanercost Chronicle, participated at the Battle of Neville's Cross, Durham, against the invading Scots, on 17 October 1346. The Franciscan 'Matthew episcopus Manchensis', previously suggested to be the bishop in question, is shown to derive from a scribal error, but even the corrected Matthew bishop Organchensis was probably not the prelate in question. Rather, it is argued, another Durham suffragan, frater Richard bishop of Bisaccia, may have been in the man at Neville's Cross. [ABSTRACT FROM AUTHOR]

What is the future of environmental and climate change education in the United States given the emergence of neofascist and Christian Nationalist political movements during a time of social secularization? In this essay we discuss the politically heterogenous appeal of environmental concern in America, the tenuous nature of environmental education's current Left-liberal political valence, and implications for climate change education amidst ongoing culture wars. We proceed by examining Bron Taylor's influential typology of Dark Green Religions and consider how the American political Right may emerge as having their own Dark Green Religious movement. We are concerned that the field of environmental education remains ideologically blinkered toward other normative educational projects on the political Right, a situation that leaves us unprepared for how projects such as climate change education can be appropriated for reactionary and sometimes violent ends. We argue that the field of environmental education needs to pay greater attention to the multifarious political and cultural conditions that shape its enactment and develop considerations for an anti-fascist environmental education accordingly. [ABSTRACT FROM AUTHOR]

Background: The prevalence of co-occurring chronic pain and posttraumatic stress disorder (PTSD) has yet to be established in a nationally representative sample of US veterans, and little is known about the individual contributing roles of these disorders to the psychiatric and functional burden of this comorbidity. Objective: To determine the prevalence of chronic pain, PTSD, and co-occurring chronic pain and PTSD, and psychiatric comorbidities and psychosocial functioning in these groups. Design: Data were analyzed from the National Health and Resilience in Veterans Study, which surveyed a nationally representative sample of US veterans. Participants: Veterans (n=4069) were classified into four groups: control (i.e., no PTSD or chronic pain), chronic pain only, PTSD only, and co-occurring chronic pain and PTSD. Main Measures: A probable PTSD diagnosis was established using the PTSD Checklist for DSM-5, and a chronic pain diagnosis using a self-report item that queried health care professional diagnoses. Psychiatric and functional status were assessed using the Patient Health Questionnaire-4, Alcohol Use Disorders Identification Test, Screen of Drug Use, Suicide Behaviors Questionnaire-Revised, Short Form Health Survey-8, Brief Inventory of Psychosocial Functioning, and Medical Outcomes Study Cognitive Functioning Scale. Key Results: A total of 3.8% of veterans reported both probable PTSD and a diagnosis of chronic pain. Relative to veterans with chronic pain alone, those with co-occurring chronic pain and probable PTSD were more likely to screen positive for psychiatric disorders (odds ratios [ORs]=2.59–9.88) and scored lower on measures of psychosocial functioning (Cohen's ds=0.38–1.43). Relative to veterans with probable PTSD only, those with co-occurring chronic pain and probable PTSD were more likely to have attempted suicide (OR=4.79; 95%CI, 1.81–12.69). Conclusions: Results underscore the importance of whole health care that considers a broad range of health and functional domains in the assessment and treatment of co-occurring chronic pain and PTSD in veterans. [ABSTRACT FROM AUTHOR]

AbstractObjectivesMethodsResultsConclusionThe Therapist Work Involvement Scales (TWIS) is a self-report research instrument that enables a multilayered description of psychotherapists’ experiences when treating clients. The TWIS was created in a comprehensive study of close to 5,000 psychotherapists, and has been used in multiple studies. The aim of the current paper is to clarify the organization and statistical characteristics of the TWIS, and to present an updated version for longitudinal and cross-sectional research.Collection of a large sample of psychotherapy trainees made possible the use of confirmatory factor analysis (CFA) to evaluate the dimensions and structure of therapists’ process experiences, assessing reliabilities, measurement invariance over gender, item statistics, and correlations with other measures to show concurrent and predictive validity.The CFAs largely confirmed the factor structure of four of the five facets, and of the global super-factors. The global factors of Healing Involvement and Stressful Involvement each showed substantial correlations with therapists’ attachment style and professional growth, and were used to describe four practice patterns that typify the experiences of therapists.The results have shown the TWIS to be a statistically sound, multidimensional research instrument enabling therapists to describe their experience in current therapeutic work. [ABSTRACT FROM AUTHOR]

Early childhood educator's emotional socialization may contribute crucially to young children's social–emotional competence. Here, we examined the contributions of self-reported reactions to children's emotions and beliefs about emotional socialization of 90 teachers to the social–emotional competence of 334 pre-schoolers. Teacher-reported emotion socialization, especially as moderated by classroom socioeconomic risk, often predicted pre-schoolers' end-of-year social–emotional behaviours, independent of child covariates, including children's beginning-of-year premeasures. Only three findings resembled the parent emotion socialization literature, however, and two appeared unique to the pre-school environment. Most were specific to classrooms where children experienced socioeconomic risk. The pattern of moderation findings highlights the importance of context in teachers' emotional socialization. Suggestions are given for expanded research on the topic and potential applications to assist teachers in their role as emotion socializers. [ABSTRACT FROM AUTHOR]

Nicolò Palazzetti's book, "Béla Bartók in Italy: The Politics of Myth-Making," explores the composer's relationship with Italy and the formation of his myth in the context of Italian politics. The book challenges the perception of Bartók as an anti-fascist, arguing that his reputation as such is a myth of our age. Palazzetti examines Bartók's visits to Italy, his reception by Italian composers, and the influence of his music in the country. The book provides a comprehensive analysis of Bartók's impact on Italian music and culture, shedding light on the complex relationship between art and politics. [Extracted from the article]

Aim: Incisional herniation (IH) is a frequent complication following midline abdominal closure with significant associated morbidity. Randomized controlled trials have demonstrated that the small bites technique (SBT) and prophylactic mesh augmentation (PMA) may reduce IH compared to mass closure techniques, but data are lacking on their implementation in contemporary surgical practice. This survey aimed to evaluate the use of the SBT and PMA and to identify factors associated with their adoption. Method: Between 22 January 2023 and 16 March 2023, consultant surgeons across the UK were asked to complete a 25‐question survey on closure of an elective primary midline incision. Results: Responses were received from 267 of 675 eligible surgeons (39.6%) in 38 NHS Trusts. Respondents were evenly split between tertiary centres (47.6%) and district general hospitals (49.4%). SBT and PMA were used by 19.9% and 3.0% of respondents, respectively. Compared to other techniques, surgeons using the SBT were more likely to close the anterior aponeurotic layer only, use single suture filaments, 2–0 gauge sutures and sharp needle points and routinely dissect abdominal layers to aid closure (all p < 0.001). Attendance at lectures/conferences on SBT (p = 0.043) and basing practice on available evidence (p < 0.001) were independently associated with use of the SBT. The commonest barriers to adopting SBT were a perceived lack of evidence (23.8%) and belief that personal IH rates were low (16.8%). Conclusion: A minority of UK consultant surgeons have adopted the SBT or PMA. Practice change should be driven by more widespread dissemination of current evidence and procedural information. [ABSTRACT FROM AUTHOR]

The Journal of Water Resources Planning and Management (JWRPM) launched a Reproducibility Review Program in 2020 to address the lack of reproducibility in water-related journals. The program encourages authors to publish data, models, code, and directions with their articles so that independent reviewers can replicate their work. The program has five objectives, including promoting reproducibility, facilitating the use of reproducible work, and recognizing authors who make their work more reproducible. The program has already awarded Silver and Bronze badges to several manuscripts and plans to expand to other journals. Challenges include incorporating reproducibility reviews into the submission process and educating authors about the program. The program aims to improve reproducibility in the water resources field and shift towards reproducibility as the default in research. [Extracted from the article]

For a fixed CM field K with maximal totally real subfield F, we consider isomorphism classes of dihedral Artin representations of F which are induced from K, distinguishing between those which are "canonically" induced from K and those which are "noncanonically" induced from K. The latter can arise only for Artin representations with image isomorphic to the dihedral group of order 8. We show that asymptotically, the number of noncanonically induced isomorphism classes is always comparable to and in some cases exceeds the number of canonically induced ones. [ABSTRACT FROM AUTHOR]

There are conflicting findings about the relationships between depression, anxiety, and cognitive dysfunction in people with multiple sclerosis (MS), and a paucity of research has examined the cumulative influence on cognition of depression plus anxiety. This study aimed to determine whether elevated symptoms of depression and anxiety alone or in combination are associated with worse cognition in people with MS. In this cross-sectional analysis, people with MS consecutively seen at a tertiary neuropsychiatry clinic completed the Hospital Anxiety and Depression Scale for symptoms of depression (HADS-D) and anxiety (HADS-A), and the Minimal Assessment of Cognitive Function in MS for cognitive indices. Accounting for covariates, regression models predicted cognitive indices from scores for HADS-D, HADS-A, and the interaction. Of 831 people with MS, 72% were female, mean age was 43.2 years, and median Expanded Disability Status Scale score was 2.0. Depressive symptoms were independently predictive of lower verbal fluency (Controlled Oral Word Association Test, p < 0.01), verbal learning (California Verbal Learning Test-II (CVLT-II) total learning, p = 0.02), verbal delayed recall (CVLT-II delayed recall, p < 0.01), and processing speed (Symbol Digit Modalities Test, p < 0.01; three-second Paced Auditory Serial Addition Test (PASAT), p = 0.05; two-second PASAT, p = 0.01). Anxiety in people with depression predicted decreased visuospatial function (Judgment of Line Orientation, p = 0.05), verbal learning (p < 0.01), verbal delayed recall (p < 0.01), visuospatial recall (Brief Visuospatial Memory Test-Revised, p = 0.02), and executive function (Delis-Kaplan Executive Function System, p < 0.01). Anxiety alone was not independently predictive of cognition. In conclusion, depression, especially with comorbid anxiety, is associated with cognitive dysfunction in people with MS. [ABSTRACT FROM AUTHOR]

This exploratory study aims to extend and strengthen the empirical base for supervision as a facilitator of professional growth, as outlined in an established conceptual model, by exploring its correlates among psychotherapists across their entire professional career. Ratings of the impact of supervision by 6267 psychotherapists of different professions, theoretical orientations, and career levels in many countries who were currently in supervision were correlated, separately for each of five career cohorts, with aspects of their treatment experience, work situation, and personal characteristics. Large percentages of psychotherapists at all career levels, including senior psychotherapists, engaged in supervision and rated its impact on their development positively. Growth-facilitating supervision was associated broadly but moderately in all career cohorts mainly with interpersonal aspects of therapists’ treatment experience, with supportive work settings, and with caring and expressive personal characteristics. Some differential findings among cohorts also reflected potential developmentally based functions of supervision. The implications of results were considered both for supervisory practice, training and for future supervision research. [ABSTRACT FROM AUTHOR]