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5. The biopsy Gleason score 3+4 in a single core does not necessarily reflect an unfavourable pathological disease after radical prostatectomy in comparison with biopsy Gleason score 3+3: looking for larger selection criteria for active surveillance candidates

Author

Schiavina, R, Borghesi, M, Brunocilla, E, Romagnoli, D, Diazzi, D, Giunchi, F, Vagnoni, V, Pultrone, C V, Dababneh, H, Porreca, A, Fiorentino, M, and Martorana, G

Subjects
*GLEASON grading system, *BIOPSY, *PROSTATECTOMY, *PROSTATE cancer prognosis, *TUMOR grading, *PROSTATE surgery
Abstract

Background:To assess whether the addition of clinical Gleason score (Gs) 3+4 to the Prostate Cancer Research International: Active Surveillance (PRIAS) criteria affects pathologic results in patients who are potentially suitable for active surveillance (AS) and to identify possible clinical predictors of unfavourable outcome.Methods:Three hundred and twenty-nine men who underwent radical prostatectomy with complete clinical and follow-up data and who would have fulfilled the inclusion criteria of the PRIAS protocol at the time of biopsy except for the addition of biopsy Gs=3+4 and with at least 10 cores taken have been evaluated. One experienced genitourinary pathologist selected those with real Gs=3+3 and 3+4 in only one core according to the 2005 International Society of Urological Pathology criteria. The primary end point was the proportion of unfavourable outcome (nonorgan confined disease or Gs⩾4+3). Logistic regressions explored the association between preoperative characteristics and the primary end point.Results:Two hundred and four patients were evaluated and 46 (22.5%) patients harboured unfavourable disease at final pathology. After a median follow-up of 73.5 months, there was no cancer-specific death, and 4 (2.0%) patients had biochemical relapse. There were no significant differences in terms of high Gs, locally advanced disease, unfavourable disease and biochemical relapse-free survival among patients with clinical Gs=3+3 vs Gs=3+4. At multivariable analysis, the presence of atypical small acinar proliferation (ASAP) and lower number of core taken were independently associated with a higher risk of unfavourable disease.Conclusion:The inclusion of Gs=3+4 in patients suitable to AS does not enhance the risk of unfavourable disease after radical prostatectomy. Additional factors such as number of cores taken and the presence of ASAP should be considered in patients suitable for AS. [ABSTRACT FROM AUTHOR]

Published
2015
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6. SC13 - Is holmium laser enucleation of the prostate (HoLEP) safe and effective in patients with a high comorbidity burden? Insights from two referral academic Centres.

Author

Verrienti, P., Bianchi, L., Sessa, F., Tellini, R., Di Camillo, M., Salvi, M., Viola, L., Campi, R., Chessa, F., Borghesi, M., Dababneh, H., Brunocilla, E., Carini, M., Minervini, A., Schiavina, R., and Tuccio, A.

Subjects
*HOLMIUM, *SURGICAL enucleation, *PROSTATE, *COMORBIDITY, *LASERS, *PROSTATE surgery, *BENIGN prostatic hyperplasia
Published
2019
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8. P264 - How to predict the likelihood of postoperative surgical nephron sparing-related complications in a large single-institution series of partial nepfrectomies.

Author

Borghesi, M., Schiavina, R., Bianchi, L., Casablanca, C., Di Fresco, S., Mineo Bianchi, F., Chessa, F., Pultrone, C., Angiolini, A., Rizzi, S., Dababneh, H., and Brunocilla, E.

Subjects
*POSTOPERATIVE care, *NEPHRONS, *SURGICAL complications, *NEPHRECTOMY, *PNEUMOTHORAX, *SURGERY, *THERAPEUTICS
Published
2018
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9. P263 - Open, laparoscopic and robot-assisted partial nephrectomy: Comparison of perioperative outcomes and trifecta rate achievement in a large, single-institution series.

Author

Borghesi, M., Schiavina, R., Bianchi, L., Di Fresco, S., Casablanca, C., Mineo Bianchi, F., Chessa, F., Pultrone, C., Angiolini, A., Rizzi, S., Dababneh, H., and Brunocilla, E.

Subjects
*NEPHRECTOMY, *SURGICAL robots, *LAPAROSCOPIC surgery, *PERIOPERATIVE care, *RENAL cell carcinoma, *PATIENTS
Published
2018
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10. P213 - The role of standard biopsy during an MRI-TRUS fusion targeted biopsy: A two cohort study in previous negative biopsy and active surveillance patients.

Author

Giampaoli, M., Barbaresi, U., Bianchi, L., Borghesi, M., Dababneh, H., Vagnoni, V., Schiavina, R., Francesco, C., Corcioni, B., Gaudiano, C., Golfieri, R., and Brunocilla, E.

Subjects
*BIOPSY, *MAGNETIC resonance imaging, *ULTRASONIC imaging, *COHORT analysis, *PROSTATE cancer patients, *GLEASON grading system
Published
2018
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11. P194 - 68Ga-PSMA PET/CT in patients with biochemical recurrence after radical prostatectomy: How to predict a positive PSMA PET/CT results and the site of recurrence.

Author

Angiolini, A., Bianchi, L., Guerra, M., Borghesi, M., Barbaresi, U., Costa, F., Chessa, F., Dababneh, H., Pultrone, C., Nanni, C., Castellucci, P., Ceci, F., Schiavina, R., Fanti, S., and Brunocilla, E.

Subjects
*POSITRON emission tomography, *COMPUTED tomography, *PROSTATECTOMY, *CANCER relapse, *REGRESSION analysis
Published
2018
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12. P191 - Clinical impact of 68Ga-PSMA PET/CT on the management of patients experiencing biochemical recurrence after radical prostatectomy.

Author

Bianchi, L., Borghesi, M., Barbaresi, U., Mineo Bianchi, F., Castellucci, P., Ceci, F., Costa, F., Chessa, F., Casablanca, C., Pultrone, C., Dababneh, H., Nanni, C., Schiavina, R., Fanti, S., and Brunocilla, E.

Subjects
*PROSTATECTOMY, *CANCER relapse, *COMPUTED tomography, *PROSTATE cancer patients, *POSITRON emission tomography
Published
2018
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13. P91 - Fast track protocol applied to patients treated with radical cystectomy and intestinal urinary diversion: An update of a two year prospective randomized study in a high-volume center.

Author

Ercolino, A., Chessa, F., Mineo Bianchi, F., Casablanca, C., Lupardi, E., Borghesi, M., Bianchi, L., Pultrone, C., Dababneh, H., Schiavina, R., and Brunocilla, E.

Subjects
*CYSTECTOMY, *URINARY diversion, *RANDOMIZED controlled trials, *REPORTING of diseases, *POSTOPERATIVE care
Published
2018
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15. P82 - The role of magnetic resonance imaging for early reclassification of patients undergoing active surveillance for prostate cancer (ROMAS PROJECT): A multi-institutional preliminary experience.

Author

Schiavina, R., Borghesi, M., Bianchi, L., Guerra, M., Verze, P., Mineo Bianchi, F., Angiolini, A., Di Fresco, S., La Rocca, R., Rizzi, S., Lambertini, L., Pultrone, C., Dababneh, H., Mirone, V., and Brunocilla, E.

Subjects
*MAGNETIC resonance imaging, *PROSTATE cancer patients, *MULTIHOSPITAL systems, *DIGITAL rectal examination, *BIOPSY
Published
2018
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18. PE33 - Preoperative multiparametric magnetic resonance imaging and neurovascular bundle management: Surgical plan change in course of robot assisted radical prostatectomy.

Author

Schiavina, R., Bianchi, L., Turri, F.M., Larcher, A., Borghesi, M., Dababneh, H., Pultrone, C., Chessa, F.P., De Groote, R., Schatteman, P., D’hondt, F., De Naeyer, G., Mottrie, A., and Brunocilla, E.

Subjects
*PROSTATECTOMY, *SURGICAL robots, *PROSTATE cancer, *MAGNETIC resonance imaging, *SURGEONS
Published
2017
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20. V24 A new single barbed bidirectional suture (Filbloc, Assut SPA) for posterior muscolofascial reconstruction and knotless urethrovesical anastomosis during RARP.

Author

Schiavina, R., Bianchi, L., Salvaggio, A., Borghesi, M., Cappa, E., Dente, D., Brunocilla, E., Dababneh, H., Chessa, F., Caffarelli, A., Vagnoni, V., Pultrone, C.V., Giampaoli, M., Martorana, G., and Porreca, A.

Subjects
*URETHRA surgery, *PLASTIC surgery, *SURGICAL anastomosis, *SUTURES, *MUSCLES, *SURGERY
Published
2016
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