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Rjinders I et al i .10 studied CXCR3 expression in T cells of patients with metastatic urothelial cancer under pembrolizumab treatment and described similar findings. Our aetiopathogenic hypothesis for the appearance of these epidermal proliferations in patients treated with anti-PD1 focuses on the transmembrane chemokine receptor CXCR3. EN CXCR3 keratinocyte pembrolizumab proliferation. e195 e197 3 05/20/22 20220501 NES 220501 We read with interest the article by Jiang I et al i .1 and report another case of a similar skin reaction in a patient on pembrolizumab. [Extracted from the article]

Dear Editor, We read with interest the article by Bhanja I et al i .1 describing a case of periorbital purpura due to hyperemesis gravidarum. We agree with the authors that anamnesis, physical examination, and a basic biochemical exploration, including coagulation profile, are the main tools for an initial approach in a patient with periorbital purpura. The presence of periorbital purpura in a patient with previous head trauma is a clinical sign that the patient must be evaluated urgently to rule out a base of skull fracture. [Extracted from the article]

The diagnosis of obesity-associated lymphedematous mucinosis (OALM) was rendered since no evidence of venous pathology, systemic lupus erythematosus, monoclonal gamma disease, or thyroid pathology was detected. Dear Editor, A 73-year-old male, with a history of type 2 diabetes, alcohol-related liver disease, and obesity, was referred to dermatology for evaluation of skin lesions affecting both legs that appeared 2 years ago. Pretibial location of the lesions can also provide the physician a diagnostic hint, considering mostly three entities: stasis mucinosis, obesity associated lymphedematous mucinosis (OALM), and pretibial myxedema. [Extracted from the article]

The first patient was a 23-year-old man with no medical history of interest who consulted for presenting asymptomatic skin lesions in both hands, elbows, and feet, all of which had suddenly appeared 3 days after SARS-CoV-2 vaccination. To this date, no other cases of PAC-like eruption or confirmed PAC caused by SARS-CoV-2 vaccination have been reported in the reviewed literature. Papular acrodermatitis of childhood-like eruption triggered by SARS-CoV-2 vaccination: Report of two cases. [Extracted from the article]