1. Transcriptional Regulation and Its Misregulation in Human Diseases.
- Author
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Casamassimi, Amelia, Ciccodicola, Alfredo, and Rienzo, Monica
- Subjects
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GENETIC transcription regulation , *MORPHOLOGY , *CIRCULAR RNA , *MOLECULAR genetics , *GENE expression , *RNA splicing , *NUCLEIC acids , *FORKHEAD transcription factors - Abstract
In this newly published study, the authors also identified aberrantly activated NKL genes, NKX2-3 and NKX2-4, in cell lines derived from two different AML subtypes, where they deregulate target genes involved in megakaryocytic and erythroid differentiation, thus providing the molecular basis to the classification of specific AML subtypes [[4]]. Transcriptional regulation is a critical biological process that allows the cell or an organism to respond to a variety of intra- and extracellular signals, to define cell identity during development, to maintain it throughout its lifetime, and to coordinate cellular activity. To this purpose, fifty female adult-onset asthma patients were categorized based on their exposure to building dampness and molds and other clinical parameters (inflammation, cytokine profile, etc.), together with gene signatures of nasal biopsies and peripheral blood mononuclear cells. An interesting study has analyzed the genetic structure and biological roles of I CLEC12A-MIR223HG i , a novel chimeric transcript produced through trans-splicing by the fusion of the cell surface receptor CLEC12A (C-Type Lectin Domain Family 12 Member A) and the miRNA-223 host gene ( I MIR223HG i ), first identified through transcriptome profiling of chronic myeloid leukemia (CML) patients. [Extracted from the article]
- Published
- 2023
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