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Abstract: Background: We aimed to evaluate the use of central catheters introduced by a peripheral vein (PICC) in children with CF. Methods: A descriptive study in patients in whom a PICC (Beckton Dickinson) was inserted. Results: 24 children aged (median (range) 10.2 years (0.3–17.3) undergoing 44 procedures were included. PICC was successfully inserted in 93.2% (41/44) of cases. Total procedure duration was (median (range)) 32.5 (10–105) minutes. The operators encountered few difficulties, median (range) 2 (1–10) (1 (absence) to 10 (maximal)); median (range) 1 (1 to 5) attempt per child). No major side effects or infections were observed. PICC obstruction in 5 (12%) cases was successfully unblocked in 4 cases (urokinase). The catheter was functional throughout the antibiotic course in 40/41 cases. A final Doppler scan (30 cases) showed total permeability of the central veins in all cases. Satisfaction index of the operators and the patients were high: median (range) 9.5 (1–10) and 8.0 (6–10) (scale: 1 (worse) to 10 (best)), respectively. Conclusion: PICCs are simple to use, and may be safely inserted in the ward. Such catheters are well tolerated, may increase the well-being of children with CF and prove an effective means by which to deliver IV therapy in this population. [Copyright &y& Elsevier]