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A series of 150-nm-thick Al-doped ZnO (AZO) thin films with various Al doping concentrations were deposited by atomic layer deposition technique to determine their applicability in transparent electronic devices. For incorporation into transparent electrodes, the electrical properties of AZO films must be modulated to minimize the parasitic effect. The results show that AZO thin films with various Al dopant concentrations had different work-functions and electrical contact properties, while the other physical characteristics were not significantly changed. Hence, AZO thin films can be used as transparent conducting oxide materials and are potential alternatives for the currently used indium-tin-oxide (ITO) thin films. [ABSTRACT FROM AUTHOR]

Hepatitis C virus (HCV) is a pathogen that causes cirrhosis and hepatocellular carcinoma through chronic hepatitis C. This study focused on the anti-HCV activity of a 70% ethanol extract of Kirengeshoma koreana Nakai (KKE) and its bioactive chemical constituent(s). The KKE and its n-butanol (n-BuOH) fraction induced a significant reduction in HCV RNA levels without inducing cytotoxicity. A high-performance liquid chromatography–mass spectrometry (HPLC-MS) analysis revealed the presence of roseoside in the n-butanol fraction of the KKE, which inhibited HCV RNA replication in a concentration- and time-dependent manner without exerting cytotoxicity. Consistent with in silico molecular docking analysis data, roseoside targets and inhibits HCV NS5A/B replicase. Collectively, our findings demonstrate that roseoside is a chemical constituent in KKE that interferes with HCV replication by targeting NS5A/B replicase. [ABSTRACT FROM AUTHOR]

Anti‐phospholipid syndrome (APS) nephropathy is an autoimmune disease that is sometimes accompanied by systemic lupus erythematosus (SLE). Here, we report the use of rituximab to treat a case of APS nephropathy in a SLE patient with recurrent vascular thrombosis. A 52‐year‐old woman, who had been diagnosed with SLE 11 years earlier, was referred to a nephrology clinic for evaluation of azotaemia and proteinuria. She had experienced spontaneous abortion at 35 years of age. The patient had been diagnosed with right popliteal thrombosis at 39 years of age, and with left pulmonary artery thrombosis and SLE at 41 years of age. Before admission, she was undergoing anticoagulant and immunosuppressive therapies, with follow‐up in the rheumatology clinic. At her last outpatient clinic visit before admission, she exhibited mild bilateral lower‐limb pitting oedema, impaired renal function and proteinuria. Renal biopsy revealed arteriolar wall thickening, with thrombi in the capillary lumina and marked inflammatory cell infiltration in the interstitium. The patient was treated with warfarin and high‐dose corticosteroids. Intravenous rituximab (500 mg) was also administered twice at a 4‐week interval. Her renal function did not worsen any further, and her proteinuria decreased. Here we report the successful use of rituximab to treat APS nephropathy in a patient with SLE, who had progressive renal insufficiency. [ABSTRACT FROM AUTHOR]

Summary Most dietary fibres improved rheological properties but negatively impacted digestibility. However, the effect of psyllium husk powder (PHP) on digestibility has not been yet reported. Thus, this study aimed to evaluate the rheological properties and digestibility of chicken myofibrillar protein (MP) containing different concentrations of PHP (0%, 0.5%, 1.0%, 1.5%) at 0.45 m NaCl. To assess the rheological properties of MP, viscosity, hydrophobicity, disulphide bond, SDS–PAGE, cooking yield and gel strength were evaluated. The addition of PHP enhanced water retention capacity and protein–protein interactions in the MP system. To evaluate the effect of PHP on digestibility, protein digestibility, SDS–PAGE and microstructure observations were performed. It was confirmed that the addition of PHP improved the protein digestibility of MP by measuring the differences in protein content (%). Therefore, the addition of PHP into MP gel improved not only the rheological properties but also the protein digestibility during in vitro digestion. [ABSTRACT FROM AUTHOR]

Background/Objectives: Transforaminal endoscopic lumbar discectomy (TELD) under local anesthesia is a promising minimally invasive surgical option for intractable lumbar disc herniation (LDH). However, our understanding of access pain prediction during foraminal pathological procedures is limited. To our knowledge, no predictive rules for access pain have been established during TELD for foraminal or extraforaminal LDH. This study, with its potential for predicting access pain during TELD and discussing strategies for pain prevention and management, could significantly benefit the field of endoscopic spine surgery. Methods: This observational study included 73 consecutive patients who underwent TELD for foraminal or extraforaminal LDH between January 2017 and December 2022. Preoperative clinical and radiographic factors affecting significant access pain and the impact of access pain on clinical outcomes were evaluated. Results: The rate of significant access pain was 13.70% (10 of 73 patients). Extraforaminal LDH tended to cause more severe pain than did foraminal LDH during TELD under local anesthesia (p < 0.05). Although the degree of access pain was not related to global clinical outcomes, increased pain was strongly associated with prolonged operative time and length of hospital stay (p < 0.05). Conclusions: TELD could be an effective surgical option for foraminal or extraforaminal LDH under local anesthesia. More access pain might develop during TELD for extraforaminal LDH. The extraforaminal component of LDH could narrow the safe working zone. Significant access pain might prolong the duration of surgery and hospitalization. Thus, a specialized technique is required for the clinical success of TELD. [ABSTRACT FROM AUTHOR]

Background/Objectives: Enhanced recovery after surgery (ERAS) protocols optimize perioperative care and improve recovery. This study evaluated the effectiveness of ERAS in one- or two-level posterior lumbar fusion surgeries, focusing on perioperative medication use, pain management, and functional outcomes. Methods: Eighty-eight patients undergoing lumbar fusion surgery between March 2021 and February 2022 were allocated into pre-ERAS (n = 41) and post-ERAS (n = 47) groups. Outcomes included opioid and antiemetic consumption, pain scores (numerical rating scale (NRS)), functional recovery (Oswestry Disability Index (ODI) and EuroQol 5 Dimension (EQ-5D)), and complication rates. Pain was assessed daily for the first four postoperative days and at 6 months. Linear Mixed Effects Model analysis evaluated pain trajectories. Results: The post-ERAS group showed significantly lower opioid (p = 0.005) and antiemetic (p < 0.001) use. No significant differences were observed in NRS pain scores in the first 4 postoperative days. At 6 months, the post-ERAS group reported significantly lower leg pain (p = 0.002). The time:group interaction was not significant for back (p = 0.848) or leg (p = 0.503) pain. Functional outcomes at 6 months, particularly ODI and EQ-5D scores, showed significant improvement in the post-ERAS group. Complication rates were lower in the post-ERAS group (4.3% vs. 19.5%, p = 0.024), while hospital stay and fusion rates remained similar. Conclusions: The ERAS protocol significantly reduced opioid and antiemetic use, improved long-term pain management and functional recovery, and lowered complication rates in lumbar fusion patients. These findings support the implementation of ERAS protocols in spinal surgery, emphasizing their role in enhancing postoperative care. [ABSTRACT FROM AUTHOR]

Background: Radiation pneumonitis (RP) is not an uncommon complication in lung cancer patients undergoing radiation therapy (RT) and symptomatic RP can affect their quality of life. Purpose: To investigate the CT findings of RP in non–small cell lung cancer (NSCLC) patients and their relationship with clinical outcomes. Materials and methods: We reviewed data from 240 NSCLC patients who underwent RT between 2014 and 2022. CT findings of RP were evaluated for parenchymal abnormalities and distribution, which were then classified into three patterns: localized pneumonia (LP), cryptogenic organizing pneumonia (COP), and acute interstitial pneumonia (AIP). Clinical outcomes of RP were evaluated based on Common Terminology Criteria for Adverse Events (CTCAE) grade. Results: Of the 153 patients, 135 developed RP. The most common pattern was LP (n = 78), followed by COP (n = 30) and AIP (n = 25). Among the three CT patterns, CTCAE grade and days between the start of RT and the onset of RP (RT-RP days) were statistically significantly different (p < 0.05). The patients with AIP patterns exhibited higher CTCAE grade, and fewer RT-RP days compared to those with non-AIP patterns (p < 0.05). In these patients, lung-to-lung metastasis and underlying interstitial lung abnormality were observed more frequently (p < 0.05). Underlying pulmonary fibrosis, the AIP pattern, and higher CT extent scores were more frequently observed in higher CTCAE grade group (p < 0.001). In multiple regression analysis, age, bilateral distribution, RT-RP days, and CT extent score ≥3 were independent predicting factors for higher CTCAE grade. Conclusions: RP in NSCLC patients can be classified into LP, COP, and AIP patterns and they exhibit different severities in clinical outcomes. [ABSTRACT FROM AUTHOR]

The higher amount of Pt usage and its poisoning in methanol oxidation reaction in acidic media is a major setback for methanol fuel cells. Herein, a promising dual application high‐performance electrocatalyst has been developed for hydrogen evolution and methanol oxidation. A low Pt‐content nanoalloy co‐doped with Cu, Mn, and P is synthesized using a modified solvothermal process. Initially, ultrasmall ≈2.9 nm PtCuMnP nanoalloy is prepared on N‐doped graphene‐oxide support and subsequently, it is characterized using several analytical techniques and examined through electrochemical tests. Electrochemical results show that PtCuMnP/N‐rGO has a low overpotential of 6.5 mV at 10 mA cm−2 in 0.3 m H2SO4 and high mass activity for the hydrogen evolution reaction. For the methanol oxidation reaction, the PtCuMnP/N‐rGO electrocatalyst exhibits robust performance. The mass activity of PtCuMnP/N‐rGO is 6.790 mA mg−1Pt, which is 7.43 times higher than that of commercial Pt/C (20% Pt). Moreover, in the chronoamperometry test, PtCuMnP/N‐rGO shows exceptionally good stability and retains 72% of the initial current density even after 20,000 cycles. Furthermore, the PtCuMnP/N‐rGO electrocatalyst exhibits outstanding performance for hydrogen evolution and methanol oxidation along with excellent anti‐poisoning ability. Hence, the developed bifunctional electrocatalyst can be used efficiently for hydrogen evolution and methanol oxidation. [ABSTRACT FROM AUTHOR]

Purpose: Adequate oxygenation and airway management during deep sedation can be challenging. We investigated the effect of high-flow nasal cannula (group HF) and conventional nasal cannula (group CO) during sedation for endoscopic submucosal dissection (ESD). Methods: Patients undergoing ESD with deep sedation were enrolled. The primary outcome was difference in lowest oxygen saturation (SpO2) between the groups. Incidence of hypoxia (SpO2 < 90%), patients with SpO2 < 95%, hypercapnia, and airway interventions; operator satisfaction; and adverse events were recorded. Results: Thirty-two patients in each group completed the study. The mean of minimum SpO2 values was significantly higher in group HF than in group CO (96.8% ± 4.2% vs. 93.3% ± 5.3%, p = 0.005). The incidence of hypoxia was comparable between the groups (4 [12.5%] vs. 6 [18.8%], p = 0.491); however, patients with SpO2 < 95% were significantly less in group HF (5 [15.6%] vs. 18 [56.3%], p = 0.003). Incidence of hypercapnia was higher in group HF than in group CO (14 [46.7%] vs. 5 [16.7%], p = 0.013). Airway rescue interventions were significantly less common in group HF. Satisfaction of operators and post-procedural complications were comparable between the two groups. In multivariable analysis, group CO and higher body mass index were risk factors for airway managements (odds ratio [95% confidence interval]: 6.204 [1.784–21.575], p = 0.004; 1.337 [1.043–1.715], p = 0.022, respectively). Conclusions: Compared to conventional nasal cannula, high-flow nasal cannula maintained higher minimum SpO2 value during deep sedation with propofol–remifentanil for ESD. Trial registration: Clinical Trial Registry of the Republic of Korea (KCT0006618, https://cris.nih.go.kr; registered September 29, 2021; principal investigator: Ji Won Choi). [ABSTRACT FROM AUTHOR]

Background: An idiopathic outflow tract premature ventricular complex (OT-PVC) is a common arrhythmia, and the accuracy of site of origin prediction using the 12-lead electrocardiogram (ECG) algorithm is not high. There are no studies about a systematic strategy that can provide practical help to electrophysiologists in OT-PVC mapping and ablation. This study aims to evaluate the efficacy and safety of the proposed ablation protocol and establish an optimal catheter ablation strategy by simultaneously investigating and synthesizing various indicators observed during the mapping procedure. Methods and design: This study (ABOUT-PVC) was designed as a prospective multicenter study to enroll 210 patients from 11 tertiary university hospitals over an estimated 27 months. Patients with idiopathic OT-PVC requiring catheter ablation will receive the procedure through a proposed ablation strategy and will be followed up for at least 12 months. The primary outcome is the acute procedural success rate. The secondary outcomes are clinical success rate, procedure time, complication rate, symptom relief, and changes in echocardiographic parameters. Conclusions: The ABOUT-PVC study was designed to investigate the efficacy and safety of the proposed ablation strategy and establish an optimal catheter ablation strategy. We expect this study to overcome the limitations of the ECG prediction algorithms and provide a practical guide to electrophysiologists, increasing the procedure's success rate and reducing complications and procedure time. [ABSTRACT FROM AUTHOR]

Background: To evaluate the clinical outcomes and patient satisfaction after implantation of an enhanced monofocal intraocular lens (TECNIS Eyhance ICB00) in patients with idiopathic epiretinal membrane (ERM) who underwent cataract surgery with pars plana vitrectomy (PPV). Methods: This is a single-center, retrospective, comparative study. In total, 61 eyes of 61 patients with idiopathic ERM and cataracts were included. We measured the uncorrected near and intermediate visual acuity (UNVA and UIVA), uncorrected and corrected distance visual acuity (UDVA and CDVA), central macular thickness, defocus curves, and contrast sensitivity 3–6 months after the surgery. Overall patient satisfaction was assessed using a questionnaire at the 1-month follow-up visit. Results: The ICB00 group showed better near and intermediate visual acuity than the monofocal group (TECNIS ZCB00); however, no statistically significant differences were found between the groups. The ICB00 group exhibited wider defocus curves at near to far distances (−3.0 to +2.0 D) than the ZCB00 group. There were no significant differences in the results of the contrast sensitivity test, dysphotopsia, spectacle dependence, or patient satisfaction between the two groups. Conclusions: In combined PPV and cataract surgery for ERM patients, ICB00 resulted in good visual acuity with a smoother defocus curve compared to the ZCB00 group. [ABSTRACT FROM AUTHOR]

Tracking changes in socioeconomic disparities in diabetes in the U.S. is important to evaluate progress in health equity and guide prevention efforts. Disparities in diabetes prevalence by educational attainment from 2001 to 2020 were investigated. Using a serial cross-sectional design, data from 33,220 adults aged 30–79 assessed in nine rounds of the National Health and Nutrition Examination Surveys between 2001 and 2020 were analyzed in 2023–2024. Diabetes was defined as self-reported prior diagnosis, elevated glycated hemoglobin (HbA 1c ≥6.5%), or use of diabetes medications. Marginalized age- and covariate-adjusted prevalence differences (PD) and prevalence ratios (PR) of diabetes by educational attainment (less than high school graduation, high school graduation, some college education or associate degree, or college graduation [reference]) by calendar period (2001–2004, 2005–2008, 2009–2012, 2013–2016, 2017–2020) were derived from logistic regression models. From 2001 to 2020, age-adjusted diabetes prevalence was consistently higher among adults without a college degree. Adults without a high school diploma exhibited the largest disparities in both 2001–2004 (PD 8.0%; 95%CI 5.6–10.5 and PR 2.1; 95%CI 1.5–2.6) and 2017-20 (PD 11.0%; 95%CI 6.7–15.2 and PR 2.1; 95%CI 1.5–2.7). Between 2001–2004 and 2017–2020, the absolute disparity in diabetes changed only among adults with a high school diploma (increase from PD 1.7%; 95%CI –0.5- 3.9 to PD 8.8% 95%CI 4.1–13.4, respectively), while the PR did not change in any group. Education-related disparities in diabetes were attenuated after accounting for socio-demographic factors and BMI. From 2001 to 2020, national education-related disparities in diabetes prevalence have shown no signs of narrowing. [ABSTRACT FROM AUTHOR]

Streptococcus parauberis, a gram-positive bacterium, causes significant mortality in cultured fish. In Korea, S. parauberis exhibits diverse serotypes (Ia, Ib/c, and II) from diseased fish including olive flounder (Paralichthys olivaceus), each with different pathogenicity. Therefore, the development of a reliable detection and serotyping assay is essential for effective disease surveillance. From the biochemical traits, although S. parauberis can be categorized into two subgroups associated with serotypes I and II, based on pyrrolidonyl arylamidase (PYR) activity, biochemical characterization is limited in differentiating between subserotypes. Furthermore, even though PCR-based serotyping assays (multiplex PCR; mPCR) have been reported, we aimed to develop an isothermal amplification-based assay for rapid and simultaneous detection and serotyping without the need for thermal cycling equipment. Based on the consensus sequence of the capsular polysaccharide (cps) locus, multiplex recombinase polymerase amplification (mRPA) primers were designed for the simultaneous detection and serotyping of S. parauberis. The optimized primer concentrations for mRPA were 280 nM for the detection of S. parauberis, 240 nM for serotypes Ia and II, and 200 nM for serotype Ib, with optimal amplification conditions determined to be 30 min at 42 °C. In the specificity test, no cross-reactivity with other fish pathogens was observed. In addition, the sensitivity of mRPA was 0.02 ng for detecting S. parauberis and serotypes Ia and Ib/c, while it was 0.2 ng for serotyping type II. Using DNA from cultured bacteria, the novel mRPA showed a detection rate consistent with that of mPCR. Moreover, using DNA from artificially infected tissues, the detection rate by mRPA was 96.7% (29/30), which was different from the results of mPCR (80%, 24/30), which exhibited an 80% detection rate. Therefore, the novel mRPA is an effective and rapid diagnostic tool for the simultaneous detection and serotyping of S. parauberis without requiring thermal cycling equipment as well as a specific bacterial culture step. [ABSTRACT FROM AUTHOR]

This study investigates the effectiveness of photobiomodulation therapy (PBMT) in treating chronic high-frequency tinnitus with the TINI device, a near-infrared (830 nm) laser. The study includes preliminary animal experiments with 28 mice and a randomized controlled trial with 56 participants to examine the functional and molecular changes in the auditory system that PBMT may cause. The animal model used sodium salicylate to induce tinnitus, followed by PBMT, which showed promising reductions in the behavioral evidence of tinnitus and a reversal of tinnitus-associated upregulation of vesicular glutamate transporters 2 expression in the ipsilateral dorsal cochlear nucleus (p < 0.05). In the clinical trial, participants with chronic high-frequency tinnitus received trans-tympanic application of the TINI device. The results did not show a significant difference in tinnitus score at the final time point when compared to the sham group. However, questionnaires revealed significant improvements in tinnitus symptoms and psychological outcomes following treatment with the TINI device compared to before treatment (p < 0.05). These findings suggest that while PBMT has potential benefits, its clinical effectiveness may be unclear due to its complex nature and interaction with other conditions. Further research is required to optimize treatment parameters and gain a complete understanding of the therapeutic potential of PBMT in managing tinnitus. [ABSTRACT FROM AUTHOR]

This study presents a simulation model to predict the nozzle surface freezing phenomenon that causes delays in refueling hydrogen vehicles. Nozzle surface freezing is known to occur when vehicles are refueled consecutively. The developed model allows consecutive refueling of vehicles and incorporates the actual nozzle material to accurately calculate the nozzle surface temperature. The simulation results indicate that, under the applied boundary conditions, the nozzle surface temperature reaches freezing conditions during the third refueling cycle, suggesting the potential suitability of using hot air or nitrogen after the second refueling. Future applications include exploring different boundary conditions in the developed hydrogen refueling model to simulate internal refueling pressure, temperature and nozzle icing conditions. This optimisation could facilitate decision making for the implementation of hot air or nitrogen, which could potentially reduce refueling time and contribute to cost savings at hydrogen refueling stations, depending on specific environmental conditions. • Charging hydrogen vehicles consecutively results in icing, causing delays. • A simulation model is proposed for consecutive vehicle charging, incorporating the nozzle where icing occurs. • Icing occurs during charging of three hydrogen vehicles consecutively (with a waiting time of 90 s). • After the second refueling, purging with heating air or similar means is considered appropriate. [ABSTRACT FROM AUTHOR]

Simple Summary: This study assessed the toxic effects of two pesticides, lambda-cyhalothrin (LCY) and spinetoram (SPI), on honey bee larvae. Through single (acute) and repeated (chronic) exposures, the research determined the lethal dose, 50% (LD50). The acute LD50 values for LCY and SPI were 0.058 (0.051–0.066) and 0.026 (0.01–0.045) μg a.i./larva, respectively. The chronic LD50 values were 0.040 (0.033–0.046) μg a.i./larva for LCY and 0.017 (0.014–0.019) μg a.i./larva for SPI, indicating higher toxicity with prolonged exposure. The study also found that the chronic no-observed-effect dose was 0.0125 μg a.i./larva for both pesticides. Chronic exposure to LCY and SPI in the larval stage resulted in deformed wings and antennae in newly emerged bees. The activities of enzymes related to detoxification, antioxidation, and neurotransmission were altered in bees exposed to these pesticides at sublethal and residue concentrations. Collectively, these data suggest that larval exposure to LCY and SPI disrupts normal development, thus posing a potential health risk to honey bees. Honeybees play a crucial role as agricultural pollinators and are frequently exposed to various pollutants, including pesticides. In this study, we aimed to evaluate the toxicity of lambda-cyhalothrin (LCY) and spinetoram (SPI) in honey bee larvae reared in vitro through single (acute) and repeated (chronic) exposure. The acute LD50 values for LCY and SPI were 0.058 (0.051–0.066) and 0.026 (0.01–0.045) μg a.i./larva, respectively. In chronic exposure, the LD50 values of LCY and SPI were 0.040 (0.033–0.046) and 0.017 (0.014–0.019) μg a.i./larva, respectively. The chronic no-observed-effect dose of LCY and SPI was 0.0125 μg a.i./larva. Adult deformation rates exceeded 30% in all LCY treatment groups, showing statistically significant differences compared to the solvent control group (SCG). Similarly, SPI-treated bees exhibited significantly more deformities than SCG. Furthermore, we examined the activities of several enzymes, namely, acetylcholinesterase (AChE), glutathione-S-transferase (GST), catalase (CAT), and superoxide dismutase (SOD), in larvae, pupae, and newly emerged bees after chronic exposure at the larval stage (honey bee larval chronic LD50, LD50/10 (1/10th of LD50), and LD50/20 (1/20th of LD50)). LCY and SPI induced significant changes in detoxification (GST), antioxidative (SOD and CAT), and signaling enzymes (AChE) during the developmental stages (larvae, pupae, and adults) of honey bees at sublethal and residue levels. Our results indicate that LCY and SPI may affect the development of honey bees and alter the activity of enzymes associated with oxidative stress, detoxification, and neurotransmission. These results highlight the potential risks that LCY and SPI may pose to the health and normal development of honey bees. [ABSTRACT FROM AUTHOR]

The emergence of drug-resistant Mycobacterium tuberculosis (M.tb) has led to the development of novel anti-tuberculosis (anti-TB) drugs. Common methods for testing the efficacy of new drugs, including two-dimensional cell culture models or animal models, have several limitations. Therefore, an appropriate model representative of the human organism is required. Here, we developed an M.tb infection model using human lung organoids (hLOs) and demonstrated that M.tb H37Rv can infect lung epithelial cells and human macrophages (hMφs) in hLOs. This novel M.tb infection model can be cultured long-term and split several times while maintaining a similar number of M.tb H37Rv inside the hLOs. Anti-TB drugs reduced the intracellular survival of M.tb in hLOs. Notably, M.tb growth in hLOs was effectively suppressed at each passage by rifampicin and bedaquiline. Furthermore, a reduction in inflammatory cytokine production and intracellular survival of M.tb were observed upon knockdown of MFN2 and HERPUD1 (host-directed therapeutic targets for TB) in our M.tb H37Rv-infected hLO model. Thus, the incorporation of hMφs and M.tb into hLOs provides a powerful strategy for generating an M.tb infection model. This model can effectively reflect host-pathogen interactions and be utilized to test the efficacy of anti-TB drugs and host-directed therapies. Author summary: Establishment of M.tb infection model is imperative to develop new anti-TB drugs based on the pathogenesis of TB. Various animal models, including mice, rats, guinea pigs, non-human primates, rabbits, cattle, and zebrafish, are commonly used in TB research to mimic TB symptoms and study immune responses to M.tb infection. In vitro models, such as agent-based models allow examination of host-pathogen interactions, early granuloma formation and drug screening, providing cellular-level insights. However, these models may not fully represent human immunopathology owing to differences in immune cell distributions. Lung organoids mimic human lung dynamics and functions, providing crucial insights into immune responses to TB. In this study, an M.tb infection model developed using hLOs demonstrated infection of lung epithelial cells and human macrophages, reflecting host-pathogen interactions. This model is attractive for evaluating the efficacy of anti-TB drugs and host-directed therapies. [ABSTRACT FROM AUTHOR]

Nuclear accidents, such as the Fukushima nuclear accident, have highlighted the necessity for accident‐tolerant fuel (ATF) cladding. Previous studies focused on coating the outside of Zr alloy currently used in nuclear reactors with an oxidation‐resistant material in a vacuum environment. This limits the coating to the inside of the cladding and does not tend to achieve a uniform coating on meter scale cladding. In this study, a room temperature and non‐vacuum‐based swaging–drawing process was demonstrated as an alternative cladding manufacturing process. It enables both the inner and outer sides of the 2‐m‐long Zr alloy cladding to be uniformly covered with a 100‐μm‐thick corrosion‐resistant material (316‐L stainless steel; SS316L), thereby minimizing its high‐temperature oxidation and avoiding failures. After the swaging–drawing process, there was a gap of less than 1 µm between outer SS316L and Zr alloy and a gap of about 12 µm between inner Zr alloy and SS316L. The high‐temperature oxidation properties of the resulting triplex Gachon ATF cladding tube (G‐tube) were evaluated up to 1,200°C in an atmospheric environment. Following heat treatment at 1,200°C, the control cladding completely oxidized and ruptured, potentially causing leakage of radioactive material during application. In contrast, only 15% of the G‐tube cladding manufactured by the swaging–drawing process was oxidized despite a gap, and the Zr alloy of the G‐tube changed phase from α‐Zr to α‐Zr (O) and prior β‐Zr. The cladding microstructure, oxide layer, and oxidation mechanism were analyzed through microscopy, X‐ray diffraction, and thermogravimetric analysis. As a result, it was confirmed that SS316L completely prevented oxygen diffusion into the bulk Zr alloy. In addition, there was no elemental diffusion between SS316L and the Zr alloy. These results demonstrate the feasibility of using room temperature, nonvacuum environment‐based swaging–drawing process to fabricate structurally stable ATF cladding at extremely high temperatures. [ABSTRACT FROM AUTHOR]

• This study examined the home language experience profiles of DLLs in MSHS. • Group 1 had bilingual exposure. Group 2 had more exposure to Spanish from adults. • Child and family characteristics were related to DLLs' profile group membership. • Children in Group 2 presented higher Spanish literacy skills. • Two groups did not differ in conceptual receptive language and English literacy. Children from migrant and seasonal farmworker (MSFW) families are among the most educationally disadvantaged and underserved groups in the United States; however, they have received limited research attention. Using a large nationally representative sample of MSFW children in Migrant and Seasonal Head Start (MSHS) programs, this study offered national portraits of MSHS Spanish-English speaking children's language experience profiles in their homes. Preschool-aged Spanish-English dual language learners (DLLs; N = 280) were classified into two distinct profiles: (1) the Bilingual Exposure group (58.9%), comprising DLLs who had Spanish-English exposure from both adults and children, and (2) the Adult-Spanish, Child-Bilingual Exposure group (41.1%), consisting of DLLs who had Spanish-dominant exposure from adults and exposure to both languages from other children. Compared to the Adult-Spanish, Child-Bilingual Exposure group, children in the Bilingual Exposure group were more likely to come from non-immigrant families, had mothers with higher educational levels, and engaged in more home learning activities. When literacy skills were compared, the Adult-Spanish, Child-Bilingual Exposure group presented higher Spanish letter-word identification skills than the Bilingual Exposure group. No group differences were found in English letter-word identification and bilingual auditory comprehension. Our findings suggest the importance of Spanish language experience at home and call for tailoring educational approaches that consider the diverse home experiences of DLLs attending MSHS. [ABSTRACT FROM AUTHOR]

Objectives: Although the relationship between functional disability and suicidal ideation among older adults has been well documented, limited research exists regarding how socioeconomic status might moderate the relationship between functional disability and suicidal ideation. The objective of this study is to identify the relationship between functional disability and suicidal ideation and assess how SES moderates this relationship among Korean older adults. Methods: Using data from wave 3 of the Korean Retirement and Income Study, this study has conducted a linear regression analysis with interaction terms. Results: There are three main findings. First, the main effects of Activities of Daily Living, Instrumental Activities of Daily Living, and economic status on suicidal ideation were identified. Second, functional disability is identified as a serious risk factor for suicidal ideation among Korean older individuals who express dissatisfaction with their economic circumstances. Last, the moderating effect of economic condition and education on the relationship between functional disability and suicidal ideation exhibited some differences. Conclusion: This study suggests that the interactions of functional disability and economic status yield a significant predictive effect on suicidal ideation in South Korea. [ABSTRACT FROM AUTHOR]

Background/Objectives: The effectiveness of a rhythm control strategy in patients with atrial fibrillation (AF) and reduced left ventricular ejection fraction (LVEF < 50%) in real-world practice remains uncertain. Our objective was to evaluate the real-world outcomes of a rhythm control strategy in patients with AF and reduced LVEF, focusing on changes in LV systolic function and brain natriuretic peptide (BNP) levels. Methods: The study retrospectively reviewed the medical records of 80 patients with concurrent AF and reduced LVEF who underwent rhythm control therapy between March 2015 and December 2021. Results: The patients had an average age of 63.6 years and an initial LVEF of 34.3%. Sinus rhythm was restored using anti-arrhythmic drugs (38, 47.5%) or electrical cardioversion (42, 52.5%). Over a follow-up period of 53.0 months, AF recurred in 65% of patients, with 57.7% undergoing catheter ablation. Significant improvements were noted in LVEF (from 34.3% to 55.1%, p < 0.001) and BNP levels (from 752 pg/mL to 72 pg/mL, p < 0.001) at the last follow-up. Nearly all patients (97.5%) continued with the rhythm control strategy during the follow-up period. Conclusions: In real-world settings, a rhythm control strategy proves to be feasible and effective for improving LVEF and reducing BNP levels in AF patients with reduced LVEF. [ABSTRACT FROM AUTHOR]

Objectives: The aim of this study was to evaluate the validity of a modified STOP-Bang questionnaire with different body mass index reference as a screening tool for obstructive sleep apnea in Korean population. Methods: The medical records of 1417 participants who underwent overnight Level I polysomnography were retrospectively analyzed. Predictive parameters were calculated for each of the 3 groups classified by obstructive sleep apnea severity with a cut-off value of 3 or 4. Responses to modified and traditional questionnaires were comparatively analyzed by receiver-operator characteristic curves and area under the receiver-operator characteristic curves. Results: The optimal cut-off values of the modified and traditional questionnaires were both 3.5. The area under the receiver-operator characteristic curve of modified STOP-Bang questionnaire for any obstructive sleep apnea group was 0.786 ± 0.018, which was significantly higher than that of the traditional questionnaire. The modified STOP-Bang questionnaire with a cut-off value ≥4 showed significantly higher sensitivity than the traditional one for any obstructive sleep apnea group. The diagnostic accuracy of the modified questionnaire was also significantly higher for the any obstructive sleep apnea group when the cut-off value was 4. Conclusion: The modified STOP-Bang questionnaire, with a cut-off value of 4, can be used as an alternative to the traditional screening tool for the Korean population. [ABSTRACT FROM AUTHOR]

In activation mapping of reentrant atrial tachycardia (AT), there was no reference for window of interest (WOI). We examined the timing of a successful termination site from end of the P wave and attempted to determine whether the critical isthmus can be identified using activation mapping when WOI was set as end to end of the P wave. Forty patients with 54 reentrant AT who underwent 3D electroanatomic mapping and radiofrequency catheter ablation were evaluated retrospectively. The critical isthmus was defined as a successful termination site. We evaluate critical isthmus timing from end of the P wave and percentage of critical isthmus timing from end of the P wave to tachycardia cycle length. In 54 reentrant AT, Macro-reentry was identified in 46 (85.2%) and micro-reentry was identified in eight (14.8%). The timing of the critical isthmus site from end of the P wave was − 4.0 ± 31.1 ms (Macro-reentry vs. Micro-reentry; − 8.9 ± 29.4 ms vs. 24.0 ± 26.7 ms; P = 0.005). The percentage of critical isthmus timing from end of the P wave/tachycardia cycle length was − 1.4 ± 10.5% (Macro-reentry vs. Micro-reentry; − 3.1 ± 9.8% vs. 8.3 ± 9.3%, P = 0.004) The critical isthmus of reentrant AT is located within 10% backward and forward from end of the P wave to tachycardia cycle length. Setting the WOI from end to end of the P wave is useful for identification of the critical isthmus through activation mapping. [ABSTRACT FROM AUTHOR]

Worldwide, significant efforts are made to identify energy sources that can help achieve carbon neutrality and promote sustainable development. The development of a catalyst that combines durability and high performance is essential for the commercialization of proton‐exchange membrane fuel cells (PEMFCs). In a fuel cell, carbon corrosion occurs during startup and shutdown due to improper local flooding caused by inadequate water management. In this study, a Pt‐based catalyst is designed with excellent durability and high activity. Introducing a metal oxide layer modified with Pt/multi‐walled carbon nanotubes reduces the direct contact between carbon and the fuel cell environment. This helps prevent carbon corrosion and inhibits the separation, aggregation, and growth of Pt nanoparticles. Moreover, the catalyst exhibits enhanced oxygen reduction activity due to the electronic effect of the metal oxide layer that is coated on it. In this study, by implementing a carbon erosion acceleration protocol, excellent catalytic properties during a load‐cycling experiment consisting of 5,000 cycles are reported. The practical application of the developed catalyst in PEMFCs offers an effective approach to developing Pt‐group metal catalysts with exceptional activity. [ABSTRACT FROM AUTHOR]

[Display omitted] • Upcycling materials were produced composite using clothing waste and PCMs. • Clothing waste, without sorting, was utilized in specimens via a physical process. • The composites demonstrated enhanced latent heat storage capacity. • Clothing waste is valuable for building due to its high insulation. The current volume of clothing waste reached 115 million tons in 2021 and is projected to increase to approximately 150 million tons by 2030. This significant surge in clothing waste has prompted heightened discussions regarding environmentally friendly recycling methods. Clothing presents complex properties, posing substantial challenges to recycling and usually resulting in environmental pollution when disposed. In this study, our recycling approach capitalizes on the differing melting points of textiles. This transformation was achieved through a physical process that included an opening procedure and high temperature heat compression. Textile materials exhibit exceptional thermal properties. Through experimentation on 50 g fiber specimens, thermal conductivities similar to commercial insulation materials were observed, registering an average of 0.0592 W/m·K at 20 °C and 0.06053 W/m·K at 40 °C. This study explores the impregnation of phase change materials (PCMs) into clothing waste-based specimens, equipping them with heat storage capabilities. During the experimental phase, we employed three distinct types of PCMs to evaluate their thermal properties and heat storage capacities in relation to their respective melting temperatures. Through thermal properties analysis, we determined the latent heat capacity of each specimen, ranging from a minimum of 6.63 J/g to a maximum of 75.81 J/g. Our observations indicated a reduction in peak temperature and time-leg effects attributable to the use of PCMs for surface heat flow. This research underscores the superior thermal performance of construction and building materials derived from clothing waste, enhanced by the integration of PCMs, when compared to traditional materials and other waste-derived alternatives. [ABSTRACT FROM AUTHOR]

Given the widespread use of whole slide imaging (WSI) for primary pathological diagnosis, we evaluated its utility in assessing histological grade and biomarker expression (ER, PR, HER2, and Ki67) compared to conventional light microscopy (CLM). In addition, we explored the utility of digital image analysis (DIA) for assessing biomarker expression. Three breast pathologists assessed the Nottingham combined histological grade, its components, and biomarker expression through the immunohistochemistry of core needle biopsy samples obtained from 101 patients with breast cancer using CLM, WSI, and DIA. There was no significant difference in variance between the WSI and CLM agreement rates for the Nottingham grade and its components and biomarker expression. Nuclear pleomorphism emerged as the most variable histologic component in intra- and inter-observer agreement (kappa ≤ 0.577 and kappa ≤ 0.394, respectively). The assessment of biomarker expression using DIA achieved an enhanced kappa compared to the inter-observer agreement. Compared to each observer's assessment, DIA exhibited an improved kappa coefficient for the expression of most biomarkers with CLM and WSI. Using WSI to assess prognostic and predictive factors, including histological grade and biomarker expression in breast cancer, is acceptable. Furthermore, incorporating DIA to assess biomarker expression shows promise for substantially enhancing scoring reproducibility. [ABSTRACT FROM AUTHOR]

Background: Attempts have been made to classify the patterns of polytraumatization using a person‐centered approach. However, most studies have only focused on maltreatment and interpersonal trauma and have been unable to examine various clinical symptoms. Objectives: This study aimed to explore patterns of negative life experiences, including maltreatment, lifetime trauma, and recent stressful life events, and compare diverse dimensions of the clinical manifestations among the subtypes in a clinical sample. Method: We investigated childhood maltreatment, lifetime trauma, and recent stressful events using a self‐report method in 1410 psychiatric patients; we classified the patterns of lifelong negative life experiences using latent profile analysis (LPA). We used the rates of psychiatric diagnosis, the Beck Depression Inventory, the Impact of Event Scale‐Revised (IES‐R‐K), and the Multiphasic Minnesota Personality Inventory‐2‐Restructured Form to compare various symptom dimensions among the derived subtypes. Results: LPA indicated a four‐class solution: mild, recent stress, maltreatment, and multiple adversity group. The multiple adversity group experiencing both lifetime trauma and recent stressful life events, in addition to maltreatment, including sexual abuse, had a high rate of severe mental illness and more symptom dimensions of thought and behavior problems. However, the rates of depressive disorders and emotional/internalizing symptoms were not more than those in the other two groups (recent stress and maltreatment groups) experiencing moderate levels of lifetime trauma. There was no significant difference between the recent stress and maltreatment groups for most symptom dimensions. Conclusions: The findings indicate that distinct symptom profiles may be associated with the pattern of negative experiences, suggesting that negative experiences need multidimensional investigation in clinical settings. [ABSTRACT FROM AUTHOR]

High-k oxide materials for metal–oxide–semiconductor field-effect transistors and metal–oxide–semiconductor (MOS) structure on SiC have been explored to enhance SiC-based device performance. In our experiments, the MOS capacitors with a high-k barium titanate (BaTiO3) insulating layer were fabricated using the aerosol deposition (AD) method, and post-deposition annealed in O2 atmospheres. We examined the effects of post-deposition annealing on the BaTiO3 films and their impact on the surface and electrical characteristics of MOS capacitors. The crystallinity and surface morphologies of the BaTiO3 films were analyzed by X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and atomic force microscopy. We conducted the electrical analysis through current–voltage and capacitance–voltage (C–V) measurements. The post-deposition annealing process effectively reduced the gate leakage current of BaTiO3/4H-SiC and elevated the rectification ratio from 9.12 × 108 to 1.61 × 109. C–V characteristics were measured at 1 MHz to investigate the oxide defect charges inside the MOS capacitors. Near-interface trap density ( N it ) decreased from 9.10 × 1011 to 5.53 × 1011 cm−2 due to post-annealing, which diminished flat band voltage hysteresis. Fixed oxide charge density ( Q f ) also diminished from 4.00 × 1011 to 3.58 × 1011 cm−2, and the oxygen vacancies were compensated by the oxygen atoms introduced from the O2 during the post-deposition annealing. Our findings suggest that the post-deposition annealed process significantly influences surface and electrical properties during BaTiO3 thin film deposition using AD. [ABSTRACT FROM AUTHOR]

The purpose of this study was to determine differences in neurocognitive hop function among individuals with chronic ankle instability, ankle sprain copers, and control participants and identify the relationship between the self-reported function and neurocognitive hop performance; 61 participants across control, ankle sprain coper, and chronic ankle instability groups completed the Cumberland Ankle Instability Tool and the Choice-Reaction Hop Test. There was no significant difference in neurocognitive hop performance among groups. However, there was a large correlation between the Cumberland Ankle Instability Tool and the Choice-Reaction Hop Test. Those with chronic ankle instability with worse self-reported disability concurrently demonstrated decreased performance during the Choice-Reaction Hop Test, reflecting poorer neurocognitive hop performance. [ABSTRACT FROM AUTHOR]

Fusion genes have been implicated in the development and progression of several types of sarcomas, serving as valuable diagnostic and prognostic markers, as well as potential therapeutic targets. We discovered a novel major facilitator superfamily domain‐containing 7 (MFSD7) and adenosine triphosphate 5I (ATP5I) gene fusion from sarcomas. In this study, the MFSD7‐ATP5I fusion transcript was screened using RNA sequencing in 55 sarcoma samples and sixteen normal samples. The MFSD7‐ATP5I fusion transcript was detected in 58% of sarcoma samples. The correlation between the expression of MFSD7‐ATP5I fusion transcript and clinicopathological information was analyzed, and MFSD7‐ATP5I expression is associated with marked pleomorphism and lower tumor necrosis. Cell migration and invasion was significantly reduced by knock‐down of MFSD7‐ATP5I. Cell migration and invasion was increased by overexpression of MFSD7‐ATP5I. A phosphokinase assay demonstrated that MFSD7‐ATP5I is involved in the GSK‐3 pathway. The current study found that MFSD7‐ATP5I is associated with increasing pleomorphism and decreasing necrosis of tumors. And our gain and loss of function experiments prove that MFSD7‐ATP5I promotes the invasiveness of tumor cells. [ABSTRACT FROM AUTHOR]

Visuoperceptual dysfunction is common in Parkinson's disease (PD) and is also reported in its prodromal phase, isolated REM sleep behavior disorder (iRBD). We aimed to investigate color discrimination ability and complex visual illusions known as pareidolias in patients with iRBD and PD compared to healthy controls, and their associating clinical factors. 46 iRBD, 43 PD, and 64 healthy controls performed the Farnsworth–Munsell 100 hue test and noise pareidolia tests. Any relationship between those two visual functions and associations with prodromal motor and non-motor manifestations were evaluated, including MDS-UPDRS part I to III, Cross-Cultural Smell Identification Test, sleep questionnaires, and comprehensive neuropsychological assessment. iRBD and PD patients both performed worse on the Farnsworth–Munsell 100 hue test and had greater number of pareidolias compared to healthy controls. No correlations were found between the extent of impaired color discrimination and pareidolia scores in either group. In iRBD patients, pareidolias were associated with frontal executive dysfunction, while impaired color discrimination was associated with visuospatial dysfunction, hyposmia, and higher MDS-UPDRS-III scores. Pareidolias in PD patients correlated with worse global cognition, whereas color discrimination deficits were associated with frontal executive dysfunction. Color discrimination deficits and pareidolias are frequent but does not correlate with each other from prodromal to clinically established stage of PD. The different pattern of clinical associates with the two visual symptoms suggests that evaluation of both color and pareidolias may aid in revealing the course of neurodegeneration in iRBD and PD patients. [ABSTRACT FROM AUTHOR]

Adequate bowel preparation is an important factor in high-quality colonoscopy. It is generally accepted that a Boston Bowel Preparation Scale (BBPS) score ≥ 6 is adequate, but some reports suggest ≥ 7. Subjects who underwent colonoscopy at least twice within 3 years from August 2015 to December 2019 were included. Polyp detection rates (PDRs), adenoma detection rates (ADRs), and number of polyps including adenomas were compared stratified by baseline colonoscopy (C1) BBPS score. Among 2352 subjects, 529 had BBPS 6 (group 1) and 1823 had BBPS 7–9 (group 2) at C1. There was no significant difference in PDR or ADR at C1 and follow-up colonoscopy (C2) between the two groups. However, the numbers of polyps (1.84 vs. 1.56, P = 0.001) and adenomas (1.02 vs. 0.88, P = 0.034) at C2 were significantly higher in group 1 than group 2, respectively. Segmental BBPS score 2 in group 1 compared to group 2, especially, showed higher PDR (P = 0.001) and ADR (P = 0.007) at C2. BBPS 6 is associated with a higher number of polyps and adenomas in short-term follow-up colonoscopy than BBPS 7–9. To reduce the risk of missed polyps, a thorough examination is necessary for BBPS 6. [ABSTRACT FROM AUTHOR]

CrAl alloy coating has advanced potential to improve corrosion inhibition, hydrophobicity, and electrical conductivity for metallic BPs. The feasibility of CrAl coating for surface modification of the BPs is thoroughly examined through comparative analysis with stainless steel 316L (SS316L). The coated specimen can reach high polarization resistance (R p) and 93% inhibition efficiency (η) from Tafel plots. Based on the various surface properties of CrAl coating, corrosion resistance mechanisms for substitutional solid solution and nanograin structures containing hydrophobic and low surface free energy are proposed. [Display omitted] • Designed as a BCC solid solution, CrAl protects the SS316L BPs in PEMFC environments. • Corrosion resistance mechanisms of CrAl are discussed in terms of the crystal structure and grain boundary diffusion. • The CrAl coated surface is more hydrophobic than SS316L and forms a lower surface free energy. • CrAl possesses lower interfacial contact resistance than bare SS316L both before and after the CA test. [ABSTRACT FROM AUTHOR]

The self-normalization of Shao and Zhang and subsample scan method of Yau and Zhao are combined to produce a test SN for testing breaks for time series data. Unlike the original break test based on self-normalization of Shao and Zhang, the proposed test has power against canceling multiple breaks. The proposed test has several advantages over an existing test TN of Zhang and Lavitas designed for the same purpose of detecting canceling multiple breaks: having no computational burden issue; having stabler size; having no need for specification of a trimming parameter. Comparison is also made with the recent test UN by Schmidt for mean break and by Schmidt et al. for variance break based on U-statistics and shows better size of SN than UN for serially correlated samples but worse power of SN than UN. Unlike UN, SN is a general purpose test which can be used for testing break in any parameter, for example, correlation, under some weak conditions. These advantages recommend us the proposed test SN as a practical alternative to TN and UN in spite of some disadvantages of smaller power and requiring specification of a parameter for the number of windows. [ABSTRACT FROM AUTHOR]

Introduction: Influence of early atrial fibrillation (AF) ablation, particularly cryoballoon ablation (CBA), on clinical outcome during long‐term follow‐up has not been clarified. The objective was to determine whether an early CBA (diagnosis‐to‐ablation of ≤6 months) strategy could affect freedom from AF recurrence after index CBA. Methods: The study included 2605 patients from Korean CBA registry data with follow‐up >12 months after de novo CBA. The primary outcome was recurrence of atrial tachyarrhythmias (ATs) of ≥30‐s after a 3‐month blanking period. Results: Compared to patients in early CBA group, patients in late CBA group had higher prevalence of diabetes, congestive heart failure, and chronic kidney disease, and higher mean CHA2DS2‐VAS score. During mean follow‐up of >21 months, ATs recurrence was detected in 839 (32.2%) patients. The early CBA group showed a significantly lower 2‐year recurrence rate of ATs than the late CBA group (26.1% vs. 31.7%, p = 0.043). In subgroup analysis, the early CBA group showed significantly higher 1‐year and 2‐year freedom from ATs recurrence than the late CBA group only in paroxysmal atrial fibrillation (PAF) patients in overall and propensity score matched cohorts. Multivariate analysis showed that early CBA was an independent factor for preventing ATs recurrence in PAF (hazard ratio: 0.637; 95% confidence intervals: 0.412–0.984). Conclusion: Early CBA strategy, resulting in significantly lower ATs recurrence during 2‐year follow‐up after index CBA, might be considered as an initial rhythm control therapy in patients with paroxysmal AF. [ABSTRACT FROM AUTHOR]

Background: This study aims to understand the clinical and pathological importance of intratumoral budding (ITB) in colorectal cancer (CRC) and its relationship with tumor-infiltrating lymphocytes (TILs). CRCs can be classified into hot (high immunoscore (IS)) and cold (low IS) tumors. Methods: We investigated the number of ITBs in a hotspot area and categorized them into high-ITB (≥5) and low-ITB (<5) groups. The clinicopathological significance of ITB in human CRCs was evaluated, and a detailed analysis based on tumor-infiltrating lymphocytes (TILs) was also performed. Results: High ITB was identified in 59 of 266 CRC cases (22.2%). High ITB significantly correlated with a poorly differentiated tumor, lympho-vascular invasion, perineural invasion, higher pT stage, lymph node metastasis, and higher metastatic lymph node ratio. High ITB was also significantly correlated with a low IS and low CD8-positive lymphocytic infiltrate. The number of ITBs was substantially higher in the low-IS group than in the high-IS group (3.28 ± 3.31 vs. 2.19 ± 2.59; p = 0.005). High ITB significantly correlated with worse overall survival (p = 0.004). In the low-IS group, CRCs with high ITB had a significantly worse prognosis than those with low ITB (p = 0.021). However, there was no significant difference in prognosis between the high- and low-ITB groups in the high-IS group (p = 0.498). Conclusions: Taken together, high ITB was significantly correlated with aggressive tumor behaviors and worse survival in patients with CRCs. In addition, ITB can be useful for the prognostic stratification of CRCs with low IS. [ABSTRACT FROM AUTHOR]

The risk factors for intrusive or problematic sexual behavior in a specific population, including abused or clinically referred children, have been occasionally explored. However, sexual behaviors broadly in the general population have not been investigated. This study aimed to determine whether child characteristics, exposure to trauma, family factors, and exposure to sexuality, which were proposed as predictors of sexual behavior problems in previous studies, significantly affected the general sexual behaviors of children under 10 years in the Korean population. The parents of 652 children aged 3–9 years in a Korean community completed questionnaires, including the Child Sexual Behavior Inventory, the Korean version of the Child Behavior Checklist, Trauma Symptom for Young Children, the Korean version of the Family Inventory of Life and Change, the Dysfunctional Parenting Scale, and exposure to trauma and sexuality. Regression analysis indicated that children's age, externalizing behavior problems, post-traumatic symptoms, exposure to trauma, and exposure to sexuality were significant predictors of overall sexual behaviors. Therefore, it may be helpful to explore trauma and exposure to sexuality even to understand a child's general sexual behavior. In addition, psychoeducation can help parents monitor and reset family boundaries and sexual exposure that can affect children's sexual behavior. [ABSTRACT FROM AUTHOR]

Cathode active materials and conductive additives for thermal batteries operating at high temperatures have attracted research interest, with a particular focus on compounds offering high thermal stability. Recently, FeF3 has been proposed as a candidate for high-voltage cathode materials; however, its commercialization is hindered by its low conductivity. In this study, conductive additives, such as Ni-coated carbon composites (multi-walled carbon nanotubes (MWCNTs) and carbon black (CB)), were utilized to enhance the thermal stability and conductivity of FeF3. The incorporation of metal–carbon conductive additives in the FeF3 composite increased the thermal stability by more than 10 wt.% and ensured high capacity upon conductivity enhancement. The FeF3@Ni/MWCB 15 wt.% composite containing 30 wt.% Ni exhibited a discharge capacity of ∼86% of the theoretical capacity of 712 mAh/g. The use of Ni-coated carbon-based conductive additives will allow the application of FeF3 as an effective high-temperature cathode material for thermal batteries. [ABSTRACT FROM AUTHOR]

Over the past decades, the design of active catalysts has been the subject of intense research efforts. However, there has been significantly less deliberate emphasis on rationally designing a catalyst system with a prolonged stability. A major obstacle comes from the ambiguity behind how catalyst degrades. Several degradation mechanisms are proposed in literature, but with a lack of systematic studies, the causal relations between degradation and those proposed mechanisms remain ambiguous. Here, a systematic study of a catalyst system comprising of small particles and single atoms of Pt sandwiched between graphene layers, GR/Pt/GR, is studied to unravel the degradation mechanism of the studied electrocatalyst for oxygen reduction reaction(ORR). Catalyst suffers from atomic dissolution under ORR harsh acidic and oxidizing operation voltages. Single atoms trapped in point defects within the top graphene layer on their way hopping through toward the surface of GR/Pt/GR architecture. Trapping mechanism renders individual Pt atoms as single atom catalyst sites catalyzing ORR for thousands of cycles before washed away in the electrolyte. The GR/Pt/GR catalysts also compare favorably to state‐of‐the‐art commercial Pt/C catalysts and demonstrates a rational design of a hybrid nanoarchitecture with a prolonged stability for thousands of operation cycles. [ABSTRACT FROM AUTHOR]

This article discusses the variations in sensitization rates to respiratory and food allergens based on age. The study analyzed data from over 344,000 suspected allergy patients and found that the sensitization rates differed across age groups. The allergens were classified into four categories based on their sensitization patterns. Category 1 allergens, such as house dust mites and animals, had the highest sensitization rates in adolescence and gradually decreased with age. Category 2 allergens, including pollen and vegetable allergens, peaked before the age of 20, declined between 21 and 30, and then had a second peak between 51 and 60. Category 3 allergens, such as cockroach and shellfish, had a relatively high sensitization rate in adolescence and no significant change thereafter. Category 4 allergens, such as hen's egg, mammalian milk, and meat, had the highest sensitization rate in children aged 1-10 and gradually declined with age. The study highlights the need for further research to understand the causes of these age-related differences in sensitization patterns. [Extracted from the article]

Objectives: The effects of foot deformities and corrections on the ankle joint without osteoarthritis has received little attention. This study aimed to investigate the effect of flatfoot correction on the ankle joint of patients without osteoarthritis. Methods: Thirty-five patients (24 men and 11 women; mean age 17.5 years) who underwent lateral column lengthening for flatfoot deformities were included. The mean postoperative follow-up period was 20.5 months (standard deviation [SD]: 15.7 months). Radiographic indices were measured pre- and postoperatively, including anteroposterior (AP) and lateral talo-first metatarsal angles, naviculocuboid overlap, position of the articulating talar surface, and lateral talar center migration. Postoperative changes in the radiographic indices were statistically analyzed. Results: There was significant postoperative improvement in flatfoot deformity in terms of AP and lateral talo-first metatarsal angles (p<0.001 and p<0.001, respectively) and naviculocuboid overlap (p<0.001). On lateral radiographs, the talar articulating surface dorsiflexed by 7.3% (p<0.001), and the center of the talar body shifted anteriorly by 0.85 mm (p<0.001) postoperatively. Conclusions: Flatfoot correction using lateral column and Achilles tendon lengthening caused dorsiflexion and an anterior shift of the articular talar body in patients without osteoarthritis. Correction of flatfoot deformity might affect the articular contact area at the ankle joint. The biomechanical effects of this change need to be investigated further. [ABSTRACT FROM AUTHOR]

We report a rare case of isolated malleus dislocation into the external auditory canal with lateralized intact tympanic membrane following a head trauma. The patient was a 63-year-old woman who presented at the outpatient department of our institute with hearing loss of 10 years' duration after a bicycle accident. During physical examination of the patient, total dislocation of the malleus-like bony structure into the external auditory canal on the right side was observed. In the computed tomography scan, an isolated malleus dislocation with intact incus-stapes articulation was identified. The patient was successfully treated with endoscopic exploratory tympanotomy and partial ossicular replacement prosthesis. The isolated malleus dislocation can rarely occur after trauma. A careful diagnostic step through history, physical examination, and temporal bone computed tomography scan are needed to confirm this rare condition. [ABSTRACT FROM AUTHOR]

Considerable research is being conducted on the use of FeF3 as a cathode replacement for FeS2 in thermal batteries. However, FeF3 alone is inefficient as a cathode active material because of its low electrical conductivity due to its wide bandgap (5.96 eV). Herein, acetylene black and multi-walled carbon nanotubes (MWCNTs) were combined with FeF3, and the ratio was optimized. When acetylene black and MWCNTs were added separately to FeF3, the electrical conductivity increased, but the mechanical strength decreased. When acetylene black and MWCNTs were both added to FeF3, the FeF3/M1AB4 sample (with 1 wt.% MWCNTs and 4% AB) afforded a discharge capacity of approximately 74% of the theoretical capacity (712 mAh/g) of FeF3. Considering the electrical conductivity and mechanical strength, this composition was confirmed to be the most suitable. [ABSTRACT FROM AUTHOR]

Individuals with Chronic Ankle Instability (CAI) demonstrate altered gait mechanics, impaired proprioception, and decreased postural control. In addition, individuals with CAI have been found to have complex neurophysiological changes, including during dual-task perturbations. However, the results of studies on whether cognitive tasks affect postural control are inconclusive. Do individuals with CAI have worse dual-task performance compared to healthy controls? We searched 4 electronic databases (PubMed, MEDLINE, Cumulative Index of Nursing and Allied Health Literature, and SPORTDiscus) from inception to October 2022. Search terms consisted of: ("dual-task*" OR "dual task*" OR dual-task OR Multitask* OR Multi-task* OR attention OR cognit*) AND (balance OR "postural control" OR "postural sway" OR kinetics OR kinematics OR gait) NOT (concussion OR "traumatic brain injury") combined using the operator "AND" ("ankle sprain" OR "ankle instability" OR CAI). Studies were included if the physical task was postural control or gait, and if they compared control and CAI groups. A total of 9 studies were included in the systematic-review portion, 5 of which were included in the meta-analysis. Due to assessing multiple types of dual-tasks, 10 effects were assessed for meta-analysis across postural control studies. A random-effects model for the control group in the mediolateral direction indicated a significant overall Fisher's Z mean effect size (Δ = 0.732, p = 0.029) with high heterogeneity between studies (Q =76.61; I 2 = 88.25% P < 0.001). There were no significant differences between dual-tasking in the CAI group individually or when comparing control to CAI groups. The results of our study indicate that cognitive loading did not affect the postural control except for the control group in the mediolateral direction. Variations in dual-task results may be due to the difficulty of the task as well as the heterogeneity of CAI groups. • No differences in dual-task effects between those with CAI and controls. • The most common cognitive load during dual-tasks in CAI research is a number-based task. • Walking nor static balance may not be challenging enough to elicit a dual-task response. [ABSTRACT FROM AUTHOR]

Simple Summary: The study focuses on colorectal cancers (CRC) and their molecular subtypes (CMS) based on gene expression. A revised classification system, iCMS, incorporates epithelial status, microsatellite instability, and fibrosis. The research uses iCMS to investigate the connection between CRC and adenomas, examining gene expression and cell types. An in silico method called CiberSortx estimates cell proportions, with a random forest model classifying CMS classes. Results suggest most CRCs are CMS2 or CMS3, while a novel subtype, iCMS2-F/iCMS3-F, is proposed due to enrichment in myofibroblasts. The study highlights the potential of iCMS and in silico methods for CRC and adenoma analysis. Colorectal cancers (CRC) are classified into consensus molecular subtypes (CMS) based on gene expression profiles. The revised classification system iCMS was proposed by considering intrinsic epithelial status, microsatellite instability (MSI), and fibrosis. This study aimed to provide molecular evidence for the adenoma–carcinoma sequence concept by examining CRC and synchronous adenomas using iCMS. Epithelial CMS cell proportion was estimated using CiberSortx, an in silico cell fractionation method that included CMS cell types among the reference cell types. A random forest (RF) model estimated the posterior probabilities of CMS classes, which were compared with the CiberSortx results. Gene expression profiles of the published iCMS signature panel were retrieved from our dataset and subjected to heatmap clustering for classification. Bulk RNA sequencing data were collected from 29 adenocarcinomas and 11 adenoma samples. CiberSortx showed all CRC contained either CMS2 or CMS3 as the major epithelial cancer cell type. The RF model classified approximately half of the CRC as CMS4, whereas CMS4 was hardly detected by CiberSortx. Because they were enriched with myofibroblasts as per the CiberSortx classification, we tentatively designated them as iCMS2-F/iCMS3-F. iCMS coupled with the application of an in silico cell fractionation method can provide the molecular dissection of CRC and adenoma. [ABSTRACT FROM AUTHOR]

Objective: To investigate whether artificial intelligence–based computer-aided diagnosis (AI-CAD) can improve radiologists' performance when used to support radiologists' interpretation of digital mammography (DM) in breast cancer screening. Methods: A retrospective database search identified 3158 asymptomatic Korean women who consecutively underwent screening DM between January and December 2019 without AI-CAD support, and screening DM between February and July 2020 with image interpretation aided by AI-CAD in a tertiary referral hospital using single reading. Propensity score matching was used to match the DM with AI-CAD group in a 1:1 ratio with the DM without AI-CAD group according to age, breast density, experience level of the interpreting radiologist, and screening round. Performance measures were compared with the McNemar test and generalized estimating equations. Results: A total of 1579 women who underwent DM with AI-CAD were matched with 1579 women who underwent DM without AI-CAD. Radiologists showed higher specificity (96% [1500 of 1563] vs 91.6% [1430 of 1561]; p < 0.001) and lower abnormal interpretation rates (AIR) (4.9% [77 of 1579] vs 9.2% [145 of 1579]; p < 0.001) with AI-CAD than without. There was no significant difference in the cancer detection rate (CDR) (AI-CAD vs no AI-CAD, 8.9 vs 8.9 per 1000 examinations; p = 0.999), sensitivity (87.5% vs 77.8%; p = 0.999), and positive predictive value for biopsy (PPV3) (35.0% vs 35.0%; p = 0.999) according to AI-CAD support. Conclusions: AI-CAD increases the specificity for radiologists without decreasing sensitivity as a supportive tool in the single reading of DM for breast cancer screening. Clinical relevance statement: This study shows that AI-CAD could improve the specificity of radiologists' DM interpretation in the single reading system without decreasing sensitivity, suggesting that it can benefit patients by reducing false positive and recall rates. Key Points: • In this retrospective-matched cohort study (DM without AI-CAD vs DM with AI-CAD), radiologists showed higher specificity and lower AIR when AI-CAD was used to support decision-making in DM screening. • CDR, sensitivity, and PPV for biopsy did not differ with and without AI-CAD support. [ABSTRACT FROM AUTHOR]

Bootstrapping tests U ∗ are implemented for the tests U by Schmidt [Detecting changes in the trend function of heteroscedastic time series; 2021. Preprint: arXiv:2108.09206 [math.ST]] for mean break and Schmidt et al. [An asymptotic test for constancy of the variance under short-range dependence. Ann Stat. 2021;49:3460–3481.] for variance break based on U-statistics. The tests U have good powers against epidemic breaks that are common in practice. The test U for variance break is proved to have the nice property of consistency against a general class of alternatives. However, the tests U have non-ignorable finite sample size distortion under serial correlation and/or conditional heteroscedasticity. Our implementation U ∗ based on autoregressive residual bootstrapping and moving block bootstrapping are shown to remedy the size distortion problems of U for mean break and for variance break, respectively, in a Monte-Carlo experiment. The experiment also demonstrates the power advantages of bootstrapping tests over the original tests and other standard break tests against epidemic breaks, which, however, are accompanied by disadvantages against simple single breaks. The proposed bootstrapping tests are well illustrated by break analyses of means and variances of the log-return and realized the volatility of the US S&P 500. [ABSTRACT FROM AUTHOR]

Background: FAM83H has been implicated in cancer progression, and PD1 is an important target for anti-cancer immune checkpoint therapy. Recent studies suggest an association between FAM83H expression and immune infiltration. However, studies on the roles of FAM83H and its relationship with PD1 in breast carcinomas have been limited. Methods: Immunohistochemical expression of FAM83H and PD1 and their prognostic significance were evaluated in 198 breast carcinomas. Results: The expression of FAM83H in cancer cells was significantly associated with the presence of PD1-positive lymphoid cells within breast carcinoma tissue. Individual and co-expression patterns of nuclear FAM83H and PD1 were significantly associated with shorter survival of breast carcinomas in univariate analysis. In multivariate analysis, the expression of nuclear FAM83H (overall survival, p < 0.001; relapse-free survival, p = 0.003), PD1 (overall survival, p < 0.001; relapse-free survival, p = 0.003), and co-expression patterns of nuclear FAM83H and PD1 (overall survival, p < 0.001; relapse-free survival, p < 0.001) were the independent indicators of overall survival and relapse-free survival of breast carcinoma patients. Conclusions: This study suggests a close association between FAM83H expression and the infiltration of PD1-positive lymphoid cells in breast carcinomas and their expression as the prognostic indicators for breast carcinoma patients, and further studies are needed to clarify this relationship. [ABSTRACT FROM AUTHOR]