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Herein, we report an effective copper-catalyzed cascade strategy for the synthesis of sulfonylated benzothiophenes, where the sulfonyl source used in the reaction system is a commercially available bulk sulfonyl chloride. This approach avoids multi-step synthesis of sulfone radical precursors and the use of expensive photocatalysts, as well as shows good functional group tolerance. [ABSTRACT FROM AUTHOR]

Cyclopropenium salts, being the smallest class of aromatic compounds, have garnered extensive scientific interests across several realms of study. Herein, we report a phase‐transfer catalyzed cascade reaction of cyclohexane‐1,3‐dione‐derived enaminones and 3‐aromacyl coumarins utilizing triaminocyclopropenium salts. This reaction efficiently synthesized a diverse set of quinoline‐2,5‐diones in good yields (78%–92%) and notably exhibited excellent diastereoselectivities, often furnishing the products as a single diastereoisomer. The successful gram‐scale reaction and structural modifications of the product fully demonstrated the application potential of this protocol. Mechanistic studies implied that the triaminocyclopropenium ion transported the carbonate ion from the solid phase to the liquid phase to abstract protons, thus dramatically accelerating the reaction process. [ABSTRACT FROM AUTHOR]

The Correction Notice from the Journal of Ovarian Research addresses errors in Table 1 of the original article on in vitro drug testing using patient-derived ovarian cancer organoids. The corrected table provides details on patients with ovarian cancer, including cancer type, treatment regimens, and outcomes. The correction ensures accurate information for research on ovarian cancer treatments and patient outcomes. [Extracted from the article]

This study proposes an agent-based quantum-like model to investigate the individual selection among three or more lotteries while incorporating the decision-making risk and uncertainty. We extend the classical expected utility functions with quantum probabilities and construct the compound belief state to compare one specific lottery belief state against others. The involved decision-making process is represented formally by the comparison operator, which can be decomposed into a few subprocesses. We give an example of individual lottery selection from three lotteries to illustrate the model. Finally, we propose ways to select from more than three lotteries. [ABSTRACT FROM AUTHOR]

We report a step-economic strategy for the direct synthesis of novel polycyclic N-heterocycle-fused naphthoquinones by merging intramolecular oxidative coupling and cascade [4 + 2] cycloaddition. In the protocol, mechanistic investigations suggest that the cascade reaction involves the intermediate spiro polycyclic N-heterocycles and [4 + 2] cycloaddition processes. This protocol is featured with moderate to excellent yields, wide substrate scope, and divergent structures of products. In addition, the photophysical properties of the synthesized products were evaluated. These products exhibit interesting fluorescence properties, and surprisingly, the compounds have the ability to selectively recognize trifluoroacetic acid. [ABSTRACT FROM AUTHOR]

In this paper, we introduce the notion of σ-symmetric amenability of Banach algebras and investigate some hereditary properties of them. We also apply our results to several abstract Segal algebras and group algebras. [ABSTRACT FROM AUTHOR]

This research report the development of an eco-friendly, magnetic nanocatalyst, Fe3O4@SiO2-ABHA-CuCl, for the efficient synthesis of diaryl sulfides incorporating imidazo[1,2-a]pyridine scaffolds. The catalyst was successfully prepared by immobilizing CuCl on magnetic Fe3O4 nanoparticles modified with 4-amino-3-hydroxybenzoic acid. Characterization revealed spherical nanoparticles with a size range of 15-30 nm. The catalyst exhibited excellent catalytic activity in promoting C–H bond sulfenylation of imidazopyridines using the green solvent PEG-400. Remarkably, the catalyst demonstrated exceptional recyclability over eight consecutive cycles without significant loss of activity. Comprehensive analysis confirmed the preservation of the catalyst's magnetic properties and structural integrity after repeated use. [ABSTRACT FROM AUTHOR]

Preeclampsia (PE) poses a life-threatening risk for both mothers and babies, and its onset and progression are linked to endothelial injury. The enzyme 15-lipoxygenase-1 (15-LOX-1), critical in arachidonic acid metabolism, is implicated in various diseases, yet its specific role and precise mechanisms in PE remain largely unknown. In this study, we found that 15-LOX-1 and its main metabolite, 15-HETE, were significantly increased in both the placenta and serum of PE patients. This increase was accompanied by elevated levels of endothelial injury markers, including intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). A positive correlation between 15-LOX-1 and those markers in the placenta. In Alox15 −/− mice, Alox15 deficiency reduced endothelial cell injury in PE-like mice induced by L-NAME. In vitro studies showed that hypoxia-induced upregulation of 15-LOX-1 reduced the cell viability, migration, and angiogenesis of human umbilical vein endothelial cells (HUVECs), while increasing apoptosis and inflammatory cell adhesion. Mechanistically, the p38 MAPK pathway was identified as a downstream target of 15-LOX-1. Knocking down 15-LOX-1 or inhibiting p38 MAPK activation improved endothelial cell injury in hypoxia-treated HUVECs. Furthermore, downregulation of miR-26a-2-3p was found to correlate negatively and colocalize with 15-LOX-1 upregulation in the placenta of PE patients. Luciferase reporter assays further confirmed that miR-26a-2-3p directly bind to the 3′UTR of 15-LOX-1, targeting its expression. Moreover, miR-26a-2-3p agomir ameliorated the PE-like phenotype in mice through the 15-LOX-1/p38 MAPK axis, improving endothelial dysfunction. Therefore, our study provides novel insights into the pathogenesis of PE and highlight modulating the miR-26a-2-3p/15-LOX-1/p38 MAPK axis as a potential therapeutic target for PE. [Display omitted] • 15-LOX-1 and its metabolite 15-HETE was significantly increased in the serum and placenta from PE patients, accompanied by an enhanced endothelial injury factor level. • Alox15 deficiency ameliorated endothelial cell injury in PE-like mice induced by L-NAME. • Abnormal upregulation of 15-LOX-1 contributed to endothelial cell injury induced by hypoxia in cultured HUVECs though inhibiting cell viability, migration, and angiogenesis, promoting cell apoptosis and inflammatory cell adhesion. • p38 MAPK was confirmed to be the downstream of 15-LOX-1. 15-LOX-1 knockdown or inhibition of p38 MAPK activation improved endothelial cell injury in hypoxia-treated HUVECs. • 15-LOX-1 was proved to be the target gene of miR-26a-2-3p. miR-26a-2-3p agomir ameliorates PE-like phenotype in mice though 15-LOX-1/p38 MAPK axis-mediated endothelial cell injury. [ABSTRACT FROM AUTHOR]

To identify differences in human immunodeficiency virus (HIV) risky behavior and healthy practices between rural and urban men who have sex with men (MSM) in Southeast China, a cross-sectional study was conducted on MSM aged ≥ 18 years recruited from four community-based organizations (CBOs) in seven cities in Zhejiang Province between October 2022 and March 2023. An electronic survey questionnaire was completed by the study participants to collect HIV risky behavior and healthy practices. The chi-square test and multiple logistic regression were used for analysis. Among the 1,993 MSM participants, 21.1% (420) were rural MSM. Compared with urban MSM, rural MSM was more likely to have a low level of education (high school and below; 46.2% vs. 40.2%, p = 0.028) and a low annual income (≤ 90,000 RMB; 71.2% vs. 64.7%, p = 0.013). Multiple logistic regression showed that, compared with urban MSM in the past 6 months behaviors, rural MSM had lower odds of finding casual sex partners on the Internet (adjusted odds ratio [aOR]: 0.790, 95% confidence interval [CI]: 0.633–0.986), using stimulants with online casual sex partners (aOR: 0.688, 95% CI: 0.506–0.936), and high odds of ever having sex with a female (aOR: 1.460, 95% CI:1.036–2.058). Rural MSM reported lower odds of an HIV knowledge score of 2–3 (aOR: 0.586, 95% CI: 0.454–0.756), HIV testing more than twice (aOR: 0.583, 95% CI: 0.455–0.748), and obtaining four to five types of HIV information (aOR: 0.661, 95% CI: 0.529–0.826), as well as higher odds of high/very high awareness of HIV infection risk (aOR: 2.312, 95% CI: 1.638–3.263), compared to urban MSM. Rural MSM and urban MSM reported discrepancies in HIV risky behavior, HIV knowledge and HIV-related healthy practices. Paying more attention to HIV risky behavior and improving healthy practices in rural areas may help to prevent HIV transmission. [ABSTRACT FROM AUTHOR]

Coal gangues i a solid waste during the coal mining process and the accumulation of coal gangue will harm the environment. Therefore, solid waste utilization of coal gangue is required to reduce the environmental damage. In this paper, cordierite ceramics are successfully prepared via a solid‐phase sintering using coal gangue, Al2O3, and MgO as raw materials. The effects of sintering temperatures on the microstructures, phase stability, and thermal properties of ceramics are investigated. The results show that the properties of cordierites prepared at 1200°C are close to those of prepared by the traditional method, and the synthesized ceramics have thermal expansion coefficients (TECs) and conductivity of 4.1–10−6 K−1 and 1.72 W·m−1 K−1 at 900°C, respectively. The sample prepared at 1200°C has good wear resistance (η) with a wear resistance coefficient of 0.507, and an excellent thermal shock resistance, which can withstand 15 times of cold and hot shocks at 1100°C without any cracks on the surface. This study systematically elucidates the thermal/mechanical properties of the synthesized cordierite, and the feasibility of using coal gangue as raw materials prepared cordierite ceramics as refractory materials. This work presents an effective solution to mitigate the challenge of coal gangue disposal. [ABSTRACT FROM AUTHOR]

Supercritical carbon dioxide (sCO2) has been proposed as one new alternative separation medium for soil remediation due to its preferrable dissolution properties and environmentally friendly nature. This study is focused on the effects of operation parameters, such as separation pressure, temperature and processing time, on the extraction efficiency of inorganic contaminants (chromium; arsenic) from soil samples by using the newly established kilogram-scale prototype. The prototype system was operated with Cyanex 302 as a chelating agent and methanol as a co-solvent. The extraction efficiency (EE) of chromium (Cr) is experimentally identified to be 97.98% at 35 MPa and 75 °C (with 60 min processing time), while it is found to drop quickly at low temperature and pressure (only 40% under 20 MPa and 35 °C). The EE of arsenic (As) has been identified generally with high efficiency, over 95% for most cases. For chromium (Cr), 30 MPa and 55 °C or higher parameter ranges are recommended to maintain an efficiency over 90%. [ABSTRACT FROM AUTHOR]

This study investigates the impact of climate change on the distribution of Corylus species in China using the MaxEnt model. Key environmental variables, such as Bio6 (mean temperature of the coldest month) and human footprint, emerged as significant determinants of habitat suitability. The study reveals substantial shifts in suitable habitats due to global warming and increased precipitation, with notable expansion towards higher latitudes. Species like Corylus heterophylla Fisch. ex Bess. and Corylus mandshurica Maxim. demonstrate resilience in extreme conditions, highlighting the importance of specific ecological traits for conservation. Future projections under various SSP scenarios predict continued habitat expansion, emphasizing the need for targeted conservation strategies to address the critical role of human activities. This research highlights the complex interplay between climatic, topographic, and anthropogenic factors in shaping Corylus habitats, advocating for integrated adaptive management approaches to ensure their sustainability amid ongoing climate change. [ABSTRACT FROM AUTHOR]

Refractory High entropy alloy (RHEA) is a potential material for coating gas turbine blades and pipeline due to its high-temperature mechanical and chemical properties. In this paper, a series of new NbTiCrFeMoX (x = 0.2, 0.4, 0.6, 0.8, 1) RHEAs were coated on GTD-111 nickel base superalloy by the laser cladding method. The effects of the Mo amount on the microstructure and tensile, creep, corrosion, and wear properties were investigated. XRD results showed that the microstructure of all five coatings included the B2 regular phase, the BCC irregular phase, C14-Laves (FeTi2), and C15-Laves (Cr2Nb). However, with the increase of Mo from 0.2 to 1, the amount of the BCC phase increased from 24.1 to 29.5%, the C14 phase increased from 55.1 to 61.4%, and the amount of the C15 phase decreased from 11.2 to 1.8%. The yield strength increased by increasing the volume fraction of BCC and C14-Laves phases from 328 MPa for the Mo0.2 sample to 685 MPa for the Mo1 specimen. The same factor increased the creep life of RHEA from 43 to 54 h under a force of 450 N and temperature of 800 °C by increasing the places of dislocation locking. The simultaneous presence of the BCC solid solution and Laves phase was one of the factors that reduced the coefficient of friction during the wear test from 0.63 to 0.44 with increasing Mo. Electrochemical tests in 3.5 wt% NaCl solution showed that the RHEAs showed significant corrosion resistance. Specimen Mo1 with the smallest Icorr (1.6103 × 10–6 A cm2) and the highest Ecorr (− 1.2025 V) showed the best corrosion resistance. [ABSTRACT FROM AUTHOR]

In this paper, a special case of the generalized 4-block n-fold IPs is investigated, where B i = B and B has a rank at most 1. Such IPs, called almost combinatorial 4-block n-fold IPs, include the generalized n-fold IPs as a subcase. We are interested in fixed parameter tractable (FPT) algorithms by taking as parameters the dimensions of the blocks and the largest coefficient. For almost combinatorial 4-block n-fold IPs, we first show that there exists some λ ≤ g (γ) such that for any nonzero kernel element g , λ g can always be decomposed into kernel elements in the same orthant whose ℓ ∞ -norm is bounded by g (γ) (while g itself might not admit such a decomposition), where g is a computable function and γ is an upper bound on the dimensions of the blocks and the largest coefficient. Based on this, we are able to bound the ℓ ∞ -norm of Graver basis elements by O (g (γ) n) and develop an O (g (γ) n 3 + o (1) L ^ 2) -time algorithm (here L ^ denotes the logarithm of the largest absolute value occurring in the input). Additionally, we show that the ℓ ∞ -norm of Graver basis elements is Ω (n) . As applications, almost combinatorial 4-block n-fold IPs can be used to model generalizations of classical problems, including scheduling with rejection, bi-criteria scheduling, and a generalized delivery problem. Therefore, our FPT algorithm establishes a general framework to settle these problems. [ABSTRACT FROM AUTHOR]

It is well documented that motherhood influences gendered outcomes in work institutions. However, how paid work influences women's private sphere and sense of self remains unclear and could vary across societies. This article focuses on identity construction among 28 college‐educated stay‐at‐home mothers in Shanghai. The findings from semi‐structured, in‐depth interviews reveal tension negotiation and reconciliation within these mothers' multiple self‐identities. Despite choosing to voluntarily leave their paid jobs and become stay‐at‐home mothers, participants differentiated between their maternal identity and their stay‐at‐home mother identity; in particular, they perceived motherhood as more valuable and socially acceptable than the choice to be a stay‐at‐home mother (i.e., participants readily identified as mothers but hesitated to describe themselves as stay‐at‐home mothers). To avoid this tension and protect their self‐image, participants incorporated aspects of their previous working identity into their stay‐at‐home mother identity, such as taking part‐time jobs and framing their childrearing experience as a future career asset. The results help explain how the notion of work shapes women's self‐image, even when they leave the labor market. Overall, the findings reinforce mothering imperatives and identities and the need to understand them from a cross‐cultural perspective in relation to societal prevailing gender norms. [ABSTRACT FROM AUTHOR]

With the gradual penetration of the Internet into the study and life of college students, the Internet not only brings convenience to young adults but also becomes a new channel for them to engage in deviant behaviors. This study explores the relationship between stressful life events and college students' online deviant behaviors, as well as the mediating role of negative automatic thoughts and the moderating role of perceived social support. Data is drawn from 448 college students (Mage = 20.10, SDage = 1.74). Results showed that stressful life events were significantly positively correlated with online deviant behaviors, and negative automatic thoughts mediated the relationship between stressful life events and online deviant behaviors. The relationship between stressful life events and online deviant behaviors, as well as that between negative automatic thoughts and online deviant behaviors, were both moderated by perceived social support. This study provides a practical guiding value for effectively preventing and intervening in college students' online deviant behaviors and maintaining the regular order of the online society. [ABSTRACT FROM AUTHOR]

The acoustoelastic technique shows considerable potential for in situ stress measurement in concrete. However, the current technology is not fully developed, and challenges primarily arise from the intricate nature of concrete, along with various factors affecting its acoustoelastic properties, such as material strength, aggregate size, porosity, temperature, and humidity. A comprehensive understanding of how these factors influence the acoustoelastic characteristics of concrete is essential for advancing acoustoelastic technology in engineering applications. This study specifically focuses on the material strength, a pivotal factor influencing the quality of concrete, and explores its correlation with the acoustoelastic coefficient (AEC). An initial theoretical investigation was conducted to establish a theoretical model between the two factors, involving two steps: (1) integrating the empirical formula correlating material strength and Young's modulus into the acoustoelastic equations for bulk waves to derive the formula connecting AECs and concrete strengths; (2) applying qualitative analysis and statistical methods to assess the monotonic properties of the formula within its defined domain. To validate the accuracy of the theoretical model, acoustoelastic tests were conducted on prismatic concrete specimens with five different strength levels under axial compressive stress. The findings revealed a consistent pattern, demonstrating that the AECs of concrete decrease with an increase in material strength under axial compressive stress. The outcomes of this study make a substantial contribution to establishing a theoretical foundation for the development of concrete stress monitoring technology based on the ultrasonic method. Practical Applications: The safety of concrete structures is paramount. Currently, structural performance assessment relies primarily on on-site inspections and evaluations by professionals to detect visible cracks and deformations. Typically, cracks become apparent only once the damage has reached a critical level. Failure to identify deterioration processes before reaching this critical stage necessitates significant repairs to prevent premature failure of concrete structural components. If the in situ stress information of structures can be nondestructively obtained would be highly beneficial for warning the early deterioration, tracking the evolution of crack or damage, and forecasting the remaining service life of structures. Acoustoelastic techniques have demonstrated significant potential in achieving this objective. Nonetheless, concrete acoustoelastic effects are influenced by various factors, such as material strength, aggregate size, porosity, and environmental conditions, which impede further advancement of this technology. Therefore, this study investigated the dependence of concrete acoustoelastic effects on material strength. Correlation equations between concrete strength and acoustoelastic coefficients have been formulated. The application of these equations in practice can mitigate the impact of material strength on acoustoelastic measurements. This research contributes to advancing the engineering applications of acoustoelastic techniques in concrete stress assessment. [ABSTRACT FROM AUTHOR]

Programmable stimuli‐responsive hydrogels have rapidly developed for various complex biomimetic actuations, but they commonly can only be programmed once. Herein, a flatworm‐like hydrogel (FLH) with bi‐surface double‐network structure (photothermal‐responsive FLH‐1 and pH‐responsive FLH‐2) has been explored, through UV‐polymerizing sodium poly(methylacrylic‐acid) (PMAA‐Na) and poly (N‐isopropylacrylamide) (PNIPAM) second‐networks on two surfaces of polyacrylamide‐graphene (PAAm‐G) substrate hydrogel first‐network respectively. First, the graphene can both control the thickness of the UV‐polymerized surface second‐network and endow the FLH with high‐efficient photothermal conversion for near‐infrared light (NIR)‐responsive actuation. More importantly, different from common pH‐/photothermal bi‐responsive actuating hydrogels, one FLH can be designed as various original shapes by pH‐responsive FLH‐2, for reprogrammable NIR‐responsive multimode complex actuations via FLH‐1. Finally, the FLH‐1 and FLH‐2 can be strongly integrated together by the interpenetrating structure of flatworm‐like structure between second‐network and first‐network, to endow the FLH with excellent stability for enduring complex deformations. Consequently, the synergy of re‐programmable original shapes via FLH‐2 and NIR‐responsive actuation by FLH‐1, can endow one FLH with multimode actuations for high‐level biomimetic devices. This work can provide a general method by non‐touching design of re‐programmable hydrogel with two stimuli‐responsive layers for multimode complex actuations, which also will inspire explorations of other reprogrammable intelligent materials. [ABSTRACT FROM AUTHOR]

Background: Prostate cancer (PCa) is a leading malignancy among men globally, with rising incidence rates emphasizing the critical need for better detection and therapeutic approaches. The roles of HSP90AB1 and PARP1 in prostate cancer cells suggest potential targets for enhancing treatment efficacy. Methods: This study investigated the overexpression of HSP90AB1 and PARP1 in prostate cancer cells and the impact of HSP90AB1 knockdown on the sensitivity of these cells to the PARP inhibitor olaparib. We also explored the combined effect of olaparib and celastrol, an HSP90 inhibitor, on the clonogenic survival, migration, proliferation, and overall viability of prostate cancer cells, alongside the modulation of the PI3K/AKT pathway. An in vivo PC3 xenograft mouse model was used to assess the antitumor effects of the combined treatment. Results: Our findings revealed significant overexpression of HSP90AB1 and PARP1 in prostate cancer cells. Knockdown of HSP90AB1 increased cell sensitivity to olaparib. The combination of olaparib and celastrol significantly reduced prostate cancer cell survival, migration, proliferation, and enhanced cumulative DNA damage. Celastrol also downregulated the PI3K/AKT pathway, increasing cell susceptibility to olaparib. In vivo experiments demonstrated that celastrol and olaparib together exerted strong antitumor effects. Conclusions: The study indicates that targeting both HSP90AB1 and PARP1 presents a promising therapeutic strategy for prostate cancer. The synergistic combination of celastrol and olaparib enhances the efficacy of treatment against prostate cancer, offering a potent approach to combat this disease. [ABSTRACT FROM AUTHOR]

Background: Fat mass and obesity‐associated gene (FTO) genes rs9939609 is strongly associated with obesity and rs17817449 is an important and potential gene for obesity, have been well established. We aim to evaluate the relationship between FTO gene and overweight/obesity and confirm the influence of obesity on glucose and lipid metabolism parameters. Methods: We investigated 183 normal weight subjects and 193 individuals with overweight/obesity. Firstly, the effect of overweight/obesity on glucose and lipid metabolism parameters was analyzed. Then, the FTO genes rs9939609 and rs17817449 were counted to explore whether polymorphisms were associated with overweight/obesity and metabolic parameters. Results: Significant differences existed in glucose and lipid parameters between the group with overweight/obesity and control group. The rs9939609 and rs17817449 were strongly correlated with overweight/obesity. Haplotype analysis revealed that GA and GT haplotypes had 2.99 and 1.81 fold risk of overweight/obesity. FTO polymorphism also has effects on glucose and lipid metabolism parameters. Conclusions: There is a linkage imbalance between rs9939609 and rs17817449 in a Central China general population cohort, which also reflected the influence of FTO gene on the risk of overweight/obesity and total cholesterol (TC), triglyceride (TG), and high‐density lipoprotein (HDL) disorders. The new findings could provide new clues to predict obesity and metabolic diseases. [ABSTRACT FROM AUTHOR]

Y3NbO7 is regarded as a prospective material for utilization in thermal barrier coating applications, given its low thermal conductivity, high thermal expansion coefficients (TECs), and low oxygen ion conductivity. This study focuses on the dominant mechanisms of thermal properties of Y3-xAxNbO7 (A = Ca, In, Mg, Al; x = 0.05, 0.1) through the introduction of different types of cations. The oxygen ion conductivity of Y3-xAxNbO7 is as low as 2.16 × 10−5 S·cm−1 at 900 °C, which is dominated by contents of oxygen vacancies and electronegativity disorder. Three factors can contribute to reduction in thermal conductivity, including the phonon scattering caused by point defects, disorders in at. wt., ionic radius, and electronegativity, as well as atomic displacement parameters (ADPs). A comparison of the correlation between lattice point defects and thermal conductivity reveals that they are not the primary factor contributing to reduction in thermal conductivity. Conversely, doping elements with larger ADPs have been shown to significantly enhance the intensity of an-harmonic vibrations, thereby increasing TECs to 11.93 × 10−6 K−1 at 1400 °C and reducing thermal conductivity to 1.25 W m−1 K−1 at 25 °C. The effects of ADPs on reducing thermal conductivity overweigh that of lattice point defects in Y3NbO7 ceramics, and both TECs and thermal conductivity are optimized at the same time. This work proposes that large atomic displacements can act as a means of reducing thermal conductivity and increasing TECs for various ceramics. [ABSTRACT FROM AUTHOR]

Background: Prostate cancer (PCa) is one of the most prevalent malignancies in males worldwide. Increasing research attention has focused on the PCa microenvironment, which plays a crucial role in tumor progression and therapy resistance. This review aims to provide a comprehensive overview of the key components of the PCa microenvironment, including immune cells, vascular systems, stromal cells, and microbiota, and explore their implications for diagnosis and treatment. Methods: Keywords such as "prostate cancer", "tumor microenvironment", "immune cells", "vascular system", "stromal cells", and "microbiota" were used for literature retrieval through online databases including PubMed and Web of Science. Studies related to the PCa microenvironment were selected, with a particular focus on those discussing the roles of immune cells, vascular systems, stromal cells, and microbiota in the development, progression, and treatment of PCa. The selection criteria prioritized peer-reviewed articles published in the last five years, aiming to summarize and analyze the latest research advancements and clinical relevance regarding the PCa microenvironment. Results: The PCa microenvironment is highly complex and dynamic, with immune cells contributing to immunosuppressive conditions, stromal cells promoting tumor growth, and microbiota potentially affecting androgen metabolism. Vascular systems support angiogenesis, which fosters tumor expansion. Understanding these components offers insight into the mechanisms driving PCa progression and opens avenues for novel therapeutic strategies targeting the tumor microenvironment. Conclusions: A deeper understanding of the PCa microenvironment is crucial for advancing diagnostic techniques and developing precision therapies. This review highlights the potential of targeting the microenvironment to improve patient outcomes, emphasizing its significance in the broader context of PCa research and treatment innovation. [ABSTRACT FROM AUTHOR]

Background Over the past 20 years, over 5 million cases of chikungunya, a mosquito-transmitted viral disease, have been reported in over 110 countries. Until recently, preventative strategies for chikungunya were largely ineffective, relying on vector control and individual avoidance of mosquito bites. Methods This review outlines the preclinical and clinical efficacy and safety data that led to the approval of VLA1553 (IXCHIQ®), a live-attenuated vaccine against chikungunya disease. It also describes the innovative development pathway of VLA1553, based on an immunological surrogate of protection, and discusses ongoing and future post-licensure studies. Results In mice and non-human primate models, VLA1553 elicited high titres of neutralizing antibodies, conferred protection against wild-type chikungunya virus challenge and raised no safety concerns. A Phase 1 clinical trial of VLA1553 demonstrated 100% seroconversion among 120 healthy participants, with sustained neutralizing antibody titres after 12 months. These results and determination of a surrogate marker of protection led to advancement of VLA1553 directly into Phase 3 clinical development, as agreed with the US Food and Drug Administration (FDA) and the European Medicines Agency. The pivotal Phase 3 trial met its primary immunogenicity endpoint, achieving seroprotective levels based on immuno-bridging in baseline seronegative participants 28 days post-vaccination. These findings enabled submission of a Biologics Licence Application to the FDA for accelerated approval of VLA1553 in the US for adults aged ≥18 years. Ongoing and planned studies will confirm the clinical efficacy/effectiveness and safety of VLA1553 in adults and younger individuals, and will generate data in chikungunya endemic countries that have the highest unmet need. Conclusion VLA1553 is the first vaccine approved for the prevention of chikungunya disease in adults, following accelerated development based on a serological surrogate marker of protection. VLA1553 adds to strategies to reduce the spread and burden of chikungunya in endemic populations and travellers. [ABSTRACT FROM AUTHOR]

Objective: To understand whether TSH suppressive therapy affect short‐term postoperative cancer‐related depression and anxiety among DTC patients. To evaluate short‐term postoperative psychological problems and its relationship with baseline parameters, fatigue, sleep quality, illness perception, and patients' quality of life. Study Design and Methods: This was a prospective, observational, single center study. This study involved 831 TC patients who consecutively admitted to the inpatient department of hospital between 1st June 2020 and 31th February 2021. Results: Mean scores of the self‐rated anxiety scale (SAS) (49.04 vs. 40.69) and self‐rated depression scale (SDS) (44.61 vs. 39.86), as well as the incidence of anxiety (41.5% vs. 22.1%) and depression (22.5% vs. 2.4%) significantly decreased 3 months after surgery. For personal and clinical characteristics, low educational background (SAS, β = 1.392; SDS, β = 1.622; and p < 0.05), without children (SAS, β = 4.068; SDS, β = 1.873, and p < 0.01), FNAC (SAS, β = −0.981; SDS, β = −2.583; and p < 0.05), and multifocal tumor (SAS, β = −1.287; SDS, β = −2.681; and p < 0.05) were the main effects for both short‐term postoperative anxiety and depression. Multiple linear regression analysis identified the serum TSH level as a significant variable associated with worse SAS (Beta = −0.695 and p = 0.043) and SDS (Beta = −3.133 and p < 0.001) scores 3 months after surgery. FT4 was independently associated with SAS scores (Beta = −0.202 and p < 0.001). Patients with middle ATA risk had a significantly higher level of SDS scores (p = 0.033). Conclusion: We confirmed that cancer‐related anxiety and depression among DTC patients significantly alleviated 3 months after surgery. TSH suppression therapy has profound effects on cancer‐related anxiety and depression, and the degree of anxiety and depression significantly deteriorated with the decrease of TSH level. [ABSTRACT FROM AUTHOR]

Background: Ovarian cancer is the most lethal gynecological cancer. As the primary treatment, chemotherapy has a response rate of only 60–70% in advanced stages, and even lower as a second-line treatment. Despite guideline recommendations, which drugs will be most effective remains unclear. Thus, a strategy to prioritize chemotherapy options is urgently needed. Cancer organoids have recently emerged as a method for in vitro drug testing. However, limited clinical correlations have been assessed with test results from cancer organoids, particularly in gynecological cancers. We therefore aimed to generate patient-derived organoids (PDOs) of ovarian cancer, to assess their drug sensitivities and correlations with patient clinical outcomes. Methods: PDOs were generated from fresh tumors obtained during surgical resection, which was then cultured under matrix gel and appropriate growth factors. Morphological and molecular characterization of PDOs were assessed by phase contrast microscopy and paraffin-embedded histopathology. Expressions of PAX8, TP53, WT1, CK7, and CK20 were tested by immunohistochemical staining and compared with parental tumor tissues and the human protein atlas database. PDOs were subjected to in vitro drug testing to determine drug sensitivity using Titer-Glo® 3D Cell Viability Assay. PDO viability was measured, and area under the curve calculated, to compare responses to various compounds. Correlations were calculated between selected patients' clinical outcomes and in vitro drug testing results. Results: We established 31 PDOs. Among them, 28 PDOs can be expanded, including 15, 11, and 2 from ovarian, endometrial, and cervical cancers, respectively. The PDOs preserved the histopathological profiles of their originating tumors. In vitro drug testing of 10 ovarian cancer PDOs revealed individual differential responses to recommended drugs, and interpersonal heterogeneity in drug sensitivity, even with the same histology type. Among four patients who were platinum sensitive, resistant, or refractory, PDO drug responses correlated well with their clinical courses. Conclusion: In vitro drug testing using ovarian cancer organoids is feasible and correlates well with patient clinical responses. These results may facilitate development of precision chemotherapy and personalized screening for repurposed or new drugs. [ABSTRACT FROM AUTHOR]

With the advancement of Industry 4.0, Time-Sensitive Networking (TSN) has become essential for ensuring prompt and reliable data transmission. As an augmentation of Ethernet, TSN aims to supply services capable of low latency, minimal jitter, and low packet loss for urgent data in decentralized, user-oriented networks. Efficient detection techniques are integral to TSN for swiftly determining the practicability of network configurations, as existing schedulability analysis proves insufficient. This paper delves into the potential of backpropagation neural networks (BPNN) in schedulability analysis efficiency. We optimize BPNN using spearman correlation feature selection combined with a voting ensemble method and Particle Swarm Optimization (PSO), forming two models: Spearman-Vote-BPNN and Spearman-PSO-BPNN. Testing on 5,000 network configurations in computer simulations, both models demonstrated high generalization accuracy, around 97.4%. Spearman-Vote-BPNN achieved the fastest training speed at 0.63 s and an accuracy of 98.2%. Meanwhile, Spearman-PSO-BPNN showed the highest accuracy (98.5%) with the quickest detection speed (5.6 ms). The outcomes of this research significantly advance the efficacy and precision of TSN network configuration detection and establish a formidable groundwork for future scholarly pursuits in this area. [ABSTRACT FROM AUTHOR]

Excellent mechanical properties are indispensable for thermal barrier coatings (TBCs), including high hardness and low modulus, as well as excellent creep and wear resistance. This study focuses on nanomechanical properties of RENbO4 (RE = La, Gd, Dy, Y, Yb), and the effects of microstructures on their properties are analyzed. The evolutions of hardness and modulus of RENbO4 are studied based on the changes of RE3+ ionic radius, and the shorter bond lengths lead to the higher hardness and modulus due to the increasing bonding strength. The existence of ferroelastic domains causes the presence of pop out during nanoindentation, which affects the elastic and plastic work. Based on the load‐displacement curves, we further analysis the creep behavior and wear resistance of RENbO4 ceramics, and the results show that these two parameters show a negative correlation. Among the studied RENbO4 ceramics, YbNbO4 exhibits the best mechanical properties, and the used methods in current paper can be employed to screen materials with outstanding properties for various applications. [ABSTRACT FROM AUTHOR]

[Display omitted] Saline–alkali land is an important cultivated land reserve resource for tackling global climate change and ensuring food security, partly because it can store large amounts of carbon (C). However, it is unclear how saline–alkali land reclamation (converting saline–alkali land into cultivated land) affects soil C storage. We collected 189 adjacent pairs of salt-affected and cultivated soil samples (0–30 cm deep) from the Songnen Plain, eastern coastal area, Hetao Plain, and northwestern arid area in China. Various soil properties, the soil inorganic C (SIC), organic C (SOC), particulate organic C (POC), and mineral-associated organic C (MAOC) densities, and plant- and microbial-derived C accumulation were determined. Saline–alkali land reclamation inconsistently affected the SIC density but significantly (P < 0.001) increased the SOC density. The SOC, POC, and MAOC densities were predicted well by the integrative soil amelioration index. Saline–alkali land reclamation significantly increased plant-derived C accumulation and the plant-derived C to microbial-derived C ratios in all saline–alkali areas, and less microbial transformation of plant-derived C (i.e., less lignin degradation or oxidation) occurred in cultivated soils than salt-affected soils. The results indicated that saline–alkali land reclamation leads to plant-derived C becoming the dominant contributor of SOC storage. POC storage and MAOC storage were strongly linked to plant- and microbial-derived C accumulation, respectively, caused by saline–alkali land reclamation. Our findings suggest that saline–alkali land reclamation increases C storage in topsoil by preferentially promoting plant-derived C accumulation. [ABSTRACT FROM AUTHOR]

This investigation comprehensively examines the nano - mechanical properties of AlTaO 4 for the first time, including Young's modulus (E), hardness (H), and fracture toughness (K IC). Variability in the regional distribution of E and H within AlTaO 4 is elucidated through an examination spanning both the grain and bulk material scales, and offers a correlational equation of E and H from fit statistical outcomes. Additionally, the H/E ratio and micro-hardness dissipation parameter of AlTaO 4 reach 0.063 and 0.61, respectively, which demonstrate its exceptional wear resistance. Further investigation emphasizes that the distinctive crystalline structure, short bond lengths, high bond strength, and elevated charge density around aluminum ions significantly contribute to the high E (208 GPa) and H (13.1 GPa) of AlTaO 4. The capacity for energy absorption during elastic deformation enhances crack formation energy and contributes to the relatively high fracture toughness (2.6 MPa m1/2) of AlTaO 4. This work elucidates the excellent mechanical properties of AlTaO 4 by applying nanoindentation and first-principle calculation, which will advance the applications of AlTaO 4 as high-temperature materials. [ABSTRACT FROM AUTHOR]

Thermal simulation of a Printed Circuit Board (PCB) can help identify potential overheating risks in the circuit. The proposed modeling method combines analytical temperature solutions and numerical approximations. Only Fourier-series analytical solutions related to the prepreg-layer surfaces need to be calculated, rather than the entire structure. Heat transfer through the lateral sides of a PCB is approximately considered as part of the compensated heat flux of the insulating-layer surface boundaries. Heat diffusion within or between metal layers is numerically approximated using the finite volume method. The core layer is treated as "thermally-thick". Temperature-dependent boundary conditions are considered through iterations. A test solver was developed based on the method. The modeling accuracy was validated by comparison with COMSOL Multiphysics for a four-layer structure with a moderate degree of discretization. Additionally, a PCB for generating DC 3.3V was designed, tested, and modeled, with the modeling results confirmed by the thermal images. The electro-thermal analysis of the distribution of electric potential and Joule heating in traces and vias was integrated into the PCB model. The layout maps of the PCB were further adjusted to reduce Joule heating in the output circuit, and the improvement on reducing the IR drop and hotspot temperature was examined. [ABSTRACT FROM AUTHOR]

Referring to the intestinal ischemic injury caused by sudden interruption of the blood supply, acute mesenteric ischemia (AMI) is a highly fatal emergency with mortality rates varying from 58 to 80%. The aim of this study was to explore the effect of temperature on AMI admission. This was a retrospective, multicentric study. The medical records of 1477 patients with verified AMI who were consecutively admitted to 3 hospitals anytime between January 2010 and December 2020 were included in the study. Distributed lag non-linear model was applied, the model was adjusted for temperature, atmospheric pressure, relative humidity, year, holiday, day of the week, time and seasonality. AMI exhibited obvious sex preference, AMI patients tended to be male (M/F ratio = 2.3:1) and in their late 50 s. Hospital admissions of acute mesenteric arterial thromboembolism (AMAT) increased significantly with high temperatures on day of exposure and lag 0–14 day. The effect curve of daily average temperature on acute mesenteric venous thromboembolism (AMVT) admission was J-shaped, and the duration of cold effect was longer, while the duration of heat effect was shorter. An increase in hospital admissions of AMVT was found above 20 °C at lag 0–30. For the first time, our study indicated that temperature is significantly associated with the risk of AMI. Although it is not possible to always avoid exposure to extreme temperatures, one should be aware of dramatic temperature fluctuations and take appropriate precautions. [ABSTRACT FROM AUTHOR]

Activated partial thromboplastin time (aPTT)-based clot waveform analysis (CWA) is a plasma-based global haemostatic assay. Elevated CWA parameters have been associated with hypercoagulability in venous thromboembolism, but its role in arterial thrombotic disease is uncertain. This study aims to explore the relationship between aPTT-based CWA and acute myocardial infarction (AMI) and its complications. In a retrospective cohort study of patients with AMI who underwent emergency cardiac catheterisation, pre-procedural aPTT and CWA parameters—min1, min2 and max2 were measured. These were compared against a control group of patients, consisting of patients who underwent elective orthopaedic and urological procedures. Within the AMI cohort, we also compared aPTT and CWA parameters of those with and without clinical complications of AMI. Results: Compared to controls (N = 109), patients with AMI (N = 214) had shorter aPTT (26.7 ± 3.3 s vs 27.9 ± 1.7 s, P < 0.001) and higher CWA parameters (min1: 6.11 ± 1.40%/s vs 5.58 ± 1.14%/s; min2: 0.98 ± 0.23%/s2 vs 0.90 ± 0.19%/s2; max2: 0.81 ± 0.20%/s2 vs 0.74 ± 0.16%/s2, all P ≤ 0.001). There was an increased incidence of elevated CWA parameters, in the AMI group, with odds ratio (OR) of 2.06 [95% CI 1.10–3.86], 2.23 (95% CI 1.18–4.24) and 2.01 (95% CI 1.07–3.77) for min1, min2 and max2, respectively. Similarly, elevated min1 and min2 were both individually associated with the presence of adverse outcomes of AMI, both with ORs of 2.63 (95% CI 1.24–5.59). Elevated aPTT-based CWA parameters are significantly associated with the occurrence of AMI and its complications. These findings identify the potential utility of CWA as risk and prognostic markers for AMI and warrants future works. [ABSTRACT FROM AUTHOR]

The experiment was to investigate the effects of three species of macroalgae on the growth performance, physiology and biochemistry index of juvenile largemouth bass. A total of 360 juvenile largemouth bass with an initial body weight of (6.04±0.03) g were randomly divided into four groups with three replicates per group and 30 perca per replicate. Group C (Control Group) was fed a basic diet, while Groups T1, T2, and T3 were fed the basic diet supplemented with 5% Gracilaria lemaneiformis powder, 5% Asparagopsis taxiformis powder, and 5% Sargassum powder, respectively, with each group's diet being isonitrogenous and isocaloric. The experiment lasted for 57 days. The results showed that compared to Group C, the feed intake rate and feed coefficient of all experimental groups was significantly increased (P<0.05), and the protein deposition rate and fat deposition rate of Groups T2 and T3 were significantly decreased (P<0.05). The whole fish moisture content of Groups T2 and T3 was significantly increased (P<0.05), while the crude protein and crude fat concentrations were significantly decreased (P<0.05). The crude fat content in the liver of Groups T2 and T3 was significantly decreased (P<0.05). The study shows that the diet with 5% Gracilaria lemaneiformis powder, Asparagopsis taxiformis powder, and Sargassum powder respectively does not affect the growth of juvenile largemouth bass, but can improve its feeding rate and reduce the crude fat of the whole body and liver, and overall effect of juvenile largemouth bass supplemented with Sargassum powder feed is the best. [ABSTRACT FROM AUTHOR]

Twelve commercial species exploited in the eastern Guangdong and southern Fujian waters were assessed using the Catch-Maximum Sustainable Yield (CMSY) and Bayesian Schaefer Model (BSM) methods. The carrying capacity (k), intrinsic rate of population growth (r), maximum sustainable yield (MSY), and relative biomass (Bend/k and B/BMSY) were estimated. The current stock status was defined by B/BMSY and fishing mortality (F/FMSY). The results indicate that seven stocks were overfished or below safe biological limits (B/BMSY < 0.5 or F/FMSY > 1), two stocks were in a recovery phase (0.5 < B/BMSY < 1, F/FMSY < 1), and three stocks were under sustainable fishing pressure with healthy biomass, capable of producing yields close to the MSY (B/BMSY > 1, F/FMSY < 1). The stock statuses are consistent with previous studies on the utilization of pelagic fisheries in the eastern Guangdong and southern Fujian waters and with those assessments in other waters. The results of the assessments suggest that these stocks could be expected to produce higher sustainable catches if permitted to rebuild; thus, more effective and proactive management is needed in this upwelling fishing ground. [ABSTRACT FROM AUTHOR]

Pine wilt disease (PWD) is a devastating plant disease caused by the pinewood nematode (PWN, Bursaphelenchus xylophilus) that is transmitted by several beetle species in the genus, Monochamus. Once present, the disease is difficult to control. Prevention rather than control is regarded as an effective strategy for PWD management. Central to this prevention strategy is the ability to predict the potential distribution of the disease. Here, we employed an integrated MaxEnt and CLIMEX approach to model the potential distribution of PWD under various climate‐change scenarios. Our results indicate that rising temperatures and lower humidity under climate change will render some of the northern regions of China more suitable for the nematode and these beetles, causing the gradual northward movement of PWD. Furthermore, suitable habitats for three pine species, Pinus massoniana, P. taiwanensis and P. shurbergia, overlap with PWN and Monochamus, suggesting that these three species are potentially at high risk of PWD. Thus, PWD management should target the northern regions of China and the three pine species that are most susceptible to PWD. [ABSTRACT FROM AUTHOR]

Background: T cells, the "superstar" of the immune system, play a crucial role in antitumor immunity. T‐cell receptors (TCR) are crucial molecules that enable T cells to identify antigens and start immunological responses. The body has evolved a unique method for rearrangement, resulting in a vast diversity of TCR repertoires. A healthy TCR repertoire is essential for the particular identification of antigens by T cells. Methods: In this article, we systematically summarized the TCR creation mechanisms and analysis methodologies, particularly focusing on the application of next‐generation sequencing (NGS) technology. We explore the TCR repertoire in health and cancer, and discuss the implications of TCR repertoire analysis in understanding carcinogenesis, cancer progression, and treatment. Results: The TCR repertoire analysis has enormous potential for monitoring the emergence and progression of malignancies, as well as assessing therapy response and prognosis. The application of NGS has dramatically accelerated our comprehension of TCR diversity and its role in cancer immunity. Conclusions: To substantiate the significance of TCR repertoires as biomarkers, more thorough and exhaustive research should be conducted. The TCR repertoire analysis, enabled by advanced sequencing technologies, is poised to become a crucial tool in the future of cancer diagnosis, monitoring, and therapy evaluation. [ABSTRACT FROM AUTHOR]

Sea surface temperature (SST) is a crucial physical parameter in meteorology and oceanography. This study demonstrates that the influence of earth incidence angle (EIA) on the SST retrieved from the microwave radiation imager (MWRI) onboard FengYun-3 (FY-3) meteorological satellites should not be ignored. Compared with algorithms that do not consider the influence of EIA in the regression, those that integrate the EIA into the regression can enhance the accuracy of SST retrievals. Subsequently, based on the recalibrated Level 1B data from the FY-3/MWRI, a long-term SST dataset was reprocessed by employing the algorithm that integrates the EIA into the regression. The reprocessed SST data, including FY-3B/MWRI SST during 2010-2019, FY-3C/MWRI SST during 2013-2019, and FY-3D/MWRI SST during 2018-2020, were compared with the in-situ SST and the SST dataset from the Operational Sea Surface Temperature and Ice Analysis (OSTIA). The results show that the FY-3/MWRI SST data were consistent with both the in-situ SST and the OSTIA SST dataset. Compared with the Copernicus Climate Change Service V2.0 SST, the absolute deviation of the reprocessed SST, with a quality flag of 50, was less than 1.5°C. The root mean square errors of the FY-3/MWRI orbital, daily, and monthly SSTs, with a quality flag of 50, were approximately 0.82°C, 0.69°C, and 0.37°C, respectively. The primary discrepancies between the FY-3/MWRI SST and the OSTIA SST were found mainly in the regions of the western boundary current and the Antarctic Circumpolar Current. Overall, this reprocessed SST product is recommended for El Niño and La Niña events monitoring. [ABSTRACT FROM AUTHOR]

Hepatocellular carcinoma (HCC), the primary form of liver cancer, is the third leading cause of cancer-related death globally. Hernandonine is a natural alkaloid derived from Hernandia nymphaeifolia that has been shown to exert various biological functions. In a previous study, hernandonine was shown to suppress the proliferation of several solid tumor cell lines without affecting normal human cell lines. However, little is known about the effect of hernandonine on HCC. Therefore, this study aimed to investigate the effect and mechanism of hernandonine on HCC in relation to autophagy. We found that hernandonine inhibited HCC cell growth in vitro and in vivo. In addition, hernandonine elicited autophagic cell death and DNA damage in HCC cells. RNA-seq analysis revealed that hernandonine upregulated p53 and Hippo signaling pathway-related genes in HCC cells. Small RNA interference of p53 resulted in hernandonine-induced autophagic cell death attenuation. However, inhibition of YAP sensitized HCC cells to hernandonine by increasing the autophagy induction. This is the first study to illustrate the complex involvement of p53 and YAP in the hernandonine-induced autophagic cell death in human HCC cells. Our findings provide novel evidence for the potential of hernandonine as a therapeutic agent for HCC treatment. [Display omitted] • Hernandonine effectively inhibited the growth of HCC cells in vitro and in vivo. • Hernandonine elicited autophagic cell death in HCC cells. • Hernandonine induced DNA damage and initiated apoptosis via inducing p53-dependent autophagy. • Elevated YAP expression may serve a cytoprotective role against hernandonine-induced autophagic cell death in HCC cells. [ABSTRACT FROM AUTHOR]

Introduction: The elderly population experiences more postoperative complications. A comprehensive geriatric assessment, which is multidimensional and coordinated, could help reduce these unfavorable outcomes. However, its effectiveness is still uncertain. Methods: We searched multiple online databases, including Medline, PubMed, Web of Science, Cochrane Library, Embase, CINAL, ProQuest, and Wiley, for relevant literature from their inception to October 2023. We included randomized trials of individuals aged 65 and older undergoing surgery. These trials compared comprehensive geriatric assessment with usual surgical care and reported on postoperative outcomes. Two researchers independently screened the literature, extracted data, and assessed the certainty of evidence from the identified articles. We conducted a meta-analysis using RevMan 5.3 to calculate the Odds Ratio (OR) and Mean Difference (MD) of the pooled data. Results: The study included 1325 individuals from seven randomized trials. Comprehensive geriatric assessment reduced the rate of postoperative delirium (28.5% vs. 37.0%; OR: 0.63; CI: 0.47–0.85; I2: 54%; P = 0.003) based on pooled data. However, it did not significantly improve other parameters such as length of stay (MD: -0.36; 95% CI: -0.376, 3.05; I2: 96%; P = 0.84), readmission rate (18.6% vs. 15.4%; OR: 1.26; CI: 0.86–1.84; I2: 0%; P = 0.24), and ADL function (MD: -0.24; 95% CI: -1.27, 0.19; I2: 0%; P = 0.64). Conclusions: Apart from reducing delirium, it is still unclear whether comprehensive geriatric assessment improves other postoperative outcomes. More evidence from higher-quality randomized trials is needed. [ABSTRACT FROM AUTHOR]

The closure of an ancient ocean basin via oceanic arc‐continent collision has two subduction styles with opposite polarities, which may proceed via subduction polarity reversal (SPR) or a subduction zone jump (SZJ). Interpreting the geometry or kinematic evolution of ancient collisional zones, especially the original subduction polarity, can be challenging. Here we used 2D thermo‐mechanical modeling to investigate the dynamic evolution process of SPR versus SZJ. Our modeling predicts different structural, topographic, magmatic, and basin histories for SPR and SZJ, which can be compared against, and help interpret, the geologic record past sites of oceanic closure during collisional orogens. Our results match geologic observations of past collisions in Kamchatka, eastern Russia, and the Banda Arc, eastern Indonesia, and thus our results can help effectively decode the evolutionary history of past arc‐continent collisions. Plain Language Summary: Determining the geometry and kinematic evolution of ancient subduction zones that experienced collision with an oceanic island arc can be challenging based on the surface geology along. Such collisions usually result in different dynamical evolution processes, namely subduction polarity reversal (SPR) or a subduction zone jump (SZJ). Here we conducted numerical modeling of oceanic island arcs that collide with a continental margin to explore the dynamic evolution process of different subduction styles. Our results reveal geologic indicators to decipher SPR versus SZJ in natural oceanic arc‐continent collisions, such as the distribution of thrust faults, metamorphic rocks, magmatism, crustal thickness, and topography. The numerical simulations help explain the geologic history of Kamchatka in eastern Russia and Banda Arc in eastern Indonesia. This study provides provide new insights and implications diagnosing the polarity of vanished subduction in arc‐continental systems. Key Points: New numerical models with convergent velocity boundary condition for deciphering subduction polarity during arc‐continent collisionsThrust faults, metamorphic rocks, magmatism, topography and Moho morphology can be used as indicators to diagnose subduction polarityThe evolution of subduction polarity reversal well explains the tectonic activities of the Kamchatka and Banda Arc in the Cenozoic [ABSTRACT FROM AUTHOR]

Aims To understand the compliance, influencing factors, and action path of family cardiac rehabilitation exercise prescriptions for children after congenital heart disease surgery. Methods and results A random sampling method was used to select 200 paediatric patients and their parents from a paediatric hospital in Shanghai. Among them, 57 cases (28.5%) of children's families followed the cardiac rehabilitation exercise prescription. Path analysis showed that peak oxygen uptake exerted a negative impact on the compliance of family cardiac-rehabilitation prescriptions for patients after congenital heart disease surgery through doctor–patient trust, with a standardized path coefficient of −0.246 (P = 0.001). Disease-related knowledge exerted a positive effect on the compliance of family cardiac-rehabilitation prescriptions for children after congenital heart surgery through doctor–patient trust, with a standardized path coefficient of 0.353 (P < 0.001). The dimension of friend support in social support had a direct positive effect on the compliance of family cardiac-rehabilitation prescriptions for children after cardiac surgery, with a standardized path coefficient of 0.641 (P = 0.006). Conclusion The compliance of cardiac rehabilitation exercise prescription in children with congenital heart disease is not good and is affected by many factors, and there is a complex path relationship between various factors; the kilogram oxygen consumption of the child, the disease-related knowledge of the caregiver, and social support all play important roles in the compliance of the child's family's health prescription. Registration ChiCTR2200062022 [ABSTRACT FROM AUTHOR]

The multifunctional autoprocessing repeat-in-toxin (MARTX) toxin is the primary virulence factor of Vibrio vulnificus displaying cytotoxic and hemolytic properties. The cysteine protease domain (CPD) is responsible for activating the MARTX toxin by cleaving the toxin precursor and releasing the mature toxin fragments. To investigate the structural determinants for inositol hexakisphosphate (InsP6)-mediated activation of the CPD, we determined the crystal structures of unprocessed and β-flap truncated MARTX CPDs of Vibrio vulnificus strain MO6-24/O in complex with InsP6 at 1.3 and 2.2Å resolution, respectively. The CPD displays a conserved domain with a central seven-stranded β-sheet flanked by three α-helices. The scissile bond Leu3587-Ala3588 is bound in the catalytic site of the InsP6-loaded form of the Cys3727Ala mutant. InsP6 interacts with the conserved basic cleft and the β-flap inducing the active conformation of catalytic residues. The β-flap of the post-CPD is flexible in the InsP6-unbound state. The structure of the CPD Δβ-flap showed an inactive conformation of the catalytic residues due to the absence of interaction between the active site and the β-flap. This study confirms the InsP6-mediated activation of the MARTX CPDs in which InsP6-binding induces conformational changes of the catalytic residues and the β-flap that holds the N terminus of the CPD in the active site, facilitating hydrolysis of the scissile bond. [ABSTRACT FROM AUTHOR]

The effects of oil type, emulsifier type, and emulsion particle size on the texture, gel strength, and rheological properties of SPI emulsion‐filled gel (SPI‐FG) and TFSP emulsion‐filled gel (TFSP‐FG) were investigated. Using soybean protein isolate or sodium caseinate as emulsifiers, emulsions with cocoa butter replacer (CBR), palm oil (PO), virgin coconut oil (VCO), and canola oil (CO) as oil phases were prepared. These emulsions were filled into SPI and TFSP gel substrates to prepare emulsion‐filled gels. Results that the hardness and gel strength of both gels increased with increasing emulsion content when CBR was used as the emulsion oil phase. However, when the other three liquid oils were used as the oil phase, the hardness and gel strength of TFSP‐FG decreased with the increasing of emulsion content, but those of SPI‐FG increased when SPI was used as emulsifier. Additionally, the hardness and gel strength of both TFSP‐FG and SPI‐FG increased with the decreasing of mean particle size of emulsions. Rheological measurements were consistent with textural measurements and found that compared with SC, TFSP‐FG, and SPI‐FG showed higher G′ values when SPI was used as emulsifier. Confocal laser scanning microscopy (CLSM) observation showed that the distribution and stability of emulsion droplets in TFSP‐FG and SPI‐FG were influenced by the oil type, emulsifier type and emulsion particle size. SPI‐stabilized emulsion behaved as active fillers in SPI‐FG reinforcing the gel matrix; however, the gel matrix of TFSP‐FG still had many void pores when SPI‐stabilized emulsion was involved. In conclusion, compared to SPI‐FG, the emulsion filler effect that could reinforce gel networks became weaker in TFSP‐FG. [ABSTRACT FROM AUTHOR]

Entoloma is a relatively large genus in Agaricales, with a rich diversity of species and a wide distribution. In this study, seven new species of Entoloma belonging to the subgenus Cubospora have been identified based on morphological and phylogenetic evidence from subtropical regions of China. Morphologically, E. excavatum is characterized by the yellow, depressed, estriate pileus and medium-sized basidiospores; E. lacticolor is recognized by the white and papillate pileus, adnexed lamellae, and presence of clamp connections; E. phlebophyllum is identified by the pink-to-maroon and estriate pileus, and lamellae with lateral veins; E. rufomarginatum differs from other cuboid-spored species by the lamellae edge which is red-brown-underlined; E. subcycneum is characterized by the white pileus and carneogriseum-type cheilocystidia; E. submurrayi is recognized by the pileus margin exceeding the lamellae, 2-layered pileipellis with hyphae of different widths, and the presence of clamp connections; E. tomentosum is identified by the tomentose pileus, heterogeneous lamella edge, and versiform cheilocystidia with brown-yellow contents. Their distinct taxonomic status is confirmed by the positions of the seven new species in both the ITS + LSU and 3-locus (LSU, tef-1α, rpb2) phylogenetic trees. Detailed descriptions, color photos, and a key to related species are presented. [ABSTRACT FROM AUTHOR]

In this article, a class of Caputo–Hadamard fractional stochastic differential equation (FSDEs) with time-delays and impulses is considered. With the help of contraction mapping principle, we derive the existence and uniqueness of the solutions to the purposed system. Subsequently, by virtue of the stochastic analysis techniques and generalized Gr o ¨ nwall inequality, the Ulam–Hyers stability (U–Hs) of the addressed system is established. Finally, we present an example to illustrate the theoretical results. [ABSTRACT FROM AUTHOR]

The summer Asian westerly jet (AWJ)'s shifting in latitudes is one important characteristic of its variability and has great impact on the East Asian summer climate. Based on the observed and reanalyzed datasets from the Hadley Center Sea Ice and Sea Surface Temperature dataset (HadISST), the Japanese 55-year reanalysis (JRA-55), and the fifth generation of the European Centre for Medium-Range Weather Forecasts atmospheric reanalysis (ERA5), this study investigates the relationship between the spring tripole North Atlantic SST (TNAT) anomalies and the summer meridional shift of the AWJ (MSJ) for the period of 1958–2020. Through the method of correlation analysis and regression analysis, we show that the '+ - +' TNAT anomalies in spring could induce a northward shift of the AWJ in the following summer. However, such a climatic effect of the spring TNAT anomalies on the MSJ is unstable, exhibiting an evident interdecadal strengthening since the early 1990s. Further analysis reveals that this is related to a strengthened intensity of the spring TNAT anomalies in the most recent three decades. Compared to the early epoch (1958–1993), the stronger spring TNAT anomalies in the post epoch (1994–2020) could cause a stronger pan-tropical climate response until the following summer through a series of ocean–atmosphere interactions. Through Gill responses, the resultant more prominent cooling in the central Pacific in response to the '+ - +' TNAT anomalies induces a pan-tropical cooling in the upper troposphere, which weakens the poleward gradient of the tropospheric temperature over subtropical Asia. As a result, the AWJ shifts northward via a thermal wind effect. By contrast, in the early epoch, the spring TNAT anomalies are relatively weaker, inducing weaker pan-tropical ocean–atmosphere interactions and thus less change in the meridional shit of the summer AWJ. Our results highlight a strengthened lagged effect of the spring TNAT anomalies on the following summer MSJ and have important implications for the seasonal climate predictability over Asia. [ABSTRACT FROM AUTHOR]

With the continuous expansion of the scale of the industrial Internet, edge computing has become an indispensable part of the industrial Internet. In order to quickly handle the massive computation tasks of production devices and monitoring devices in industrial production and ensure the safety and efficiency of industrial production. This article considers the Joint Task Offloading and Resource Allocation (JTORA) optimization problem, which is measured by the weighted sum of task completion time and energy consumption, and includes the joint optimization of task offloading decision, uplink power allocation, and computing resource allocation. Also further decompose the JTORA problem into (i) a Resource Allocation (RA) problem with fixed task offloading decision and (ii) a Task Offloading (TO) problem that optimizes the optimal-value function corresponding to the RA problem for hierarchical optimization. This paper adopts Deep Reinforcement Learning (DRL) algorithm to solve the RA problem and a heuristic algorithm for the TO problem. Simulation experimental results show that the proposed JTORA optimization scheme can significantly reduce the production time and device energy consumption in industrial production over traditional approaches. [ABSTRACT FROM AUTHOR]

AbstractThis work reveals the transient dynamics of supercritical carbon dioxide (sCO2) under a joint heat and mass interactions with resident polycyclic aromatic hydrocarbons (PAHs) in sedimentary microporous media. A variant of Multiphase Color Fluid Lattice Boltzmann model is developed to simulate spatiotemporal evolution of sCO2 front with degradation of a 5 μm mass-film of resident PAHs. The injection conditions of sCO2 range from 305 K to 315 K, and from 8 MPa to 10 MPa, with a mass flow rate of 0.05–0.15 kg/min. It has been found in this study that the growth of clusters reveals a critical operating time to promote the solvation power of sCO2. However, the cluster of such contaminants is affected by a secondary degradation inside the pore throats of the microporous. The heat and mass coefficients are remarkably relied on the nature of the contaminants and their clustering/clogging processes inside the pores. Hence, the saturation amount of CO2 will jump from a prompt movement to a quick equilibrium state while facing the balanced phase of clustering/degradation of resident contaminants inside the microporous media. [ABSTRACT FROM AUTHOR]

Seawater electrolysis for the production of fuels and chemicals involved in onshore and offshore plants powered by renewable energies offers a promising avenue and unique advantages for energy and environmental sustainability. Nevertheless, seawater electrolysis presents long-term challenges and issues, such as complex composition, potential side reactions, deposition of and poisoning by microorganisms and metal ions, as well as corrosion, thus hindering the rapid development of seawater electrolysis technology. This review focuses on the production of value-added fuels (hydrogen and beyond) and fine chemicals through seawater electrolysis, as a promising step towards sustainable energy development and carbon neutrality. The principle of seawater electrolysis and related challenges are first introduced, and the redox reaction mechanisms of fuels and chemicals are summarized. Strategies for operating anodes and cathodes including the development and application of chloride- and impurity-resistant electrocatalysts/membranes are reviewed. We comprehensively summarize the production of fuels and chemicals (hydrogen, carbon monoxide, sulfur, ammonia, etc.) at the cathode and anode via seawater electrolysis, and propose other potential strategies for co-producing fine chemicals, even sophisticated and electronic chemicals. Seawater electrolysis can drive the oxidation and upgrading of industrial pollutants or natural organics into value-added chemicals or degrade them into harmless substances, which would be meaningful for environmental protection. Finally, the perspective and prospects are outlined to address the challenges and expand the application of seawater electrolysis. [ABSTRACT FROM AUTHOR]