Search

A two years old female Pug and a four months old German Shepherd dogs were presented with history of unilateral corneal wound of traumatic origin. Detailed examination revealed corneal ulceration, oedema and protruding of iris through a full thickness wound on cornea in both cases and was diagnosed as staphyloma. Under general anaesthesia, surgical correction was resorted to. The eyes were cleaned and irrigated with 0.5% Povidone iodine solution prior to surgery, adhesions of iris with corneal wound margin was gently cleared and partly resected and protruding iris was carefully repositioned into anterior chamber. A conjunctival pedicle graft was created by measuring area of ulceration and by rotating a finger shaped piece of bulbar conjunctiva onto corneal surface. This was followed by topical anti-inflammatory and antibiotic eye drops. Routine post-operative therapy was given. Both animals had an uneventful recovery. [ABSTRACT FROM AUTHOR]

BACKGROUND: Prevalence of Crohn's disease (CD) among patients with rheumatic illnesses in India is grossly under estimated, especially when it has overtaken that of Ulcerative Colitis in the West. AIM: To study the frequency of histologically unequivocal CD amongst clinically suspected patients with enteropathic arthropathy and to ascertain if the arthritics with CD have any independent clinical predictor. Settings and designs: Retrospective datasheet analysis from a Rheumatology clinic of a large tertiary care centre. MATERIALS AND METHODS: Patients of suspected enteropathic arthropathy were studied by ileocolonoscopy and segmental colonic biopsy for histological evidence of Crohn's disease and followed up. STATISTICAL ANALYSIS: Logistic regression analysis was done to find out any clinical predictor of histologically proven CD. RESULTS: Fourteen of the twenty-nine patients studied had histologically confirmed CD. Those with CD were younger than those without (34.7 yr vs 41.6 yrs, p=0.057). The CD group also had significantly higher number of people with loss of weight (12 vs 1), fever (11 vs 0), perianal fistula (4 vs 0), abdominal pain (8 vs 2), history of dysentery (4 vs 0) and uveitis (6 vs 1) (p=0.00002, 0.00001, 0.026, 0.013, 0.026 & 0.01 respectively). However logistic regression analysis of the most relevant ones among these, namely, loss of weight, fever, and perianal fistula showed loss of weight as only independent predictor of CD in this subset of patients (p=0.03 with odds ratio of 28). CONCLUSION: Presence of significant loss of weight in an Indian patient with clinically suspected enteropathic arthropathy is an independent predictor of CD. [ABSTRACT FROM AUTHOR]

Background: Prevalence of Crohn's disease (CD) among patients with rheumatic illnesses in India is grossly under estimated, especially when it has overtaken that of Ulcerative Colitis in the West. Aim: To study the frequency of histologically unequivocal CD amongst clinically suspected patients with enteropathic arthropathy and to ascertain if the arthritics with CD have any independent clinical predictor. Settings and designs: Retrospective datasheet analysis from a Rheumatology clinic of a large tertiary care centre. Materials and Methods: Patients of suspected enteropathic arthropathy were studied by ileocolonoscopy and segmental colonic biopsy for histological evidence of Crohn's disease and followed up. Statistical Analysis: Logistic regression analysis was done to find out any clinical predictor of histologically proven CD. Results: Fourteen of the twenty-nine patients studied had histologically confirmed CD. Those with CD were younger than those without (34.7 yr vs 41.6 yrs, p=0.057). The CD group also had significantly higher number of people with loss of weight (12 vs 1), fever (11 vs 0), perianal fistula (4 vs 0), abdominal pain (8 vs 2), history of dysentery (4 vs 0) and uveitis (6 vs 1) (p=0.00002, 0.00001, 0.026, 0.013, 0.026 & 0.01 respectively). However logistic regression analysis of the most relevant ones among these, namely, loss of weight, fever, and perianal fistula showed loss of weight as only independent predictor of CD in this subset of patients ( p = 0.03 with odds ratio of 28). Conclusion: Presence of significant loss of weight in an Indian patient with clinically suspected enteropathic arthropathy is an independent predictor of CD. [ABSTRACT FROM AUTHOR]

The article offers information about the tutorial "Liver failure during pregnancy" hosted on BMJ Learning. It focuses on the clinical management of acute liver failure that occurs in pregnancy. It also discusses the difference between pregnancy-related liver dysfunction and liver dysfunction caused by other factors unrelated to pregnancy.

The article presents information of Adenosine Triphosphate (ATP) 7b gene responsible for Wilson's disease. Copper and copper containing proteins are essential for a variety of metabolic processes in human metabolism. An average adult diet contains approximately 5mg of copper, 40% of which is absorbed in the upper gastrointestinal tract. Almost all of the absorbed copper is excreted in the bile as a complex that has no enterohepatic circulation. Wilson's disease results from impaired biliary excretion of copper with the accumulation of copper in the liver and other organs. Mutations in the ATP7b gene have been associated with a variety of effects including abnormalities associated with other hepatic proteins.