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The hospital/city transition and the return to the usual environment after hospitalization for withdrawal in an addiction service represents a critical point: sometimes problematic management of drug intake at home, possible non-compliance and interruption of treatment or misuse. favoring the resumption of consumption of psychoactive substances and the "relapse", the maintenance of a follow-up by the attending physician. The continuity of drug treatment must be supervised because of the communication difficulties between the hospital and the city medicine/pharmacy. [ABSTRACT FROM AUTHOR]

The first phytochemical investigation of the roots of Zanthoxylum atchoum has led to the isolation of two new nitro-benzo[ c ]phenanthridine alkaloids 6-nitronitidine ( 1 ) and 6-nitro-8-methoxy-7,8-dihydronitidine ( 2 ), two new salts of indolopyridoquinazoline alkaloids 3-hydroxy-8,13-dihydro-14-methyl-5-oxo-7 H -indolo[2’,3’:3,4]pyrido[2,1- b ]quinazolin-14-ium ( 3 ) and its zwitterionic form 3-phenolate-8,13-dihydro-14-methyl-5-oxo-7 H -indolo[2’,3’:3,4]pyrido[2,1- b ]quinazolin-14-ium ( 4 ) along with 18 ( 5 – 22 ) known compounds. Their chemical structures were elucidated by spectroscopic analysis including 1D and 2D NMR and MS techniques. This is the first report of the nitro group on the biosynthesis of the natural benzo[ c ]phenantridine alkaloids. Compound 2 exhibited potent antibacterial activity against Staphylococcus aureus of MIC 50 = 4 μg·mL −1 . [ABSTRACT FROM AUTHOR]

Some ombrotrophic peatlands in temperate regions have been characterized by a process of rapid densification of their forest cover for several decades. This phenomenon is particularly marked in southern Québec (Canada), where a number of peatlands now contain mixed forest stands. The present study aimed to document the woody encroachment dynamics of a peatland colonized by Larix laricina (Du Roi) K. Koch and Acer rubrum L. The specific objectives were to characterize the contemporary dynamics of the forest cover through analysis of dendrometric, dendrochronological, and aerial photographs, and to reconstruct the evolution of tree species present in situ since the peatland's origin through botanical identification of ligneous remains collected in excavations of the peat as well as macrofossil analysis of a sedimentary core. The vegetation cover underwent rapid transformation beginning in the 1970s, first by the densification of L. laricina, followed by the expansion of A. rubrum. This transformation followed several millennia during which the peatland continuously presented a shrub-dominated cover with a few scattered coniferous trees. The rapid expansion of a mixed forest cover is a unique event in the peatland's history. Acer rubrum progressively replaced L. laricina and, in the more or less long-term, should become the dominant species. [ABSTRACT FROM AUTHOR]