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Mental health encompasses the ability to cope with important stresses of life and to realize one's abilities in the community, and the COVID-19 pandemic represented a very stressful event for people with mental illnesses. Our aim was to assess mental well-being in people living with different mental disorders, comparing results obtained in 2016 with those observed after the COVID-19 pandemic. Ninety-six participants were assessed using the Mental Health Continuum Short Form and classified as "flourishing," "moderately mentally healthy," and "languishing." Overall, a significant increase in the prevalence of "flourishing" and "moderately mentally healthy" subjects and a reduction of "languishing" subjects (p = 0.003) were observed. However, a significant improvement in well-being (p = 0.005) was observed only in the schizophrenia spectrum disorder group. Moreover, only subjects that never contracted SARS-CoV-2 showed a significant (p = 0.019) increase in positive well-being states. Lockdowns may have led caregivers to spend more time with the participants, also increasing treatment adherence, resulting in an improvement of overall well-being in several participants. [ABSTRACT FROM AUTHOR]

Background: Although suspicions of cancer may be raised in patients who visit the emergency department, little is known about emergency department use before a cancer diagnosis. We sought to describe emergency department use among patients in Ontario within the 90 days before confirmed cancer diagnosis and to evaluate factors associated with this emergency department use. Methods: We conducted a retrospective, population-based study of patients aged 18 years or older who had a confirmed cancer diagnosis in Ontario from 2014 to 2021 using linked administrative databases. The primary outcome was any emergency department visit within 90 days before the cancer diagnosis date. We used multivariable logistic regression to evaluate factors associated with emergency department use, such as demographics (e.g., age, sex, rurality, Ontario Health region, indicators of marginalization), comorbidities, previous emergency department visits and hospital admissions, continuity of primary care, type of cancer, and year of cancer diagnosis. Results: We included 651 071 patients with cancer. Of these, 229 683 (35.3%) had an emergency department visit within 90 days before diagnosis, 51.4% of whom were admitted to hospital from the emergency department. Factors associated with increased odds of emergency department use before cancer diagnosis included rurality (odds ratio [OR] 1.15, 95% confidence interval [CI] 1.13–1.17), residence in northern Ontario (North East region OR 1.14, 95% CI 1.10–1.17 and North West region OR 1.27, 95% CI 1.21–1.32, v. Toronto region), and living in the most marginalized areas (material resources OR 1.37, 95% CI 1.35–1.40 and housing OR 1.09, 95% CI 1.06–1.11, v. least marginalized quintile). We observed significant variation in emergency department use by cancer type, with high odds of emergency department use among patients with intracranial, pancreatic, liver or gallbladder, or thoracic cancer. Interpretation: Emergency department use is common before cancer diagnosis, with about one-third of patients with cancer in Ontario using the emergency department before diagnosis. Understanding why patients visit the emergency department before cancer diagnosis is important, particularly for patients who live in rural or marginalized areas, or those who have specific cancer types. [ABSTRACT FROM AUTHOR]

Collaborative robots, or cobots, offer a unique combination of productivity and flexibility that has led to significant growth in adoption over the past decade. Moreover, recently, there has been a shift towards a human-centered design of the workspace, known as one of the drivers of Industry 5.0, which prioritizes the well-being of operators. To achieve this, various human factors such as ergonomics, mental workload, personal skills, and capabilities need to be considered in the workspace design, and their impact on system productivity must be evaluated. The integration of a human and a cobot in the same workplace can affect the performance of the human operator, as the perception of the cobot can impact their work. This highlights the importance of taking human factors into account, as a lack of consideration in these aspects has contributed to the failure of many implementations. To link the objectives of productivity, flexibility, and human factors consideration, a dynamic real-time multi-objective task allocation strategy for collaborative assembly systems is developed. This approach considers the different characteristics of the resources and optimizes for two objectives, makespan, and energy expenditure of the operator. By using this approach, it is possible to modify the behavior of the cobot by reallocating tasks between the two resources based on the operator's current needs. In other words, if the operator appears too stressed due to time constraints or their energy rate level is too high, some of their assigned tasks can be transferred to the cobot. This helps to maintain a balanced system while reducing the operator's stress. [ABSTRACT FROM AUTHOR]

The prevalence of web tracking and its key characteristics have been extensively investigated by the research community by means of large-scale web measurements. Most such measurements however are limited to the choice of a specific client used for data collection, which is insufficient to characterize the relative privacy guarantees offered by the adoption of different clients to access the Web. Recent work on comparative privacy analyses involving multiple clients is still preliminary and relies on relatively simple heuristics to detect web tracking based on the inspection of HTTP requests, cookies and API usage. In this paper, we propose a more sophisticated methodology based on information flow tracking, which is better suited for the complexity of comparing tracking behavior observed in different clients. After clarifying the key challenges of comparative privacy analyses, we apply our methodology to investigate web tracking practices on the top 10k websites from Tranco as observed by different clients, i.e., Firefox and Brave, under different configuration settings. Our analysis estimates information flow reduction to quantify the privacy benefits offered by the filter lists implemented in Firefox and Brave, as well as the effectiveness of their partitioned storage mechanism against cross-site tracking. [ABSTRACT FROM AUTHOR]

The Atmospheric Dynamics Mission ADM-Aeolus was successfully launched in August 2018 by the European Space Agency (ESA). The Aeolus mission carried a single instrument, the first-ever Doppler wind lidar (DWL) in space, called Atmospheric LAser Doppler INstrument (ALADIN). Aeolus circled the Earth, providing vertical profiles of horizontal line-of-sight (HLOS) winds on a global scale. The Aeolus satellite's measurements filled critical gaps in existing wind observations, particularly in remote regions such as the Brazilian Amazon. This area, characterized by dense rainforests and rich biodiversity, is essential for global climate dynamics. The weather patterns of the Amazon are influenced by atmospheric circulation driven by Hadley cells and the Intertropical Convergence Zone (ITCZ), which are crucial for the distribution of moisture and heat from the equator to the subtropics. The data provided by Aeolus can significantly enhance our understanding of these complex atmospheric processes. In this long-term validation study, we used radiosonde data collected from three stations in the Brazilian Amazon (Cruzeiro do Sul, Porto Velho, and Rio Branco) as a reference to assess the accuracy of the Level 2B (L2B) Rayleigh-clear and Mie-cloudy wind products. Statistical validation was conducted by comparing Aeolus L2B wind products and radiosonde data covering the period from October 2018 to March 2023 for Cruzeiro do Sul and Porto Velho, and from October 2018 to December 2022 for Rio Branco. Considering all available collocated winds, including all stations, a Pearson's coefficient (r) of 0.73 was observed in Rayleigh-clear and 0.85 in Mie-cloudy wind products, revealing a strong correlation between Aeolus and radiosonde winds, suggesting that Aeolus wind products are reliable for capturing wind profiles in the studied region. The observed biases were −0.14 m/s for Rayleigh-clear and −0.40 m/s for Mie-cloudy, fulfilling the mission requirement of having absolute biases below 0.7 m/s. However, when analyzed annually, in 2022, the bias for Rayleigh-clear was −0.95 m/s, which did not meet the mission requirements. [ABSTRACT FROM AUTHOR]

Psychosocial functioning represents a core treatment target of Schizophrenia Spectrum Disorders (SSD), and several clinical and cognitive factors contribute to its impairment. However, determinants of psychosocial functioning in people living with SSD that committed violent offences remain to be more thoroughly explored. This study aims to separately assess and compare predictors of psychosocial functioning in people with SSD that did and that did not commit violent offences considering several clinical, cognitive and violence-related parameters. Fifty inmates convicted for violent crimes in a forensic psychiatry setting diagnosed with SSD (OP group) and fifty participants matched for age, gender, education, and diagnosis (Non-OP group) were included in the study. A higher risk of violent relapse as measured by HCR-20 clinical subscale scores (p < 0.002) and greater global clinical severity as measured by CGI-S scores (p = 0.023) emerged as individual predictors of worse psychosocial functioning, as measured by PSP scores, in the OP group. Greater global clinical severity (p < 0.001), worse performance in the processing speed domain as measured by the BACS Symbol Coding (p = 0.002) and TMT-A tests (p = 0.016) and higher levels of non-planning impulsivity as measured by BIS-11 scores (p < 0.001) emerged as individual predictors of worse psychosocial functioning in the Non-OP group. These results confirm that clinical severity impacts psychosocial functioning in all individuals diagnosed with SSD and suggest that while cognitive impairment clearly represents a determinant of worse functional outcomes in most patients, the risk of violent relapse is a specific predictor of worse psychosocial functioning in people with SSD that committed criminal offences. [ABSTRACT FROM AUTHOR]

Cognitive impairment associated with schizophrenia (CIAS) represents one of the core features of the disorder and has a significant impact on functional and rehabilitation outcomes of people living with schizophrenia spectrum disorders (SSD). The aim of this critical review is to highlight the most recent evidence on effective treatments available for CIAS, to discuss the current challenges in this field, and to present future perspectives that may help to overcome them. Concerning psychopharmacological approaches, among the most indicated strategies for the management and prevention of CIAS is to favor second-generation antipsychotic medications and avoid long-term and high-dose treatments with anticholinergic medications and benzodiazepines. Moreover, non-pharmacological approaches such as cognitive remediation and physical exercise-based programs represent evidence-based interventions in the treatment of CIAS that have shown reliable evidence of effectiveness on both cognitive and functional outcomes. These treatments, however, are still delivered to people accessing mental health services with a diagnosis of CIAS in an uneven manner, even in high-income countries. Academic and clinical partnership and collaboration, as well as advocacy from service users, families, carers, and stakeholders' organizations could help to reduce the bench to bedside gap in the treatment of CIAS. Future perspectives include the development of novel pharmacological agents that could be effective in the treatment of CIAS, the implementation of novel technologies such as telemedicine and virtual reality in the delivery of evidence-based interventions to improve accessibility and engagement, and further research in the field of non-invasive brain stimulation. [ABSTRACT FROM AUTHOR]

Background: A few patients report intense pain and other unpleasant sensations, such as burning, dysesthesia and hyperalgesia, after even brief exposure to the sun and in the absence of any skin lesion. Sometimes they also develop systemic symptoms, such as mild fever, fatigue, faintness and fainting. As a result, these patients carefully avoid even short‐term sun exposure with a consequent severe negative impact on their lives. Methods: We have reviewed the clinical findings and the results of photobiological investigations of 10 patients who presented this clinical picture. Six of these patients were previously described by our group with the diagnosis of sun pain. We have reviewed the similarities with other previously described disorders such as solar dysesthesia and PUVA pain and have evaluated possible pathogenetic mechanisms. Results: During phototesting our patients experienced intense pain in the exposed area and in the surrounding skin, without any visible lesion, even with very low sub‐erythemal doses. At follow‐up, five patients were diagnosed with fibromyalgia, three with a major depressive disorder, one with bipolar syndrome and one with a conversion disorder. The pathogenesis remains unclear, but the use of a psychopharmacological treatment with antidepressants improved both the neuropsychiatric symptoms and sensitivity to the sun in most subjects. Conclusion: For patients with pain and other severe symptoms in the absence of skin lesions and clinical and laboratory manifestations of known photodermatoses, a neuropsychiatric evaluation should be suggested. [ABSTRACT FROM AUTHOR]

Background: Photochemotherapy with bathwater delivery of psoralens plus UVA exposures (bath‐PUVA) is mainly used for those psoriatic patients who are not responsive to narrowband (NB)‐UVB phototherapy and oral‐PUVA therapy and belong to two categories (1) patients with psoriasis without systemic comorbidities who do not need long‐term continuous treatment and (2) patients who have contraindications to immunosuppressive drugs and oral‐PUVA or refuse systemic drugs, including oral ingestion of psoralens, for personal reasons. However, it is not known how many patients belong to the second group and how much bath‐PUVA is effective and safe for them. Methods: We have reviewed the treatment results of a cohort of 120 patients with clinical indication to bath‐PUVA for the above‐mentioned reasons between 2010 and 2019. These patients were selected among 2640 patients with moderate and severe psoriasis who were treated in our department in the same time interval. Results: Ninety‐six patients completed at least one treatment cycle with bath‐PUVA. A per‐protocol analysis showed that average number of treatment sessions was 21.3 ± 9.0 and the cumulative UVA dose was 80.4 ± 60.0 J/cm2. The average PASI scores decreased from 20.8 ± 7.9 to 5.1 ± 5.4 (p <.01). Sixty‐seven (69.7%) patients achieved at least a 75% improvement (PASI75) and, of them, 38 (39.6%) had an improvement greater than 90% (PASI90). Adverse effects were mild and transitory. Conclusion: These findings demonstrate that bath‐PUVA is still a valuable treatment option for a high number of patients who reject systemic treatments or have contraindications to systemic immune‐modifying drugs and have had a limited or no improvement with NB‐UVB phototherapy. [ABSTRACT FROM AUTHOR]

Gallium‐rich heavy metal oxide glasses have become highly attractive optical materials since they exhibit a wide transparency window spanning from the ultraviolet ∼270 nm up to the mid‐infrared (IR) region ∼6 μm making them promising for a future integration in optical fiber devices. Nonetheless, in most composition, surface crystallization is a key limiting factor for optical fiber drawing using the classical preform‐to‐fiber method. Herein, taking advantage of structural information from vibrational spectroscopies (Raman/IR) and 71Ga Solid‐State Nuclear Magnetic Resonance, we describe the key role of lanthanum and yttrium rare—earth elements on the glass structure and their impact on the capability to draw those new glass compositions into optical fibers. This approach emphasizes that yttrium ions as compared with lanthanum ones favor the glass disorder, increasing significantly the fraction of GaO5 units with respect to GaO4. That, combined with thermal analysis and examination of the crystallization behaviors, highlights that Y2O3 prevents the glass devitrification during the glass shaping. The smaller yttrium radius is believed to be the key physical parameter preventing the precipitation of the BayGa5‐yGey+1La3‐yO14 (y = 0, 1, 2, 3) langasite‐type crystal phase. This study remains particularly relevant and opens up the way for the development of highly robust power scaled fiber devices operating from the visible up to the challenging mid‐IR domain. [ABSTRACT FROM AUTHOR]

The migration from Industry 4.0 to Industry 5.0 is becoming more relevant nowadays, with a consequent increase in interest in the operators' wellness in their working environment. In modern industry, there are different activities that require the flexibility of human operators in performing different tasks, while some others can be performed by collaborative robots (cobots), which promote a fair division of the tasks among the resources in industrial applications. Initially, these robots were used to increase productivity, in particular in assembly systems; currently, new goals have been introduced, such as reducing operator's fatigue, so that he/she can be more effective in the tasks that require his/her flexibility. For this purpose, a model that aims to realize a multi-objective optimization for task allocation is here proposed. It includes makespan minimization, but also the operator's energy expenditure and average mental workload reduction. The first objective is to reach the required high productivity standards, while the latter is to realize a human-centered workplace, as required by the Industry 5.0 paradigms. A method for average mental workload evaluation in the entire assembly process and a new constraint, related to resources' idleness, are here suggested, together with the evaluation of the methodology in a real case study. The results show that it is possible to combine all these elements finding a procedure to define the optimal task allocation that improves the performance of the systems, both for efficiency and for workers' well-being. [ABSTRACT FROM AUTHOR]

Background. Little is known about the effects of disclosure of HIV-serodiscordant relationships on clinical outcomes. We aimed to evaluate the effect of relationship disclosure on HIV viral suppression, and hypothesized that disclosure by HIV-positive and HIV-negative partners would be associated with viral suppression in the HIV-positive partner. Methods. We conducted a Canadian national online and telephone-administered survey of HIV-positive and HIV-negative partners in serodiscordant relationships. The primary outcome was self-reported viral suppression. Multivariable analyses were undertaken using Firth logistic regression. Results. We recruited 540 participants in current serodiscordant relationships (n = 228 HIV-negative; n = 312 HIV-positive). Similar proportions of HIV-positive and HIV-negative partners disclosed their relationship to healthcare professionals (82% v. 76%, p = 0.13). Among HIV-positive partners, disclosure of the relationship to healthcare professionals increased the odds of viral suppression (aOR = 4.7; CI: 2.13, 10.51) after adjusting for age, education, and relationship turmoil due to HIV. Increasing age (aOR = 1.28; 95% CI = 1.07, 1.55) and education (aOR = 2.43; 95% CI = 1.15, 5.26) were also associated with viral suppression. Among HIV-negative partners, relationship disclosure was not associated with viral suppression and HIV-negative heterosexual men were less likely to report that their HIV-positive partners were virally suppressed (aOR = 0.24; CI: 0.09, 0.61). Conclusions. Disclosure of HIV-serodiscordant status by HIV-positive participants to healthcare professionals was associated with increased odds of viral suppression. Similar effects were not evident among HIV-negative participants. Future work should explore factors that empower relationship disclosure and incorporate them into supportive services for HIV-serodiscordant relationships. [ABSTRACT FROM AUTHOR]

Introduction: peripheral nerve tumors are a heterogeneous group, predominantly benign and rare in the general population. Schwannoma is the most common, having its origin in Schwann cells. They occur frequently in the head and neck region, but only 1% are intraoral. The treatment of choice is surgical excision. Objective: to report the case of a patient with benign schwannoma in the jugal mucosa. Case report: a 59-year-old female patient with a cystic mass on the right lower lip for one year, painless and progressively growing. Outpatient surgery performed to excise the lesion. The anatomopathological study revealed the presence of low histological grade spindle cell proliferation, and the immunohistochemical revealed the presence of Benign Schwannoma (Neurilemoma grade I). After removal of the nodule, the patient did not present recurrences. Conclusion: The diagnosis of this pathology is a great challenge. Therefore, to evaluate its impact and forms of presentation in the population is crucial. This involves identifying neurological complications associated with the tumor and supportive and rehabilitative measures to improve the well-being of those affected. It is relevant for early diagnosis, the appropriate choice of treatment, scientific advancement in the understanding of the tumor, and the improvement of the quality of life of affected patients. [ABSTRACT FROM AUTHOR]

Actinic keratosis is caused by excessive lifetime sun exposure. It must be treated, regardless of thickness, because it is the biologic precursor of invasive squamous cell carcinoma, a potentially deadly malignancy. Physical ablative techniques such as cryotherapy, lasers, and curettage are the most used treatments for isolated lesions. Multiple lesions are treated with topical drugs, chemical peelings, and physical techniques. Drug preparations containing diclofenac plus hyaluronate, aminolevulinic acid, and methyl aminolevulinate and different concentrations of imiquimod and 5-fluorouracil are approved for this clinical indication. All treatments have a good profile of efficacy and tolerability although there are relevant differences in the clearance rate, tolerability, and type and frequency of adverse effects. In addition, they have very different mechanisms of action and treatment protocols. No differences in the efficacy and tolerability were found in older patients compared with younger patients, therefore no dose adjustments are needed. That said, older patients often need to be motivated to treat actinic keratoses and a careful attention to expectations, needs, and preferences should be used to obtain the maximal adherence and prevent treatment failure. This goal can be achieved with a careful evaluation not only of published efficacy, toxicity, and tolerability data but also of practical topics such as the frequency of daily applications, the overall duration of therapy, and the need for a caregiver. Finally, particular attention must be paid in the case of frail patients and immunosuppressed patients. [ABSTRACT FROM AUTHOR]

Background Social determinants of health (SDOH) have been associated with coronavirus disease 2019 (COVID-19) outcomes. We examined patterns in COVID-19–related mortality by SDOH and compared these patterns to those for non–COVID-19 mortality. Methods Residents of Ontario, Canada, aged ≥20 years were followed from 1 March 2020 to 2 March 2021. COVID-19–related death was defined as death within 30 days following or 7 days prior to a positive COVID-19 test. Area-level SDOH from the 2016 census included median household income; proportion with diploma or higher educational attainment; proportion essential workers, racially minoritized groups, recent immigrants, apartment buildings, and high-density housing; and average household size. We examined associations between SDOH and COVID-19–related mortality, and non-COVID-19 mortality using cause-specific hazard models. Results Of 11 810 255 individuals, we observed 3880 COVID-19–related deaths and 88 107 non–COVID-19 deaths. After accounting for demographics, baseline health, and other area-level SDOH, the following were associated with increased hazards of COVID-19–related death (hazard ratio [95% confidence interval]: lower income (1.30 [1.04–1.62]), lower educational attainment (1.27 [1.07–1.52]), higher proportions essential workers (1.28 [1.05–1.57]), racially minoritized groups (1.42 [1.08–1.87]), apartment buildings (1.25 [1.07–1.46]), and large vs medium household size (1.30 [1.12–1.50]). Areas with higher proportion racially minoritized groups were associated with a lower hazard of non–COVID-19 mortality (0.88 [0.84–0.92]). Conclusions Area-level SDOH are associated with COVID-19–related mortality after accounting for demographic and clinical factors. COVID-19 has reversed patterns of lower non–COVID-19 mortality among racially minoritized groups. Pandemic responses should include strategies to address disproportionate risks and inequitable coverage of preventive interventions associated with SDOH. [ABSTRACT FROM AUTHOR]

Machine learning has proved invaluable for a range of different tasks, yet it also proved vulnerable to evasion attacks, i.e., maliciously crafted perturbations of inputs designed to force mispredictions. In this article we propose a novel technique to certify the security of machine learning models against evasion attacks with respect to an expressive threat model, where the attacker can be represented by an arbitrary imperative program. Our approach is based on a transformation of the model under attack into an equivalent imperative program, which is then analyzed using the traditional abstract interpretation framework. This solution is sound, efficient and general enough to be applied to a range of different models, including decision trees, logistic regression and neural networks. Our experiments on publicly available datasets show that our technique yields only a minimal number of false positives and scales up to cases which are intractable for a competitor approach. [ABSTRACT FROM AUTHOR]

Introduction Dupilumab demonstrated robust efficacy in patients with moderate-to-severe atopic dermatitis (AD) in randomized controlled trials. Long-term effectiveness of dupilumab in real-world AD treatment is one of the main objectives of the ongoing GLOBOSTAD study. Objective To report dupilumab effectiveness, through physician-assessed AD clinical tools that measure disease severity over time, and a summary of adverse events in patients one year after initiating treatment. Methods The GLOBOSTAD five-year, multinational, prospective, observational study (NCT03992417) enrolled patients aged ≥12 years with moderate-to-severe AD. Patients received dupilumab based on country-specific prescribing information. Assessments were performed at baseline, 3 months (M; ±1M), 6M (±2M), and 12M (±2M). Data are reported as observed for enrollment/safety (N = 955; data cutoff: March 2023) and follow-up (N = 903) populations. Results 758/863/705 patients completed ≥1 follow-up assessment at 3M/6M/12M, respectively. During the study, mean (SD) eczema area and severity index (EASI; >21 = severe; ≤7 = mild/no disease) score rapidly improved from 25.1 (12.8) at baseline to 6.1 (8.0) at 3M, and was sustained until the end of observation period [12M; 4.2 (8.4)]. Similarly, scoring of atopic dermatitis (SCORAD; >50 = severe; <25 = mild/no disease) score improved from 59.3 (16.6) at baseline to 25.3 (16.4) at 3M, further improving to [17.6 (13.0)] at 12M. Adverse events considered related to dupilumab by the investigator were reported in 187 (19.6%) patients. Adverse events leading to permanent dupilumab discontinuation were reported in 23 (2.4%) patients. Conclusion In a real-world scenario, clinical AD assessments rapidly improved upon initiating dupilumab treatment, and were sustained through the end of the one-year observation period. Safety data were consistent with previous studies. [ABSTRACT FROM AUTHOR]

Despite rising rates of sexually transmitted infections (STIs) and inequitable access to education and services, few studies have addressed the unique sex education needs of newcomer youth in Canada and other increasingly demographically diverse Western countries. This study involved the design, implementation and evaluation of a novel and innovative participatory action research project, SExT: Sex Education by Theatre. SExT is a theatre-based, culturally empowering, peer education intervention piloted in a multicultural area of Toronto. Young people were trained as peer educators through participation in theatre-based workshops culminating in the performance of a new play for peers. Mixed methods evaluation involved surveys, focus groups, peer interviews and arts-based data collection. Paired-samples t-tests were conducted to investigate changes in sexual health self-efficacy (protection, STI/HIV testing, sexual limit-setting) over three time-points (pre, post, 4-month follow-up). Thematic analysis was used to gain a deeper understanding of outcomes. Quantitative analysis demonstrated significant improvements in outcome measures from pre– to post-intervention that were maintained at follow-up. Qualitative data indicated increased sexual health self-efficacy attributed to SExT. Pilot study findings suggest that SExT may serve as a model for sexual health interventions in areas populated by newcomer and other priority youth groups. [ABSTRACT FROM AUTHOR]

Photodermatoses are characterized by the development of skin eruptions following exposure to ultraviolet radiation or visible light. We report here the clinical findings and results of laboratory investigations and phototesting of 6 patients who experience debilitating and excruciating pain after sun exposure ("sun pain") in the absence of any skin eruption. Phototesting with sub-erythemal doses of ultraviolet A radiation triggered localized pain in 4 patients. At follow-up, 3 female patients were found to have developed fibromyalgia, 2 male patients experienced a major depressive disorder, and another male patient had a conversion disorder. One patient also developed allodynia to tactile stimuli and one developed allodynia to thermal and tactile stimuli. Psychiatric conditions should be taken into consideration in patients presenting with excruciating and debilitating pain on exposure to ultraviolet radiation, but with absence of skin eruption. Further research is needed to evaluate whether it represents a type of allodynia triggered by exposure to ultraviolet radiation. [ABSTRACT FROM AUTHOR]

Glasses in the system BaO – La 2 O 3 – Ga 2 O 3 – GeO 2 and Langasite crystalline phases with the same stoichiometry have been studied considering the possible use of these glasses for laser-induced space-selective growth of crystalline architectures in the glass compositions. For better understanding of mechanisms involved in such controlled crystallization process, crystalline and glass compounds with same stoichiometry and different La/Ba ratios have been synthesized to compare their local structure. Solid-state Nuclear Magnetic Resonance evidence 4- and 5-coordinated gallium units in the glass matrix, denying unambiguously the formation of 6-coordinated gallium sites observed in crystalline phases. Moreover vibrational spectroscopies suggest a link between a 3D network formed by 4- and 5-coordinated gallium, connected to each other and to 4- coordinated Q4 and Q3 germanium units in the glass and their congruent crystallization. The transition from 4- and 5-coordinated gallium to 6-coordinated gallium sites observed in Langasite crystalline phases remains not still elucidated. [ABSTRACT FROM AUTHOR]

Light intensity plays a crucial role in N uptake and assimilation in plants, but its interaction with different N sources is overlooked. Considering the high energy required for N assimilation, it is hypothesised that low light is critical for the seedling development with both N sources, but with increased light intensity, growing with nitrate (NO 3 -) becomes favourable in relation to ammonium (NH 4 +). Seedlings of Cecropia pachystachya (pioneer), Guarea kunthiana (shade-tolerant, understory) and Cariniana estrellensis (shade-tolerant, canopy) were grown in hydroponic medium with NO 3 - or NH 4 + as the sole N source and subjected to low (LL) or high light (HL) for 60 days. All three species showed a decrease in growth when cultivated with NH 4 +, compared to NO 3 -, under HL, but not under LL. The decrease in biomass reached 54 % in C. pachystachya , 36 % in G. kunthiana and 26 % in C. estrellensis. Growth reduction was associated with stomatal limitation of photosynthesis and reduced leaf area in C. pachystachya , and with non-stomatal limitation of photosynthesis and oxidative stress in G. kunthiana. Cation uptake was negatively affected by NH 4 + in all species. Cariniana estrellensis showed no photosynthetic limitation and showed a higher tolerance to NH 4 + under HL in terms of nutrient content. In conclusion, neither N source significantly favors seedling development under LL, while NH 4 + is considerably more unfavorable for seedling development than NO 3 - under HL. • Regardless of the N source, low light limited seedling growth in all three species. • Under high light, NH 4 + was considerably unfavorable for seedling development. • Photosynthesis was impaired by NH 4 + in two species under high light. • Carbon drain for NH 4 + assimilation was a symptom of NH 4 + toxicity under high light. • Cation uptake was negatively affected by NH 4 + in all species. [ABSTRACT FROM AUTHOR]

• Schizophrenia spectrum disorders (SSD) weight substantially on healthcare systems. • Direct healthcare costs were analyzed in a sample of 276 individuals with SSD. • A mean direct cost of 16477.23 (±32856.47) € per patient per year was identified. • Cost predictors were psychosocial functioning, age of onset and symptom severity. • Socially useful activities and negative symptoms outranked other scale items. The economic burden of schizophrenia amounts for 1.5-3 % of healthcare expenses in developed countries, and ∼50 % derives from direct costs: 81 % of these are due to hospitalization, residential facilities and semi-residential facilities. Therefore, a better characterization of variables that influence direct costs represents a relevant issue. A total of 276 individuals with schizophrenia spectrum disorders receiving treatment from the Community Mental Health Centers of Brescia (Italy) were included in the study: for each participant socio-demographic, clinical and functional characteristics were assessed, and data related to the use of services in 2022 (then converted to costs) were collected. Regression analyses were performed to identify predictors of costs. A direct healthcare expenditure of 16477.23 (±32856.47) € per patient per year was identified. The main cost predictor was the PSP total score (p=0.005), followed by age of onset (p=0.020), and PANSS total score (p=0.033). Including PANSS sub-scales scores and PSP single items as potential predictors, the main predictor was the "socially useful activities" PSP item (p=0.002), followed by age of onset (p=0.011), and PANSS negative scale score (p=0.027). Our findings underline the need to implement rehabilitative intervention focused on the improvement of psychosocial functioning and negative symptoms, also to reduce healthcare expenses. [ABSTRACT FROM AUTHOR]

In this article, we question the particular mode of language used by autistic subjects. Based on readings of autobiographies of autistic adolescents and adults and on fragments of listening to a clinical case, we used applied psychoanalysis as a research method associated with a bibliographical review and the construction of the clinical case from the memory of fragments of listening to it. We made a bibliographic journey through the main authors who deal with issues related to language in autism and a journey through some autobiographical reports of autistic subjects and their actions with the enunciation. We conclude, from the Luca case, that the use of two languages to express oneself, the technical language supported by its island of competence, and the use of neologisms point to the structural dimension of autism. That means this subject, by not agreeing to the incorporation of the Other's voice to later refuse it, demonstrates his difficulty in establishing a subject position of the enunciation. However, in a particular way, Luca shows his unique way of structuring knowledge in front of language to become an enunciator. [ABSTRACT FROM AUTHOR]

Background incidence rates are critical in pharmacovigilance to facilitate identification of vaccine safety signals. We estimated background incidence rates of 11 adverse events of special interest related to COVID-19 vaccines in Ontario, Canada. We conducted a population-based retrospective observational study using linked health administrative databases for hospitalizations and emergency department visits among Ontario residents. We estimated incidence rates of Bell's palsy, idiopathic thrombocytopenia, febrile convulsions, acute disseminated encephalomyelitis, myocarditis, pericarditis, Kawasaki disease, Guillain-Barré syndrome, transverse myelitis, acute myocardial infarction, and anaphylaxis during five pre-pandemic years (2015–2019) and 2020. The average annual population was 14 million across all age groups with 51% female. The pre-pandemic mean annual rates per 100,000 population during 2015–2019 were 191 for acute myocardial infarction, 43.9 for idiopathic thrombocytopenia, 28.8 for anaphylaxis, 27.8 for Bell's palsy, 25.0 for febrile convulsions, 22.8 for acute disseminated encephalomyelitis, 11.3 for myocarditis/pericarditis, 8.7 for pericarditis, 2.9 for myocarditis, 2.0 for Kawasaki disease, 1.9 for Guillain-Barré syndrome, and 1.7 for transverse myelitis. Females had higher rates of acute disseminated encephalomyelitis, transverse myelitis and anaphylaxis while males had higher rates of myocarditis, pericarditis, and Guillain-Barré syndrome. Bell's palsy, acute disseminated encephalomyelitis, and Guillain-Barré syndrome increased with age. The mean rates of myocarditis and/or pericarditis increased with age up to 79 years; males had higher rates than females: from 12 to 59 years for myocarditis and ≥12 years for pericarditis. Febrile convulsions and Kawasaki disease were predominantly childhood diseases and generally decreased with age. Our estimated background rates will permit estimating numbers of expected events for these conditions and facilitate detection of potential safety signals following COVID-19 vaccination. [ABSTRACT FROM AUTHOR]

Introduction: The concept of "life engagement" encompasses several aspects of one's life, including personal well-being, contentment, purpose, and engagement in meaningful activities. In 2006, the group led by Scheier designed a 6-item scale to measure this concept in the general population: the Life Engagement Test (LET), however, this tool was never validated in clinical populations (Scheier et al. 2006 J Clin Psychiatry 2006; 29 291-298). In subjects living with schizophrenia life engagement can be measured through the Positive and Negative Syndrome Scale-Life Engagement (PANSS-LE), derived by isolating 11 items (i.e., N01, N02, N03, N04, N05, N06, G06, G07, G13, G15, G16) from the PANSS (Correll et al. 2022 J Clin Psychiatry 2022; 83-4) (Correll et al. 2022 J Clin Psychiatry 2022; 83-5). Objectives: The aim of this study was to investigate the clinical and functional correlates of two different measures of life engagement in a cohort of individuals living with schizophrenia spectrum disorders (SSD). Methods: Ninety-five subjects living with SSD recruited from the ASST Spedali Civili of Brescia (Italy) were included in the preliminary ad-interim analysis of the present study: for each patient information regarding the clinical presentation were measured with the Clinical Global Impression (CGI) scale, the Health of the Nation Outcome Scales (HoNOS), the Brief Negative Symptoms Scale (BNSS) and the PANSS; additionally, information related to the psychosocial functioning were collected through the Global Assessment of Functioning (GAF) scale; finally, life engagement was evaluated through the LET and the PANSS-LE. Spearman's correlations were performed using SPSS v28 and p values < 0.05 were considered significant. Results: Both the LET and the PANSS-LE were correlated with the CGI (p=0.002 and p<0.001 respectively), but only the PANSS-LE was found to be correlated with the GAF (p<0.001), the BNSS (p<0.001) and the HoNOS (p<0.001). Conclusions: The concept of life engagement is of growing interest for healthcare professionals working in the mental health field, in line with the concept of reaching a full functional recovery and considering patient-reported outcomes. From our study it is evident that life engagement in individuals living with SSD is better characterized through the PANSS-LE rather than the LET, as the former is more specific to define the complexity of the SSD symptomatology. Disclosure of Interest: None Declared [ABSTRACT FROM AUTHOR]

Introduction: In Italy, it was recently estimated that the total economic burden for schizophrenia is € 2.7 billions, of which around 50% is derived from direct costs and 81% of these are due to hospitalization, residential facilities and semi-residential facilities, whereas only 10% of direct costs is derived from pharmacotherapy (Marcellusi et al. BMJ Open 2018; 8, e018359). Considered the high economic burden that schizophrenia has on healthcare systems (estimated to be between 1.4 % and 3 % of the total), a better characterization of the clinical variables that mostly influence the costs represent a topic of great clinical interest (Altamura et al. 2014 Official Journal of the Italian Society of Psychopathology 2014; 20, 223–243). Objectives: The aim of this study was to analyze whether duration of illness has an impact on the costs derived from the use of services (which account for the majority of the direct costs) in a cohort of subjects living with schizophrenia spectrum disorders (SSD). Methods: A total of 496 subjects receiving treatment from the Community Mental Health Centers (CMHC) of Brescia (Italy) were included in the study: for each patient demographic data, data regarding the duration of illness (in months), and data related to the use of service between January 1st, 2022 and December 31st, 2022 were derived from the regional database of mental health ("SIPRL"). Data on the use of service were then converted to costs using the regional rate tables for outpatient services, residential and semi-residential facilities, and the Diagnosis-Related Groups (DRG)-driven rate tables for hospitalization data. Partial correlations analyses were performed between duration of illness, corrected for age, and cost-related variables. All analyses were performed through SPSS v28 and p values <0.05 were considered significant. Results: A higher duration of illness was correlated with higher costs for outpatient non-pharmacological interventions (p=0.010), for residential facilities (p=0.025) and total costs, both including and excluding hospital admissions (p=0.005 and p=0.007, respectively), but not with hospitalization costs (p=0.773). Conclusions: The total expenditure for people living with SSD is higher for people with a longer duration of illness. These findings raise an important issue, which is that the mental health system in Italy invests more in subjects with a longer history of disease: this is in contrast with the international guidelines which prompt to intervene early in the course of the disease in patients living with SSD with outpatient rehabilitation interventions. Disclosure of Interest: None Declared [ABSTRACT FROM AUTHOR]

Topical therapies have been available for the treatment of psoriasis for several decades. Despite this and the availability of several types of topicals, with varying potency, and numerous vehicles of administration, the majority of clinical data and guidance is on short-term use in the management of psoriasis. The aim of this manuscript is to review the unmet needs that exist in the long-term management of psoriasis and provide the dermatology community with an understanding that a treatment regimen with topical therapies could be the best treatment option at least for some phases of this chronic relapsing disease. We present a 'call to action' on the need for clinical alignment on terminology in the field and recommend the term 'long-term management' be adopted as the most appropriate in the context of this manuscript. This expert opinion report provides a detailed review of the limited evidence available regarding long-term use of topical therapies for the management of psoriasis, alongside our key considerations and recommendations to assist dermatologists with the implementation of topicals as part of long-term management strategies. Long-term management should be considered mandatory to ensure patients receive appropriate proactive treatment which may help optimize adherence and long-term outcomes. [ABSTRACT FROM AUTHOR]

Based on the Social Cognitive Theory, this work aimed to measure the self-regulation and self-efficacy of undergraduate and graduate students, in the performance construction activity, and to establish a comparison considering the levels of education, age, years of experience and hours of study. It is a field research, descriptive, with an almost exploratory character and data collection online. 93 pianists participated, students from seven higher education institutions from different regions of Brazil. The results showed the profile of selfregulation and self-efficacy of the participants, with statistically significant differences when comparing educational level, age and daily hours of study. The research has relevant implications for performance pedagogy. [ABSTRACT FROM AUTHOR]

Background: Psoriasis has important physical and psychosocial effects that extend beyond the skin. Understanding the impact of treatment on health‐related quality of life (HRQoL) and patient‐perceived symptom severity in psoriasis is key to clinical decision‐making. Objectives: This post hoc analysis of the PSO‐LONG trial data assessed the impact of long‐term proactive or reactive management with fixed‐dose combination calcipotriene 50 µg/g and betamethasone dipropionate 0.5 mg/g (Cal/BD) foam on patient‐reported outcomes (PROs) in patients with psoriasis vulgaris. Methods: Five hundred and twenty‐one patients from the Phase 3, randomized, double‐blind PSO‐LONG trial were included. An initial 4‐week, open‐label phase of fixed‐dose combination Cal/BD foam once daily (QD) was followed by a 52‐week maintenance phase, at the start of which patients were randomized to a proactive management arm (Cal/BD foam twice weekly) or reactive management arm (vehicle foam twice weekly). Patient‐perceived symptom severity and HRQoL were assessed using the Psoriasis Symptom Inventory (PSI), the Dermatology Life Quality Index (DLQI) and the EuroQol‐5D for psoriasis (EQ‐5D‐5L‐PSO). Results: Statistically and clinically significant improvements were observed across all PRO measures. The mean difference (standard deviation) from baseline to Week 4 was −8.97 (6.18) for PSI, −6.02 (5.46) for DLQI and 0.11 (0.15) for EQ‐5D‐5L‐PSO scores. During maintenance, patients receiving reactive management had significantly higher DLQI (15% [p = 0.007]) and PSI (15% [p = 0.0128]) and a numerically lower EQ‐5D‐5L‐PSO mean area under the curve score than patients receiving proactive management (1% [p = 0.0842]). Conclusions: Cal/BD foam significantly improved DLQI, EQ‐5D‐5L‐PSO and PSI scores during the open‐label and maintenance phases. Patients assigned to proactive management had significantly better DLQI and PSI scores and numerically better EQ‐5D‐5L‐PSO versus reactive management. Additionally, baseline flare was associated with worse PROs than the start of a relapse, and patients starting a relapse also had worse PROs than patients in remission. [ABSTRACT FROM AUTHOR]

In vivo and in vitro studies have shown that prolonged oral administration of flavanol‐rich cocoas extracts have photoprotective effects. The aim of the present study was to assess the photoprotective activity of short‐time administration of a new variety of naturally selected cocoa extract rich in bioactive compounds. We selected a cocoa powder particularly rich in polyphenols, flavanols, caffeine, theobromine and theophylline. We then investigated, in 10 healthy subjects, the photoprotective effects of one week of daily oral administration of two doses of such powder. Phototesting with solar simulated radiation was performed at baseline and after cocoa supplementation. Visual assessment of the minimal erythema dose and spectrophotometric measurement of the "a" parameter were done after 24 h from the irradiation. Oral daily supplementation of 1 g of high‐flavanol cocoa was not effective but a one‐week administration of 4–6 g of cocoa induced a statistically significant increase in the visual erythema threshold and a significant reduction in the "a" parameter. We demonstrated that a new variety of naturally selected cocoa extract, even when administered for a short time, retains a dose‐dependent photoprotective effect. These results are also indicative of the fact that topical sunscreens could be supplemented by a specific diet. [ABSTRACT FROM AUTHOR]

Contexte: Optimiser la réponse de la santé publique pour diminuer le fardeau de la COVID-19 nécessite la caractérisation de l'hétérogénéité du risque posé par la maladie à l'échelle de la population. Cependant, l'hétérogénéité du dépistage du SRAS-CoV-2 peut fausser les estimations selon le modèle d'étude analytique utilisé. Notre objectif était d'explorer les biais collisionneurs dans le cadre d'une vaste étude portant sur les déterminants de la maladie et d'évaluer les déterminants individuels, environnementaux et sociaux du dépistage et du diagnostic du SRAS-CoV-2 parmi les résidents de l'Ontario, au Canada. Méthodes: Nous avons exploré la présence potentielle de biais collisionneurs et caractérisé les déterminants individuels, environnementaux et sociaux de l'obtention d'un test de dépistage et d'un résultat positif à la présence de l'infection au SRAS-CoV-2 à l'aide d'analyses transversales parmi les 14,7 millions de personnes vivant dans la collectivité en Ontario, au Canada. Parmi les personnes ayant obtenu un diagnostic, nous avons utilisé des études analytiques distinctes afin de comparer les prédicteurs pour les personnes d'obtenir un résultat de test de dépistage positif plutôt que négatif, pour les personnes symptomatiques d'obtenir un résultat de test de dépistage positif plutôt que négatif et pour les personnes d'obtenir un résultat de test de dépistage positif plutôt que de ne pas obtenir un résultat positif (c.-à-d., obtenir un résultat de test de dépistage négatif ou ne pas obtenir de test de dépistage). Nos analyses comprennent des tests de dépistage réalisés entre le 1er mars et le 20 juin 2020. Résultats: Sur 14 695 579 personnes, nous avons constaté que 758 691 d'entre elles ont passé un test de dépistage du SRAS-CoV-2, parmi lesquelles 25 030 (3,3 %) ont obtenu un résultat positif. Plus la probabilité d'obtenir un test de dépistage s'éloignait de zéro, plus la variabilité généralement observée dans la probabilité d'un diagnostic était grande parmi les modèles d'études analytiques, particulièrement en ce qui a trait aux facteurs individuels. Nous avons constaté que la variabilité dans l'obtention d'un test de dépistage était moins importante en fonction des déterminants sociaux dans l'ensemble des études analytiques. Les facteurs tels que le fait d'habiter dans une région ayant une plus haute densité des ménages (rapport de cotes corrigé 1,86; intervalle de confiance [IC] à 95 % 1,75–1,98), une plus grande proportion de travailleurs essentiels (rapport de cotes corrigé 1,58; IC à 95 % 1,48–1,69), une population atteignant un plus faible niveau de scolarité (rapport de cotes corrigé 1,33; IC à 95 % 1,26–1,41) et une plus grande proportion d'immigrants récents (rapport de cotes corrigé 1,10; IC à 95 % 1,05–1,15), étaient systématiquement corrélés à une probabilité plus importante d'obtenir un diagnostic de SRAS-CoV-2, peu importe le modèle d'étude analytique employé. Interprétation: Lorsque la capacité de dépister est limitée, nos résultats suggèrent que les facteurs de risque peuvent être estimés plus adéquatement en utilisant des comparateurs populationnels plutôt que des comparateurs de résultat négatif au test de dépistage. Optimiser la lutte contre la COVID-19 nécessite des investissements dans des interventions structurelles déployées de façon suffisante et adaptées à l'hétérogénéité des déterminants sociaux du risque, dont le surpeuplement des ménages, l'occupation professionnelle et le racisme structurel. [ABSTRACT FROM AUTHOR]

Environmental conditions influence the use of different nitrogen (N) sources by plants. We hypothesized that an increase in light intensity favors the use of nitrate (NO3−) relative to ammonium (NH4+) by seedlings of neotropical tree species from different functional groups, that is, Cecropia pachystachya (a shade‐intolerant species), Cariniana estrellensis (a shade‐tolerant canopy species), and Guarea kunthiana (a shade‐tolerant understory species). We analyzed the growth and N metabolism in seedlings simultaneously provided with NH4+ and NO3−, under lower (LL) and higher (HL) light intensity. 15N incorporation into amino acids was monitored after incubation with 15N‐labeled NH4+or NO3−. Under HL, all species showed decreased leaf area ratio, and increased growth, nitrate reductase activity and assimilated N content. Cecropia pachystachya increased the use of both N sources under HL, with substantial increases in 15N‐amino acids derived from 15NO3− (12.5‐ and 4.0‐fold in roots and leaves, respectively) and 15NH4+ (4.5‐ and 3.0‐fold in roots and leaves, respectively). Guarea kunthiana showed the greatest plasticity in N use, as the assimilation of 15NO3− in roots and leaves increased substantially under HL (11.2‐ and 17.0‐fold, respectively). Cariniana estrellensis increased the assimilation of 15NH4+ in roots and 15NO3− in leaves under HL. Therefore, the responses of N use strategies to light intensity varied with the species according to their ecological characteristics. [ABSTRACT FROM AUTHOR]

Background: Optimizing the public health response to reduce the burden of COVID-19 necessitates characterizing population-level heterogeneity of risks for the disease. However, heterogeneity in SARS-CoV-2 testing may introduce biased estimates depending on analytic design. We aimed to explore the potential for collider bias in a large study of disease determinants, and evaluate individual, environmental and social determinants associated with SARS-CoV-2 testing and diagnosis among residents of Ontario, Canada.Methods: We explored the potential for collider bias and characterized individual, environmental and social determinants of being tested and testing positive for SARS-CoV-2 infection using cross-sectional analyses among 14.7 million community-dwelling people in Ontario, Canada. Among those with a diagnosis, we used separate analytic designs to compare predictors of people testing positive versus negative; symptomatic people testing positive versus testing negative; and people testing positive versus people not testing positive (i.e., testing negative or not being tested). Our analyses included tests conducted between Mar. 1 and June 20, 2020.Results: Of 14 695 579 people, we found that 758 691 were tested for SARS-CoV-2, of whom 25 030 (3.3%) had a positive test result. The further the odds of testing from the null, the more variability we generally observed in the odds of diagnosis across analytic design, particularly among individual factors. We found that there was less variability in testing by social determinants across analytic designs. Residing in areas with the highest household density (adjusted odds ratio [OR] 1.86, 95% confidence interval [CI] 1.75-1.98), highest proportion of essential workers (adjusted OR 1.58, 95% CI 1.48-1.69), lowest educational attainment (adjusted OR 1.33, 95% CI 1.26-1.41) and highest proportion of recent immigrants (adjusted OR 1.10, 95% CI 1.05-1.15) were consistently related to increased odds of SARS-CoV-2 diagnosis regardless of analytic design.Interpretation: Where testing is limited, our results suggest that risk factors may be better estimated using population comparators rather than test-negative comparators. Optimizing COVID-19 responses necessitates investment in and sufficient coverage of structural interventions tailored to heterogeneity in social determinants of risk, including household crowding, occupation and structural racism. [ABSTRACT FROM AUTHOR]

This article starts with a clinical case, assisted at the Psychology Service of a university, whose demand, brought by the mother, was to continue the treatment of her daughter, who had started at the age of six. In her report, what was being done was the possibility of reassigning the child's sex. She was eight years old when we started the work. Anatomically, it is a girl and presents stereotypes of a boy. In this case, our attention is drawn to the phrase said by the mother to the child at the age of three, when she asked her if it was a boy or a girl: "I told my daughter that she could be whatever she wants". Faced with this statement to the daughter at such a young age, we asked about the incidence of the mother's word in the meaning of the child's identity. Likewise, the treatment already started by a psychologist, when the patient was six years old, who guided the possibility of sex reassignment, made us a question, supported by psychoanalysis, the issues related to sex and gender in the subjects and the direction of treatment in children. Furthermore, the issues with the body presented by the patient required an understanding of how to face such early demands for sex reassignment. In the analytical path so far, we sought, through the word, to bring out the possibility of knowing about the child's sex. In addition, the contradiction present in the incidence of the Other's word in its guiding and devastating elements in the subject's life was confronted, and the constant critical reflection of psychological practice was faced. Bet on psychoanalysis and listening to the individual aimed at allowing something more unique of his desire to be presented and heard. [ABSTRACT FROM AUTHOR]

Recently, the need for assembly systems of better following the market demand has led to the spread of alternative solutions with respect to the traditional fixed worker strategy. Walking worker systems, where operators move across the line to produce the finished product, are gaining always more interest. In this paper, a comparison between the fixed worker (FW) and the walking worker (WW) assembly strategies is provided, by taking into account their differences both in terms of performed activities during assembly and of material exposure at the assembly workstations. The evaluation is carried out through the proposal of a mathematical model, to understand the impact on assembly time and on operators' energy expenditure. The behavior of the model is investigated both with a parametric analysis and a real case study. The results show that the FW is the best one when the system is working at its maximum throughput, while the WW strategy turns out to be preferable for the lower values of market demand, both from a time and an energy expenditure perspective. [ABSTRACT FROM AUTHOR]

Objective: Routinely collected health administrative data can be used to efficiently assess disease burden in large populations, but it is important to evaluate the validity of these data. The objective of this study was to develop and validate International Classification of Disease 10th revision (ICD -10) algorithms that identify laboratory-confirmed influenza or laboratory-confirmed respiratory syncytial virus (RSV) hospitalizations using population-based health administrative data from Ontario, Canada. Study design and setting: Influenza and RSV laboratory data from the 2014–15, 2015–16, 2016–17 and 2017–18 respiratory virus seasons were obtained from the Ontario Laboratories Information System (OLIS) and were linked to hospital discharge abstract data to generate influenza and RSV reference cohorts. These reference cohorts were used to assess the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the ICD-10 algorithms. To minimize misclassification in future studies, we prioritized specificity and PPV in selecting top-performing algorithms. Results: 83,638 and 61,117 hospitalized patients were included in the influenza and RSV reference cohorts, respectively. The best influenza algorithm had a sensitivity of 73% (95% CI 72% to 74%), specificity of 99% (95% CI 99% to 99%), PPV of 94% (95% CI 94% to 95%), and NPV of 94% (95% CI 94% to 95%). The best RSV algorithm had a sensitivity of 69% (95% CI 68% to 70%), specificity of 99% (95% CI 99% to 99%), PPV of 91% (95% CI 90% to 91%) and NPV of 97% (95% CI 97% to 97%). Conclusion: We identified two highly specific algorithms that best ascertain patients hospitalized with influenza or RSV. These algorithms may be applied to hospitalized patients if data on laboratory tests are not available, and will thereby improve the power of future epidemiologic studies of influenza, RSV, and potentially other severe acute respiratory infections. [ABSTRACT FROM AUTHOR]

Ion-pairing and dehydration phenomena occurring in ZnBr[sub 2] aqueous solutions from normal to critical T, P conditions were investigated by x-ray absorption spectroscopy. The respective influences of temperature, pressure, and concentration were studied. The evolution of the density of solute ions, probed by the height of the absorption edge, allowed us to get information on phase diagrams and salt precipitation. The average structural evolution deduced from extended x-ray absorption fine structure was related to the formation of complexes identified from x-ray absorption near edge structure analysis. Consequently, in noncritical conditions, an increase of temperature or concentration produces dehydration and ion-pairing, while a rise of pressure destroys the ion-pairs. In contrast, concentration and pressure have weaker effects on the local order in high P, T conditions. Moreover, ion pairing formation is found not to be specifically enhanced when the fluid is close to supercritical conditions as it also occurs at lower temperatures. In a discussion, the modifications induced by a variation of the different structural parameters are related to the macroscopic properties of the solvent. [ABSTRACT FROM AUTHOR]

Local-order evolution around ions in aqueous solutions has been investigated between normal and hydrothermal conditions. The behavior of cations and anions in aqueous ZnBr[sub 2] solution were studied by performing x-ray absorption spectroscopy experiments at both Br and Zn edges. Extended x-ray absorption fine structure analyses are made on account of anharmonic treatment and multiple scattering contributions involving H atoms at the Br edge. The extended x-ray absorption fine structure results are coupled to x-ray absorption near-edge structure simulations in order to identify the complexes formed under normal and hydrothermal conditions. It appears that both Zn and Br ions are largely hydrated under normal conditions and that Zn–Br pairs are formed in hydrothermal conditions. This is related to an octahedral-to-tetrahedral evolution of the Zn local environment, the majority of Zn atoms being surrounded by water octahedra in normal conditions and by distorted tetrahedra involving Br and O atoms in hydrothermal conditions. © 2002 American Institute of Physics. [ABSTRACT FROM AUTHOR]

Kitting – meaning to supply assembly with components in presorted kits – is widely seen as beneficial for assembly quality and efficiency when there is a multitude of component variants. However, the process by which kits are prepared – the kit preparation – is labour-intensive, and kit errors are problematic at assembly processes. The use of robotics to support kit preparation has received some attention by researchers, but literature is lacking with respect to how collaborative robots – cobots – can support kit preparation activities. The purpose of this paper is to identify the potential of a cobot to support time-efficient batch preparation of kits. To address the purpose, the paper presents a mathematical model for estimation of the cycle time associated with cobot-supported kit preparation. The model is applied in a numerical example with experimental data from laboratory experiments, and cobot-supported kit preparation is compared with manual kit preparation. The findings suggest that cobot-supported kit preparation is beneficial with diverse kits and smaller components quantities per SKU (Stock Keeping Unit) and provides less variability of the outcome, when compared to manual kit preparation. The paper reveals several insights about cobot-supported kit preparation that can be valuable for both academics and practitioners. The model developed can be used by practitioners to assess the potential of cobots to support kit-batch preparation in association with assembly, spare parts, repair and maintenance, or business to business industry. [ABSTRACT FROM AUTHOR]

Abstract Mid-infrared transparent germano-gallate glasses (with gallium oxide as main component) have been studied following the composition law (100- x)[48.3GaO 3/2 -32.2GeO 2 -19.5BaO]- x KO 1/2 (with x = 0, 5, 10, 13, 17 mol%). All prepared glasses are transparent from approximately 280 nm up to 5.5 μm, with a measured linear refractive index and density decreasing respectively from 1.72 to 1.67 (at 1538 nm) and 4.79 to 4.34 g/cm3 with increasing potassium oxide content. As expected, the increase of potassium oxide content also results in a decrease of the glass transition temperature (698 to 671 °C) and the viscosity in the softening regime whereas the thermal expansion coefficient increases (4.8 to 10.3 × 10−6 K−1). These results are related to the depolymerization of the 3D interconnected glass network which has been studied by Raman spectroscopy. Large thermal stability criteria (difference between onset of crystallization and glass transition temperatures) ranging from 182 to 199 °C have been measured by DSC for the compositions containing potassium oxide, suggesting strong potential for fiber drawing from glass preforms. The 40.1GaO 3/2 -26.7GeO 2 -16.2BaO-17KO 1/2 glass composition (in cation mol.%, which corresponds to 28Ga 2 O 3 -37GeO 2 -23BaO-12K 2 O in mol.%) was then selected for further investigation. Its mechanical properties (Young and shear moduli, Poisson's ratio, hardness) were measured, showing values close to those reported for well-known barium gallo-germanate (BGG) glasses. A thorough crystallization study was then carried out using DSC (Marotta's method), X-Ray diffraction and electron microscopies (TEM and SEM) to better understand the unexpected surface crystallization issues observed during the glass preform fiber drawing process. The potential of using such germano-gallate glasses to produce mid-infrared optical fiber of high mechanical strength is discussed. Highlights • Addition of K 2 O results in Ga 2 O 3 -GeO 2 -BaO-K 2 O (GGBK) glass network depolymerization • Mid-infrared transparent gallium-rich GGBK glasses possess high Tg (≥ 671 °C). • Gallium-rich GGBK glasses exhibit high thermal stability against crystallization (~200 °C). • Surface crystallization is the limiting factor to fiber drawing from glass preforms. [ABSTRACT FROM AUTHOR]

Light-response curves of seedlings of five light-demanding (LD) and four shade-tolerant (ST) neotropical tree species, native to the Brazilian Atlantic biome, were analyzed, aiming to verify differences between these functional groups regarding the light use. We hypothesized that variations in the light requirement of seedlings would occur not only between LD and ST species, but also within these functional groups. The apparent quantum yield of CO2 assimilation, dark respiration rate (RD), photorespiration rate (RP), light-compensation point (Icomp), light-saturation point (Imax), and light-saturated photosynthetic rate (PNmax) were estimated from fitted light-responses curves and using equations available in the literature. The results revealed great differences between the functional groups. RD, RP, Icomp, Imax, and PNmax were effectively higher in the LD than those in the ST species. Furthermore, a continuum of strategies regarding the light use was observed, matching with some ecological characteristics of the species studied here. [ABSTRACT FROM AUTHOR]

Introduction The GLOBOSTAD study aims to assess the extended realworld effectiveness of dupilumab in patients with atopic dermatitis (AD) receiving dupilumab as part of their normal care. Objectives: To report patient-reported outcomes and physician-assessed AD clinical measures for evaluating disease characteristics, severity, and treatment effectiveness 1 year after initiating dupilumab treatment. Methods: This 5-year, multinational, prospective, observational study (NCT03992417) enrolled patients aged =12 years with moderate-to-severe AD. Patients received dupilumab based on country-specific prescribing information. Assessments were performed at baseline, 3 months (± 1 month), 6 months (± 2 months), and 12 months (± 2 months). Data are reported as observed for enrollment/safety (N = 955; data cutoff: March 2023) and follow-up (N = 903) populations including 13 adolescent patients with AD (=12 and <18 years old). Results: In this study, 758/863/705 patients completed =1 follow-up assessment at 3 months/6 months/12 months, respectively. During the study the mean (standard deviation [SD]) Eczema Area and Severity Index (EASI; >21 = severe; =7 = mild/no disease) scores decreased from 25.1 (12.8) at baseline to 6.1 (8.0) at 3 months, 4.6 (6.4) at 6 months and sustaining throughout the observation period [12 months; 4.2 (8.4)]. Mean Patient-Oriented Eczema Measure (SD) improved from 19.7 (6.4) at baseline descending to 8.7 (6.6) at 3 months, 7.7 (6.0) at 6 months and 7.1 (5.8) at 12 months. A significant improvement was also observed in Dermatology Life Quality Index (DLQI) from 13.7 (7.1) to 5.3 (5.1) to 4.4 (4.4) to 3.9 (4.2); and children's DLQI from 12.2 (6.2) to 2.7 (2.9) to 2.9 (3.0) to 4.8 (4.8) by the end of the 3, 6 and 12-months observational period respectively. Dupilumab-related adverse events were reported in 187 (20.8%) patients. Conclusions: In a real-world scenario, the initiation of dupilumab treatment led to early and sustained improvements in AD outcome measures throughout the 1-year observational period. Safety data remained consistent with findings from previous studies. [ABSTRACT FROM AUTHOR]

Experimental investigations have definitely assessed that ultraviolet A (UVA) as well as ultraviolet B (UVB) radiation induce mutagenic DNA photoproducts and other cell damages with a carcinogenic potential. Artificial tanning increases significantly the lifetime risk for basal cell carcinoma, squamous cell carcinoma and melanoma particularly in subjects with fair skin type, subjects with a history of skin cancer or frequent childhood sunburn or if exposures took place at an age younger than 18 years. In addition, experimental and clinical evidence indicate that UVA exposure promotes skin photoageing. Therefore we are dealing with a recreational activity (for customers) and a profitable business (for the tanning industry) with human costs, i.e. an increase in morbidity and mortality by skin cancer, and health and social costs leading to an increased expenditure by the European national health systems. In a few European countries, legislation has recently prohibited the use of sunbeds for minors, pregnant women, people with skin cancer or a history of skin cancer and individuals who do not tan or who burn easily from sun exposure. However, this legislation seems to be insufficient from a photobiological perspective, and importantly, it is largely disregarded by consumers and tanning industry. Therefore the Euromelanoma group proposes a new, more stringent regulation for the tanning industry and restrictions for customers, particularly for those individuals with constitutional and anamnestic risk factors. Finally, we ask for an enhanced commitment to increase the awareness of the general population on the risk of artificial tanning. [ABSTRACT FROM AUTHOR]

Since cookies act as the only proof of a user identity, web sessions are particularly vulnerable to session hijacking attacks, where the browser run by a given user sends requests associated to the identity of another user. When n > 1 cookies are used to implement a session, there might actually be n sub-sessions running at the same website, where each cookie is used to retrieve part of the state information related to the session. Sub-session hijacking breaks the ideal view of the existence of a unique user session by selectively hijacking m sub-sessions, with m < n. This may reduce the security of the session to the security of its weakest sub-session. In this paper, we take a systematic look at the root causes of sub-session hijacking attacks and we introduce sub-session linking as a possible defense mechanism. Out of two flavors of sub-session linking desirable for security, which we call intra-scope and inter-scope sub-session linking respectively, only the former is relatively smooth to implement. Luckily, we also identify programming practices to void the need for inter-scope sub-session linking. We finally present Warden, a server-side proxy which automatically enforces intra-scope sub-session linking on incoming HTTP(S) requests, and we evaluate it in terms of protection, performances, backward compatibility and ease of deployment. [ABSTRACT FROM AUTHOR]

Background: The cost of topical treatments for actinic keratosis (AK) has historically been evaluated in relation to the number of lesions requiring treatment or simply by the price of a single tube/sachet of the drug used. Objective: To demonstrate a new method of costing topical treatments in AK, which takes into account the actual cancerization area treated. Methods: In order to evaluate the actual cost of each treatment, the official approval status of the drug was used to estimate the amount of cream needed per one cm2. This value was then applied to the hypothetical cancerization area sizes to demonstrate the impact of the size treated on the actual cost of treatment. The price considered was the ex‐factory price in Italy. Results: Areas which could be treated with a single tube/sachet of Metvix®, Picato®, Aldara®, Solaraze® and Zyclara® were 200, 25, 25, 33.3 and 200 cm2, respectively. For the treatment of smaller areas (<100 cm2), treatment with Metvix® was the most costly topical option in Italy. However, for the treatment of cancerization areas larger than 100 cm2, Metvix® was the least expensive treatment option. Treatment with Metvix® was least long, requiring a single day of treatment for an area of up to 200 cm2, compared with up to 224 days of treatment with Aldara® for the treatment of a similar size. Conclusion: Changing treatment costing strategy in the management of multiple AKs towards costing per cancerization area instead of costing per lesion is a much more accurate representation of the 'real world cost' for AK. [ABSTRACT FROM AUTHOR]

The article offers information on the comparison of clinical and ultrasound scores in patients with hidradenitis suppurativa (HS). Topics discussed include information on the use of the ultrasound techniques for diagnosis and assessment of HS disease severity; discussions on the using sonographic scoring system for HS; and the information on the clinical assessment for the complementary tests.

Abstract: Despite the great diversity of plant growth‐promoting bacteria (PGPB) with potential to partially replace the use of N fertilisers in agriculture, few PGPB have been explored for the production of commercial inoculants, reinforcing the importance of identifying positive plant–bacteria interactions. Aiming to better understand the influence of PGPB inoculation in plant development, two PGPB species with distant phylogenetic relationship were inoculated in maize. Maize seeds were inoculated with Bacillus sp. or Azospirillum brasilense. After germination, the plants were subjected to two N treatments: full (N+) and limiting (N−) N supply. Then, anatomical, biometric and physiological analyses were performed. Both PGPB species modified the anatomical pattern of roots, as verified by the higher metaxylem vessel element (MVE) number. Bacillus sp. also increased the MVE area in maize roots. Under N+ conditions, both PGPB decreased leaf protein content and led to development of shorter roots; however, Bacillus sp. increased root and shoot dry weight, whereas A. brasilense increased photosynthesis rate and leaf nitrate content. In plants subjected to N limitation (N−), photosynthesis rate and photosystem II efficiency increased in maize inoculated with Bacillus sp., whilst A. brasilense contained higher ammonium, amino acids and total soluble sugars in leaves, compared to the control. Plant developmental and metabolical patterns were switched by the inoculation, regardless of the inoculant bacterium used, producing similar as well as distinct modifications to the parameters studied. These results indicate that even non‐diazotrophic inoculant strains can improve the plant N status as result of the morpho‐anatomical and physiological modifications produced by the PGPB. [ABSTRACT FROM AUTHOR]

Considering that the encounter with the language is determinant in the way of being of each one as subject, the objective of this article is to reflect on the effects in the body of the autistic subject in the encounter with the language. Firstly, we will deal with the constitution of the Self supported by Freud and Lacan, outlining the importance of the presence of the Other in its constitution. Next, we will deal with the constitution of a body, which differs from the organism by its inscription in the language and how the body in the autistic subject, despite being in the language, demonstrates that the symbolic dimension of the body is not a resource in every subject. Finally, we consider that a subject who can not rely on the symbolic protection marked by language can, in his/her own way and in a unique way, invent a way of being in the world. [ABSTRACT FROM AUTHOR]

The efficacy and safety of dupilumab have been reported previously based on data from controlled clinical trials. The GLOBOSTAD study extends the scope of these trials by providing real-world data. This analysis reports baseline demographics and family disease history in patients with atopic dermatitis (AD) who received treatment with dupilumab in a real-world setting. This 5-year, international, multicentre, non-interventional study (GLOBOSTAD; NCT03992417) included patients ≥12 years old with moderate-to-severe AD (Investigator’s Global Assessment score ≥3) who received dupilumab treatment based on country-specific prescribing criteria. Data reported are for the population at baseline (N=952; data cut-off: March 2022) in 22 countries. In the 952 patients included at baseline, mean (standard deviation) age at AD onset was 11.1 (16.0) years. Male patients represented 57.8% of patients and White patients 65.2%. The majority of patients were enrolled from Italy (17.2%), Japan (12.4%) and Spain (11.3%). Family history of type 2 inflammatory conditions (number of patients [%]) was prevalent, including AD (364 [38.2%]), asthma (238 [25%]), allergic rhinitis (219 [23%]), food allergies (74 [7.8%]), recurrent or chronic urticaria (31 [3.3%]), nasal polyposis (21 [2.2%]), eosinophilic esophagitis (11 [1.2%]) and other atopic/allergic conditions (39 [4.1%]). Most cases of type 2 inflammatory conditions were reported in first-degree relatives. Most patients enrolled in the GLOBOSTAD study developed AD during pre-adolescence. Family history of select type 2 inflammatory conditions, including AD, asthma and allergic rhinitis, was present in a moderate proportion of patients. [ABSTRACT FROM AUTHOR]