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Aim Method Results Interpretation To investigate non‐clinical factors that affect health‐related decision‐making in mothers with young ambulatory children living with cerebral palsy (CP).Guided by phenomenology, we asked parents to describe early experiences of raising a young ambulatory child living with CP. Conversations were audio‐recorded, transcribed, coded, and analysed using a qualitative inductive approach.Eighteen parents (all mothers) of 20 children participated. Five themes emerged related to decision‐making, each influencing goal setting, prioritization, and health service use. Mothers had to balance both child and family well‐being. Acceptance of their child's diagnosis and abilities changed over time, partially influenced by their child's emerging voice. Uncertainty arose when weighing multiple factors regarding child, family, and what the future held. Experiences were laden with system‐level burdens related to underinsurance and care coordination. Themes regularly overlapped and persisted.Our findings highlight the complexity of the decision‐making experienced by mothers of young ambulatory children living with CP. Probing this information can inform appropriate shared care planning that meets the preferences and circumstances of mothers and their families. [ABSTRACT FROM AUTHOR]

Background: High-frequency headache/migraine (HFM) and overuse of acute medication (medication overuse [MO]) are associated with increased disability and impact. Experiencing both HFM and MO can potentially compound impacts, including stigma; however, evidence of this is limited. The objective of this report was to evaluate self-reported stigma, health-related quality of life (HRQoL), disability, and migraine symptomology in US adults with HFM + MO from the Harris Poll Migraine Report Card survey. Methods: US adults (≥ 18 yrs., no upper age limit) who screened positive for migraine per the ID Migraine™ screener completed an online survey. Participants were classified into "current HFM + MO" (≥ 8 days/month with headache/migraine and ≥ 10 days/month of acute medication use over last few months) or "previous HFM + MO" (previously experienced HFM + MO, headaches now occur ≤ 7 days/month with ≤ 9 days/month of acute medication use). Stigma, HRQoL, disability, and most bothersome symptom (MBS) were captured. The validated 8-item Stigma Scale for Chronic Illnesses (SSCI-8) assessed internal and external stigma (scores ≥ 60 are clinically significant). Raw data were weighted to the US adult population. Statistically significant differences were determined by a standard t-test of column proportions and means at the 90% (p < 0.1) and 95% (p < 0.05) confidence levels. Results: Participants (N = 550) were categorized as having current (n = 440; mean age 41.1 years; 54% female; 57% White, not Hispanic; 24% Hispanic; 11% Black, not Hispanic) or previous (n = 110; mean age 47.2 years; 49% female; 75% White, not Hispanic; 13% Hispanic; 4% Black, not Hispanic) HFM + MO. Compared to those with previous HFM + MO (21%), adults with current HFM + MO were more likely to experience clinically significant levels of stigma (47%). Men with current HFM + MO (52% compared to men with previous HFM + MO [25%] and women with current [41%] or previous [18%] HFM + MO), non-Hispanic Black (51% compared to White, not Hispanic [45%] and Hispanic [48%] current HFM + MO groups and White, not Hispanic previous HFM + MO [12%]), current HFM + MO aged 18–49 years (50% compared to those with current HFM + MO aged ≥ 50 years [33%] and those with previous HFM + MO aged 18–49 [34%] and ≥ 50 years [4%]), and employed respondents (53% current and 29% previous compared to those not employed [32% current and 12% previous]) reported higher rates of clinically significant stigma. Those with current HFM + MO were more likely to have worse HRQoL and disability due to headache/migraine. Respondents aged ≥ 50 years with current HFM + MO were more likely than respondents aged 18–49 years with current HFM + MO to indicate that their overall quality of life (66% vs. 52%) and their ability to participate in hobbies/activities they enjoy were negatively impacted by headache/migraine (61% vs. 49%). Pain-related symptoms were identified as the MBS. Conclusions: Together these data suggest that current and previous HFM + MO can be associated with undesirable outcomes, including stigma and reduced HRQoL, which were greatest among people with current HFM + MO, but still considerable for people with previous HFM + MO. [ABSTRACT FROM AUTHOR]

We aimed to describe spinal biomechanics and injury patterns in rowing. In this systematic literature review, a Google and PubMed literature search was undertaken using keywords "rowing," "biomechanics," and "spine." Relevant articles were reviewed and synthesized to describe biomechanics, injury patterns, treatment options, and techniques for injury prevention. Rowing has increased in popularity throughout the United States. Up-to-date knowledge of rowing biomechanics and spinal injury patterns is necessary for prompt diagnosis and appropriate treatment of the injured rowing athlete. [ABSTRACT FROM AUTHOR]

To determine how depression state impacts postoperative Patient-Reported Outcomes Measurement Information System (PROMIS) scores and achievement of minimum clinically important difference (MCID) following lumbar fusion. Depression has been shown to negatively impact outcomes following numerous orthopedic surgeries. Situational and major clinical depression can differentially affect postoperative outcomes. Adult patients undergoing elective 1–3 level lumbar fusion were reviewed. Patients with a formal diagnosis of major depression were classified as "clinically depressed" whereas patients with at least "mild" PROMIS Depression scores in the absence of formal depression diagnosis were deemed "situationally depressed." analysis of variance testing was used to assess differences within and between groups. Multivariate regression was used to identify features associated with the achievement of MCID. Two hundred patients were included. The average age was 65.9 ± 12.2 years. 75 patients (37.5%) were nondepressed, 66 patients (33.0%) were clinically depressed, and 59 patients (29.5%) were situationally depressed. Situationally depressed patients had worse preoperative physical function (PF) and pain interference (PI) scores and were more likely to have severe symptoms (P = 0.001, P = 0.001). All groups improved significantly from preoperative baseline scores. All groups met MCID PF at different rates, with highest proportion of situationally depressed reaching this metric (P = 0.03). Rates of achieving MCID PI were not significantly different between groups (P = 0.47). Situational depression was predictive of achieving MCID PF (P = 0.002) but not MCID PI. Our study investigated the relationship between depression and postoperative PROMIS scores and identified situationally depressed patients as having the worst preoperative impairment. Despite this, the situationally depressed cohort had the highest likelihood of achieving MCID PF, suggestive of a bidirectional relationship between lumbar degenerative disease and subclinical, situational depression. These findings may help guide preoperative counseling on expectations, and patient selection. [ABSTRACT FROM AUTHOR]

Background: Polygenic risk scores (PRS) are linear combinations of genetic markers weighted by effect size that are commonly used to predict disease risk. For complex heritable diseases such as late-onset Alzheimer's disease (LOAD), PRS models fail to capture much of the heritability. Additionally, PRS models are highly dependent on the population structure of the data on which effect sizes are assessed and have poor generalizability to new data. Objective: The goal of this study is to construct a paragenic risk score that, in addition to single genetic marker data used in PRS, incorporates epistatic interaction features and machine learning methods to predict risk for LOAD. Methods: We construct a new state-of-the-art genetic model for risk of Alzheimer's disease. Our approach innovates over PRS models in two ways: First, by directly incorporating epistatic interactions between SNP loci using an evolutionary algorithm guided by shared pathway information; and second, by estimating risk via an ensemble of non-linear machine learning models rather than a single linear model. We compare the paragenic model to several PRS models from the literature trained on the same dataset. Results: The paragenic model is significantly more accurate than the PRS models under 10-fold cross-validation, obtaining an AUC of 83% and near-clinically significant matched sensitivity/specificity of 75%. It remains significantly more accurate when evaluated on an independent holdout dataset and maintains accuracy within APOE genotype strata. Conclusions: Paragenic models show potential for improving disease risk prediction for complex heritable diseases such as LOAD over PRS models. [ABSTRACT FROM AUTHOR]

Spine tumors, both primary and metastatic, impose significant morbidity and mortality on patients and physicians. Patient-reported outcomes are valuable tools to assess a patient's impression of their health status and enhance communication between physicians and patients. Various spine generic patient-reported outcome tools have traditionally been used but have not been validated in the spine tumor patient population. The Spine Oncology Study Group Outcome Questionnaire, which is disease-specific for the metastatic spine patient population, has been shown to have strong validity, even across multiple languages. Patient-Reported Outcomes Measurement Information System, which has recently been developed, employs computerized adaptive testing to assess multiple health domains. It has been shown to capture information in both generic and specific questionnaires and has the potential to be used as a universal tool in the spine oncology patient population. Further long-term studies, as well as, cross-cultural adaptations, are needed to validate Patient-Reported Outcomes Measurement Information System's applicability and effectiveness. [ABSTRACT FROM AUTHOR]

Study Design. Retrospective review of a single institution cohort. Objective. The goal of this study is to identify features that predict delayed achievement of minimum clinically important difference (MCID) following elective lumbar spine fusion using PatientReported Outcomes Measurement Information System (PROMIS) surveys. Summary of Background Data. Preoperative prediction of delayed recovery following lumbar spine fusion surgery is challenging. While many studies have examined factors impacting the achievement of MCID for patient-reported outcomes in similar cohorts, few studies have assessed predictors of early functional improvement. Methods. We retrospectively reviewed patients undergoing elective one-level posterior lumbar fusion for degenerative pathology. Patients were subdivided into two groups based on achievement of MCID for each respective PROMIS domain either before six months (“early responders”) or after six months (“late responders”) following surgical intervention. Multivariable logistic regression analysis was used to determine features associated with odds of achieving distribution-based MCID before or after six months follow up. Results. 147 patients were included. The average age was 64.3± 13.0 years. At final follow-up, 57.1% of patients attained MCID for PI and 72.8% for PF. However, 42 patients (49.4%) reached MCID for PI by six months, compared to 44 patients (41.1%) for PF. Patients with severe symptoms had the highest probability of attaining MCID for PI (OR 10.3; P=0.001) and PF (OR 10.4; P=0.001) Preoperative PROMIS symptomology did not predict early achievement of MCID for PI or PF. Patients who received concomitant iliac crest autograft during their lumbar fusion had increased odds of achieving MCID for PI (OR 8.56; P=0.001) before six months. Conclusion. Our study demonstrated that the majority of patients achieved MCID following elective one-level lumbar spine fusion at long-term follow-up, although less than half achieved this clinical benchmark for each PROMIS metric by six months. We also found that preoperative impairment was not associated with when patients would achieve MCID. Further prospective investigations are warranted to characterize the trajectory of clinical improvement and identify the risk factors associated with poor outcomes more accurately. [ABSTRACT FROM AUTHOR]

Background: Migraine is a disabling neurologic disease that can fluctuate over time in severity, frequency, and acute medication use. Harris Poll Migraine Report Card was a US population-based survey to ascertain quantifiable distinctions amongst individuals with current versus previous high-frequency headache/migraine and acute medication overuse (HFM+AMO). The objective of this report is to compare self-reported experiences in the migraine journey of adults with HFM+AMO to those who previously experienced HFM+AMO but currently have a sustained reduction in headache/migraine frequency and acute medication use. Methods: An online survey was available to a general population panel of adults (≥18 years) with migraine per the ID Migraine™ screener. Respondents were classified into "current HFM+AMO" (within the last few months had ≥8 headache days/month and ≥10 days/month of acute medication use; n=440) or "previous HFM+AMO" (previously had HFM+AMO, but within the last few months had ≤7 headache days/month and ≤9 days/month of acute medication use; n=110). Survey questions pertained to demographics, diagnosis, living with migraine, healthcare provider (HCP) communication, and treatment. Results: Participants in the current HFM+AMO group had 15.2 monthly headache days and 17.4 days of monthly acute medication use in last few months compared to 4.2 and 4.1 days for the previous HFM+AMO group, respectively. Overall, current preventive pharmacologic treatment use was low (15-16%; P>0.1 for current vs previous) in both groups. Previous HFM+AMO respondents reported better current acute treatment optimization. More respondents with current (80%) than previous HFM+AMO (66%) expressed concern with their current health (P<0.05). More than one-third of both groups wished their HCP better understood their mental/emotional health (current 37%, previous 35%; P>0.1 for current vs previous) and 47% (current) to 54% (previous) of respondents worried about asking their HCP too many questions (P>0.1 for current vs previous). Conclusion: Apart from optimization of acute medication, medical interventions did not significantly differentiate between the current and previous HFM+AMO groups. Use of preventive pharmacological medication was low in both groups. Adults with current HFM+AMO more often had health concerns, yet both groups expressed concerns of disease burden. Optimization of acute and preventive medication and addressing mental/emotional health concerns of patients are areas where migraine care may impact outcomes regardless of their disease burden. [ABSTRACT FROM AUTHOR]

This paper analyzes three labor documentaries released from 1989 to 1991, which depict the United States' assumed transition from a Fordist to post-Fordist economy. Feminist textual analysis focuses on the depiction of workplaces and gender roles in Roger and Me, American Dream, and Fast Food Women. The analysis demonstrated that discourses of epochal change in the context only held true if one looked at a slice of the U.S. labor market largely dominated by White men. Focusing on feminine sex-typed labor demonstrated the worst elements of industrial Fordism remained in post-Fordist workplaces. Long-standing sexual divisions of labor were unambiguously repeated in post-Fordist work and intensified in a discussion of the family wage. [ABSTRACT FROM AUTHOR]

Racism continues to be a major source of stress for African Americans and can impair psychological functioning. Adolescents experiencing discrimination may engage in self-soothing, but risky behaviors, which leave them at risk for negative life trajectories. Black pride has been identified as a key factor in explaining the heterogeneity in responses to discrimination. Racial socialization, strategies parents use to promote Black pride and protect youth from discrimination, is an important focus of family-based prevention programs serving African American families. This study tests the efficacy of a culturally tailored preventive intervention for rural African American families to disrupt the negative consequences of discrimination on adolescent psychological functioning. Four waves of data from the Strong African American Families (SAAF) efficacy trial (Murry & Brody in Journal of Marital & Family Therapy 30(3):271-283, 2004) with 667 African American families in rural Georgia were used for this study. Structural equation modeling was used to test study hypotheses. Adolescent experiences with discrimination at age 15 predicted concurrent psychological functioning and multiple risk behaviors at age 16, including sexual risk behavior, substance use problems, academic failure, and juvenile justice involvement. Mediation analyses demonstrated that psychological functioning was a significant mediator of these relations. The SAAF program was associated with increases in racial socialization, which in turn fostered gains in adolescent Black pride. Black pride was indirectly associated with reduced risk behavior through adolescent psychological functioning, but Black pride did not moderate the effect of discrimination on psychological functioning. This study confirms that family-based prevention can support African American adolescent mental health in the context of discrimination. However, more emphasis on reducing exposure to discrimination is needed. [ABSTRACT FROM AUTHOR]

Ammonia is a significant precursor of PM 2.5 particles and thus contributes to poor air quality in many regions. Furthermore, ammonia concentrations are rising due to the increase of large-scale, intensive agricultural activities, which are often accompanied by greater use of fertilizers and concentrated animal feedlots. Ammonia is highly reactive and thus highly variable and difficult to measure. Satellite-based instruments, such as the Atmospheric Infrared Sounder (AIRS) and the Cross-Track Infrared Sounder (CrIS), have been shown to provide much greater temporal and spatial coverage of ammonia distribution and variability than is possible with in situ networks or aircraft campaigns, but the validation of these data is limited. Here we evaluate MUSES (multi-spectra, multi-species, multi-sensors) ammonia retrievals from AIRS and CrIS against ammonia measurements from aircraft in the California Central Valley and in the Colorado Front Range. These are small datasets taken over high-source regions under very different conditions: winter in California and summer in Colorado. Direct comparisons of the surface values of the retrieved profiles are biased very low in California (∼ 40 ppbv) and slightly high in Colorado (∼ 4 ppbv). This bias appears to be primarily due to smoothing error, since applying the instrument operator effectively reduces the bias to zero; even after the smoothing error is accounted for, the average uncertainty at the surface is in the 20 %–30 % range. We also compare 3 years of CrIS ammonia against an in situ network in the Magic Valley in Idaho We show that CrIS ammonia captures both the seasonal signal and the spatial variability in the Magic Valley, although it is biased low here also. In summary, this analysis substantially adds to the validation record but also points to the need for more validation under many different conditions and at higher altitudes. [ABSTRACT FROM AUTHOR]

Socioeconomic status (SES) has been associated with differential healthcare outcomes and may be proxied using the area-deprivation index (ADI). Few studies to date have investigated the role of ADI on patient-reported outcomes and clinically meaningful improvement following lumbar spine fusion surgery. The purpose of this study is to investigate the role of SES on lumbar fusion outcomes using Patient-Reported Outcomes Measurement Information System (PROMIS) surveys. Retrospective review of a single institution cohort. About 205 patients who underwent elective one-to-three level posterior lumbar spine fusion. Change in PROMIS scores and achievement of minimum clinically important difference (MCID). Patients 18 years or older undergoing elective one-to-three level lumbar spine fusion secondary to spinal degeneration from January 2015 to September 2021 with minimum one year follow-up were reviewed. ADI was calculated using patient-supplied addresses and patients were grouped into quartiles. Higher ADI values represent worse deprivation. Minimum clinically important difference (MCID) thresholds were calculated using distribution-based methods. Analysis of variance testing was used to assess differences within and between the quartile cohorts. Multivariable regression was used to identify features associated with the achievement of MCID. About 205 patients met inclusion and exclusion criteria. The average age of our cohort was 66±12 years. The average time to final follow-up was 23±8 months (range 12–36 months). No differences were observed between preoperative baseline scores amongst the four quartiles. All ADI cohorts showed significant improvement for pain interference (PI) at final follow-up (p<.05), with patients who had the lowest socioeconomic status having the lowest absolute improvement from preoperative baseline physical function (PF) and PI (p=.01). Only those patients who were in the lowest socioeconomic quartile failed to significantly improve for PF at final follow-up (p=.19). There was a significant negative correlation between socioeconomic level and the absolute proportion of patients reaching MCID for PI (p=.04) and PF (p=.03). However, while ADI was a significant predictor of achieving MCID for PI (p=.02), it was nonsignificant for achieving MCID for PF. Our study investigated the influence of ADI on postoperative PROMIS scores and identified a negative correlation between ADI quartile and the proportion of patients reaching MCID. Patients in the worse ADI quartile had lower chances of reaching clinically meaningful improvement in PI. Policies focused on alleviating geographical deprivation may augment clinical outcomes following lumbar surgery. [ABSTRACT FROM AUTHOR]

Following the release of the first COVID‐19 vaccinations many people utilized social media to promote vaccination among their social circles. These attempts to persuade others to get vaccinated ranged from positive encouragement (e.g., emphasizing the prosocial benefits and positive outcomes) to shame and threats (e.g., name calling and threating to end friendships over vaccination status). The present study investigated how these different social media messages affected COVID‐19 vaccination intentions. In June 2021, shortly after vaccines had been made freely available to anyone over the age of 16 in the United States, unvaccinated participants read a manipulated Twitter message designed to be either encouraging or shaming. Message‐type did not significantly affect intentions to become vaccinated against COVID‐19; however, participants who saw the encouraging message reported that the post made them feel more likely to get vaccinated. Self‐efficacy was also manipulated but did not reveal any significant effects. Additional analyses suggest that having personal experience with COVID‐19 moderates reactions to these different messages. We discuss limitations and promising avenues for future research on the effects of social media messages on health behaviors. [ABSTRACT FROM AUTHOR]

We performed a scoping review of literature on schools' transfer of rights practices under the Individuals with Disabilities Education Act (IDEA) with respect to students with intellectual and developmental disabilities. The review found only limited empirical evidence of how IDEA transfer of rights policies are implemented in schools and affect students and parents. We found a substantial disconnect between this limited empirical evidence and generalizations about school practice made in recent literature that is not empirically based. In addition, we found some misunderstanding of relevant federal policy and little attention to variation in states' policies and schools' practices. Further research is needed to understand the intersection of relevant public policy, school practice, and student postsecondary education, employment, and independent living outcomes. [ABSTRACT FROM AUTHOR]

Patterns of species' distribution and abundance are dynamic in response to changes in land cover, climate, interspecific relationships, and other factors. There are many examples of latitudinal range expansions, contractions, and shifts associated with warming climate. Global change effects are also manifested along gradients of longitude, and woody plant encroachment westward into the Great Plains might also be creating opportunities for species to expand into new areas. We used data from the North American Breeding Bird Survey (BBS) to examine the abundance of Red-bellied Woodpecker (Melanerpes carolinus) at a western edge of its distribution in Texas, Oklahoma, and Kansas. We compared BBS data from 1968–1992 to data from 1993–2018, fitting a series of generalized linear models to best explain variability in abundance. The best performing model included an interaction between time period and longitude, indicating both a change in abundance and in the distribution of abundance over time. Specifically, we found that Red-bellied Woodpecker increased in abundance near its western distributional limit over the past 5 decades, beginning at approximately – 94 degrees longitude. Los patrones de distribución y abundancia de las especies son dinámicos en respuesta a los cambios en uso del suelo, el clima, las relaciones interespecíficas y otros factores. Existen muchos ejemplos de expansiones, contracciones y desplazamientos latitudinales de área de distribución asociados al calentamiento del clima. Los efectos del cambio global también se manifiestan a lo largo de gradientes de longitud y la invasión de plantas leñosas hacia el oeste en las Great Plains también podría estar creando oportunidades para que las especies colonicen nuevas áreas. Utilizamos datos del North American Breeding Bird Survey (BBS) para examinar la abundancia del carpintero Melanerpes carolinus en el límite occidental de su distribución en Texas, Oklahoma y Kansas. Comparamos los datos de BBS de 1968–1992 con los de 1993–2018, ajustando una serie de modelos lineales generalizados para explicar mejor la variabilidad en la abundancia. El modelo con mejores resultados incluyó una interacción entre el periodo de tiempo analizado y la longitud, indicando un cambio en la abundancia y un cambio en la distribución de la abundancia a lo largo del tiempo. Específicamente, encontramos que la abundancia de este carpintero aumentó cerca de su límite de distribución occidental durante las últimas 5 décadas, comenzando aproximadamente a – 94 grados de longitud. Palabras clave: distribution, expansión, longitud. [ABSTRACT FROM AUTHOR]

Rates of parental incarceration in the USA have increased dramatically over the past four decades. The Adverse Childhood Experiences study identified parental incarceration as one of several risk factors related to multiple health outcomes during childhood and adulthood. Parents and other caregivers are widely regarded as sources of resilience for children experiencing adversity, yet few studies have examined caregivers' parenting practices as sources of resilience for children with incarcerated parents. This study used secondary data from a longitudinal randomized controlled trial of the prison-based parent management training program Parenting Inside Out (PIO). Specifically, it included 149 caregivers (i.e., the non-incarcerated parent, extended family member, or other adult who provides the day-to-day caretaking of a child during parental incarceration) of children aged 2–14 years whose incarcerated parents were randomly assigned to receive PIO or the control condition. Path analysis was used to examine associations between caregivers' parenting, social support, self-efficacy, and change in child internalizing and externalizing symptoms across a 6-month period. Direct effects of caregivers' parenting were found on improvements in child behavioral health from baseline (conducted when the parent was incarcerated) to the 6-month follow-up (conducted after most parents had been released). Indirect effects were found for caregiver social support and self-efficacy. The findings highlight the importance of caregivers' adaptive parenting as a protective resource for children who experience parental incarceration and have implications for the design of preventive interventions for this underserved population. [ABSTRACT FROM AUTHOR]

This article summarizes data collected from key informants in Iowa, Maryland, and Oklahoma regarding efforts to support integrated employment for people with intellectual and developmental disabilities (IDD). We highlight features that contribute to the effectiveness of collaborative structures that have resulted in each state's success in achieving integrated employment outcomes for individuals with IDD across three state systems: IDD, vocational rehabilitation, and education. We present these features using the seven elements of the High-Performing States Employment Model. These elements have been found to be important in achieving higher rates of competitive integrated employment outcomes for people with IDD. [ABSTRACT FROM AUTHOR]

Background: Real-world evidence (RWE)—based on information obtained from sources such as electronic health records (EHRs), claims and billing databases, product and disease registries, and personal devices and health applications—is increasingly used to support healthcare decision making. There is variability in the collection of EHR data, which includes "structured data" in predefined fields (e.g., problem list, open claims, medication list, etc.) and "unstructured data" as free text or narrative. Healthcare providers are likely to provide more complete information as free text, but extracting meaning from these fields requires newer technologies and a rigorous methodology to generate higher-quality evidence. Herein, an approach to identify concepts associated with the presence and progression of migraine was developed and validated using the complete patient record in EHR data, including both the structured and unstructured portions. Methods: "Traditional RWE" approaches (i.e., capture from structured EHR fields and extraction using structured queries) and "Advanced RWE" approaches (i.e., capture from unstructured EHR data and processing by artificial intelligence [AI] technology, including natural language processing and AI-based inference) were evaluated against a manual chart abstraction reference standard for data collected from a tertiary care setting. The primary endpoint was recall; differences were compared using chi square. Results: Compared with manual chart abstraction, recall for migraine and headache were 66.6% and 29.6%, respectively, for Traditional RWE, and 96.8% and 92.9% for Advanced RWE; differences were statistically significant (absolute differences, 30.2% and 63.3%; P < 0.001). Recall of 6 migraine-associated symptoms favored Advanced RWE over Traditional RWE to a greater extent (absolute differences, 71.5–88.8%; P < 0.001). The difference between traditional and advanced techniques for recall of migraine medications was less pronounced, approximately 80% for Traditional RWE and ≥ 98% for Advanced RWE (P < 0.001). Conclusion: Unstructured EHR data, processed using AI technologies, provides a more credible approach to enable RWE in migraine than using structured EHR and claims data alone. An algorithm was developed that could be used to further study and validate the use of RWE to support diagnosis and management of patients with migraine. [ABSTRACT FROM AUTHOR]

This manuscript explores the unique construction of community that young, low-income, women create, based on the embodied internal and external spaces they occupy as lone mothers. Issues related to diverse women's representation, voice, and power, within these socially constructed communities are examined. Attention is paid to how young low-income mothers experience and actively create their own supportive community within both geographic and social boundaries, in active resistance to dominant and oppressive assumptions. To explore these concepts in-depth, results are presented from an ethnographic study that examined the community participation of eleven young, low-income, racially diverse single mothers living in a small U.S. Midwestern city. Findings focus on the multiple ways that women's lives embodied the idea of community through the prism of motherhood, race, class, and geographic/physical space. The use of qualitative participatory mapping techniques is also emphasized to examine these physically and socially constructed boundaries. Implications are discussed for ways that social workers can best advocate for social justice by using an intersectional lens to locate and partner with the organic communities of mothering that these women created. [ABSTRACT FROM AUTHOR]

Student employees are essential to academic libraries on college and university campuses. The employment programme at this mid-sized university library intentionally seeks to engage students in work that not only benefits the library, but also provides students the opportunity to learn and hone skills that can contribute to academic and professional success. The pandemic had a significant impact on the student employment programme. The pivot to remote and hybrid services changed how library supervisors worked with student employees. In order to continue to offer students meaningful work, library staff conducted an evaluation of the programme, using a survey and focus groups. The evaluation team implemented programme changes and improvements based on student feedback in regard to scheduling and career preparation, with more plans to follow. This article describes how academic library staff can work with student workers on developing a meaningful employment programme, beneficial to both students and library services. [ABSTRACT FROM AUTHOR]

Background: Deep brain stimulation (DBS) for Parkinson's disease (PD) is generally contraindicated in persons with dementia but it is frequently performed in people with mild cognitive impairment or normal cognition, and current clinical guidelines are primarily based on these cohorts. Objectives: To determine if moderately cognitive impaired individuals including those with mild dementia could meaningfully benefit from DBS in terms of motor and non‐motor outcomes. Methods: In this retrospective case‐control study, we identified a cohort of 40 patients with PD who exhibited moderate (two or more standard deviations below normative scores) cognitive impairment (CI) during presurgical workup and compared their 1‐year clinical outcomes to a cohort of 40 matched patients with normal cognition (NC). The surgery targeted subthalamus, pallidus or motor thalamus, in a unilateral, bilateral or staged approach. Results: At preoperative baseline, the CI cohort had higher Unified Parkinson's Disease Rating Scale (UPDRS) subscores, but similar levodopa responsiveness compared to the NC cohort. The NC and CI cohorts demonstrated comparable degrees of postoperative improvement in the OFF‐medication motor scores, motor fluctuations, and medication reduction. There was no difference in adverse event rates between the two cohorts. Outcomes in the CI cohort did not depend on the target, surgical staging, or impaired cognitive domain. Conclusions: Moderately cognitively impaired patients with PD can experience meaningful motor benefit and medication reduction with DBS. [ABSTRACT FROM AUTHOR]

Ammonia is a significant precursor of PM2.5 particles and thus contributes to poor air quality in many regions. Furthermore, ammonia concentrations are rising due to the increase of large scale, intensive agricultural activities, which are often accompanied by greater use of fertilizers and concentrated animal feedlots. Ammonia is highly reactive, and thus highly variable and difficult to measure. Satellite based instruments, such as the Atmospheric Infrared Sounder (AIRS), and the Cross-Track Infrared Sounder (CrIS) sensors, have been shown to provide much greater temporal and spatial coverage of ammonia distribution and variability than is possible with in situ networks or aircraft campaigns, but the validation of these data is limited. Here we evaluate ammonia retrievals from AIRS and CrIS against ammonia measurements from aircraft in the California Central Valley and in the Colorado Front Range. The satellite datasets were small and in California were obtained under difficult conditions. We show that the surface values of the retrieved profiles are biased very low in California and slightly high in Colorado, and that the bias appears to be primarily due to smoothing error. We also compare three years of CrIS ammonia against an in situ network in the Magic Valley in Idaho We show that CrIS ammonia captures both the seasonal signal and the spatial variability in the Magic Valley, though it is biased low here also. In summary, analysis adds to the validation record but also points to the need for more validation under different conditions. [ABSTRACT FROM AUTHOR]

The mass spectral database of tree species built by US Fish and Wildlife Service has thousands of entries and has been a valuable resource to combat illegal logging and international trade. The database was and continues to be constructed using a particular ambient ionization time-of-flight mass spectrometry (TOF-MS) platform in the agency branch in Ashland, OR, with which queries of unknown wood samples are investigated exclusively. Laboratories that operate different MS instruments also have an interest in using the database if they can produce valid matches to known samples compatible with the database. Four species were selected for inter-laboratory comparison using Orbitrap MS instruments and the equivalent TOF-MS platform with direct analysis in real time ionization of institution-sourced wood samples. Identities of the known samples were confirmed by examination of their microscopic wood anatomy. Orbitrap analysis was able to identify each species as confidently as the TOF instruments, often with less variation in spectra but not necessarily greater mass accuracy or better-matched signal abundance to the control database. The Orbitrap program also had to be doubled to two scanned mass ranges appended for greater peak intensity, before spectra could be correctly matched to the database, but the program was successful. • Alternate instrumentation is used to identify wood species with the ForeST© database. • Integrated DART-Orbitrap mass scans replicated DART-time-of-flight compound analysis. • Environmental conditions were not crucial to successfully matching mass spectra with species. • The wood identification method can be accessible to labs without specifically an AccuTOF MS platform. [ABSTRACT FROM AUTHOR]

Foundational literature on 'insurgent citizenship' highlights how spaces of both exclusion and encounter among marginalized groups lead them to reimagine traditional practices of citizenship through mobilization, occupation, and claims related to place and legal rights. Recent scholarship, especially work written by undocumented activists themselves, illustrates the power of this approach in contemporary movements for justice in North America, especially in the construction of spaces of abolitionist sanctuary, and the valuable role of critical participatory methods in illuminating such forms of social action. Building on this praxis-based body of scholarship, our case study centers on a mobilization by detained activists against abuses and violations of rights during the Covid-19 pandemic at Butler County Jail in Hamilton, Ohio, and the role of strategic alliances between external allies and people within the jail. Through a mixed-methods approach (interviews, discourse analysis, and participant observation) and drawing on critical methodologies of accompaniment and witnessing, we examine how this mobilization constituted a form of 'insurgent citizenship'. [ABSTRACT FROM AUTHOR]

Introduction: Phytoestrogens found in soy, fruits, peanuts, and other legumes, have been identified as metabolites capable of providing beneficial effects in multiple pathological conditions due to their ability to mimic endogenous estrogen. Interestingly, the health-promoting effects of some phytoestrogens, such as isoflavones, are dependent on the presence of specific gut bacteria. Specifically, gut bacteria can metabolize isoflavones into equol, which has a higher affinity for endogenous estrogen receptors compared to dietary isoflavones. We have previously shown that patients with multiple sclerosis (MS), a neuroinflammatory disease, lack gut bacteria that are able to metabolize phytoestrogen. Further, we have validated the importance of both isoflavones and phytoestrogen-metabolizing gut bacteria in disease protection utilizing an animal model of MS. Specifically, we have shown that an isoflavone-rich diet can protect from neuroinflammatory diseases, and that protection was dependent on the ability of gut bacteria to metabolize isoflavones into equol. Additionally, mice on a diet with isoflavones showed an anti-inflammatory response compared to the mice on a diet lacking isoflavones. However, it is unknown how isoflavones and/or equol mediates their protective effects, especially their effects on host metabolite levels. Objectives: In this study, we utilized untargeted metabolomics to identify metabolites found in plasma that were modulated by the presence of dietary isoflavones. Results: We found that the consumption of isoflavones increased anti-inflammatory monounsaturated fatty acids and beneficial polyunsaturated fatty acids while reducing pro-inflammatory glycerophospholipids, sphingolipids, phenylalanine metabolism, and arachidonic acid derivatives. Conclusion: Isoflavone consumption alters the systemic metabolic landscape through concurrent increases in monounsaturated fatty acids and beneficial polyunsaturated fatty acids plus reduction in pro-inflammatory metabolites and pathways. This highlights a potential mechanism by which an isoflavone diet may modulate immune-mediated disease. [ABSTRACT FROM AUTHOR]

Complement activation has been implicated in delayed hemolytic transfusion reaction (DHTR) in patients with sickle cell disease (SCD), and eculizumab has been reported as an effective treatment for patients with DHTR. Previously reported patients with SCD and DHTR responded well after a few doses of eculizumab. We report on the long-term use of eculizumab in a pediatric sickle cell patient with prolonged hemolysis of unknown etiology after a DHTR who had a slow and less sustained response. Long-term use of eculizumab in this young patient with SCD was successful with limited adverse effects. [ABSTRACT FROM AUTHOR]

Objective: To determine whether families would make use of a pediatric-specific inpatient hospice facility for end-of-life care for children. Background: Location of end-of-life care and death are important considerations when treating children with life-limiting conditions. There is very limited research on utilization of an inpatient hospice facility for end-of-life care if a pediatric-specific facility is available. We examined changes in family utilization of inpatient hospice services with the availability of an inpatient pediatric hospice facility (PHF). Methods: We conducted a retrospective cohort study with data collected on location of end-of-life care and death five years prior to and five years following the opening of a PHF that receives referrals from a large children s hospital in United States. Two data sources from the hospice organization were used: (1) a dataset on origins and outcomes of referrals to pediatric inpatient hospice care and (2) a dataset on location of death for all pediatric patients who had any contact with the hospice system. Chi-square analyses were conducted to assess the associations between the PHF opening and referral outcomes and location of death. Results: Significant results were found with respect to both referral outcomes and location of death. Engagement in inpatient hospice care increased between 2- and 10-fold following the opening of the inpatient PHF. The percent of patients who died in an inpatient hospice unit also increased significantly with the opening of the pediatric facility. Discussion: Results of this study show that providers are more likely to refer, and families are more likely to use inpatient hospice services when pediatric facilities are available. These results are important for establishing an evidence base in support for increasing access to PHFs. [ABSTRACT FROM AUTHOR]

Woody plant encroachment in grasslands represents one of the greatest challenges for global biodiversity conservation. Furthermore, this is a social-ecological problem, where human activity and behavior have resulted in significant changes in ecological processes that control woody plants, and failure to fully recognize the role of human activity has led to continued loss of grasslands worldwide. It is therefore critical that conservation professionals understand how ecological systems, settlement patterns, and fragmentation from anthropogenic development interact to influence rates of woody plant encroachment. Using annual estimates of tree cover derived from regionally available remote-sensing data, our objectives were, first, to describe rates of woody plant encroachment over the last 20 years (2000-2019) across three ecologically and socially diverse ecoregions in the Southern Great Plains of North America. Then, we examined how anthropogenic and biophysical variables influenced rates of encroachment (both directly and indirectly) within the region. Results indicate that, despite marked differences in social and ecological characteristics, all three ecoregions have experienced consistent increases in woody plant encroachment during the study period. This included the Flint Hills ecoregion of Kansas and Oklahoma, an area that experiences widespread and frequent fires. At the regional scale, rates of encroachment were directly and negatively related to the average area burned in a county, initial cover of trees, and fragmentation from row crops. Percent cover of development and row crop agriculture also indirectly alter rates of encroachment in a county by influencing initial tree cover and fire activity. The pervasive nature of woody plant encroachment, even in regions that experience frequent fires, suggests that many grasslands are being managed outside of critical ecological thresholds needed to maintain grasslands and limit woody encroachment, which can have significant implications for biodiversity. Our results show that anthropogenic or ecological factors do not act in isolation in their influence on woody plant encroachment and can form complex relationships that shape regional trends in woody plant encroachment. [ABSTRACT FROM AUTHOR]

Background: Good quality colostrum is characterized by high immunoglobulin concentration and low pathogen load. Some methods of pathogen reduction can decrease immunoglobulin concentration and potentially affect their function. Objectives were to determine the effect of formic acid treatment on colostral bacterial and immunoglobulin (IgG) levels before feeding, and serum immunoglobulin concentration and neutralizing capabilities after feeding. Fifteen female Holstein calf pairs born < 12 h apart from different dams were randomly assigned to receive four liters of either untreated pooled (both dams) colostrum (MC) or colostrum acidified to pH 4.0–4.5 (AC). Colostrum characteristics estimated; pH, bacterial load, IgG concentration, and neutralization of Infectious Bovine Rhinotracheitis (IBRV/BoHV-1), Bovine Viral Diarrhea (BVDV) Types 1 and 2. Blood samples were collected on days 1, 3 and monthly for 6 months and were analyzed for IgG, and both viral plus leptospiral neutralization, and total protein (day 3 only). Results: Compared to MC (mean 6.7, SD 0.4; median 6.8, range 6.0–7.3), AC pH was significantly reduced (mean 4.3, SD 0.2; median 4.3, range 4.0–4.5; P < 0.001). Total coliform count (cfu/mL) was also reduced (MC mean 149, SD 444; median 1, range 0–1,700; AC mean 8, SD 31; median 0, range 0–120; P = 0.02). Colostrum IgG concentration was not significantly different between MC (mean 93.3, SD 39.7; median 92.8, range 36.7–164.4 g/L) and AC (mean 101.9, SD 36.7; median 108.3, range 33.8–164.4 g/L; P = 0.54). In calves, serum IgG peaked on day 3 (MC mean 26.1, SD 34.9; median 169.2, range 8.3–151.0 g/L; AC mean 30.2, SD 48.7; median 188.8, range 3.1–204.4 g/L; P = 0.77), and apparent efficiency of IgG absorption was not different between groups (MC mean 24.3, SD 11.4, median 25.3, range 8.6–51.3%; AC mean 22.6, SD 21.7, median 21.6, range 4.1–58.9%; P = 0.65). Thereafter, IgG levels declined but did not differ between groups. MC and AC serum neutralizing titers for IBRV, BVDV Types 1 and 2, or Leptospira interrogans serovars Canicola, and Pomona and L. borgpetersenii serovar Hardjo were not different. Conclusions: Colostrum acidification significantly decreased bacterial load fed to newborn calves without affecting colostral IgG concentration or virus neutralization. In addition, acid treatment did not affect serum IgG concentration in calves or its activity against common pathogens. [ABSTRACT FROM AUTHOR]

This document is a correction notice for an article titled "The Strong African American Families Program: Disrupting the Negative Consequences of Racial Discrimination Through Culturally Tailored, Family-Based Prevention." The authors of the article have decided to make it an Open Access publication under the Creative Commons Attribution 4.0 International License. The document provides information on how the copyright of the article has changed and the terms of use for the content. The correction notice also includes a note from the publisher stating their neutrality regarding jurisdictional claims and institutional affiliations. [Extracted from the article]

Objectives: In response to the coronavirus disease 2019 (COVID-19) pandemic, neuropsychologists rapidly adopted teleneuropsychology (TeleNP) services to ensure continued clinical care. Prior to COVID-19, TeleNP was not widely used nor was it included in the majority of traditional practice or training models across graduate, internship, and postdoctoral programs. Out of necessity, the pandemic was a catalyst that promoted greater adoption of TeleNP services. In response, neuropsychological guidelines for modified assessments were developed and further empirical studies have been published. Numerous surveys in response to service delivery changes during COVID-19 now exist, but what follows is a commentary based on neuropsychologists' experiences with adapting clinical practice to TeleNP. Methods: Co-authors represent settings across academic medical centers, Veterans Affairs hospitals, and private practices that serve multiculturally diverse pediatric, adult, and geriatric populations in the United States. Results: The perspectives within this commentary aim to highlight the growth of TeleNP and highlight lessons learned from implementation across practice settings. Conclusions: Our goal is to help foster the development of further empirical studies through candid discussion of various TeleNP experiences and approaches. Through this reflective process, TeleNP presents both opportunities and challenges but it ultimately has potential to reduce healthcare disparities and enhance patient care. [ABSTRACT FROM AUTHOR]

• Comparison of accuracy of the Microsoft Speech Services conversational ASR system finds that phonetic error rates are higher for speech samples of nonwhite, than for white, speakers • Sociophonetic variables account for 20% of ASR errors • CLOx allows automated transcription of conversational speech in one-fifth of the time required to manually produce an orthographic transcription • Steady improvements to ASR systems greatly expedite and simplify the task of sociolinguistic data analysis Addressing racial bias in automatic speech recognition is an area of concern in fields associated with human-computer interaction. Research to date suggests that sociolinguistic variation, namely systematic sources of sociophonetic variation, has yet to be extensively exploited in acoustic model architectures. This paper reports a study that evaluates the performance of one ASR system for a multi-ethnic sample of speakers from the American Pacific Northwest (including Native American, African American, European American and ChicanX speakers). Using a sociophonetic approach to characterizing vocalic and consonantal variation, we ask which dialect features appear to be most challenging for our ASR system. We also ask which error types are particular to the four ethnic dialects sampled. Recordings of both conversational and read speech were coded for a common set of 18 sociophonetic variables with distinct phonetic profiles. Automatic transcription was achieved using CLOx , a custom-built ASR system created for sociolinguistic analysis. Normalized error frequency rates were compared across ethnic samples to evaluate CLOx performance. N f error rates demonstrate clear differential performance in the ASR system, pointing to racial bias in system output. Specific predictions are made regarding approaches that might be taken to leverage sociophonetic knowledge to improve social dialect-recognition accuracy in ASR systems. [ABSTRACT FROM AUTHOR]

The toxicity of many "inert" ingredients of pesticide formulations, such as safeners, is poorly characterized, despite evidence that humans may be exposed to these chemicals. Analysis of ToxCast data for dichloroacetamide safeners with the ToxPi tool identified benoxacor as the safener with the highest potential for toxicity, especially liver toxicity. Benoxacor was subsequently administered to mice via oral gavage for 3 days at concentrations of 0, 0.5, 5, and 50 mg/kg bodyweight (b.w.). Bodyweight-adjusted liver and testes weights were significantly increased in the 50 mg/kg b.w. group. There were no overt pathologies in either the liver or the intestine. 16S rRNA analysis of the cecal microbiome revealed no effects of benoxacor on α- or β-diversity; however, changes were observed in the abundance of certain bacteria. RNAseq analysis identified 163 hepatic genes affected by benoxacor exposure. Benoxacor exposure expressed a gene regulation profile similar to dichloroacetic acid and the fungicide sedaxane. Metabolomic analysis identified 9 serum and 15 liver metabolites that were affected by benoxacor exposure, changes that were not significant after correcting for multiple comparisons. The activity of antioxidant enzymes was not altered by benoxacor exposure. In vitro metabolism studies with liver microsomes and cytosol from male mice demonstrated that benoxacor is enantioselectively metabolized by cytochrome P450 enzymes, carboxylesterases, and glutathione S -transferases. These findings suggest that the minor toxic effects of benoxacor may be due to its rapid metabolism to toxic metabolites, such as dichloroacetic acid. This result challenges the assumption that inert ingredients of pesticide formulations are safe. [ABSTRACT FROM AUTHOR]

Idiopathic congenital clubfoot is the most common serious musculoskeletal birth defect in the United States and the world. The natural history of the deformity is to persist into adult life with a significant decrease in function and quality of life. The Ponseti method (serial casting, Achilles tenotomy, and bracing of the clubfoot) has become the most effective and accepted treatment of children born with clubfoot worldwide. The treatment is successful, particularly when the Ponseti-trained practitioner (often a pediatric orthopedic surgeon), the primary care clinician, and the family work together to facilitate success. An important factor in the ultimate success of the Ponseti method is parental understanding of the bracing phase. There is a very high rate of recurrent deformity when bracing is not done properly or is stopped prematurely. The importance of positive education and support for the parents to complete the entire treatment protocol cannot be overstated. The goal of treatment is a deformity-free, functional, comfortable foot. Ponseti clubfoot programs have been launched in most countries throughout the world, including many countries with limited resources. Ultimately, the goal is that every infant born with a clubfoot will have access to care with the Ponseti method. This clinical report is intended for medical practitioners who are involved in the care of pediatric patients with clubfoot. Understanding the standard of care will help these practitioners to care for patients and their families. [ABSTRACT FROM AUTHOR]

Single-footprint retrievals of carbon monoxide from the Atmospheric Infrared Sounder (AIRS) are evaluated using aircraft in situ observations. The aircraft data are from the HIAPER Pole-to-Pole Observations (HIPPO, 2009–2011), the first three Atmospheric Tomography Mission (ATom, 2016–2017) campaigns, and the National Oceanic and Atmospheric Administration (NOAA) Global Monitoring Laboratory (GML) Global Greenhouse Gas Reference Network aircraft program in years 2006–2017. The retrievals are obtained using an optimal estimation approach within the MUlti-SpEctra, MUlti-SpEcies, MUlti-SEnsors (MUSES) algorithm. Retrieval biases and estimated errors are evaluated across a range of latitudes from the subpolar to tropical regions over both ocean and land points. AIRS MUSES CO profiles were compared with HIPPO, ATom, and NOAA GML aircraft observations with a coincidence of 9 h and 50 km to estimate retrieval biases and standard deviations. Comparisons were done for different pressure levels and column averages, latitudes, day, night, land, and ocean observations. We found mean biases of +6.6±4.6 %, +0.6±3.2 %, and -6.1±3.0 % for three representative pressure levels of 750, 510, and 287 hPa, as well as column average mean biases of 1.4±3.6 %. The mean standard deviations for the three representative pressure levels were 15 %, 11 %, and 12 %, and the column average standard deviation was 9 %. Observation errors (theoretical errors) from the retrievals were found to be broadly consistent in magnitude with those estimated empirically from ensembles of satellite aircraft comparisons, but the low values for these observation errors require further investigation. The GML aircraft program comparisons generally had higher standard deviations and biases than the HIPPO and ATom comparisons. Since the GML aircraft flights do not go as high as the HIPPO and ATom flights, results from these GML comparisons are more sensitive to the choice of method for extrapolation of the aircraft profile above the uppermost measurement altitude. The AIRS retrieval performance shows little sensitivity to surface type (land or ocean) or day or night but some sensitivity to latitude. Comparisons to the NOAA GML set spanning the years 2006–2017 show that the AIRS retrievals are able to capture the distinct seasonal cycles but show a high bias of ∼20% in the lower troposphere during the summer when observed CO mixing ratios are at annual minimum values. The retrieval bias drift was examined over the same years 2006–2017 and found to be small at <0.5%. [ABSTRACT FROM AUTHOR]

The dominant mechanical failure mechanism in brittle or quasi-brittle materials is cracking, and the parameters that characterize the fracture process of a given material are the extension of cracked region as a function of externally applied load and the resistance of the deforming material to the advance of cracking, also known as fracture toughness. In the present investigation we develop and demonstrate a technique for observing and studying the process of macroscopic crack initiation and propagation, and for determining the fracture toughness of the brittle or quasi-brittle materials. We will address issues such as specimen design using only small amount of material, loading configuration that can generate stable crack growth in brittle solids, diagnostics for identifying crack initiation and quantifying the extent of crack growth, and scheme for extracting the stress intensity factor at the tip of a growing crack. The technique described is applied to the brittle material graphite. [ABSTRACT FROM AUTHOR]

NPs care for persons across the age continuum and transitions commonly occur. Some are unexpected, like hospitalizations for acute illness or injury. Others are an expected consequence of growing up, like moving from pediatric to adult care models. Understanding the factors impacting healthcare transition is critical for successful outcomes. [ABSTRACT FROM AUTHOR]

The purpose of this study is to describe the post-discharge needs of children and adolescents when transitioning home after an inpatient comprehensive rehabilitation stay following an acute neurological injury and to evaluate if trends in those needs changed with implementation of a discharge nurse intervention. Retrospective medical record review was conducted 1-year prior (T1) and 1-year after (T2) a discharge nurse intervention. Medical charts of 80 pediatric patients with acute neurological injury (T1 = 39; T2 = 41) were reviewed. Post-discharge communication from the 8-week post-discharge period was reviewed to identify and categorize care coordination needs, using 18 pre-defined care coordination categories. T1 and T2 findings were compared using two sample proportion z-test. Patients discharged following inpatient rehabilitation for acute neurological injury have unmet care coordination needs. The proportion of unmet needs decreased significantly for 10/18 care coordination categories after implementation of the discharge nurse intervention. Data from this study support proactive care coordination by inpatient rehabilitation nurses to reduce unmet post-discharge care coordination needs and provides preliminary evidence that the role of a discharge nurse may have a positive impact on the transition from inpatient rehabilitation to home. [ABSTRACT FROM AUTHOR]

[Display omitted] • Adapting cell viability assays from research to bioprocessing drives innovation. • Multicellular compositions do not conform with standard staining or imaging assays. • Microfluidics, biosensors, and 3D microscopy can characterize viable cell behavior. • Automated image analysis and machine learning can interpret large, high-res datasets. • Rapid, high-throughput, and/or label-free assays can facilitate bioprocess control. Cell viability is an essential facet of mammalian and microbial bioprocessing. While robust methods of monitoring cellular health remain critically important to biomanufacturing and biofabrication, the complexity of advanced cell culture platforms often poses challenges for conventional viability assays. This review surveys novel approaches to discern the metabolic, morphological, and mechanistic hallmarks of living systems — spanning subcellular and multicellular scales. While fluorescent probes coupled with 3D image analysis generate rapid results with spatiotemporal detail, molecular techniques like viability PCR can distinguish live cells with genetic specificity. Notably, label-free biosensors can detect nuanced attributes of cellular vital signs with single-cell resolution via optical, acoustic, and electrical signals. Ultimately, efforts to integrate these modalities with automation, machine learning, and high-throughput workflows will lead to exciting new vistas across the cell viability landscape. [ABSTRACT FROM AUTHOR]