Search

The objective of this study was to describe the nutritional profile of children and adolescents benefited by the Bolsa Família Program in Nova Lima / MG. This is an ecological study with data from the Information Record of the Nutritional Status of Program Beneficiaries included in the Food and Nutrition Surveillance System provided by the SUS's Department of Informatics. A total of 4,935 children and adolescents were found, of which 2,868 were female. It was found that 76.1% of the study population was classified in the Nutritional Status Index as eutrophic, 9.7% with nutritional risk (≥3rd percentile <10th percentile), 7.3% with risk of overweight (≥97th percentile), 5.5% with low weight (≥0.1 percentile

Coronavirus disease 2019 (COVID-19) continues to significantly impact the global population, thus countermeasure platforms that enable rapid development of therapeutics against variants of SARS-CoV-2 are essential. We report use of a phage display human antibody library approach to rapidly identify neutralizing antibodies (nAbs) against SARS-CoV-2. We demonstrate the binding and neutralization capability of two nAbs, STI-2020 and STI-5041, against the SARS-CoV-2 WA-1 strain as well as the Alpha and Beta variants. STI-2020 and STI-5041 were protective when administered intravenously or intranasally in the golden (Syrian) hamster model of COVID-19 challenged with the WA-1 strain or Beta variant. The ability to administer nAbs intravenously and intranasally may have important therapeutic implications and Phase 1 healthy subjects clinical trials are ongoing. [ABSTRACT FROM AUTHOR]