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BIM (building information modelling) has developed into a powerful solution that can improve many aspects of construction industry. Current research regarding the impact of orientation on a building's energy needs seldom tap into the potential of BIM. This study investigates the impact of orientation on energy consumption in small-scale construction, and assesses how BIM can be used to facilitate this process. The methods adopted are three-fold. Firstly, a real-life building is modelled using Revit, one of the leading BIM tools. Secondly, through green building Extensible Markup Language, the model is exported to Green Building Studio, one of the leading energy simulation software. Thirdly, in the Green Building Studio, different building orientations are adopted and their impacts of the whole building energy are investigated. Based on the analysis of the energy consumption corresponding to the different orientations, it emerged that a well-orientated building can save a considerable amount of energy throughout its life cycle. Specifically, a total electricity use difference of 17 056 kWh and a total gas use difference of 27 988 MJ leading to a combined energy cost savings of £878 throughout a 30 year period between the best (+180°) and worst (+45°) orientations of the building was achieved. [ABSTRACT FROM AUTHOR]

Purpose/objective(s): Concurrent chemoradiotherapy (CCRT) with etoposide and platinum (carboplatin/cisplatin) plus the anti‒PD-1 antibody pembrolizumab (pembro) has shown antitumor activity and acceptable safety in patients (pts) with limited-stage small-cell lung cancer (LS-SCLC). The poly (ADP-ribose) polymerase (PARP) inhibitor, olaparib, has shown activity in combination with checkpoint inhibitors in SCLC. KEYLYNK-013 (NCT04624204) is a randomized, placebo-controlled, double-blind phase 3 trial of pembro plus CCRT followed by pembro with or without olaparib in pts with newly diagnosed LS-SCLC.Materials/methods: Eligible pts are those aged ≥18 years with previously untreated LS-SCLC, ECOG PS 0/1, and adequate pulmonary function. Pts are randomized 1:1:1 to receive pembro 200 mg Q3W (groups A and B) or pembro placebo (saline) Q3W (group C) during the chemoradiation phase. All pts also receive 4 cycles of chemotherapy (etoposide 100 mg/m2 on days 1, 2, and 3 of each cycle and investigator's choice of carboplatin AUC 5 mg/mL/min or cisplatin 75 mg/m2 on day 1 of each cycle) with definitive thoracic radiotherapy (total dose of 45 Gy in 30 fractions twice daily over 3 weeks or 66 Gy in 33 fractions once daily over 6.5 weeks starting on day 1 of cycle 2). After chemoradiation, prophylactic cranial irradiation is strongly recommended for pts with CR/PR or at investigator's discretion for pts with SD. Postchemoradiation pts receive pembro 400 mg Q6W plus olaparib placebo (group A), or pembro 400 mg Q6W plus olaparib 300 mg BID (group B), or pembro placebo plus olaparib placebo (group C) for 9 cycles/12 months. Randomization is stratified by ECOG PS (0 vs 1), SCLC stage (I/II vs III), radiation fractionation (twice vs once daily), and region (east Asia vs North America/western Europe/UK/Australia vs rest of world). Tumor imaging occurs at baseline, within 12 weeks of cycle 1 day 1, followed by Q9W to the end of year 2, Q12W in year 3, Q16W in year 4, every 6 months in year 5, and annually thereafter. Imaging is assessed per RECIST v1.1 by blinded independent central review. AEs are made per NCI-CTCAE v5.0. Health-related quality of life is assessed using EORTC-QLQ-C30 and QLQ-LC13. Primary endpoints are OS and PFS per RECIST v1.1 by blinded independent central review. OS and PFS are estimated by the Kaplan-Meier method. Between-group differences will be evaluated with stratified log-rank tests and Cox proportional hazard models with Efron's method of tie handling. Secondary endpoints include ORR, duration of response, safety, and pt-reported outcomes. Enrollment began in Dec 2020 and is ongoing at 43 sites in 11 countries as of Feb 24, 2021.Results: TBD CONCLUSION: TBD. [ABSTRACT FROM AUTHOR]

In a group context, African American women told stories about their caregiving experiences. We audiotaped these stories and constructed vignettes that served as cases from the field. Lessons learned from vignettes about challenges and strengths in caregiving inform empowerment group practice with African American women caregivers of African American elders. [ABSTRACT FROM AUTHOR]