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A patient previously diagnosed with chronic neutrophilic leukemia (CNL) was studied using fluorescent in situ hybridization (FISH) to determine clonality of neutrophils. By cytogenetic studies the patient's blood and bone marrow had an 11q14 deletion and were negative for the Philadelphia (Ph) chromosome. FISH was performed on peripheral blood smears using probes for the bcr/abl translocation and a probe for 11q23 (MLL). The patient's white blood cells were negative for the bcr/abl translocation; neutrophils and eosinophils, but not lymphocytes, were monosomic for the 11q23 probe indicating a clonal population within the neutrophil population. [ABSTRACT FROM AUTHOR]

Comments on the classification of acute megakaryoblastic leukemia or M7 by the French-American-British (FAB) leukemia cooperative study. Significance of the criteria for M7; Additional diagnostic studies required for M7; Set of specific criteria to define M7 proposed by the FAB.