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Background: Little is known about the best strategy for weaning patients with chronic obstructive pulmonary disease (COPD) from mechanical ventilation. Spontaneous breathing trials (SBT) using a T-piece or pressure-support ventilation (PSV) have a central role in this process. Our aim was to compare T-piece and PSV SBTs according to the duration of mechanical ventilation (MV) in patients with COPD. Methods: Patients with COPD who had at least 48 hours of invasive MV support were randomized to 30 minutes of T-piece or PSV at 10 cm H2O after being considered able to undergo a SBT. All patients were preemptively connected to non-invasive ventilation after extubation. Tracheostomized patients were excluded. The primary outcome was total invasive MV duration. Time to liberation from MV was assessed as secondary outcome. Results: Between 2012 and 2016, 190 patients were randomized to T-piece (99) or PSV (91) groups. Extubation at first SBT was achieved in 78% of patients. The mean total MV duration was 10.82 ± 9.1 days for the T-piece group and 7.31 ± 4.9 days for the PSV group (p < 0.001); however, the pre-SBT duration also differed (7.35 ± 3.9 and 5.84 ± 3.3, respectively; p = 0.002). The time to liberation was 8.36 ± 11.04 days for the T-piece group and 4.06 ± 4.94 for the PSV group (univariate mean ratio = 2.06 [1.29–3.27], p = 0.003) for the subgroup of patients with difficult or prolonged weaning. The study group was independently associated with the time to liberation in this subgroup. Conclusions: The SBT technique did not influence MV duration for patients with COPD. For the difficult/prolonged weaning subgroup, the T-piece may be associated with a longer time to liberation, although this should be clarified by further studies. Trial registration: ClinicalTrials.gov , at November 3, 2011. [ABSTRACT FROM AUTHOR]

Objective: To describe the pre-hospital, emergency department, and intensive care unit (ICU) care and prognosis of patients with inhalation injury after exposure to indoor fire and smoke.Materials and Methods: This is a prospective observational cohort study that includes patients admitted to seven ICUs after a fire disaster. The following data were collected: demographic characteristics; use of fiberoptic bronchoscopy; degree of inhalation injury; percentage of burned body surface area; mechanical ventilation parameters; and subsequent events during ICU stay. Patients were followed to determine the ICU and hospital mortality rates.Results: Within 24h of the incident, 68 patients were admitted to seven ICUs. The patients were young and had no comorbidities. Most patients (n=35; 51.5%) only had an inhalation injury. The mean ventilator-free days for patients with an inhalation injury degree of 0 or I was 12.5±8.1 days. For patients with an inhalation injury degree of II or III, the mean ventilator-free days was 9.4±5.8 days (p=0.12). In terms of the length of ICU stay for patients with degrees 0 or I, and patients with degrees II or III, the median was 7.0 days (5.0-8.0 days) and 12.0 days (8.0-23.0 days) (p<0.001), respectively. In addition, patients with a larger percentage of burned surface areas also had a longer ICU stay; however, no association with ventilator-free days was found. The patients with <10% of burned body surface area showed a mean of 9.2±5.4 ventilator-free days. The mean ventilator-free days for patients who had >10% burned body surface area was 11.9±9.5 (p=0.26). The length of ICU stay for the <10% and >10% burned body surface area patients was 7.0 days (5.0-10.0 days) and 23.0 days (11.5-25.5 days) (p<0.001), respectively.Conclusions: We conclude that burn patients with inhalation injuries have different courses of disease, which are mainly determined by the percentage of burned body surface area. [ABSTRACT FROM AUTHOR]

Abstract: Aim: To describe the reasons for medical emergency team (MET) activation, and to verify the association of the MET score with 30-day mortality. Methods: This retrospective observational study took place in a 794-bed university-affiliated hospital. The population included all adult admissions reviewed by the MET during the period between January 2007 and June 2008. MET score was defined as the sum of each of the physiological triggers, and score zero was considered the calls made due to concern about the patient, without any physiological alteration. Results: During the period of the study, 1051 calls were generated for 901 patients. Respiratory distress and hypotension accounted for most of MET calls. The triggers that showed an independent association with mortality were threatened airway, systolic blood pressure <90mmHg, decrease in Glasgow Coma Scale score ≥2 points and respiratory frequency >36breaths/min. Logistic regression analysis revealed MET score, age, medical patient, documented do not resuscitate orders and MET decision to transfer to the intensive care unit to be significant predictors of 30-day mortality. Conclusions: MET score presents a strong association with 30-day mortality in patients seen on the ward. [Copyright &y& Elsevier]

To determine whether Stewart’s approach can improve our ability to diagnose acid–base disorders compared to the traditional model. This prospective cohort study took place in a university-affiliated hospital during the period of February–May 2007. We recorded clinical data and acid–base variables from one hundred seventy-five patients at intensive care unit admission. Of the 68 patients with normal standard base excess (SBE) (SBE between −4.9 and +4.9), most ( n = 59; 86.8%) had a lower effective strong ion difference (SIDe), and of these, 15 (25.4%) had SIDe < 30 mEq/L. Thus, the evaluation according to Stewart’s method would allow an additional diagnosis of metabolic disorder in 33.7% patients. The Stewart approach, compared to the traditional evaluation, results in identification of more patients with major acid–base disturbances. [ABSTRACT FROM AUTHOR]

This is a cohort study that included consecutive family members of patients with persistent critical illness, defined as an ICU stay of longer than 10 days, between April 2018 and October 2019, in the Hospital de Clínicas de Porto Alegre, Brazil. Multivariable linear regression models using caregiving burden, anxiety and depression as outcomes and including independent variables previously chosen that could plausibly contribute to the occurrence of outcomes were performed. [Extracted from the article]

The objective of our study was to investigate the patterns of use of psychoactive substances among students of a medical school in Southern Brazil and to explore a putative role of discrete behavioral and social variables in their drug use.This is a descriptive and transversal cut study. All regularly enrolled medical students at the University of Caxias do Sul were invited to participate in the study. A self-administered questionnaire, which analyses lifetime drug use as well as drug use in the previous 30 days and 12 months was utilized to collect data. From a total of 318 regularly enrolled students, 183 (57.5%) completed and returned the questionnaires. The highest prevalence rates of lifetime drug use, drug use in the last 12 months and drug use in the last 30 days were observed, according to drug type, as follow in descending order: alcohol, tobacco, marijuana, inhalants, tranquilizers, amphetamine and cocaine. A multivariate analysis indicated that research respondents who live with their parents as well as those whose parents live together harmoniously, those who deny close ties to drug users, those who disapprove drug use, those who are not tobacco smokers and those who manifest religious beliefs and practice presented the most reduced levels of illicit drug use. The use of psychoactive substances among medical students in the University of Caxias do Sul is a significant problem. Appropriate and timely initiatives are needed to prevent and curb drug use among medical students. [Boniatti MM, Zubaran C, Panarotto D, Delazeri DJ, Tirello JL, de Oliveira Feldens M, Sperotto VFR. The use of psychoactive substances among medical students in southern Brazil. Drug Alcohol Rev 2007;26:] [ABSTRACT FROM AUTHOR]

To evaluate the association of body temperature with mortality in septic patients admitted to the ICU from the ward. In addition, we intend to investigate whether the timing of antibiotic administration was different between febrile and afebrile patients and whether this difference contributed to mortality. This is a retrospective cohort study that included sepsis patients admitted to the ICU from the ward between July 2017 and July 2019. Antibiotic administration was defined as the initiation of antimicrobial treatment or the expansion of the antimicrobial spectrum within 48 h prior to admission to the ICU. Regarding vital signs, the most altered vital sign in the 48 h prior to admission to the ICU was considered. Two hundred and eight patients were included in the final analysis. Antibiotic administration occurred earlier in patients with fever than in patients without fever. Antibiotic administration occurred before admission to the ICU in 27 (90.0%) patients with fever and in 101 (64.7%) patients without fever (p = 0.006). The mortality rate in the ICU was 88 in 176 (50.0%; 95% CI 42.5–57.5%) patients without fever and 7 in 32 (21.9%; 95% CI 6.7–37.0%) patients with fever (p = 0.004). In the multivariate analysis, absence of fever significantly increased the risk of ICU mortality (OR 3.462; 95% CI 1.293–9.272). We found an inverse association between body temperature and mortality in patients with sepsis admitted to the ICU from the ward. Although antibiotic administration was earlier in patients with fever and precocity was associated with reduced mortality, the time of antibiotic administration did not fully explain the lower mortality in these patients. [ABSTRACT FROM AUTHOR]

Purpose: To determine whether Stewart's approach can improve our ability to diagnose acid-base disorders compared to the traditional model.Methods: This prospective cohort study took place in a university-affiliated hospital during the period of February-May 2007. We recorded clinical data and acid-base variables from one hundred seventy-five patients at intensive care unit admission.Results: Of the 68 patients with normal standard base excess (SBE) (SBE between -4.9 and +4.9), most (n = 59; 86.8%) had a lower effective strong ion difference (SIDe), and of these, 15 (25.4%) had SIDe < 30 mEq/L. Thus, the evaluation according to Stewart's method would allow an additional diagnosis of metabolic disorder in 33.7% patients.Conclusions: The Stewart approach, compared to the traditional evaluation, results in identification of more patients with major acid-base disturbances. [ABSTRACT FROM AUTHOR]