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1. Stimulation of B-cells by Dextran Sulphate <em> in vitro </em>.

Author

Diamantstein, T., Rühl, H., Vogt, W., and Bochert, G.

Subjects
*B cells, *DEXTRAN, *SULFATASES, *LABORATORY mice, *CELLS, *MITOGENS, *IMMUNOLOGY
Abstract

Dextran sulphate (DS) stimulates [³H]TdR incorporation in spleen cells of various strains of mice including athymic nude mice. In spleen cells of normal mice an additive effect of DS on the PHA-response was detected. The results suggest that DS is a B-cell mitogen. It seems that the mitogenic activity of polyanions may be related to their effects on antibody formation. [ABSTRACT FROM AUTHOR]

Published
1973

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