Search

Aims of the study. – Only a good knowledge of the effects of age on postural stability allows differentiating between physiological aging and pathologies leading to its impairment. The aims of this study were to define the posturographic parameters which best reflected the effects of aging on postural stability and to determine the slope of postural stability impairment related to aging.Patients and methods. – Postural stability of 50 normal volunteers aged 25–83 years (55.4) was studied with one Kistler force plate. Subjects were asked to stand for 30 s on two-legged stance, eyes open then closed. The center of pressure displacement (COPd) and velocities (COPv), in the antero-posterior (x) and the medio-lateral (z) axis, the sway axis, and the integral of COP displacement vs. time were computed. Eleven subjects were retested at 3 and 6 months to estimate the reliability of posturographic measurements. In addition, 28 subjects aged 25–83 years (60.2) were retested 2.2 years after their first posturographic assessment.Results. – COPxv best reflected postural stability impairment with aging. Closure of the eyes increased the variance of the results. This change was higher in subjects more than 60 years old: 0.019–0.157 cm2 s–2 than in younger ones: 0.011–0.043 cm2 s–2. Retesting at 3 and 6 months showed a reliability of 79%. According to the cross-sectional part of the study, the slope of postural stability impairment with aging was estimated at 0.0038 cm/s/year. These results were confirmed by the longitudinal part of the study, which showed that COPxv increased from 0.66–0.75 cm/s/year (P = 0.0001) (slope = 0.0041 cm/s/year).Conclusion. – (1) Measurement of COPxv, on two-legged stance, is a simple and reliable way to assess postural stability. (2) Thanks to both a cross sectional and a longitudinal study, the rate of postural stability impairment due to aging was precisely estimated, which will be useful to help distinguishing between the part of postural stability impairment attributable to aging from the one due to neuro-degenerative diseases. [Copyright &y& Elsevier]

Examines the effect of organic complex compounds on Bacillus thermoamylovorans growth and glucose fermentation. Growth limitation with the presence of excess glucose; Comparison on fermentation patterns between thermoamylovorans and lactic bacteria; Coupling between cellular synthesis and energy production.