1. Myeloperoxidase: Molecular Mechanisms of Action and Their Relevance to Human Health and Disease.
- Author
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Betty S. van der Veen, Menno P.J. de Winther, and Peter Heeringa
- Subjects
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PEROXIDASE , *BIOCHEMICAL mechanism of action , *GENETIC polymorphisms , *GENETIC transcription , *IMMUNOREGULATION , *LABORATORY mice , *ANIMAL models in research - Abstract
IntroductionProperties of MPOCellular origin of MPOMPOgeneGene structureTranscriptional activationGenetic polymorphismsMPO protein biosynthesis, processing, and structureEnzymatic properties of MPOCatalytic mechanisms and redox intermediates of MPOMPO-derived oxidantsMPO in HealthMicrobicidal effects of MPOLessons learned from MPO-deficient miceMPO in DiseaseProperties of MPO in modulating immune responses and inflammationMPO and cardiovascular diseasesClinical studiesMPO in endothelial dysfunctionLipoprotein modification mediated by MPOLessons learned from MPO mouse modelsMPO and carcinogenesisMPO and neurodegenerative diseasesMPO and renal diseasesMPO and lung diseasesMPO in other chronic inflammatory diseasesMPO as autoantigen in systemic vasculitisClinical observationsIn vitrostudies involving MPO-ANCALessons learned from MPO-ANCA animal modelsMPO Detection in Tissues and Biologic FluidsConclusions [ABSTRACT FROM AUTHOR]
- Published
- 2009
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