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Study Design: Retrospective review.Objective: To evaluate the effect of preoperative Halo-gravity traction (HGT) in the treatment of severe focal kyphosis in the upper thoracic spine (UTS), and to propose the indications that HGT could serve as an alternative for three-column osteotomy (3CO) among these patients.Summary Of Background Data: The HGT has been proven to be effective for severe kyphoscoliosis secondary to multiple etiologies. However, the safety and efficacy of HGT in severe focal kyphosis in UTS was still unclear.Methods: Patients with focal kyphosis in UTS undergoing HGT and without 3CO operation were reviewed. The sagittal focal kyphosis was measured at pre-, posttraction, and postoperation. The neurologic function at pretraction, posttraction, and postoperation were assessed according to the American Spinal Injury Association (ASIA) grading. The complications during HGT, operation, and follow-up were recorded. The comparison between pretraction and posttraction was performed using paired samples t test.Results: A total of 19 patients were included in this study, with a mean age of 13.2 ± 5.8 years. The average duration of HGT was 62.6 ± 8.4 days, during which the average kyphosis decreased from 95.3 ± 16.4° to 64.1 ± 19.2° (P < 0.001). After HGT, the ASIA grade improved from C to D in three patients and from C to E in three patients, from D to E in seven patients, from B to D in one patient. No deterioration in neurologic function was observed during HGT. The neurological status in one patient improved from ASIA C at pretraction to ASIA E at postoperation, but deteriorated to C at 4 years follow-up.Conclusion: Preoperative HGT could help to correct deformity and improve neurological deficit. 3CO procedure might be unnecessary in patients with severe focal kyphosis in UTS with the utilization of HGT.Level of Evidence: 4. [ABSTRACT FROM AUTHOR]

Study Design: A retrospective study.Objective: To determine the significance of postoperative upper instrumented vertebra (UIV) horizontalization on the evolution of proximal compensatory curve after hemivertebra resection and short fusion in young patients with lumbosacral hemivertebra (LSHV).Summary Of Background Data: Postoperative compensatory curve progression (CCP) is an undesired complication in patients undergoing spinal fusion. Posterior-only hemivertebra resection and short fusion has gradually become a preferred treatment for young patients with LSHV. Postoperative UIV horizontalization might play an important role in the behavior of compensatory curve after surgery.Methods: This study reviewed a consecutive series of patients undergoing posterior-only LSHV resection and short fusion from August 2006 to June 2016. The radiographic parameters were measured at preoperation, immediately postoperation, and the last follow-up. Based on the immediately postoperative UIV tilt, patients were divided into horizontal group (UIV tilt < 5°) and inclined group (UIV tilt ≥5°). Postoperative CCP was defined as the Cobb angle of compensatory curve increased more than 10° than the immediately postoperative value.Results: Forty-eight patients (8.1 ± 3.4 yrs) were recruited. Seventeen patients with immediately postoperative UIV tilt more than or equal to 5° constituted the inclined group, while the other 31 patients were in horizontal group. The two groups had similar age, fusion levels, preoperative spinal curvatures, and sagittal profiles. Compared with horizontal group, patients in inclined group had greater CBD (20.7 ± 14.8 mm vs. 13.2 ± 9.9 mm, P = 0.041) and greater Cobb angle of compensatory curve (17.7 ± 8.2° vs. 9.1 ± 5.3°, P < 0.001) at the last follow-up. Thirteen patients of inclined group experienced postoperative CCP, which was more prevalent than that in horizontal group (76.5% vs. 9.7%, P < 0.001).Conclusion: Horizontalizing the UIV can reduce the risk of postoperative CCP in LSHV patients undergoing posterior-only hemivertebra resection and short fusion.Level Of Evidence: 3. [ABSTRACT FROM AUTHOR]

Study Design: A retrospective and comparative study.Objective: To evaluate the difference of DNA methylation in protocadherin10 (PCDH10) genes between adolescent idiopathic scoliosis (AIS) and normal controls, and to assess the association between DNA methylation and the etiology of AIS.Summary Of Background Data: The PCDH10 gene showed abnormal expression in AIS. However, the mechanism was still unclear. DNA methylation was an important epigenetic mechanism at the interface between genetics and environmental phenotype, seeming to be a suitable epigenetic mark for the abnormal expression of PCDH10 in AIS.Methods: There were 50 AIS patients and 50 healthy controls included in the study. The peripheral blood sample of each participant was taken. The pyrosequencing assay was used to assess the methylation status of PCDH10 promoter and real time PCR (RT-PCR) was used to detect the PCDH10 gene expression. The comparison analysis was performed using independent t test and 2-tailed Pearson coefficients was calculated for the correlation analysis.Results: The average methylation level was 4.32 ± 0.73 in AIS patients and 3.14 ± 0.97 in healthy controls (P < 0.001). The PCDH10 gene expression was 0.23 ± 0.04 in AIS patients and 0.36 ± 0.08 in normal controls (P < 0.0001). Statistically significant linear correlation was found between PCDH10 gene methylation level and Cobb angle of major curve (P < 0.001). Besides, a significant negative correlation between PCDH10 methylation and PCDH10 gene expression was found (P < 0.001).Conclusion: AIS patients were associated with high DNA methylation level and low gene expression of PCDH10 gene rather than normal controls. The high methylation level indicated high Cobb angle of major curves in AIS. The abnormal DNA methylation may widely exist and serve as a potential mechanism for AIS.Level Of Evidence: 3. [ABSTRACT FROM AUTHOR]

Background: The new simplified thumb ossification composite index (TOCI) based on ossification of the thumb epiphyses and adductor sesamoid has demonstrated simplicity, excellent reliability, and high accuracy for predicting skeletal maturity, comparable with the Sanders simplified skeletal maturity system (SSMS). It was our belief that, because the terminology of the SSMS system has been commonly used for skeletal maturity prediction in idiopathic scoliosis in publications over the past decade, the clinical applicability of the TOCI system would increase if the stages in the 2 systems were found to be interchangeable and highly correlated.Methods: Hand radiographs of 125 premenarchal girls with newly diagnosed adolescent idiopathic scoliosis who had been followed longitudinally until skeletal maturity were all scored with use of the Tanner-Whitehouse III (TW3) system (stages E through I), the TOCI, and the SSMS. The scores for the epiphyses of the ulnar 4 digits were compared with those for the thumb and correlated with the timing of peak height velocity. Correlations were analyzed with the chi-square test and Cramer V and Somers delta correlations.Results: Six hundred and forty-five hand radiographs (an average of 5 for each girl with idiopathic scoliosis) and 11,517 epiphyses were scored. The rate of concordance between TW3 stages F, G, and I for the thumb proximal phalangeal epiphysis and those for all of the epiphyses of the ulnar 4 digits were 72.5%, 72.5%, and 89.9%, respectively. The overall concordance rate (including all epiphyses) was 71.3%, with a very high Cramer V correlation and significance (p < 0.01). High interchangeability was demonstrated for the TOCI and SSMS stages, supported by a high Somers delta correlation (>0.8) with significance (p < 0.05).Conclusions: The TOCI is highly practical for clinical use, and its stages are highly interchangeable with those of the SSMS.Clinical Relevance: The TOCI could serve as a simplified "marker" of skeletal maturity on hand radiographs and minimize the learning-curve problems associated with the SSMS in a busy clinical practice. [ABSTRACT FROM AUTHOR]

Background: Height velocity (HV) is traditionally used to monitor the residual growth potential in idiopathic scoliosis (IS). The temporal timing of rapid increase in standing height often does not match exactly that of the increase in spine height. The purposes of this study were to analyze the correlation between change of angle velocity (AV) vs the changes of spinal growth velocity (SGV) and HV, and the associated predictive value on curve progression in IS.Methods: Pre-pubertal IS girls with single curve receiving standardized bracing treatment followed longitudinally with documented curve progression >5° were retrospectively reviewed. The age, standing height, Cobb angle (main curve), spinal length, Risser sign, HV, SGV and AV at each visit were measured and calculated. The visit with the highest AV value of each patient was selected for the final analysis and correlated with the corresponding peak height velocity (PHV) and peak spinal growth velocity (PSGV).Results: Sixty-two IS girls were reviewed. Chi-square test revealed PSGV contributed more to the highest AV than PHV (P = 0.001). Pearson correlation analysis demonstrated that AV was correlated with SGV (r = 0.454, P < 0.001) and HV (r = 0.280, P = 0.027). Multiple linear regression analysis showed that high AV was better predicted by higher SGV (B = 0.321, P = 0.007) rather than higher HV (B = 0.259, P = 0.362) (R = 0.467).Conclusions: Variations of spinal growth velocity exerted more direct influence over changes in angle velocity as compared with height velocity. High spinal growth velocity predisposed to more rapid curve progression in patients with idiopathic scoliosis. [ABSTRACT FROM AUTHOR]

Study Design. A retrospective study. Objective. To study how the supine magnetic resonance image (MRI) correlates with standing radiographs of different curve severity in adolescent idiopathic scoliosis (AIS). Summary of Background Data. Linear correlation between Cobb angles measured on supine MRI and standing radiographs has been identified. However, the effects of different curve severity on the correlation have not been studied in depth. Methods. Girls with AIS with standing radiographs and supine MRI were reviewed. From standing radiographs, all structural and nonstructural Cobb angles were measured. For those with simultaneous lateral radiographs, thoracic kyphosis (TK) and lumbar lordosis (LL) angles were measured. On supine MRI, the coronal Cobb angles, TK and LL were measured accordingly. The coronal Cobb angles were divided into 3 groups based on values measured on standing radiographs: mild group for Cobb angles less than 20 ° , moderate group for 20 ° to 40 ° , and severe group for more than 40 ° . Correlation was analyzed using scatter plot. Results. Eighty patients with AIS with 122 coronal curves were reviewed. On standing radiographs, the coronal Cobb angles were 14.7 ° ± 3.2 ° , 28.2 ° ± 5.1 ° , and 54.9 ° ± 11.3 ° for mild, moderate, and severe groups. On supine MRI, the Cobb angles averaged 10.1 ° ± 5.6 ° , 20.0 ° ± 6.3 ° , and 49.4 ± 12.3 ° for each group, respectively. TK were 16.3 ± 9.1 ° and 11.8 ± 6.1 ° for radiographs and MRI ( P < 0.001), whereas the LL averaged 45.5 ± 12.2 ° and 39.5 ± 10.5 ° for radiographs and MRI ( P < 0.001). Cobb angles measured on standing radiographs and supine MRI were linearly correlated with the adjusted R 2 being 0.0627, 0.2118, and 0.7999 for the mild, moderate, and severe groups. Conclusion. Cobb angles measured on supine MRI were linearly correlated with Cobb angles measured on standing radiographs and the correlation was more reliable in those with Cobb angles more than 40 ° . Therefore, the supine MRI could serve as a reliable alternative to standing radiographs in the assessment of Cobb angles more than 40 ° in AIS. [ABSTRACT FROM AUTHOR]

Study design. A retrospective study. Objective. To identify independent risk factors and construct a prediction model for lumbar curve correction (LCC) after selective thoracic fusion (STF) in patients with Lenke 1 and 2 adolescent idiopathic scoliosis (AIS). Summary of Background Data. STF has been widely applied to Lenke 1 and 2 AIS patients. However, LCC after STF is still controversial. Methods. One hundred twenty-eight patients undergoing STF with at least 2 years of follow-up were included. Cases were divided into a high-LCC group and a low-LCC group according to a rounded-up median of 65%. Forty-nine variables were taken into account. Logistic regression was applied to identify independent predictive factors. A prediction model was established by backward stepwise regression, and its evaluation was implemented on R. Results. Five parameters showed independent predictive value for low LCC: right shoulder higher before surgery (right shoulder higher versus balanced: odds ratio [OR] =0.244, P=0.014), postoperative Cobb angle of lumbar curve (LC) (OR=1.415, P=0.001, cutoff value=11°), lowest instrumented vertebra (LIV) distal to end vertebra (no vs. yes: OR=4.587, P=0.013), postoperative LIV tilt (OR=0.686, P= 0.010, cutoff value= 6.85°) and postoperative LIV+1 tilt (OR=1.522, P=0.005, cutoff value=6.25°). The prediction model included 6 variables: lumbar modifier, preoperative shoulder balance, postoperative Cobb angle of LC, LIV position, postoperative LIV tilt, and postoperative LIV+1 tilt. The model evaluation demonstrated satisfactory capability and stability (area under curve =0.890, 10-fold cross-validation accuracy=0.782). Conclusion. Preoperative shoulder balance, Cobb angle of LC, LIV position, postoperative LIV and LIV+1 tilt could be used to prognosticate LCC after STF. A model with solid prediction ability was established, which could further our understanding of LCC and assist in making clinical decisions. [ABSTRACT FROM AUTHOR]

Study Design: A retrospective study.Objective: The aim of this study was to investigate the incidence and risk factors for distal adding-on (AO) phenomenon after posterior spinal fusion (PSF) in scoliosis secondary to Chiari malformation type I (CMS) patients with right major thoracic curve.Summary Of Background Data: Distal AO phenomenon is a common complication observed in adolescent idiopathic scoliosis (AIS), which is significantly associated with unsatisfactory outcomes. However, few studies specifically focused on the incidence and risk factors of distal AO in CMS.Methods: Seventy-eight CMS adolescents were included with a minimum of 2-year follow-up after PSF. patients with distal AO at the final follow-up were divided into AO group and those without were No-AO group. The coronal and sagittal parameters were evaluated preoperatively, immediately after surgery, and at the last follow-up. Clinical outcome was analyzed using the Chicago Chiari Outcome Scale (CCOS).Results: Distal AO was observed in 18 of 78 patients (23.1%). Compared with No-AO group, patients with distal AO had significantly lower Risser sign (P = 0.001), more flexibility of lumbar curve (P = 0.021), higher incidence of lowest instrumented vertebra-last substantially touched vertebra (LIV-LSTV) ≤0 (P = 0.001), smaller postoperative Cobb angle of lumbar curve (P < 0.001), and greater correction rate of lumbar curve (P = 0.001). Logistic regression analysis revealed that low Risser sign (Grade 1-2, odds ratio [OR] = 5.7, P = 0.029) and LIV-LSTV ≤0 (OR = 6.4, P = 0.019) were independent risk factors for distal AO. There was no significant difference of CCOS scores between two groups at the final follow-up (P > 0.05 for all).Conclusion: The incidence of distal AO was 23.1% in CMS patients after PSF. Patients with low Risser sign and LIV-LSTV ≤0 were high risk factors for distal AO.Level of Evidence: 3. [ABSTRACT FROM AUTHOR]

Background: The pedicle screw placement in scoliosis correction at the apex underlies potential risk for neurological injury. This research is to investigate the relative position of spinal cord at the apex in idiopathic thoracic scoliosis and to explore the risk of spinal cord injury from pedicle screw at the apex.Methods: Thirty-three adolescents with thoracic scoliosis were recruited in this study. The relative position of the spinal cord in the spinal canal was calculated by measuring the distance between the spinal cord and the medial wall of the pedicle on the convex and concave side through the axial plane of the apex in T2 weighted MR image. The distance from the spinal cord to the medial wall of pedicle between concave and convex side was compared respectively. The percentage of patients was calculated according to hypothesized different space (0 mm, less than 1 mm and less than 2 mm) between medial wall of pedicle and spinal cord at the apex.Results: The average distance from the spinal cord to the medial wall of pedicle at the concave side was significantly less than that at the convex side (p = 0.000) of the apex in the major thoracic curves before operation. In the concave side of the apex, the percentage of patients was 39.4, 66.7, 84. 5 % in hypothesized space (0 mm, less than 1 mm and less than 2 mm) between medial wall of pedicle and spinal cord. However, in the convex side of apex, the percentage of cases was 0, 0, 3.0 % in the same hypothesized space respectively.Conclusions: The screw placement is at a higher risk of spinal cord injury on the concave side than that on the convex side of apex in thoracic curve in MRI images. The screw placement in the concave side of apex should be evaluated carefully with MRI before operation. [ABSTRACT FROM AUTHOR]