1. Rituximab plus gemcitabine and oxaliplatin (R-GemOx) in refractory/relapsed diffuse large B-cell lymphoma: a real-life study in patients ineligible for autologous stem-cell transplantation.
- Author
-
Cazelles, Clarisse, Belhadj, Karim, Vellemans, Hélène, Camus, Vincent, Poullot, Elsa, Gaulard, Philippe, Veresezan, Liana, Itti, Emmanuel, Becker, Stéphanie, Carvalho, Muriel, Dupuis, Jehan, Le Bras, Fabien, Lemonnier, François, Roulin, Louise, El Gnaoui, Taoufik, Jardin, Fabrice, Mounier, Nicolas, Tilly, Hervé, and Haioun, Corinne
- Subjects
- *
DIFFUSE large B-cell lymphomas , *STEM cell transplantation , *AUTOTRANSPLANTATION , *RITUXIMAB , *GEMCITABINE - Abstract
There is no established standard treatment for relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) in patients who are not eligible to receive an intensive treatment. The combination of rituximab gemcitabine and oxaliplatin (R-GemOx) is widely used in this population but data are scarce. We retrospectively collected the data of 196 patients with R/R DLBCL treated with R-GemOx in two French centers over a period of 15 years. The median age of the population was 72 years (range, 24–89), 63% of the patients had an international prognostic index of 3 or higher and 57% were refractory to the last treatment. At the end of R-GemOx treatment, 33% of the patients obtained a complete response. The median progression-free survival (PFS) of the population was 5 months and the median overall survival (OS) was 10 months. Several factors were predictors of unfavorable survival: age over 75 years, international prognostic index of 2 or higher, refractory disease and de novo DLBCL. The median PFS and OS of the patients who obtained a complete response were 22 months and 40 months, respectively. The most significant toxicities were grade 3–4 hematological toxicities (31% of patients). Given its efficacy and tolerability, R-GemOx can be used in patients ineligible for intensive treatment and serve as a basis for new regimen combinations. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF