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Several approaches to quantum gravity lead to nonlocal modifications of fields' dynamics. This, in turn, can give rise to nonlocal modifications of quantum mechanics at non-relativistic energies. Here, we analyze the nonlocal Schrödinger evolution of a quantum harmonic oscillator in one such scenario, where the problem can be addressed without the use of perturbation theory. We demonstrate that although deviations from standard quantum predictions occur at low occupation numbers, where they could potentially be detected or constrained by high-precision experiments, the classical limits of quantum probability densities and free energy remain unaffected up to energies comparable with the nonlocality scale. These results provide an example of nonlocal quantum dynamics compatible with classical predictions, suggesting massive quantum objects as a promising avenue for testing some phenomenological aspects of quantum gravity. [ABSTRACT FROM AUTHOR]

Background: Obese and pre-diabetic women have a higher risk for cardiovascular death than age-matched men with the same symptoms, and there are no effective treatments. We reported that obese and pre-diabetic female Zucker Diabetic Fatty (ZDF-F) rats recapitulate metabolic and cardiac pathology of young obese and pre-diabetic women and exhibit suppression of cardio-reparative AT2R. Here, we investigated whether NP-6A4, a new AT2R agonist with the FDA designation for pediatric cardiomyopathy, mitigate heart disease in ZDF-F rats by restoring AT2R expression. Methods: ZDF-F rats on a high-fat diet (to induce hyperglycemia) were treated with saline, NP-6A4 (10 mg/kg/day), or NP-6A4 + PD123319 (AT2R-specific antagonist, 5 mg/kg/day) for 4 weeks (n = 21). Cardiac functions, structure, and signaling were assessed by echocardiography, histology, immunohistochemistry, immunoblotting, and cardiac proteome analysis. Results: NP-6A4 treatment attenuated cardiac dysfunction, microvascular damage (−625%) and cardiomyocyte hypertrophy (−263%), and increased capillary density (200%) and AT2R expression (240%) (p < 0.05). NP-6A4 activated a new 8-protein autophagy network and increased autophagy marker LC3-II but suppressed autophagy receptor p62 and autophagy inhibitor Rubicon. Co-treatment with AT2R antagonist PD123319 suppressed NP-6A4's protective effects, confirming that NP-6A4 acts through AT2R. NP-6A4-AT2R-induced cardioprotection was independent of changes in body weight, hyperglycemia, hyperinsulinemia, or blood pressure. Conclusions: Cardiac autophagy impairment underlies heart disease induced by obesity and pre-diabetes, and there are no drugs to re-activate autophagy. We propose that NP-6A4 can be an effective drug to reactivate cardiac autophagy and treat obesity- and pre-diabetes-induced heart disease, particularly for young and obese women. [ABSTRACT FROM AUTHOR]

We make use of the powerful formalism of quantum parameter estimation to assess the characteristic rates of a continuous spontaneous localization (CSL) model affecting the motion of a massive mechanical system. We show that a study performed in non-equilibrium conditions unveils the advantages provided by the use of genuinely quantum resources—such as quantum correlations—in estimating the CSL-induced diffusion rate. In stationary conditions, instead, the gap between quantum performance and a classical scheme disappears. Our investigation contributes to the ongoing effort aimed at identifying suitable conditions for the experimental assessment of collapse models. [ABSTRACT FROM AUTHOR]

Graph neural networks have proven their effectiveness across a wide spectrum of graph-based tasks. Despite their successes, they share the same limitations as other deep learning architectures and pose additional challenges for their formal verification. To overcome these problems, we proposed a specification language, μ G , that can be used to program graph neural networks. This language has been implemented in a Python library called libmg that handles the definition, compilation, visualization, and explanation of μ G graph neural network models. We illustrate its usage by showing how it was used to implement a Computation Tree Logic model checker in our previous work, and evaluate its performance on the benchmarks of the Model Checking Contest. In the future, we plan to use μ G to further investigate the issues of explainability and verification of graph neural networks. [ABSTRACT FROM AUTHOR]

Advances in quantum technologies are giving rise to a revolution in the way fundamental physics questions are explored at the empirical level. At the same time, they are the seeds for future disruptive technological applications of quantum physics. Remarkably, a space-based environment may open many new avenues for exploring and employing quantum physics and technologies. Recently, space missions employing quantum technologies for fundamental or applied studies have been proposed and implemented with stunning results. The combination of quantum physics and its space application is the focus of this review: we cover both the fundamental scientific questions that can be tackled with quantum technologies in space and the possible implementation of these technologies for a variety of academic and commercial purposes. [ABSTRACT FROM AUTHOR]

Whether the cosmological expansion can influence the local dynamics, below the galaxy clusters scale, has been the subject of intense investigations in the past three decades. In this work, we consider McVittie and Kottler spacetimes, embedding a spherical object in a FLRW spacetime. We calculate the influence of the cosmological expansion on the frequency shift of a resonator and estimate its effect on the exchange of light signals between local observers. In passing, we also clarify some of the statements made in the literature. [ABSTRACT FROM AUTHOR]

Quantum technologies are opening novel avenues for applied and fundamental science at an impressive pace. In this perspective article, we focus on the promises coming from the combination of quantum technologies and space science to test the very foundations of quantum physics and, possibly, new physics. In particular, we survey the field of mesoscopic superpositions of nanoparticles and the potential of interferometric and non-interferometric experiments in space for the investigation of the superposition principle of quantum mechanics and the quantum-to-classical transition. We delve into the possibilities offered by the state-of-the-art of nanoparticle physics projected in the space environment and discuss the numerous challenges, and the corresponding potential advancements, that the space environment presents. In doing this, we also offer an ab-initio estimate of the potential of space-based interferometry with some of the largest systems ever considered and show that there is room for tests of quantum mechanics at an unprecedented level of detail. This perspective presents current and future possibilities offered by space technology for testing quantum mechanics, with a focus on mesoscopic superposition of nanoparticles and the potential of interferometric and non-interferometric experiments in space. [ABSTRACT FROM AUTHOR]

Quantum hypothesis testing has shown the advantages that quantum resources can offer in the discrimination of competing hypothesis. Here, we apply this framework to optomechanical systems and fundamental physics questions. In particular, we focus on an optomechanical system composed of two cavities employed to perform quantum channel discrimination. We show that input squeezed optical noise, and feasible measurement schemes on the output cavity modes, allow to obtain an advantage with respect to any comparable classical schemes. We apply these results to the discrimination of models of spontaneous collapse of the wavefunction, highlighting the possibilities offered by this scheme for fundamental physics searches. [ABSTRACT FROM AUTHOR]

When a massive quantum body is put into a spatial superposition, it is of interest to consider the quantum aspects of the gravitational field sourced by the body. We argue that in order to understand how the body may become entangled with other massive bodies via gravitational interactions, it must be thought of as being entangled with its own Newtonian-like gravitational field. Thus, a Newtonian-like gravitational field must be capable of carrying quantum information. Our analysis supports the view that table-top experiments testing entanglement of systems interacting via gravity do probe the quantum nature of gravity, even if no "gravitons" are emitted during the experiment. [ABSTRACT FROM AUTHOR]

Vitamin D is an essential nutrient that is metabolized in the body to generate an active metabolite (1,25(OH)2D) with hormone-like activity and highly diverse roles in cellular function. Vitamin D deficiency (VDD) is a prevalent but easily p reventable nutritional disturbance. Emerging evidence demonstrates the importance of s ufficient vitamin D concentrations during fetal life with deficiencies leading to long-term effects into adulthood. Here, we provide a detailed review and perspective of evidence for the role of maternal VDD in offspring long-term health, particularly as i t relates to developmental origins of health and disease (DOHaD). We focus on the roles in neurobehavioral and cardiometabolic disorders in humans and highlight recent finding s from zebrafish and rodent models that probe potential mechanisms linking early life VDD to later life health outcomes. Moreover, we explore evidence implicating epigenetic mechanisms as a mediator of this link. Gaps in our current understanding of how maternal VDD might result in deleterious offspring outcomes later in life are also addressed. [ABSTRACT FROM AUTHOR]

Purpose: Maternal vitamin D deficiency during pregnancy is a widespread issue that may have long-lasting consequences on offspring adiposity. We sought to determine how maternal vitamin D deficiency during the perinatal period would affect offspring adipose tissue development and gene expression.Methods: Female C57BL/6 J mice were fed either a vitamin D deficient (VDD) or control diet from 4 weeks before pregnancy (periconception) until 7 days postparturition. Male offspring were weighed and euthanized at 75 days of age (early adult period), at which point serum was collected for biochemical analyses, and perigonadal and subcutaneous white adipose tissue (PGAT and SQAT, respectively) were excised, weighed, then flash-frozen for later histology and analyses of adipogenic gene expression.Results: All adult male offspring were nonobese; there were no significant differences in body weight, adipose pad weight, or adipocyte size. However, VDD-exposed offspring had greater expression of the adipogenic-regulating genes peroxisome proliferator-activated receptor gamma (Pparg) and vitamin D receptor (Vdr).Conclusions: This study suggests that exposure to vitamin D deficiency during the perinatal period can directly affect genes involved in the development of adipose tissue in nonobese offspring. These novel findings invite further investigation into the mechanisms by which maternal vitamin D status during pregnancy affects adipose development and metabolic health of offspring. [ABSTRACT FROM AUTHOR]

The fetal period represents an important window of susceptibility for later obesity and metabolic disease. Maternal vitamin D deficiency (VDD) during pregnancy is a global concern that may have long-lasting consequences on offspring metabolic health. We sought to determine whether a VDD in utero environment affects fetal adipose tissue development and offspring metabolic disease predisposition in adulthood. Furthermore, we sought to explore the extent to which the VDD intrauterine environment interacts with genetic background or postnatal environment to influence metabolic health. Eight-week-old P0 female C57BL/6J mice were fed either a VDD diet or sufficient diet (VDS) from four weeks before pregnancy (periconception) then bred to male Avy/a mice. Females were maintained on the diets throughout gestation. At weaning, Avy/a and a/a male F1 offspring were randomized to low-fat (LFD) or high-fat diet (HFD) until 19 weeks of age, at which point serum and adipose tissue were harvested for analyses. Mice born to VDD dams weighed less at weaning than offspring born to VDS dams but experienced rapid weight gain in the four weeks post weaning, and acquired a greater ratio of perigonadal (PGAT) to subcutaneous (SQAT) than control offspring. Additionally, these mice were more susceptible to HFD-induced adipocyte hypertrophy. Offspring of VDD dams also had greater expression of Pparg transcript. These novel findings demonstrate that in utero VDD, an easily correctable but highly prevalent health concern, predisposes offspring to long-term adipose tissue consequences and possible adverse metabolic health complications. [ABSTRACT FROM AUTHOR]

It is known that there is disruption of the blood–brain barrier during terminal AIDS encephalitis in both human immunodeficiency virus (HIV)-infected humans and simian immunodeficiency virus (SIV)-infected rhesus macaques. Much, although by no means all, of the neuropathological findings of HIV and SIV infection involves accumulation of monocytes/macrophages that have likely crossed the blood–brain barrier (BBB). There is no convincing, rigorous, demonstration of HIV (or SIV) infecting endothelial cells in vivo. However, this is not to say that HIV infection would not have any effects on the physiology of microvascular brain endothelial cells. Because of the elaborate nature of cerebral microvessels, previous studies of cerebral endothelial cells have been constrained by sectioning artifacts. Examination of freshly isolated cerebral microvessels allows investigation of extended lengths of vessels (>150 μm) without sectioning artifacts. These studies determine the changes in the expression of the tight junction protein zo-1 protein on the endothelial cells of cerebral capillaries at terminal acquired immune deficiency syndrome, demonstrating that there is a decreased expression of zo-1 protein over extended lengths of microvessels. [ABSTRACT FROM AUTHOR]

Quantum field theory is completely characterized by the field correlations between spacetime points. In turn, some of these can be accessed by locally coupling to the field simple quantum systems, also known as particle detectors. In this letter we consider what happens when a quantum-controlled superposition of detectors at different space-time points is used to probe the correlations of the field. We show that, due to quantum interference effects, two detectors can gain information on field correlations that would not be accessible, otherwise. This has relevant consequences for information theoretic quantities, like entanglement and mutual information harvested from the field. In particular, the quantum control allows for extraction of entanglement in scenarios where this is, otherwise, provably impossible. [ABSTRACT FROM AUTHOR]

Motivated by the development of on-going optomechanical experiments aimed at constraining non-local effects inspired by some quantum gravity scenarios, the Hamiltonian formulation of a non-local harmonic oscillator, and its coupling to a cavity field mode(s), is investigated. In particular, we consider the previously studied model of non-local oscillators obtained as the non-relativistic limit of a class of non-local Klein–Gordon operators, , with f  an analytical function. The results of previous works, in which the interaction was not included, are recovered and extended by way of standard perturbation theory. At the same time, the perturbed energy spectrum becomes available in this formulation, and we obtain the Langevin’s equations characterizing the interacting system. [ABSTRACT FROM AUTHOR]

In order to understand the detailed mechanism by which a fundamental discreteness can provide a finite entanglement entropy, we consider the entanglement entropy of two classes of free massless scalar fields on causal sets that are well approximated by causal diamonds in Minkowski spacetime of dimensions 2, 3 and 4. The first class is defined from discretised versions of the continuum retarded Green functions, while the second uses the causal set’s retarded nonlocal d’Alembertians parametrised by a length scale lk. In both cases we provide numerical evidence that the area law is recovered when the double-cutoff prescription proposed in Sorkin and Yazdi (2016 Entanglement entropy in causal set theory (arXiv:1611.10281)) is imposed. We discuss in detail the need for this double cutoff by studying the effect of two cutoffs on the quantum field and, in particular, on the entanglement entropy, in isolation. In so doing, we get a novel interpretation for why these two cutoff are necessary, and the different roles they play in making the entanglement entropy on causal sets finite. [ABSTRACT FROM AUTHOR]

Modifications of Einstein’s theory of gravitation have been extensively considered in the past years, in connection to both cosmology and quantum gravity. Higher-curvature and higher-derivative gravity theories constitute the main examples of such modifications. These theories exhibit, in general, more degrees of freedom than those found in standard general relativity; counting, identifying, and retrieving the description/representation of such dynamical variables is currently an open problem, and a decidedly nontrivial one. In this work we review, via both formal arguments and custom-made examples, the most relevant methods to unveil the gravitational degrees of freedom of a given model, discussing the merits, subtleties and pitfalls of the various approaches. [ABSTRACT FROM AUTHOR]

The continuum limit of a 4-dimensional, discrete d’Alembertian operator for scalar fields on causal sets is studied. The continuum limit of the mean of this operator in the Poisson point process in 4-dimensional Minkowski spacetime is shown to be the usual continuum scalar d’Alembertian . It is shown that the mean is close to the limit when there exists a frame in which the scalar field is slowly varying on a scale set by the density of the Poisson process. The continuum limit of the mean of the causal set d’Alembertian in 4-dimensional curved spacetime is shown to equal , where R is the Ricci scalar, under certain conditions on the spacetime and the scalar field. [ABSTRACT FROM AUTHOR]

Causal set non-local wave operators allow both for the definition of an action for causal set theory and the study of deviations from local physics that may have interesting phenomenological consequences. It was previously shown that, in all dimensions, the (unique) minimal discrete operators give averaged continuum non-local operators that reduce to in the local limit. Recently, dropping the constraint of minimality, it was shown that there exist an infinite number of discrete operators satisfying basic physical requirements and with the right local limit in flat spacetime. In this work, we consider this entire class of generalized causal set d’Alembertins in curved spacetimes and extend to them the result about the universality of the −R/2 factor. Finally, we comment on the relation of this result to the Einstein equivalence principle. [ABSTRACT FROM AUTHOR]

Several quantum gravity scenarios lead to physics below the Planck scale characterized by nonlocal, Lorentz invariant equations of motion. We show that such nonlocal effective field theories lead to a modified Schrödinger evolution in the nonrelativistic limit. In particular, the nonlocal evolution of optomechanical quantum oscillators is characterized by a spontaneous periodic squeezing that cannot be generated by environmental effects. We discuss constraints on the nonlocality obtained by past experiments, and show how future experiments (already under construction) will either see such effects or otherwise cast severe bounds on the nonlocality scale (well beyond the current limits set by the Large Hadron Collider). This paves the way for table top, high precision experiments on massive quantum objects as a promising new avenue for testing some quantum gravity phenomenology. [ABSTRACT FROM AUTHOR]

Proximal tubular epithelial cells (PTEC) in the S1 segment of the kidney abundantly express sodium-glucose co-transporters (SGLT) that play a critical role in whole body glucose homeostasis. We recently reported suppression of RECK (Re version Inducing C ysteine Rich Protein with K azal Motifs), a membrane anchored endogenous MMP inhibitor and anti-fibrotic mediator, in the kidneys of db/db mice, a model of diabetic kidney disease (DKD), as well as in high glucose (HG) treated human kidney proximal tubule cells (HK−2). We further demonstrated that empagliflozin (EMPA), an SGLT2 inhibitor, reversed these effects. Little is known regarding the mechanisms underlying RECK suppression under hyperglycemic conditions, and its rescue by EMPA. Consistent with our previous studies, HG (25 mM) suppressed RECK expression in HK-2 cells. Further mechanistic investigations revealed that HG induced superoxide and hydrogen peroxide generation, oxidative stress-dependent TRAF3IP2 upregulation, NF-κB and p38 MAPK activation, inflammatory cytokine expression (IL-1β, IL-6, TNF-α, and MCP-1), miR-21 induction, MMP2 activation, and RECK suppression. Moreover, RECK gain-of-function inhibited HG-induced MMP2 activation and HK-2 cell migration. Similar to HG, advanced glycation end products (AGE) induced TRAF3IP2 and suppressed RECK, effects that were inhibited by EMPA. Importantly, EMPA treatment ameliorated all of these deleterious effects, and inhibited epithelial-to-mesenchymal transition (EMT) and HK-2 cell migration. Collectively, these findings indicate that hyperglycemia and associated AGE suppress RECK expression via oxidative stress/TRAF3IP2/NF-κB and p38 MAPK/miR-21 induction. Furthermore, these results suggest that interventions aimed at restoring RECK or inhibiting SGLT2 have the potential to treat kidney inflammatory response/fibrosis and nephropathy under chronic hyperglycemic conditions, such as DKD. Unlabelled Image • High glucose and associated AGE suppress RECK, an anti-fibrotic MMP-regulator, in proximal tubule epithelial cells (PTEC). • High glucose induces oxidative stress and TRAF3IP2-dependent inflammatory cytokine expression in renal PTEC. • Empagliflozin, a SGLT2 inhibitor, reverses HG- and AGE-induced RECK suppression and TRAF3IP2 upregulation in renal PTEC. • Empagliflozin suppresses EMT and PTEC migration, hallmarks of diabetic kidney disease. • Empagliflozin has therapeutic potential in diabetic kidney disease. [ABSTRACT FROM AUTHOR]

Many children and adolescents with autism spectrum disorder (ASD) have significant gastrointestinal (GI) symptoms, but the etiology is currently unknown. Some individuals with ASD show altered reactivity to stress and altered immune markers relative to typically-developing individuals, particularly stress-responsive cytokines including tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6). Acute and chronic stress is associated with the onset and exacerbation of GI symptoms in those without ASD. The present study examined whether GI symptoms in ASD were associated with increases in cortisol, a stress-associated endocrine marker, and TNF-α and IL-6 in response to stress. As hypothesized, a greater amount of lower GI tract symptoms were significantly associated with post-stress cortisol concentration. The relationship between cortisol response to stress and GI functioning was greater for children who had a history of regressive autism. Exploratory analyses revealed significant correlations between cortisol response, intelligence, and inappropriate speech. In contrast, symptoms of the lower GI tract were not associated with levels of TNF-α or IL-6. Significant correlations were found, however, between TNF-α and IL-6 and irritability, socialization, and intelligence. These findings suggest that individuals with ASD and symptoms of the lower GI tract may have an increased response to stress, but this effect is not associated with concomitant changes in TNF-α and IL-6. The relationship between cortisol stress response and lower GI tract symptoms in children with regressive autism, as well as the relationships between cortisol, IL-6, and intelligence in ASD, warrant further investigation. [ABSTRACT FROM AUTHOR]

• Paraxanthine (PARA) is a more reliable population biomarker than pMMoV for WBE. • Normalization coefficients can be used for direct SARS-CoV-2 normalization. • Clinical case numbers should be normalized by real-time population. • Paraxanthine demonstrated excellent utility for estimating real-time population. • Normalization by PARA improved the correlation between viral load and case number. Wastewater-based epidemiology (WBE) has been one of the most cost-effective approaches to track the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) levels in the communities since the coronavirus disease 2019 (COVID-19) outbreak in 2020. Normalizing SARS-CoV-2 concentrations by the population biomarkers in wastewater is critical for interpreting the viral loads, comparing the epidemiological trends among the sewersheds, and identifying the vulnerable communities. In this study, five population biomarkers, pepper mild mottle virus (PMMoV), creatinine (CRE), 5-hydroxyindoleacetic acid (5-HIAA), caffeine (CAF) and its metabolite paraxanthine (PARA) were investigated and validated for their utility in normalizing the SARS-CoV-2 loads through two normalizing approaches using the data from 64 wastewater treatment plants (WWTPs) in Missouri. Their utility in assessing the real-time population contributing to the wastewater was also evaluated. The best performing candidate was further tested for its capacity for improving correlation between normalized SARS-CoV-2 loads and the clinical cases reported in the City of Columbia, Missouri, a university town with a constantly fluctuating population. Our results showed that, except CRE, the direct and indirect normalization approaches using biomarkers allow accounting for the changes in wastewater dilution and differences in relative human waste input over time regardless flow volume and population of the given WWTP. Among selected biomarkers, PARA is the most reliable population biomarker in determining the SARS-CoV-2 load per capita due to its high accuracy, low variability, and high temporal consistency to reflect the change in population dynamics and dilution in wastewater. It also demonstrated its excellent utility for real-time assessment of the population contributing to the wastewater. In addition, the viral loads normalized by the PARA-estimated population significantly improved the correlation (rho =0.5878, p < 0.05) between SARS-CoV-2 load per capita and case numbers per capita. This chemical biomarker complements the current normalization scheme recommended by CDC and helps us understand the size, distribution, and dynamics of local populations for forecasting the prevalence of SARS-CoV2 within each sewershed. [Display omitted] [ABSTRACT FROM AUTHOR]

• Wastewater facilities that exhibit SARS-CoV-2 suppression have been identified. • Average SARS-CoV-2 load per reported case was calculated to be 5 × 1011. • Metabolomic profiling was used to identify the compounds suppressing the SARS-CoV-2. • Four compounds are positively correlated with SARS-CoV-2 signal suppression rates. Recent SARS-CoV-2 wastewater-based epidemiology (WBE) surveillance have documented a positive correlation between the number of COVID-19 patients in a sewershed and the level of viral genetic material in the wastewater. Efforts have been made to use the wastewater SARS-CoV-2 viral load to predict the infected population within each sewershed using a multivariable regression approach. However, reported clear and sustained variability in SARS-CoV-2 viral load among treatment facilities receiving industrial wastewater have made clinical prediction challenging. Several classes of molecules released by regional industries and manufacturing facilities, particularly the food processing industry, can significantly suppress the SARS-CoV-2 signals in wastewater by breaking down the lipid-bilayer of the membranes. Therefore, a systematic ranking process in conjugation with metabolomic analysis was developed to identify the wastewater treatment facilities exhibiting SARS-CoV-2 suppression and identify and quantify the chemicals suppressing the SARS-COV-2 signals. By ranking the viral load per diagnosed case among the sewersheds, we successfully identified the wastewater treatment facilities in Missouri, USA that exhibit SARS-CoV-2 suppression (significantly lower than 5 × 1011 gene copies/reported case) and determined their suppression rates. Through both untargeted global chemical profiling and targeted analysis of wastewater samples, 40 compounds were identified as candidates of SARS-CoV-2 signal suppressors. Among these compounds, 14 had higher concentrations in wastewater treatment facilities that exhibited SARS-CoV-2 signal suppression compared to the unsuppressed control facilities. Stepwise regression analyses indicated that 4-nonylphenol, palmitelaidic acid, sodium oleate, and polyethylene glycol dioleate are positively correlated with SARS-CoV-2 signal suppression rates. Suppression activities were further confirmed by incubation studies, and the suppression kinetics for each bioactive compound were determined. According to the results of these experiments, bioactive molecules in wastewater can significantly reduce the stability of SARS-CoV-2 genetic marker signals. Based on the concentrations of these chemical suppressors, a correction factor could be developed to achieve more reliable and unbiased surveillance results for wastewater treatment facilities that receive wastewater from similar industries. [Display omitted] [ABSTRACT FROM AUTHOR]

The information on a quantum process acquired through measurements plays a crucial role in the determination of its nonequilibrium thermodynamic properties. We report on the experimental inference of the stochastic entropy production rate for a continuously monitored mesoscopic quantum system. We consider an optomechanical system subjected to continuous displacement Gaussian measurements and characterize the entropy production rate of the individual trajectories followed by the system in its stochastic dynamics, employing a phase-space description in terms of the Wigner entropy. Owing to the specific regime of our experiment, we are able to single out the informational contribution to the entropy production arising from conditioning the state on the measurement outcomes. Our experiment embodies a significant step towards the demonstration of full-scale control of fundamental thermodynamic processes at the mesoscopic quantum scale. [ABSTRACT FROM AUTHOR]