Search

In microarray experiments, the sample size is considerably smaller than that of the feature size, thereby imposing the curse of dimensionality problem. To resolve this issue, evolutionary algorithms are often utilized. In this paper, a novel framework for feature selection and classification of the microarray data is presented. Initially, a statistical filter, namely ANOVA, is used to select the relevant genes (features) from the original set of genes. Then, an evolutionary wrapper-based approach utilizing the principles of enhanced Jaya (EJaya) algorithm and forest optimization algorithm (FOA) is proposed to find the optimal set of genes from the previously selected genes. The main objective of using EJaya is to tune the two important parameters, namely local seeding changes and global seeding changes of FOA. During the selection of the optimal set of genes, support vector machine is employed as a classifier to classify the microarray data. To perform a comprehensive experimental study, the proposed method is tested on both binary-class and multi-class microarray datasets. From the extensive result analysis, it has been observed that the proposed technique achieves better classification accuracy with considerably less number of features than that of the benchmark schemes. [ABSTRACT FROM AUTHOR]

• A MapReduce-based Fisher score and ReliefF algorithms are proposed for feature selection. • A MapReduce-based probabilistic neural network (PNN) is implemented for classification. • Weighted chaotic grey wolf optimization algorithm is used to select the optimal value of σ in PNN. Background : The size of genomics data has been growing rapidly over the last decade. However, the conventional data analysis techniques are incapable of processing this huge amount of data. For the efficient processing of high dimensional datasets, it is essential to develop some new parallel methods. Methods : In this work, a novel distributed method is presented using Map-Reduce (MR)-based approach. The proposed algorithm consists of MR-based Fisher score (mrFScore), MR-based ReliefF (mrRefiefF), and MR-based probabilistic neural network (mrPNN) using a weighted chaotic grey wolf optimization technique (WCGWO). Here, mrFScore, and mrRefiefF methods are introduced for feature selection (FS), and mrPNN is implemented as an effective method for microarray classification. The proper choice of smoothing parameter (σ) plays a major role in the prediction ability of the PNN which is addressed using a novel technique namely, WCGWO. The WCGWO algorithm is used to select the optimal value of σ in PNN. Results : These algorithms have been successfully implemented using the Hadoop framework. The proposed model is tested by using three large and one small microarray datasets, and a comparative analysis is carried out with the existing FS and classification techniques. The results suggest that WCGWO-mrPNN can outperform other methods for high dimensional microarray classification. Conclusion : The effectiveness of the proposed methods are compared with other existing schemes. Experimental results reveal that the proposed scheme is accurate and robust. Hence, the suggested scheme is considered to be a reliable framework for microarray data analysis. Significance : Such a method promotes the application of parallel programming using Hadoop cluster for the analysis of large-scale genomics data, particularly when the dataset is of high dimension. [ABSTRACT FROM AUTHOR]