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Eating, shopping and cooking habits have radically changed over the last 50 years. This paper examines a number of food categories that have developed significantly over this time period and highlights where food science and specifically reformulation have played a role in developing foods, to better fit into modern, healthy diets. Underpinned by the growing knowledge and application of food science and technology, changes in food and drink composition in response to increased understanding of the links between diet and health have been significant. This trend is expected to continue into the foreseeable future. [ABSTRACT FROM AUTHOR]

Summary: Bone mineral density declines with increasing older age. We examined the levels of circulating factors known to regulate bone metabolism in healthy young and older adults. The circulating levels of dickkopf-1, osteocalcin, osteoprotegerin and sclerostin were positively associated with whole-body bone mineral density (WBMD) in older adults, despite the average WBMD being lower and circulating dickkopf-1, osteoprotegerin and sclerostin being higher in old than young. Introduction: This study aims to investigate the relationship between whole-body bone mineral density (WBMD) and levels of circulating factors with known roles in bone remodelling during 'healthy' ageing. Methods: WBMD and fasting plasma concentrations of dickkopf-1, fibroblast growth factor-23, osteocalcin, osteoprotegerin, osteopontin and sclerostin were measured in 272 older subjects (69 to 81 years; 52% female) and 171 younger subjects (18-30 years; 53% female). Results: WBMD was lower in old than young. Circulating osteocalcin was lower in old compared with young, while dickkopf-1, osteoprotegerin and sclerostin were higher in old compared with young. These circulating factors were each positively associated with WBMD in the older adults and the relationships remained after adjustment for covariates ( r values ranging from 0.174 to 0.254, all p < 0.01). In multivariate regression, the body mass index, circulating sclerostin and whole-body lean mass together accounted for 13.8% of the variation with WBMD in the older adults. In young adults, dickkopf-1 and body mass index together accounted for 7.7% of variation in WBMD. Conclusion: Circulating levels of dickkopf-1, osteocalcin, osteoprotegerin and sclerostin are positively associated with WBMD in community-dwelling older adults, despite the average WBMD being lower and circulating dickkopf-1, osteoprotegerin and sclerostin being higher in old than young. [ABSTRACT FROM AUTHOR]

Objective: To develop and evaluate the effectiveness of referral guidelines for the referral of orthodontic patients to consultant and specialist practitioner orthodontists.Design: Single centre randomised controlled trial with random allocation of referral guidelines for orthodontic treatment to general dental practitioners.Setting: Hospital orthodontic departments and specialist orthodontic practices in Manchester and Stockport.Subjects: General dental practitioners and the patients they referred for orthodontic treatment.Main Outcome Measure: Appropriateness of referral, defined as whether the patient was accepted for orthodontic treatment.Results: The referral guidelines did not reduce the number of inappropriate referrals.Conclusions: Referral guidelines for orthodontic referrals did not influence the behaviour of the general dental practitioners. More research into the optimum methods of dissemination and implementation of referral guidelines for use in the general dental service is needed. [ABSTRACT FROM AUTHOR]