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The article discusses the absolute configuration for epoxy alcohols via exciton chirality protocol. It is said that chiral epoxy alcohols are active natural products which is important in the organic synthesis. However, it is mentioned that stereochemistry cannot be assigned until several diastereomers are synthesized. Porphyrin tweezer was used to assign the absolute stereochemistry of chiral organic molecules.

Allene esters are unique not only as excellent electrophiles but also because of their ability for subsequent reactivity after the initial nucleophilic attack. A mechanistically inspired cyclization using ethyl-2,3-butadienoate and acyclic enones to provide dihydropyrans in excellent yields and enantioselectivity under solvent-free conditions at room temperature is reported. [ABSTRACT FROM AUTHOR]

Proteases BACE1 (β-secretases) enzymes have been recognized as a promising target associated with Alzheimer's disease (AD). This study was carried out on the principles of molecular docking, chemical synthesis, and enzymatic inhibition of BACE1 enzymes via biaryl guanidine-based ligands. Based on virtual screening, thirteen different compounds were synthesized and subsequently evaluated via in vitro and in vivo studies. Among them, 1,3-bis(5,6-difluoropyridin-3-yl)guanidine (compound (9)) was found the most potent (I C 50 = 97 ± 0.91 nM) and active to arrest (99%) β-secretase enzymes (FRET assay). Furthermore, it was found to improve the novel object recognition test and Morris water maze test significantly (p < 0.05). Improved pharmacokinetic parameters, viz., Log P o / w (1.76), Log S (-2.73), and better penetration to the brain (BBB permeation) with zero Lipinski violation, made it possible to hit the BACE1 as a potential therapeutic source for AD. [ABSTRACT FROM AUTHOR]

N-Acylated N-chlorohydantoins are shown to be competent chlorenium sources in the (DHQD)2PHAL-mediated asymmetric chlorolactonization. The derivatives demonstrate the exact role of the N1 and N3 chlorine atoms in the parent dichlorohydantoins with the N1 chlorine serving as an inductive activator and the N3 chlorine being delivered to the substrate. The putative associated catalyst/chlorine source complex was experimentally demonstrated through a series of matched/mismatched experiments employing chiral N-chlorinated hydantoins. [ABSTRACT FROM AUTHOR]

• Fluoro-benzimidazole derivatives were synthesized to treat Alzheimer's disease in future. • Newly synthesized compounds were structurally characterized. • Limited structure activity relation (SAR) was studied. • In vitro and in vivo activities performed to check effectiveness against Alzheimer's disease. • In-silico studies were also performed. [ABSTRACT FROM AUTHOR]