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1. Synthesis of tert-Butyl 6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate.

Author

Marvin J. Meyers, Inouk Muizebelt, Jim van Wiltenburg, David L. Brown, and Atli Thorarensen

Subjects
*ORGANIC synthesis, *CARBOXYLIC acids, *HEPTANE, *INTERMEDIATES (Chemistry), *CYCLOBUTANE, *PIPERIDINE
Abstract

Two efficient and scaleable synthetic routes to previously unknown bifunctional tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate are described. This compound and related intermediates described herein are useful for further selective derivation on the azetidine and cyclobutane rings providing a convenient entry point to novel compounds accessing chemical space complementary to piperidine ring systems. [ABSTRACT FROM AUTHOR]

Published
2009
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