Search

It is demonstrated that the photodissociation of oxyhemoglobin in cutaneous blood vessels and capillaries allows additional extraction of molecular oxygen, prevents hypoxia, and stimulates aerobic metabolism of cells. On the basis of the studied phenomena, a new optical technology of local oxygenation of tissue directly in the zone of laser irradiation has been developed. It is shown that the efficiency of the proposed method for laser-induced oxygenation of biotissues is comparable with the efficiency of hyperbaric oxygenation, with local action being an additional advantage. Various aspects of the applications of the new technology in modern medicine in which the elimination of local hypoxia is needed are discussed. The proposed optical method for local oxygenation of biotissues makes it possible to solve the hypoxia problem in malignant tissue and substantially increase the efficiency of photodynamic, radiation, and chemical therapy in modern oncology. [ABSTRACT FROM AUTHOR]

We propose and examine an optical method for eliminating the toxic effect of carbon monoxide. The developed method is based on laser-induced photodissociation of carboxyhemoglobin in blood vessels and capillaries. By numerical simulation of the interaction of laser radiation with tissue, we calculate the spectra of the action of carboxyhemoglobin and oxyhemoglobin in cutaneous blood vessels. We show that, despite the sufficiently strong overlap of the action spectra of carboxyhemoglobin and oxyhemoglobin, the substantial difference in the quantum yield values makes it possible to develop an optical method for eliminating the toxic effect of carbon monoxide. We determine the criteria for the efficiency of laser-induced photodissociation of carboxyhemoglobin under direct action on lung alveoli through the skin tissue and intravenously. [ABSTRACT FROM AUTHOR]

The action spectra of the complex of hemoglobin (Hb) with the ligand CO in cutaneous blood vessels have been determined. It is proposed to use the photodissociation of the HbCO complex for elimination of the poisoning action of the CO gas. [ABSTRACT FROM AUTHOR]